Spontaneously increased production of nitric oxide and aberrant expression of the inducible nitric oxide synthase in vivo in the transforming growth factor beta 1 null mouse

doi:10.1084/jem.183.5.2337

This Article

	Full Text (PDF, 1469K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Vodovotz, Y.
	Articles by Roberts, A. B.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Vodovotz, Y.
	Articles by Roberts, A. B.


Social Bookmarking

	What's this?

ARTICLES

Spontaneously increased production of nitric oxide and aberrant expression of the inducible nitric oxide synthase in vivo in the transforming growth factor beta 1 null mouse

Y Vodovotz, AG Geiser, L Chesler, JJ Letterio, A Campbell, MS Lucia, MB Sporn and AB Roberts
Laboratory of Chemoprevention, National Institutes of Health, Bethesda, Maryland 20892, USA.

Transforming growth factor beta 1 null mice (TGF-beta 1-/-) suffer from multifocal inflammation and die by 3-4 wk of age. In these mice, levels of nitric oxide (NO) reaction products in serum are elevated approximately fourfold over levels in controls, peaking at 15-17 d of life. Shortterm treatment of TGF-beta 1-/- mice with NG-monomethyl-L- arginine suppressed this elevated production of NO. Expression of inducible NO synthase (iNOS) mRNA and protein is increased in the kidney and heart of TGF-beta 1-/- mice. These findings demonstrate that TGF-beta 1 negatively regulates iNOS expression in vivo, as had been inferred from mechanistic studies on the control of iNOS expression by TGF-beta 1 in vitro.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Broadbelt, N. V., Chen, J., Silver, R. B., Poppas, D. P., Felsen, D. (2009). Pressure activates epidermal growth factor receptor leading to the induction of iNOS via NF{kappa}B and STAT3 in human proximal tubule cells. Am. J. Physiol. Renal Physiol. 297: F114-F124 [Abstract] [Full Text]
Somers, J. R., Beck, P. L., Lees-Miller, J. P., Roach, D., Li, Y., Guo, J., Loken, S., Zhan, S., Semeniuk, L., Duff, H. J. (2008). iNOS in cardiac myocytes plays a critical role in death in a murine model of hypertrophy induced by calcineurin. Am. J. Physiol. Heart Circ. Physiol. 295: H1122-H1131 [Abstract] [Full Text]
Hong, S., Lee, C., Kim, S.-J. (2007). Smad7 Sensitizes Tumor Necrosis Factor Induced Apoptosis through the Inhibition of Antiapoptotic Gene Expression by Suppressing Activation of the Nuclear Factor-{kappa}B Pathway. Cancer Res. 67: 9577-9583 [Abstract] [Full Text]
Vyas-Read, S., Shaul, P. W., Yuhanna, I. S., Willis, B. C. (2007). Nitric oxide attenuates epithelial-mesenchymal transition in alveolar epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 293: L212-L221 [Abstract] [Full Text]
Piotrkowski, B., Fraga, C. G., de Cavanagh, E. M. V. (2007). Mitochondrial function and nitric oxide metabolism are modified by enalapril treatment in rat kidney. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292: R1494-R1501 [Abstract] [Full Text]
Takaki, H., Minoda, Y., Koga, K., Takaesu, G., Yoshimura, A., Kobayashi, T. (2006). TGF-beta1 suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation.. GENES CELLS 11: 871-882 [Abstract] [Full Text]
Saura, M., Zaragoza, C., Herranz, B., Griera, M., Diez-Marques, L., Rodriguez-Puyol, D., Rodriguez-Puyol, M. (2005). Nitric Oxide Regulates Transforming Growth Factor-{beta} Signaling in Endothelial Cells. Circ. Res. 97: 1115-1123 [Abstract] [Full Text]
McCartney-Francis, N., Jin, W., Wahl, S. M. (2004). Aberrant Toll Receptor Expression and Endotoxin Hypersensitivity in Mice Lacking a Functional TGF-{beta}1 Signaling Pathway. J. Immunol. 172: 3814-3821 [Abstract] [Full Text]
Xiao, C., Shim, J.-h., Kluppel, M., Zhang, S. S.-M., Dong, C., Flavell, R. A., Fu, X.-Y., Wrana, J. L., Hogan, B. L.M., Ghosh, S. (2003). Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev. 17: 2933-2949 [Abstract] [Full Text]
Comalada, M., Cardo, M., Xaus, J., Valledor, A. F., Lloberas, J., Ventura, F., Celada, A. (2003). Decorin Reverses the Repressive Effect of Autocrine-Produced TGF-{beta} on Mouse Macrophage Activation. J. Immunol. 170: 4450-4456 [Abstract] [Full Text]
McCartney-Francis, N. L., Wahl, S. M. (2002). Dysregulation of IFN-{gamma} Signaling Pathways in the Absence of TGF-{beta}1. J. Immunol. 169: 5941-5947 [Abstract] [Full Text]
Flanagan, D. M., Jennings, C. D., Goes, S. W., Caywood, B. E., Gross, R., Kaplan, A. M., Bryson, J. S. (2002). Nitric oxide participates in the intestinal pathology associated with murine syngeneic graft-versus-host disease. J. Leukoc. Biol. 72: 762-768 [Abstract] [Full Text]
Shah, A. H., Tabayoyong, W. B., Kimm, S. Y., Kim, S.-J., van Parijs, L., Lee, C. (2002). Reconstitution of Lethally Irradiated Adult Mice with Dominant Negative TGF-{beta} Type II Receptor-Transduced Bone Marrow Leads to Myeloid Expansion and Inflammatory Disease. J. Immunol. 169: 3485-3491 [Abstract] [Full Text]
Kelley, T. J., Elmer, H. L., Corey, D. A. (2001). Reduced Smad3 Protein Expression and Altered Transforming Growth Factor-beta 1-Mediated Signaling in Cystic Fibrosis Epithelial Cells. Am. J. Respir. Cell Mol. Bio. 25: 732-738 [Abstract] [Full Text]
Wort, S. J., Mitchell, J. A., Evans, T. W. (2001). Inducible nitric oxide synthase: a tissue-specific affair?. Am. J. Physiol. Lung Cell. Mol. Physiol. 280: L387-L389 [Full Text]
Rutschman, R., Lang, R., Hesse, M., Ihle, J. N., Wynn, T. A., Murray, P. J. (2001). Cutting Edge: Stat6-Dependent Substrate Depletion Regulates Nitric Oxide Production. J. Immunol. 166: 2173-2177 [Abstract] [Full Text]
Streit, J. A., Recker, T. J., Filho, F. G., Beverley, S. M., Wilson, M. E. (2001). Protective Immunity Against the Protozoan Leishmania chagasi Is Induced by Subclinical Cutaneous Infection with Virulent But Not Avirulent Organisms. J. Immunol. 166: 1921-1929 [Abstract] [Full Text]
Bitzer, M., von Gersdorff, G., Liang, D., Dominguez-Rosales, A., Beg, A. A., Rojkind, M., Böttinger, E. P. (2000). A mechanism of suppression of TGF-beta /SMAD signaling by NF-kappa B/RelA. Genes Dev. 14: 187-197 [Abstract] [Full Text]
Chin, S. Y., Pandey, K. N., Shi, S.-J., Kobori, H., Moreno, C., Navar, L. G. (1999). Increased activity and expression of Ca2+-dependent NOS in renal cortex of ANG II-infused hypertensive rats. Am. J. Physiol. Renal Physiol. 277: F797-F804 [Abstract] [Full Text]
Zeller, J. C., Panoskaltsis-Mortari, A., Murphy, W. J., Ruscetti, F. W., Narula, S., Roncarolo, M. G., Blazar, B. R. (1999). Induction of CD4+ T Cell Alloantigen-Specific Hyporesponsiveness by IL-10 and TGF-{beta}. J. Immunol. 163: 3684-3691 [Abstract] [Full Text]
Murray, P. J., Young, R. A. (1999). Increased Antimycobacterial Immunity in Interleukin-10-Deficient Mice. Infect. Immun. 67: 3087-3095 [Abstract] [Full Text]
KELLY, F. J., ANDERSON, S., THOMPSON, M. M., OYAMA, T. T., KENNEFICK, T. M., CORLESS, C. L., ROMAN, R. J., KURTZBERG, L., PRATT, B. M., LEDBETTER, S. R. (1999). Acute and Chronic Renal Effects of Recombinant Human TGF-{beta}2 in the Rat. J. Am. Soc. Nephrol. 10: 1264-1273 [Abstract] [Full Text]
Valdivielso, J. M., Perez-Barriocanal, F., Garcia-Estan, J., Lopez-Novoa, J. M. (1999). Role of nitric oxide in the early renal hemodynamic response after unilateral nephrectomy. Am. J. Physiol. Regul. Integr. Comp. Physiol. 276: R1718-R1723 [Abstract] [Full Text]
Lagadec, P., Raynal, S., Lieubeau, B., Onier, N., Arnould, L., Saint-Giorgio, V., Lawrence, D. A., Jeannin, J.-F. (1999). Evidence for Control of Nitric Oxide Synthesis by Intracellular Transforming Growth Factor-�1 in Tumor Cells : Implications for Tumor Development. Am. J. Pathol. 154: 1867-1876 [Abstract] [Full Text]
Vodovotz, Y., Chesler, L., Chong, H., Kim, S.-J., Simpson, J. T., DeGraff, W., Cox, G. W., Roberts, A. B., Wink, D. A., Barcellos-Hoff, M. H. (1999). Regulation of Transforming Growth Factor {beta}1 by Nitric Oxide. Cancer Res. 59: 2142-2149 [Abstract] [Full Text]
Wilson, M. E., Young, B. M., Davidson, B. L., Mente, K. A., McGowan, S. E. (1998). The Importance of TGF-{beta} in Murine Visceral Leishmaniasis. J. Immunol. 161: 6148-6155 [Abstract] [Full Text]
Gorham, J. D., Guler, M. L., Fenoglio, D., Gubler, U., Murphy, K. M. (1998). Low Dose TGF-{beta} Attenuates IL-12 Responsiveness in Murine Th Cells. J. Immunol. 161: 1664-1670 [Abstract] [Full Text]
Bingisser, R. M., Tilbrook, P. A., Holt, P. G., Kees, U. R. (1998). Macrophage-Derived Nitric Oxide Regulates T Cell Activation via Reversible Disruption of the Jak3/STAT5 Signaling Pathway. J. Immunol. 160: 5729-5734 [Abstract] [Full Text]
Borkowski, T. A., Letterio, J. J., Farr, A. G., Udey, M. C. (1996). A Role for Endogenous Transforming Growth Factor {beta}1 in Langerhans Cell Biology: The Skin of Transforming Growth Factor {beta}1 Null Mice Is Devoid of Epidermal Langerhans Cells. JEM 184: 2417-2422 [Abstract] [Full Text]