Regulated expression of telomerase activity in human T lymphocyte development and activation

doi:10.1084/jem.183.6.2471

This Article

	Full Text (PDF, 1465K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Weng, N. P.
	Articles by Hodes, R. J.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Weng, N. P.
	Articles by Hodes, R. J.


Social Bookmarking

	What's this?

ARTICLES

Regulated expression of telomerase activity in human T lymphocyte development and activation

NP Weng, BL Levine, CH June and RJ Hodes
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

Telomerase, a ribonucleoprotein that is capable of synthesizing telomeric repeats, is expressed in germline and malignant cells, and is absent in most normal human somatic cells. The selective expression of telomerase has thus been proposed to be a basis for the immortality of the germline and of malignant cells. In the present study, telomerase activity was analyzed in normal human T lymphocytes. It was found that telomerase is expressed at a high level in thymocyte subpopulations, at an intermediate level in tonsil T lymphocytes, and at a low to undetectable level in peripheral blood T lymphocytes. Moreover, telomerase activity is highly inducible in peripheral T lymphocytes by activation through CD3 with or without CD28 costimulation, or by stimulation with phorbol myristate acetate (PMA)/ionomycin. The induction of telomerase by anti-CD3 plus anti-CD28 (anti-CD3/CD28) stimulation required RNA and protein synthesis, and was blocked by herbimycin A, an inhibitor of S pi protein tyrosine kinases. The immunosuppressive drug cyclosporin A selectively inhibited telomerase induction by PMA/ionomycin and by anti-CD3, but not by anti-CD3/CD28. Although telomerase activity in peripheral T lymphocytes was activation dependent and correlated with cell proliferation, it was not cell cycle phase restricted. These results indicate that the expression of telomerase in normal human T lymphocytes is both developmentally regulated and activation induced. Telomerase may thus play a permissive role in T cell development and in determining the capacity of lymphoid cells for cell division and clonal expansion.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Else, T. (2009). Telomeres and telomerase in adrenocortical tissue maintenance, carcinogenesis, and aging. J Mol Endocrinol 43: 131-141 [Abstract] [Full Text]
Fujii, H., Shao, L., Colmegna, I., Goronzy, J. J., Weyand, C. M. (2009). Telomerase insufficiency in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 106: 4360-4365 [Abstract] [Full Text]
Carpenito, C., Milone, M. C., Hassan, R., Simonet, J. C., Lakhal, M., Suhoski, M. M., Varela-Rohena, A., Haines, K. M., Heitjan, D. F., Albelda, S. M., Carroll, R. G., Riley, J. L., Pastan, I., June, C. H. (2009). Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains. Proc. Natl. Acad. Sci. USA 106: 3360-3365 [Abstract] [Full Text]
Hrdlickova, R., Nehyba, J., Bose, H. R. Jr. (2009). Regulation of Telomerase Activity by Interferon Regulatory Factors 4 and 8 in Immune Cells. Mol. Cell. Biol. 29: 929-941 [Abstract] [Full Text]
Lichterfeld, M., Mou, D., Cung, T. D. H., Williams, K. L., Waring, M. T., Huang, J., Pereyra, F., Trocha, A., Freeman, G. J., Rosenberg, E. S., Walker, B. D., Yu, X. G. (2008). Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors. Blood 112: 3679-3687 [Abstract] [Full Text]
Newrzela, S., Cornils, K., Li, Z., Baum, C., Brugman, M. H., Hartmann, M., Meyer, J., Hartmann, S., Hansmann, M.-L., Fehse, B., von Laer, D. (2008). Resistance of mature T cells to oncogene transformation. Blood 112: 2278-2286 [Abstract] [Full Text]
Yamada, O., Ozaki, K., Nakatake, M., Akiyama, M., Kawauchi, K., Matsuoka, R. (2008). Multistep regulation of telomerase during differentiation of HL60 cells. J. Leukoc. Biol. 83: 1240-1248 [Abstract] [Full Text]
Else, T., Giordano, T. J., Hammer, G. D. (2008). Evaluation of Telomere Length Maintenance Mechanisms in Adrenocortical Carcinoma. J. Clin. Endocrinol. Metab. 93: 1442-1449 [Abstract] [Full Text]
Yang, Y., An, J., Weng, N.-p. (2008). Telomerase Is Involved in IL-7-Mediated Differential Survival of Naive and Memory CD4+ T Cells. J. Immunol. 180: 3775-3781 [Abstract] [Full Text]
Joshi, N. S., Kaech, S. M. (2008). Effector CD8 T Cell Development: A Balancing Act between Memory Cell Potential and Terminal Differentiation. J. Immunol. 180: 1309-1315 [Abstract] [Full Text]
Plunkett, F. J., Franzese, O., Finney, H. M., Fletcher, J. M., Belaramani, L. L., Salmon, M., Dokal, I., Webster, D., Lawson, A. D. G., Akbar, A. N. (2007). The Loss of Telomerase Activity in Highly Differentiated CD8+CD28-CD27- T Cells Is Associated with Decreased Akt (Ser473) Phosphorylation. J. Immunol. 178: 7710-7719 [Abstract] [Full Text]
Hsu, C., Jones, S. A., Cohen, C. J., Zheng, Z., Kerstann, K., Zhou, J., Robbins, P. F., Peng, P. D., Shen, X., Gomes, T. J., Dunbar, C. E., Munroe, D. J., Stewart, C., Cornetta, K., Wangsa, D., Ried, T., Rosenberg, S. A., Morgan, R. A. (2007). Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene. Blood 109: 5168-5177 [Abstract] [Full Text]
Akbar, A. N., Vukmanovic-Stejic, M. (2007). Telomerase in T Lymphocytes: Use It and Lose It?. J. Immunol. 178: 6689-6694 [Abstract] [Full Text]
Miyoshi, T., Hirohata, S., Ogawa, H., Doi, M., Obika, M., Yonezawa, T., Sado, Y., Kusachi, S., Kyo, S., Kondo, S., Shiratori, Y., Hudson, B. G., Ninomiya, Y. (2006). Tumor-specific expression of the RGD-{alpha}3(IV)NC1 domain suppresses endothelial tube formation and tumor growth in mice. FASEB J. 20: 1904-1906 [Abstract] [Full Text]
Trapp, S., Parcells, M. S., Kamil, J. P., Schumacher, D., Tischer, B. K., Kumar, P. M., Nair, V. K., Osterrieder, N. (2006). A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesis. JEM 203: 1307-1317 [Abstract] [Full Text]
Zhou, J., Shen, X., Huang, J., Hodes, R. J., Rosenberg, S. A., Robbins, P. F. (2005). Telomere Length of Transferred Lymphocytes Correlates with In Vivo Persistence and Tumor Regression in Melanoma Patients Receiving Cell Transfer Therapy. J. Immunol. 175: 7046-7052 [Abstract] [Full Text]
Roth, A., Baerlocher, G. M., Schertzer, M., Chavez, E., Duhrsen, U., Lansdorp, P. M. (2005). Telomere loss, senescence, and genetic instability in CD4+ T lymphocytes overexpressing hTERT. Blood 106: 43-50 [Abstract] [Full Text]
Kawauchi, K., Ihjima, K., Yamada, O. (2005). IL-2 Increases Human Telomerase Reverse Transcriptase Activity Transcriptionally and Posttranslationally through Phosphatidylinositol 3'-Kinase/Akt, Heat Shock Protein 90, and Mammalian Target of Rapamycin in Transformed NK Cells. J. Immunol. 174: 5261-5269 [Abstract] [Full Text]
Li, Y., Zhi, W., Wareski, P., Weng, N.-p. (2005). IL-15 Activates Telomerase and Minimizes Telomere Loss and May Preserve the Replicative Life Span of Memory CD8+ T Cells In Vitro. J. Immunol. 174: 4019-4024 [Abstract] [Full Text]
Kundra, V., Krane, J. F., Nikolaidis, P., Green, D. S., Zou, K. H., Tuncali, K., vanSonnenberg, E., Silverman, S. G. (2005). Telomerase Activity Predicts Malignancy in Percutaneous Image-guided Needle Biopsy Specimens of the Abdomen and Pelvis. Radiology 234: 941-947 [Abstract] [Full Text]
Matsumura-Arioka, Y., Ohtani, K., Hara, T., Iwanaga, R., Nakamura, M. (2005). Identification of two distinct elements mediating activation of telomerase (hTERT) gene expression in association with cell growth in human T cells. Int Immunol 17: 207-215 [Abstract] [Full Text]
Gimeno, R., Weijer, K., Voordouw, A., Uittenbogaart, C. H., Legrand, N., Alves, N. L., Wijnands, E., Blom, B., Spits, H. (2004). Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- {gamma}c-/- mice: functional inactivation of p53 in developing T cells. Blood 104: 3886-3893 [Abstract] [Full Text]
Hess, K., Yang, Y., Golech, S., Sharov, A., Becker, K. G., Weng, N.-p. (2004). Kinetic assessment of general gene expression changes during human naive CD4+ T cell activation. Int Immunol 16: 1711-1721 [Abstract] [Full Text]
Dagarag, M., Evazyan, T., Rao, N., Effros, R. B. (2004). Genetic Manipulation of Telomerase in HIV-Specific CD8+ T Cells: Enhanced Antiviral Functions Accompany the Increased Proliferative Potential and Telomere Length Stabilization. J. Immunol. 173: 6303-6311 [Abstract] [Full Text]
Sinha-Datta, U., Horikawa, I., Michishita, E., Datta, A., Sigler-Nicot, J. C., Brown, M., Kazanji, M., Barrett, J. C., Nicot, C. (2004). Transcriptional activation of hTERT through the NF-{kappa}B pathway in HTLV-I-transformed cells. Blood 104: 2523-2531 [Abstract] [Full Text]
Reed, J. R., Vukmanovic-Stejic, M., Fletcher, J. M., Soares, M. V. D., Cook, J. E., Orteu, C. H., Jackson, S. E., Birch, K. E., Foster, G. R., Salmon, M., Beverley, P. C.L., Rustin, M. H.A., Akbar, A. N. (2004). Telomere Erosion in Memory T Cells Induced by Telomerase Inhibition at the Site of Antigenic Challenge In Vivo. JEM 199: 1433-1443 [Abstract] [Full Text]
Verra, N. C. V., Jorritsma, A., Weijer, K., Ruizendaal, J. J., Voordouw, A., Weder, P., Hooijberg, E., Schumacher, T. N. M., Haanen, J. B. A. G., Spits, H., Luiten, R. M. (2004). Human Telomerase Reverse Transcriptase-Transduced Human Cytotoxic T Cells Suppress the Growth of Human Melanoma in Immunodeficient Mice. Cancer Res. 64: 2153-2161 [Abstract] [Full Text]
Schroers, R., Shen, L., Rollins, L., Rooney, C. M., Slawin, K., Sonderstrup, G., Huang, X. F., Chen, S.-Y. (2003). Human Telomerase Reverse Transcriptase-Specific T-Helper Responses Induced by Promiscuous Major Histocompatibility Complex Class II-Restricted Epitopes. Clin. Cancer Res. 9: 4743-4755 [Abstract] [Full Text]
Takeda, T., Inaba, H., Yamazaki, M., Kyo, S., Miyamoto, T., Suzuki, S., Ehara, T., Kakizawa, T., Hara, M., DeGroot, L. J., Hashizume, K. (2003). Tumor-Specific Gene Therapy for Undifferentiated Thyroid Carcinoma Utilizing the Telomerase Reverse Transcriptase Promoter. J. Clin. Endocrinol. Metab. 88: 3531-3538 [Abstract] [Full Text]
Kurosaka, D., Yasuda, J., Yoshida, K., Yokoyama, T., Ozawa, Y., Obayashi, Y., Kingetsu, I., Saito, S., Yamada, A. (2003). Telomerase activity and telomere length of peripheral blood mononuclear cells in SLE patients. Lupus 12: 591-599 [Abstract]
Roth, A., Yssel, H., Pene, J., Chavez, E. A., Schertzer, M., Lansdorp, P. M., Spits, H., Luiten, R. M. (2003). Telomerase levels control the lifespan of human T lymphocytes. Blood 102: 849-857 [Abstract] [Full Text]
Dagarag, M., Ng, H., Lubong, R., Effros, R. B., Yang, O. O. (2003). Differential Impairment of Lytic and Cytokine Functions in Senescent Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes. J. Virol. 77: 3077-3083 [Abstract] [Full Text]
Gorbunova, V., Seluanov, A., Pereira-Smith, O. M. (2003). Evidence That High Telomerase Activity May Induce a Senescent-like Growth Arrest in Human Fibroblasts. J. Biol. Chem. 278: 7692-7698 [Abstract] [Full Text]
Hathcock, K. S., Kaech, S. M., Ahmed, R., Hodes, R. J. (2003). Induction of Telomerase Activity and Maintenance of Telomere Length in Virus-Specific Effector and Memory CD8+ T Cells. J. Immunol. 170: 147-152 [Abstract] [Full Text]
Allsopp, R. C., Cheshier, S., Weissman, I. L. (2002). Telomerase Activation and Rejuvenation of Telomere Length in Stimulated T Cells Derived from Serially Transplanted Hematopoietic Stem Cells. JEM 196: 1427-1433 [Abstract] [Full Text]
Schroers, R., Huang, X. F., Hammer, J., Zhang, J., Chen, S.-Y. (2002). Identification of HLA DR7-restricted Epitopes from Human Telomerase Reverse Transcriptase Recognized by CD4+ T-Helper Cells. Cancer Res. 62: 2600-2605 [Abstract] [Full Text]
Liu, K., Catalfamo, M., Li, Y., Henkart, P. A., Weng, N.-p. (2002). IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells. Proc. Natl. Acad. Sci. USA 99: 6192-6197 [Abstract] [Full Text]
Weng, N.-p. (2001). Interplay between telomere length and telomerase in human leukocyte differentiation and aging. J. Leukoc. Biol. 70: 861-867 [Abstract] [Full Text]
KUROSAKA, D, OZAWA, Y, YASUDA, J, YOKOYAMA, T, YAMADA, A, AKIYAMA, M, SAITO, S, TAJIMA, N (2001). Telomerase activity in peripheral blood mononuclear cells from patients with SLE. Ann Rheum Dis 60: 1158-1159 [Full Text]
Komata, T., Kondo, Y., Kanzawa, T., Hirohata, S., Koga, S., Sumiyoshi, H., Srinivasula, S. M., Barna, B. P., Germano, I. M., Takakura, M., Inoue, M., Alnemri, E. S., Shay, J. W., Kyo, S., Kondo, S. (2001). Treatment of Malignant Glioma Cells with the Transfer of Constitutively Active Caspase-6 Using the Human Telomerase Catalytic Subunit (Human Telomerase Reverse Transcriptase) Gene Promoter. Cancer Res. 61: 5796-5802 [Abstract] [Full Text]
Lin, Z., Lim, S., Viani, M. A., Sapp, M., Lim, M. S. (2001). Down-Regulation of Telomerase Activity in Malignant Lymphomas by Radiation and Chemotherapeutic Agents. Am. J. Pathol. 159: 711-719 [Abstract] [Full Text]
Rufer, N., Migliaccio, M., Antonchuk, J., Humphries, R. K., Roosnek, E., Lansdorp, P. M. (2001). Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential. Blood 98: 597-603 [Abstract] [Full Text]
Liu, K., Li, Y., Prabhu, V., Young, L., Becker, K. G., Munson, P. J., Weng, N.-p. (2001). Augmentation in Expression of Activation-Induced Genes Differentiates Memory from Naive CD4+ T Cells and Is a Molecular Mechanism for Enhanced Cellular Response of Memory CD4+ T Cells. J. Immunol. 166: 7335-7344 [Abstract] [Full Text]
Chaves-Dias, C., Hundley, T. R., Gilfillan, A. M., Kirshenbaum, A. S., Cunha-Melo, J. R., Metcalfe, D. D., Beaven, M. A. (2001). Induction of Telomerase Activity During Development of Human Mast Cells from Peripheral Blood CD34+ Cells: Comparisons with Tumor Mast-Cell Lines. J. Immunol. 166: 6647-6656 [Abstract] [Full Text]
Liu, K., Hodes, R. J., Weng, N.-p. (2001). Cutting Edge: Telomerase Activation in Human T Lymphocytes Does Not Require Increase in Telomerase Reverse Transcriptase (hTERT) Protein But Is Associated with hTERT Phosphorylation and Nuclear Translocation. J. Immunol. 166: 4826-4830 [Abstract] [Full Text]
Rufer, N., Brummendorf, T. H., Chapuis, B., Helg, C., Lansdorp, P. M., Roosnek, E. (2001). Accelerated telomere shortening in hematological lineages is limited to the first year following stem cell transplantation. Blood 97: 575-577 [Abstract] [Full Text]
Migliaccio, M., Amacker, M., Just, T., Reichenbach, P., Valmori, D., Cerottini, J.-C., Romero, P., Nabholz, M. (2000). Ectopic Human Telomerase Catalytic Subunit Expression Maintains Telomere Length But Is Not Sufficient for CD8+ T Lymphocyte Immortalization. J. Immunol. 165: 4978-4984 [Abstract] [Full Text]
Hooijberg, E., Ruizendaal, J. J., Snijders, P. J. F., Kueter, E. W. M., Walboomers, J. M. M., Spits, H. (2000). Immortalization of Human CD8+ T Cell Clones by Ectopic Expression of Telomerase Reverse Transcriptase. J. Immunol. 165: 4239-4245 [Abstract] [Full Text]
Wu, K., Higashi, N., Hansen, E. R., Lund, M., Bang, K., Thestrup-Pedersen, K. (2000). Telomerase Activity Is Increased and Telomere Length Shortened in T Cells from Blood of Patients with Atopic Dermatitis and Psoriasis. J. Immunol. 165: 4742-4747 [Abstract] [Full Text]
Son, N. H., Murray, S., Yanovski, J., Hodes, R. J., Weng, N.-p. (2000). Lineage-Specific Telomere Shortening and Unaltered Capacity for Telomerase Expression in Human T and B Lymphocytes with Age. J. Immunol. 165: 1191-1196 [Abstract] [Full Text]
Sun, W., Kang, K.-S., Morita, I., Trosko, J. E., Chang, C.-C. (1999). High Susceptibility of a Human Breast Epithelial Cell Type with Stem Cell Characteristics to Telomerase Activation and Immortalization. Cancer Res. 59: 6118-6123 [Abstract] [Full Text]
Tangkijvanich, P., Tresukosol, D., Sampatanukul, P., Sakdikul, S., Voravud, N., Mahachai, V., Mutirangura, A. (1999). Telomerase Assay for Differentiating between Malignancy-related and Nonmalignant Ascites. Clin. Cancer Res. 5: 2470-2475 [Abstract] [Full Text]
Tamura, K., Liu, H., Takahashi, H. (1999). Auxin Induction of Cell Cycle Regulated Activity of Tobacco Telomerase. J. Biol. Chem. 274: 20997-21002 [Abstract] [Full Text]
Rufer, N., Brummendorf, T. H., Kolvraa, S., Bischoff, C., Christensen, K., Wadsworth, L., Schulzer, M., Lansdorp, P. M. (1999). Telomere Fluorescence Measurements in Granulocytes and T Lymphocyte Subsets Point to a High Turnover of Hematopoietic Stem Cells and Memory T Cells in Early Childhood. JEM 190: 157-168 [Abstract] [Full Text]
Soria, J.-C., Gauthier, L. R., Raymond, E., Granotier, C., Morat, L., Armand, J.-P., Boussin, F. D., Sabatier, L. (1999). Molecular Detection of Telomerase-positive Circulating Epithelial Cells in Metastatic Breast Cancer Patients. Clin. Cancer Res. 5: 971-975 [Abstract] [Full Text]
Liu, K., Schoonmaker, M. M., Levine, B. L., June, C. H., Hodes, R. J., Weng, N.-p. (1999). Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes. Proc. Natl. Acad. Sci. USA 96: 5147-5152 [Abstract] [Full Text]
Maini, M. K., Soares, M. V. D., Zilch, C. F., Akbar, A. N., Beverley, P. C. L. (1999). Virus-Induced CD8+ T Cell Clonal Expansion Is Associated with Telomerase Up-Regulation and Telomere Length Preservation: A Mechanism for Rescue from Replicative Senescence. J. Immunol. 162: 4521-4526 [Abstract] [Full Text]
Zhu, J., Wang, H., Bishop, J. M., Blackburn, E. H. (1999). Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc. Natl. Acad. Sci. USA 96: 3723-3728 [Abstract] [Full Text]
Wolthers, K. C., Otto, S. A., Wisman, G. B. A., Fleury, S., Reiss, P., ten Kate, R. W., van der Zee, A. G.J., Miedema, F. (1999). Normal T-Cell Telomerase Activity and Upregulation in Human Immunodeficiency Virus-1 Infection. Blood 93: 1011-1019 [Abstract] [Full Text]
Vieira, M., Soares, D., Borthwick, N. J., Maini, M. K., Janossy, G., Salmon, M., Akbar, A. N. (1998). IL-7-Dependent Extrathymic Expansion of CD45RA+ T Cells Enables Preservation of a Naive Repertoire. J. Immunol. 161: 5909-5917 [Abstract] [Full Text]
Hathcock, K. S., Weng, N.-p., Merica, R., Jenkins, M. K., Hodes, R. (1998). Cutting Edge: Antigen-Dependent Regulation of Telomerase Activity in Murine T Cells. J. Immunol. 160: 5702-5706 [Abstract] [Full Text]
De Boer, R. J., Noest, A. J. (1998). T Cell Renewal Rates, Telomerase, and Telomere Length Shortening. J. Immunol. 160: 5832-5837 [Abstract] [Full Text]
Yui, J., Chiu, C.-P., Lansdorp, P. M. (1998). Telomerase Activity in Candidate Stem Cells From Fetal Liver and Adult Bone Marrow. Blood 91: 3255-3262 [Abstract] [Full Text]
Greider, C. W. (1998). Telomerase activity, cell proliferation, and�cancer. Proc. Natl. Acad. Sci. USA 95: 90-92 [Full Text]
Sidransky, D. (1997). Nucleic Acid-Based Methods for the Detection of Cancer. Science 278: 1054-1058 [Abstract] [Full Text]
Weng, N.-p., Granger, L., Hodes, R. J. (1997). Telomere lengthening and telomerase activation during human B cell�differentiation. Proc. Natl. Acad. Sci. USA 94: 10827-10832 [Abstract] [Full Text]
Li, H., Zhao, L.-L., Funder, J. W., Liu, J.-P. (1997). Protein Phosphatase 2A Inhibits Nuclear Telomerase Activity in Human Breast Cancer Cells. J. Biol. Chem. 272: 16729-16732 [Abstract] [Full Text]
Palmer, L. D., Weng, N.-p., Levine, B. L., June, C. H., Lane, H. C., Hodes, R. J. (1997). Telomere Length, Telomerase Activity, and Replicative Potential in HIV Infection: Analysis of CD4+ and CD8+T Cells from HIV-discordant Monozygotic Twins. JEM 185: 1381-1386 [Abstract] [Full Text]
Wolthers, K. C., Wisman, G. B. A., Otto, S. A., de Roda Husman, A.-M., Schaft, N., de Wolf, F., Goudsmit, J., Coutinho, R. A., van der Zee, A. G. J., Meyaard, L., Miedema, F. (1996). T Cell Telomere Length in HIV-1 Infection: No Evidence for Increased CD4+ T Cell Turnover. Science 274: 1543-1547 [Abstract] [Full Text]
Liu, K., Catalfamo, M., Li, Y., Henkart, P. A., Weng, N.-p. (2002). IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells. Proc. Natl. Acad. Sci. USA 99: 6192-6197 [Abstract] [Full Text]