Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils

doi:10.1084/jem.183.6.2437

This Article

	Full Text (PDF, 1530K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Ponath, P. D.
	Articles by Mackay, C. R.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Ponath, P. D.
	Articles by Mackay, C. R.


Social Bookmarking

	What's this?

ARTICLES

Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils

PD Ponath, S Qin, TW Post, J Wang, L Wu, NP Gerard, W Newman, C Gerard and CR Mackay
LeukoSite, Inc., Cambridge, Massachusetts 02142, USA.

The chemokine eotaxin is unusual in that it appears to be a highly specific chemoattractant for eosinophils. Ligand-binding studies with radiolabeled eotaxin demonstrated a receptor on eosinophils distinct from the known chemokine receptors CKR-1 and -2. The distinct eotaxin binding site on human eosinophils also bound RANTES (regulated on activation T expressed and secreted) and monocyte chemotactic protein (MCP)3. We have now isolated a cDNA from eosinophils, termed CKR-3, with significant sequence similarity to other well characterized chemokine receptors. Cells transfected with CKR-3 cDNA bound radiolabeled eotaxin specifically and with high affinity, comparable to the binding affinity observed with eosinophils. This receptor also bound RANTES and MCP-3 with high affinity, but not other CC or CXC chemokines. Furthermore, receptor transfectants generated in a murine B cell lymphoma cell line migrated in transwell chemotaxis assays to eotaxin, RANTES, and MCP-3, but not to any other chemokines. A monoclonal antibody recognizing CKR-3 was used to show that eosinophils, but not other leukocyte types, expressed this receptor. This pattern of expression was confirmed by Northern blot with RNA from highly purified leukocyte subsets. The restricted expression of CKR-3 on eosinophils and the fidelity of eotaxin binding to CKR-3, provides a potential mechanism for the selective recruitment and migration of eosinophils within tissues.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Mason, A. B., Hoh, J. (2009). CCR3: Shedding New Light on a Dark Problem?. J Mol Cell Biol 1: 17-19 [Abstract] [Full Text]
Barth, M. C., Ahluwalia, N., Anderson, T. J. T., Hardy, G. J., Sinha, S., Alvarez-Cardona, J. A., Pruitt, I. E., Rhee, E. P., Colvin, R. A., Gerszten, R. E. (2009). Kynurenic Acid Triggers Firm Arrest of Leukocytes to Vascular Endothelium under Flow Conditions. J. Biol. Chem. 284: 19189-19195 [Abstract] [Full Text]
Zabel, B. A., Nakae, S., Zuniga, L., Kim, J.-Y., Ohyama, T., Alt, C., Pan, J., Suto, H., Soler, D., Allen, S. J., Handel, T. M., Song, C. H., Galli, S. J., Butcher, E. C. (2008). Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis. JEM 205: 2207-2220 [Abstract] [Full Text]
Poh, T. Y., Pease, J., Young, J. R., Bumstead, N., Kaiser, P. (2008). Re-evaluation of Chicken CXCR1 Determines the True Gene Structure: CXCLi1 (K60) AND CXCLi2 (CAF/INTERLEUKIN-8) ARE LIGANDS FOR THIS RECEPTOR. J. Biol. Chem. 283: 16408-16415 [Abstract] [Full Text]
Liu, J., Louie, S., Hsu, W., Yu, K. M., Nicholas, H. B. Jr., Rosenquist, G. L. (2008). Tyrosine Sulfation Is Prevalent in Human Chemokine Receptors Important in Lung Disease. Am. J. Respir. Cell Mol. Bio. 38: 738-743 [Abstract] [Full Text]
Su, Y.-C., Rolph, M. S., Hansbro, N. G., Mackay, C. R., Sewell, W. A. (2008). Granulocyte-Macrophage Colony-Stimulating Factor Is Required for Bronchial Eosinophilia in a Murine Model of Allergic Airway Inflammation. J. Immunol. 180: 2600-2607 [Abstract] [Full Text]
Gaertner, H., Lebeau, O., Borlat, I., Cerini, F., Dufour, B., Kuenzi, G., Melotti, A., Fish, R. J., Offord, R., Springael, J.-Y., Parmentier, M., Hartley, O. (2008). Highly potent HIV inhibition: engineering a key anti-HIV structure from PSC-RANTES into MIP-1{beta}/CCL4. Protein Eng Des Sel 21: 65-72 [Abstract] [Full Text]
Wise, E. L., Duchesnes, C., da Fonseca, P. C. A., Allen, R. A., Williams, T. J., Pease, J. E. (2007). Small Molecule Receptor Agonists and Antagonists of CCR3 Provide Insight into Mechanisms of Chemokine Receptor Activation. J. Biol. Chem. 282: 27935-27943 [Abstract] [Full Text]
Ellyard, J. I., Simson, L., Bezos, A., Johnston, K., Freeman, C., Parish, C. R. (2007). Eotaxin Selectively Binds Heparin: AN INTERACTION THAT PROTECTS EOTAXIN FROM PROTEOLYSIS AND POTENTIATES CHEMOTACTIC ACTIVITY IN VIVO. J. Biol. Chem. 282: 15238-15247 [Abstract] [Full Text]
Whitehead, G. S., Wang, T., DeGraff, L. M., Card, J. W., Lira, S. A., Graham, G. J., Cook, D. N. (2007). The Chemokine Receptor D6 Has Opposing Effects on Allergic Inflammation and Airway Reactivity. Am. J. Respir. Crit. Care Med. 175: 243-249 [Abstract] [Full Text]
Wegmann, M., Goggel, R., Sel, S., Sel, S., Erb, K. J., Kalkbrenner, F., Renz, H., Garn, H. (2007). Effects of a Low-Molecular-Weight CCR-3 Antagonist on Chronic Experimental Asthma. Am. J. Respir. Cell Mol. Bio. 36: 61-67 [Abstract] [Full Text]
Gays, F., Aust, J. G., Reid, D. M., Falconer, J., Toyama-Sorimachi, N., Taylor, P. R., Brooks, C. G. (2006). Ly49B Is Expressed on Multiple Subpopulations of Myeloid Cells. J. Immunol. 177: 5840-5851 [Abstract] [Full Text]
Das, A. M., Vaddi, K. G., Solomon, K. A., Krauthauser, C., Jiang, X., McIntyre, K. W., Yang, X. X., Wadman, E., Welch, P., Covington, M., Graden, D., Yeleswaram, K., Trzaskos, J. M., Newton, R. C., Mandlekar, S., Ko, S. S., Carter, P. H., Davies, P. (2006). Selective Inhibition of Eosinophil Influx into the Lung by Small Molecule CC Chemokine Receptor 3 Antagonists in Mouse Models of Allergic Inflammation. J. Pharmacol. Exp. Ther. 318: 411-417 [Abstract] [Full Text]
Huaux, F., Gharaee-Kermani, M., Liu, T., Morel, V., McGarry, B., Ullenbruch, M., Kunkel, S. L., Wang, J., Xing, Z., Phan, S. H. (2005). Role of Eotaxin-1 (CCL11) and CC Chemokine Receptor 3 (CCR3) in Bleomycin-Induced Lung Injury and Fibrosis. Am. J. Pathol. 167: 1485-1496 [Abstract] [Full Text]
Min, J.-W., Jang, A.-S., Park, S.-M., Lee, S.-H., Lee, J.-H., Park, S.-W., Park, C.-S. (2005). Comparison of Plasma Eotaxin Family Level in Aspirin-Induced and Aspirin-Tolerant Asthma Patients. Chest 128: 3127-3132 [Abstract] [Full Text]
Kobayashi, Y., Ueki, S., Mahemuti, G., Chiba, T., Oyamada, H., Saito, N., Kanda, A., Kayaba, H., Chihara, J. (2005). Physiological Levels of 15-Deoxy-{Delta}12,14-Prostaglandin J2 Prime Eotaxin-Induced Chemotaxis on Human Eosinophils through Peroxisome Proliferator-Activated Receptor-{gamma} Ligation. J. Immunol. 175: 5744-5750 [Abstract] [Full Text]
Chou, D. L., Daugherty, B. L., McKenna, E. K., Hsu, W. M., Tyler, N. K., Plopper, C. G., Hyde, D. M., Schelegle, E. S., Gershwin, L. J., Miller, L. A. (2005). Chronic Aeroallergen during Infancy Enhances Eotaxin-3 Expression in Airway Epithelium and Nerves. Am. J. Respir. Cell Mol. Bio. 33: 1-8 [Abstract] [Full Text]
Chang, H. S., Kim, J. S., Lee, J. H., Cho, J. I., Rhim, T. Y., Uh, S.-T., Park, B. L., Chung, I. Y., Park, C.-S., Shin, H. D. (2005). A Single Nucleotide Polymorphism on the Promoter of eotaxin1 Associates with Its mRNA Expression and Asthma Phenotypes. J. Immunol. 174: 1525-1531 [Abstract] [Full Text]
Zabel, B. A., Silverio, A. M., Butcher, E. C. (2005). Chemokine-Like Receptor 1 Expression and Chemerin-Directed Chemotaxis Distinguish Plasmacytoid from Myeloid Dendritic Cells in Human Blood. J. Immunol. 174: 244-251 [Abstract] [Full Text]
Forssmann, U., Hartung, I., Balder, R., Fuchs, B., Escher, S. E., Spodsberg, N., Dulkys, Y., Walden, M., Heitland, A., Braun, A., Forssmann, W.-G., Elsner, J. (2004). n-Nonanoyl-CC Chemokine Ligand 14, a Potent CC Chemokine Ligand 14 Analogue That Prevents the Recruitment of Eosinophils in Allergic Airway Inflammation. J. Immunol. 173: 3456-3466 [Abstract] [Full Text]
Chtanova, T., Tangye, S. G., Newton, R., Frank, N., Hodge, M. R., Rolph, M. S., Mackay, C. R. (2004). T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells. J. Immunol. 173: 68-78 [Abstract] [Full Text]
Petkovic, V., Moghini, C., Paoletti, S., Uguccioni, M., Gerber, B. (2004). Eotaxin-3/CCL26 Is a Natural Antagonist for CC Chemokine Receptors 1 and 5: A HUMAN CHEMOKINE WITH A REGULATORY ROLE. J. Biol. Chem. 279: 23357-23363 [Abstract] [Full Text]
Bumbacea, D, Scheerens, J, Mann, B S, Stirling, R G, Chung, K F (2004). Failure of sputum eosinophilia after eotaxin inhalation in asthma. Thorax 59: 372-375 [Abstract] [Full Text]
Schraufstatter, I., Takamori, H., Sikora, L., Sriramarao, P., DiScipio, R. G. (2004). Eosinophils and monocytes produce pulmonary and activation-regulated chemokine, which activates cultured monocytes/macrophages. Am. J. Physiol. Lung Cell. Mol. Physiol. 286: L494-L501 [Abstract] [Full Text]
Ogilvie, P., Paoletti, S., Clark-Lewis, I., Uguccioni, M. (2003). Eotaxin-3 is a natural antagonist for CCR2 and exerts a repulsive effect on human monocytes. Blood 102: 789-794 [Abstract] [Full Text]
Warrior, U., Mckeegan, E. M., Rottinghaus, S. M., Garcia, L., Traphagen, L., Grayson, G., Komater, V., McNally, T., Helfrich, R., Harris, R. R., Bell, R. L., Burns, D. J. (2003). Identification and Characterization of Novel Antagonists of the CCR3 Receptor. J Biomol Screen 8: 324-331 [Abstract]
Shin, H. D., Kim, L. H., Park, B. L., Jung, J. H., Kim, J. Y., Chung, I.-Y., Kim, J. S., Lee, J. H., Chung, S. H., Kim, Y. H., Park, H.-S., Choi, J. H., Lee, Y. M., Park, S. W., Choi, B. W., Hong, S.-J., Park, C.-S. (2003). Association of Eotaxin gene family with asthma and serum total IgE. Hum Mol Genet 12: 1279-1285 [Abstract] [Full Text]
Price, K. S., Friend, D. S., Mellor, E. A., De Jesus, N., Watts, G. F. M., Boyce, J. A. (2003). CC Chemokine Receptor 3 Mobilizes to the Surface of Human Mast Cells and Potentiates Immunoglobulin E-Dependent Generation of Interleukin 13. Am. J. Respir. Cell Mol. Bio. 28: 420-427 [Abstract] [Full Text]
Kleinhans, M., Tun-Kyi, A., Gilliet, M., Kadin, M. E., Dummer, R., Burg, G., Nestle, F. O. (2003). Functional expression of the eotaxin receptor CCR3 in CD30+ cutaneous T-cell lymphoma. Blood 101: 1487-1493 [Abstract] [Full Text]
Lamkhioued, B., Abdelilah, S. G., Hamid, Q., Mansour, N., Delespesse, G., Renzi, P. M. (2003). The CCR3 Receptor Is Involved in Eosinophil Differentiation and Is Up-Regulated by Th2 Cytokines in CD34+ Progenitor Cells. J. Immunol. 170: 537-547 [Abstract] [Full Text]
Shinkai, A., Komuta-Kunitomo, M., Sato-Nakamura, N., Anazawa, H. (2002). N-terminal domain of eotaxin-3 is important for activation of CC chemokine receptor 3. Protein Eng Des Sel 15: 923-929 [Abstract] [Full Text]
Beaulieu, S., Robbiani, D. F., Du, X., Rodrigues, E., Ignatius, R., Wei, Y., Ponath, P., Young, J. W., Pope, M., Steinman, R. M., Mojsov, S. (2002). Expression of a Functional Eotaxin (CC Chemokine Ligand 11) Receptor CCR3 by Human Dendritic Cells. J. Immunol. 169: 2925-2936 [Abstract] [Full Text]
Zhang, L., Soares, M. P., Guan, Y., Matheravidathu, S., Wnek, R., Johnson, K. E., Meisher, A., Iliff, S. A., Mudgett, J. S., Springer, M. S., Daugherty, B. L. (2002). Functional Expression and Characterization of Macaque C-C Chemokine Receptor 3 (CCR3) and Generation of Potent Antagonistic Anti-macaque CCR3 Monoclonal Antibodies. J. Biol. Chem. 277: 33799-33810 [Abstract] [Full Text]
Shen, H., O'Byrne, P. M., Ellis, R., Wattie, J., Tang, C., Inman, M. D. (2002). The Effects of Intranasal Budesonide on Allergen-induced Production of Interleukin-5 and Eotaxin, Airways, Blood, and Bone Marrow Eosinophilia, and Eosinophil Progenitor Expansion in Sensitized Mice. Am. J. Respir. Crit. Care Med. 166: 146-153 [Abstract] [Full Text]
Lucchinetti, C. F., Mandler, R. N., McGavern, D., Bruck, W., Gleich, G., Ransohoff, R. M., Trebst, C., Weinshenker, B., Wingerchuk, D., Parisi, J. E., Lassmann, H. (2002). A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica. Brain 125: 1450-1461 [Abstract] [Full Text]
Bryan, S. A., Jose, P. J., Topping, J. R., Wilhelm, R., Soderberg, C., Kertesz, D., Barnes, P. J., Williams, T. J., Hansel, T. T., Sabroe, I. (2002). Responses of Leukocytes to Chemokines in Whole Blood and Their Antagonism by Novel CC-Chemokine Receptor 3 Antagonists. Am. J. Respir. Crit. Care Med. 165: 1602-1609 [Abstract] [Full Text]
Borchers, M. T., Ansay, T., DeSalle, R., Daugherty, B. L., Shen, H., Metzger, M., Lee, N. A., Lee, J. J. (2002). In vitro assessment of chemokine receptor-ligand interactions mediating mouse eosinophil migration. J. Leukoc. Biol. 71: 1033-1041 [Abstract] [Full Text]
Gurish, M. F., Humbles, A., Tao, H., Finkelstein, S., Boyce, J. A., Gerard, C., Friend, D. S., Austen, K. F. (2002). CCR3 Is Required for Tissue Eosinophilia and Larval Cytotoxicity After Infection with Trichinella spiralis. J. Immunol. 168: 5730-5736 [Abstract] [Full Text]
Jopling, L. A., Sabroe, I., Andrew, D. P., Mitchell, T. J., Li, Y., Hodge, M. R., Williams, T. J., Pease, J. E. (2002). The Identification, Characterization, and Distribution of Guinea Pig CCR4 and Epitope Mapping of a Blocking Antibody. J. Biol. Chem. 277: 6864-6873 [Abstract] [Full Text]
Watanabe, K., Jose, P. J., Rankin, S. M. (2002). Eotaxin-2 Generation Is Differentially Regulated by Lipopolysaccharide and IL-4 in Monocytes and Macrophages. J. Immunol. 168: 1911-1918 [Abstract] [Full Text]
Sabroe, I., Lloyd, C.M., Whyte, M.K.B., Dower, S.K., Williams, T.J., Pease, J.E. (2002). Chemokines, innate and adaptive immunity, and respiratory disease. Eur Respir J 19: 350-355 [Abstract] [Full Text]
Lilly, C. M., Daugherty, B. L. (2001). A Novel LPS-Inducible CCR3 Activator . Why So Many CCR3 Ligands?. Am. J. Respir. Cell Mol. Bio. 25: 673-675 [Full Text]
Penido, C., Castro-Faria-Neto, H. C., Vieira-de-Abreu, A., Figueiredo, R. T., Pelled, A., Martins, M. A., Jose, P. J., Williams, T. J., Bozza, P. T. (2001). LPS Induces Eosinophil Migration via CCR3 Signaling Through a Mechanism Independent of RANTES and Eotaxin. Am. J. Respir. Cell Mol. Bio. 25: 707-716 [Abstract] [Full Text]
Martinelli, R., Sabroe, I., LaRosa, G., Williams, T. J., Pease, J. E. (2001). The CC Chemokine Eotaxin (CCL11) Is a Partial Agonist of CC Chemokine Receptor 2b. J. Biol. Chem. 276: 42957-42964 [Abstract] [Full Text]
Nakamura, H., Luster, A. D., Tateno, H., Jedrzkiewicz, S., Tamura, G., Haley, K. J., Garcia-Zepeda, E. A., Yamaguchi, K., Lilly, C. M. (2001). IL-4 differentially regulates eotaxin and MCP-4 in lung epithelium and circulating mononuclear cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 281: L1288-L1302 [Abstract] [Full Text]
El-Asrar, A. M A., Struyf, S., Al-Mosallam, A. A, Missotten, L., Van Damme, J., Geboes, K. (2001). Expression of chemokine receptors in vernal keratoconjunctivitis. Br J Ophthalmol 85: 1357-1361 [Abstract] [Full Text]
Gouon-Evans, V., Pollard, J. W. (2001). Eotaxin Is Required for Eosinophil Homing into the Stroma of the Pubertal and Cycling Uterus. Endocrinology 142: 4515-4521 [Abstract] [Full Text]
Hoeck, J., Woisetschlager, M. (2001). Activation of Eotaxin-3/CCL26 Gene Expression in Human Dermal Fibroblasts Is Mediated by STAT6. J. Immunol. 167: 3216-3222 [Abstract] [Full Text]
Dulkys, Y., Kluthe, C., Buschermohle, T., Barg, I., Kno{beta}, S., Kapp, A., Proudfoot, A. E. I., Elsner, J. (2001). IL-3 Induces Down-Regulation of CCR3 Protein and mRNA in Human Eosinophils. J. Immunol. 167: 3443-3453 [Abstract] [Full Text]
TERADA, N., HAMANO, N., KIM, W. J., HIRAI, K., NAKAJIMA, T., YAMADA, H., KAWASAKI, H., YAMASHITA, T., KISHI, H., NOMURA, T., NUMATA, T., YOSHIE, O., KONNO, A. (2001). The Kinetics of Allergen-induced Eotaxin Level in Nasal Lavage Fluid . Its Key Role in Eosinophil Recruitment in Nasal Mucosa. Am. J. Respir. Crit. Care Med. 164: 575-579 [Abstract] [Full Text]
Ensminger, S. M., Spriewald, B. M., Sorensen, H. V., Witzke, O., Flashman, E. G., Bushell, A., Morris, P. J., Rose, M. L., Rahemtulla, A., Wood, K. J. (2001). Critical Role for IL-4 in the Development of Transplant Arteriosclerosis in the Absence of CD40-CD154 Costimulation. J. Immunol. 167: 532-541 [Abstract] [Full Text]
Berkman, N., Ohnona, S., Chung, F. K., Breuer, R. (2001). Eotaxin-3 but Not Eotaxin Gene Expression Is Upregulated in Asthmatics 24 Hours after Allergen Challenge. Am. J. Respir. Cell Mol. Bio. 24: 682-687 [Abstract] [Full Text]
Drake, P. M., Gunn, M. D., Charo, I. F., Tsou, C.-L., Zhou, Y., Huang, L., Fisher, S. J. (2001). Human Placental Cytotrophoblasts Attract Monocytes and Cd56bright Natural Killer Cells via the Actions of Monocyte Inflammatory Protein 1{alpha}. JEM 193: 1199-1212 [Abstract] [Full Text]
Ferland, C., Guilbert, M., Davoine, F., Flamand, N., Chakir, J., Laviolette, M. (2001). Eotaxin promotes eosinophil transmigration via the activation of the plasminogen-plasmin system. J. Leukoc. Biol. 69: 772-778 [Abstract] [Full Text]
Wilbanks, A., Zondlo, S. C., Murphy, K., Mak, S., Soler, D., Langdon, P., Andrew, D. P., Wu, L., Briskin, M. (2001). Expression Cloning of the STRL33/BONZO/TYMSTR Ligand Reveals Elements of CC, CXC, and CX3C Chemokines. J. Immunol. 166: 5145-5154 [Abstract] [Full Text]
Hoeck, J., Woisetschlager, M. (2001). STAT6 Mediates Eotaxin-1 Expression in IL-4 or TNF-{{alpha}}-Induced Fibroblasts. J. Immunol. 166: 4507-4515 [Abstract] [Full Text]
Qiu, B., Frait, K. A., Reich, F., Komuniecki, E., Chensue, S. W. (2001). Chemokine Expression Dynamics in Mycobacterial (Type-1) and Schistosomal (Type-2) Antigen-Elicited Pulmonary Granuloma Formation. Am. J. Pathol. 158: 1503-1515 [Abstract] [Full Text]
Ogilvie, P., Bardi, G., Clark-Lewis, I., Baggiolini, M., Uguccioni, M. (2001). Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5. Blood 97: 1920-1924 [Abstract] [Full Text]
Buri, C., Korner, M., Scharli, P., Cefai, D., Uguccioni, M., Mueller, C., Laissue, J. A., Mazzucchelli, L. (2001). CC chemokines and the receptors CCR3 and CCR5 are differentially expressed in the nonneoplastic leukocytic infiltrates of Hodgkin disease. Blood 97: 1543-1548 [Abstract] [Full Text]
Weber, C., Weber, K. S. C., Klier, C., Gu, S., Wank, R., Horuk, R., Nelson, P. J. (2001). Specialized roles of the chemokine receptors CCR1 and CCR5 in the recruitment of monocytes and TH1-like/CD45RO+ T cells. Blood 97: 1144-1146 [Abstract] [Full Text]
Chernock, R. D., Cherla, R. P., Ganju, R. K. (2001). SHP2 and cbl participate in {alpha}-chemokine receptor CXCR4-mediated signaling pathways. Blood 97: 608-615 [Abstract] [Full Text]
Fukunaga, K., Asano, K., Mao, X-Q., Gao, P-S., Roberts, M.H., Oguma, T., Shiomi, T., Kanazawa, M., Adra, C.N., Shirakawa, T., Hopkin, J.M., Yamaguchi, K. (2001). Genetic polymorphisms of CC chemokine receptor 3 in Japanese and British asthmatics. Eur Respir J 17: 59-63 [Abstract] [Full Text]
Andrew, D. P., Ruffing, N., Kim, C. H., Miao, W., Heath, H., Li, Y., Murphy, K., Campbell, J. J., Butcher, E. C., Wu, L. (2001). C-C Chemokine Receptor 4 Expression Defines a Major Subset of Circulating Nonintestinal Memory T Cells of Both Th1 and Th2 Potential. J. Immunol. 166: 103-111 [Abstract] [Full Text]
de Paulis, A., De Palma, R., Di Gioia, L., Carfora, M., Prevete, N., Tosi, G., Accolla, R. S., Marone, G. (2000). Tat Protein Is an HIV-1-Encoded {beta}-Chemokine Homolog That Promotes Migration and Up-Regulates CCR3 Expression on Human Fc{epsilon}RI+ Cells. J. Immunol. 165: 7171-7179 [Abstract] [Full Text]
Heinemann, A., Hartnell, A., Stubbs, V. E. L., Murakami, K., Soler, D., LaRosa, G., Askenase, P. W., Williams, T. J., Sabroe, I. (2000). Basophil Responses to Chemokines Are Regulated by Both Sequential and Cooperative Receptor Signaling. J. Immunol. 165: 7224-7233 [Abstract] [Full Text]
Nanki, T., Lipsky, P. E. (2000). Lack of correlation between chemokine receptor and Th1/Th2 cytokine expression by individual memory T cells. Int Immunol 12: 1659-1667 [Abstract] [Full Text]
Nanki, T., Hayashida, K., El-Gabalawy, H. S., Suson, S., Shi, K., Girschick, H. J., Yavuz, S., Lipsky, P. E. (2000). Stromal Cell-Derived Factor-1-CXC Chemokine Receptor 4 Interactions Play a Central Role in CD4+ T Cell Accumulation in Rheumatoid Arthritis Synovium. J. Immunol. 165: 6590-6598 [Abstract] [Full Text]
El-Asrar, A. M A., Struyf, S., Al-Kharashi, S. A, Missotten, L., Van Damme, J., Geboes, K. (2000). Chemokines in the limbal form of vernal keratoconjunctivitis. Br J Ophthalmol 84: 1360-1366 [Abstract] [Full Text]
Zimmermann, N., Hogan, S. P., Mishra, A., Brandt, E. B., Bodette, T. R., Pope, S. M., Finkelman, F. D., Rothenberg, M. E. (2000). Murine Eotaxin-2: A Constitutive Eosinophil Chemokine Induced by Allergen Challenge and IL-4 Overexpression. J. Immunol. 165: 5839-5846 [Abstract] [Full Text]
SINIGAGLIA, F., D'AMBROSIO, D. (2000). Regulation of Helper T Cell Differentiation and Recruitment in Airway Inflammation. Am. J. Respir. Crit. Care Med. 162: S157-160 [Abstract] [Full Text]
Zimmermann, N., Daugherty, B. L., Kavanaugh, J. L., El-Awar, F. Y., Moulton, E. A., Rothenberg, M. E. (2000). Analysis of the CC chemokine receptor 3 gene reveals a complex 5' exon organization, a functional role for untranslated exon 1, and a broadly active promoter with eosinophil-selective elements. Blood 96: 2346-2354 [Abstract] [Full Text]
Pan, J., Kunkel, E. J., Gosslar, U., Lazarus, N., Langdon, P., Broadwell, K., Vierra, M. A., Genovese, M. C., Butcher, E. C., Soler, D. (2000). Cutting Edge: A Novel Chemokine Ligand for CCR10 And CCR3 Expressed by Epithelial Cells in Mucosal Tissues. J. Immunol. 165: 2943-2949 [Abstract] [Full Text]
Gonzalo, J.-A., Lloyd, C. M., Peled, A., Delaney, T., Coyle, A. J., Gutierrez-Ramos, J.-C. (2000). Critical Involvement of the Chemotactic Axis CXCR4/Stromal Cell-Derived Factor-1{alpha} in the Inflammatory Component of Allergic Airway Disease. J. Immunol. 165: 499-508 [Abstract] [Full Text]
FUKUYAMA, S., INOUE, H., AIZAWA, H., OIKE, M., KITAURA, M., YOSHIE, O., HARA, N. (2000). Effect of Eotaxin and Platelet-activating Factor on Airway Inflammation and Hyperresponsiveness in Guinea Pigs in Vivo. Am. J. Respir. Crit. Care Med. 161: 1844-1849 [Abstract] [Full Text]
Schweickart, V. L., Epp, A., Raport, C. J., Gray, P. W. (2000). CCR11 Is a Functional Receptor for the Monocyte Chemoattractant Protein Family of Chemokines. J. Biol. Chem. 275: 9550-9556 [Abstract] [Full Text]
Kampen, G. T., Stafford, S., Adachi, T., Jinquan, T., Quan, S., Grant, J. A., Skov, P. S., Poulsen, L. K., Alam, R. (2000). Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases. Blood 95: 1911-1917 [Abstract] [Full Text]
Elsner, J., Mack, M., Bruhl, H., Dulkys, Y., Kimmig, D., Simmons, G., Clapham, P. R., Schlondorff, D., Kapp, A., Wells, T. N. C., Proudfoot, A. E. I. (2000). Differential Activation of CC Chemokine Receptors by AOP-RANTES. J. Biol. Chem. 275: 7787-7794 [Abstract] [Full Text]
Stine, J. T., Wood, C., Hill, M., Epp, A., Raport, C. J., Schweickart, V. L., Endo, Y., Sasaki, T., Simmons, G., Boshoff, C., Clapham, P., Chang, Y., Moore, P., Gray, P. W., Chantry, D. (2000). KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells. Blood 95: 1151-1157 [Abstract] [Full Text]
Zhang, J., Lathbury, L. J., Salamonsen, L. A. (2000). Expression of the Chemokine Eotaxin and Its Receptor, CCR3, in Human Endometrium. Biol. Reprod. 62: 404-411 [Abstract] [Full Text]
Nibbs, R. J. B., Salcedo, T. W., Campbell, J. D. M., Yao, X.-T., Li, Y., Nardelli, B., Olsen, H. S., Morris, T. S., Proudfoot, A. E. I., Patel, V. P., Graham, G. J. (2000). C-C Chemokine Receptor 3 Antagonism by the {beta}-Chemokine Macrophage Inflammatory Protein 4, a Property Strongly Enhanced by an Amino-Terminal Alanine-Methionine Swap. J. Immunol. 164: 1488-1497 [Abstract] [Full Text]
Lloyd, C. M., Delaney, T., Nguyen, T., Tian, J., Martinez-A, C., Coyle, A. J., Gutierrez-Ramos, J.-C. (2000). Cc Chemokine Receptor (Ccr)3/Eotaxin Is Followed by Ccr4/Monocyte-Derived Chemokine in Mediating Pulmonary T Helper Lymphocyte Type 2 Recruitment after Serial Antigen Challenge in Vivo. JEM 191: 265-274 [Abstract] [Full Text]
Zimmermann, N., Daugherty, B. L., Stark, J. M., Rothenberg, M. E. (2000). Molecular Analysis of CCR-3 Events in Eosinophilic Cells. J. Immunol. 164: 1055-1064 [Abstract] [Full Text]
Burns, J. M., Lewis, G. K., DeVico, A. L. (1999). Soluble complexes of regulated upon activation, normal T cells expressed and secreted (RANTES) and glycosaminoglycans suppress HIV-1 infection but do not induce Ca2+ signaling. Proc. Natl. Acad. Sci. USA 96: 14499-14504 [Abstract] [Full Text]
Camarda, G., Spinetti, G., Bernardini, G., Mair, C., Davis-Poynter, N., Capogrossi, M. C., Napolitano, M. (1999). The Equine Herpesvirus 2 E1 Open Reading Frame Encodes a Functional Chemokine Receptor. J. Virol. 73: 9843-9848 [Abstract] [Full Text]
Proudfoot, A. E. I., Buser, R., Borlat, F., Alouani, S., Soler, D., Offord, R. E., Schroder, J.-M., Power, C. A., Wells, T. N. C. (1999). Amino-terminally Modified RANTES Analogues Demonstrate Differential Effects on RANTES Receptors. J. Biol. Chem. 274: 32478-32485 [Abstract] [Full Text]
Zabel, B. A., Agace, W. W., Campbell, J. J., Heath, H. M., Parent, D., Roberts, A. I., Ebert, E. C., Kassam, N., Qin, S., Zovko, M., LaRosa, G. J., Yang, L.-L., Soler, D., Butcher, E. C., Ponath, P. D., Parker, C. M., Andrew, D. P. (1999). Human G Protein-Coupled Receptor Gpr-9-6/Cc Chemokine Receptor 9 Is Selectively Expressed on Intestinal Homing T Lymphocytes, Mucosal Lymphocytes, and Thymocytes and Is Required for Thymus-Expressed Chemokine-Mediated Chemotaxis. JEM 190: 1241-1256 [Abstract] [Full Text]
Pype, J. L., Dupont, L. J., Menten, P., Van Coillie, E., Opdenakker, G., Van Damme, J., Fan Chung, K., Demedts, M. G., Verleden, G. M. (1999). Expression of Monocyte Chemotactic Protein (MCP)-1, MCP-2, and MCP-3 by Human Airway Smooth-Muscle Cells . Modulation by Corticosteroids and T-Helper 2 Cytokines. Am. J. Respir. Cell Mol. Bio. 21: 528-536 [Abstract] [Full Text]
Ying, S., Robinson, D. S., Meng, Q., Barata, L. T., McEuen, A. R., Buckley, M. G., Walls, A. F., Askenase, P. W., Kay, A. B. (1999). C-C Chemokines in Allergen-Induced Late-Phase Cutaneous Responses in Atopic Subjects: Association of Eotaxin with Early 6-Hour Eosinophils, and of Eotaxin-2 and Monocyte Chemoattractant Protein-4 with the Later 24-Hour Tissue Eosinophilia, and Relationship to Basophils and Other C-C Chemokines (Monocyte Chemoattractant Protein-3 and RANTES). J. Immunol. 163: 3976-3984 [Abstract] [Full Text]
Romagnani, P., De Paulis, A., Beltrame, C., Annunziato, F., Dente, V., Maggi, E., Romagnani, S., Marone, G. (1999). Tryptase-Chymase Double-Positive Human Mast Cells Express the Eotaxin Receptor CCR3 and Are Attracted by CCR3-Binding Chemokines. Am. J. Pathol. 155: 1195-1204 [Abstract] [Full Text]
Kitaura, M., Suzuki, N., Imai, T., Takagi, S., Suzuki, R., Nakajima, T., Hirai, K., Nomiyama, H., Yoshie, O. (1999). Molecular Cloning of a Novel Human CC Chemokine (Eotaxin-3) That Is a Functional Ligand of CC Chemokine Receptor 3. J. Biol. Chem. 274: 27975-27980 [Abstract] [Full Text]
Jundt, F., Anagnostopoulos, I., Bommert, K., Emmerich, F., Muller, G., Foss, H.-D., Royer, H.-D., Stein, H., Dorken, B. (1999). Hodgkin/Reed-Sternberg Cells Induce Fibroblasts to Secrete Eotaxin, a Potent Chemoattractant for T Cells and Eosinophils. Blood 94: 2065-2071 [Abstract] [Full Text]
Rothenberg, M. E. (1999). Eotaxin . An Essential Mediator of Eosinophil Trafficking into Mucosal Tissues. Am. J. Respir. Cell Mol. Bio. 21: 291-295 [Full Text]
Han, S. J., Kim, J. H., Noh, Y. J., Chang, H. S., Kim, C. S., Kim, K.-S., Ki, S. Y., Park, C. S., Chung, I. Y. (1999). Interleukin (IL)-5 Downregulates Tumor Necrosis Factor (TNF)-Induced Eotaxin Messenger RNA (mRNA) Expression in Eosinophils . Induction of Eotaxin mRNA by TNF and IL-5 in Eosinophils. Am. J. Respir. Cell Mol. Bio. 21: 303-310 [Abstract] [Full Text]
Chung, K F, Barnes, P J (1999). Cytokines in asthma. Thorax 54: 825-857 [Full Text]
Devouassoux, G., Metcalfe, D. D., Prussin, C. (1999). Eotaxin Potentiates Antigen-Dependent Basophil IL-4 Production. J. Immunol. 163: 2877-2882 [Abstract] [Full Text]
Jahnsen, F. L., Haye, R., Gran, E., Brandtzaeg, P., Johansen, F.-E. (1999). Glucocorticosteroids Inhibit mRNA Expression for Eotaxin, Eotaxin-2, and Monocyte-Chemotactic Protein-4 in Human Airway Inflammation with Eosinophilia. J. Immunol. 163: 1545-1551 [Abstract] [Full Text]
Shinkai, A., Yoshisue, H., Koike, M., Shoji, E., Nakagawa, S., Saito, A., Takeda, T., Imabeppu, S., Kato, Y., Hanai, N., Anazawa, H., Kuga, T., Nishi, T. (1999). A Novel Human CC Chemokine, Eotaxin-3, Which Is Expressed in IL-4-Stimulated Vascular Endothelial Cells, Exhibits Potent Activity Toward Eosinophils. J. Immunol. 163: 1602-1610 [Abstract] [Full Text]