Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis

doi:10.1084/jem.183.5.2293

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Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis

S Nicholson, G Bonecini-Almeida M da, JR Lapa e Silva, C Nathan, QW Xie, R Mumford, JR Weidner, J Calaycay, J Geng and N Boechat
Beatrice and Samuel A. Seaver Laboratory, Division of Hematology- Oncology Cornell University Medical College, New York 10021, USA.

The high-output pathway of nitric oxide production helps protect mice from infection by several pathogens, including Mycobacterium tuberculosis. However, based on studies of cells cultured from blood, it is controversial whether human mononuclear phagocytes can express the corresponding inducible nitric oxide synthase (iNOS;NOS2). The present study examined alveolar macrophages fixed directly after bronchopulmonary lavage. An average of 65% of the macrophages from 11 of 11 patients with untreated, culture-positive pulmonary tuberculosis reacted with an antibody documented herein to be monospecific for human NOS2. In contrast, a mean of 10% of bronchoalveolar lavage cells were positive from each of five clinically normal subjects. Tuberculosis patients' macrophages displayed diaphorase activity in the same proportion that they stained for NOS2, under assay conditions wherein the diaphorase reaction was strictly dependent on NOS2 expression. Bronchoalveolar lavage specimens also contained NOS2 mRNA. Thus, macrophages in the lungs of people with clinically active Mycobacterium tuberculosis infection often express catalytically competent NOS2.
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Fang, F. C., Nathan, C. F. (2007). Man is not a mouse: reply. J. Leukoc. Biol. 81: 580-580 [Full Text]
Pereira-Suarez, A. L., Estrada-Chavez, C., Arriaga-Diaz, C., Espinosa-Cueto, P., Mancilla, R. (2006). Coexpression of NRAMP1, iNOS, and Nitrotyrosine in Bovine Tuberculosis.. Vet Pathol 43: 709-717 [Abstract] [Full Text]
Carranza, C., Juarez, E., Torres, M., Ellner, J. J., Sada, E., Schwander, S. K. (2006). Mycobacterium tuberculosis Growth Control by Lung Macrophages and CD8 Cells from Patient Contacts. Am. J. Respir. Crit. Care Med. 173: 238-245 [Abstract] [Full Text]
Yuhas, Y., Berent, E., Ovadiah, H., Azoulay, I., Ashkenazi, S. (2006). Rifampin Augments Cytokine-Induced Nitric Oxide Production in Human Alveolar Epithelial Cells. Antimicrob. Agents Chemother. 50: 396-398 [Abstract] [Full Text]
Smith, I., Nathan, C., Peavy, H. H. (2005). Progress and New Directions in Genetics of Tuberculosis: An NHLBI Working Group Report. Am. J. Respir. Crit. Care Med. 172: 1491-1496 [Abstract] [Full Text]
Nathan, C., Calingasan, N., Nezezon, J., Ding, A., Lucia, M. S., La Perle, K., Fuortes, M., Lin, M., Ehrt, S., Kwon, N. S., Chen, J., Vodovotz, Y., Kipiani, K., Beal, M. F. (2005). Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase. JEM 202: 1163-1169 [Abstract] [Full Text]
Stenger, S (2005). Immunological control of tuberculosis: role of tumour necrosis factor and more. Ann Rheum Dis 64: iv24-iv28 [Abstract] [Full Text]
Chan, G. C., Fish, J. E., Mawji, I. A., Leung, D. D., Rachlis, A. C., Marsden, P. A. (2005). Epigenetic Basis for the Transcriptional Hyporesponsiveness of the Human Inducible Nitric Oxide Synthase Gene in Vascular Endothelial Cells. J. Immunol. 175: 3846-3861 [Abstract] [Full Text]
Schluger, N. W. (2005). The Pathogenesis of Tuberculosis: The First One Hundred (and Twenty-Three) Years. Am. J. Respir. Cell Mol. Bio. 32: 251-256 [Full Text]
Akerstrom, S., Mousavi-Jazi, M., Klingstrom, J., Leijon, M., Lundkvist, A., Mirazimi, A. (2005). Nitric Oxide Inhibits the Replication Cycle of Severe Acute Respiratory Syndrome Coronavirus. J. Virol. 79: 1966-1969 [Abstract] [Full Text]
Wickremasinghe, M. I., Thomas, L. H., O'Kane, C. M., Uddin, J., Friedland, J. S. (2004). Transcriptional Mechanisms Regulating Alveolar Epithelial Cell-specific CCL5 Secretion in Pulmonary Tuberculosis. J. Biol. Chem. 279: 27199-27210 [Abstract] [Full Text]
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Botha, T., Ryffel, B. (2003). Reactivation of Latent Tuberculosis Infection in TNF-Deficient Mice. J. Immunol. 171: 3110-3118 [Abstract] [Full Text]
Smith, I. (2003). Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence. Clin. Microbiol. Rev. 16: 463-496 [Abstract] [Full Text]
Schon, T., Elias, D., Moges, F., Melese, E., Tessema, T., Stendahl, O., Britton, S., Sundqvist, T. (2003). Arginine as an adjuvant to chemotherapy improves clinical outcome in active tuberculosis. Eur Respir J 21: 483-488 [Abstract] [Full Text]
Morris, K. R., Lutz, R. D., Choi, H.-S., Kamitani, T., Chmura, K., Chan, E. D. (2003). Role of the NF-{kappa}B Signaling Pathway and {kappa}B cis-Regulatory Elements on the IRF-1 and iNOS Promoter Regions in Mycobacterial Lipoarabinomannan Induction of Nitric Oxide. Infect. Immun. 71: 1442-1452 [Abstract] [Full Text]
Lang, J. D., McArdle, P. J., O'Reilly, P. J., Matalon, S. (2002). Oxidant-Antioxidant Balance in Acute Lung Injury. Chest 122 : 314S-320S [Abstract] [Full Text]
Qadoumi, M., Becker, I., Donhauser, N., Rollinghoff, M., Bogdan, C. (2002). Expression of Inducible Nitric Oxide Synthase in Skin Lesions of Patients with American Cutaneous Leishmaniasis. Infect. Immun. 70: 4638-4642 [Abstract] [Full Text]
Nathan, C. (2002). Inducible Nitric Oxide Synthase in the Tuberculous Human Lung. Am. J. Respir. Crit. Care Med. 166: 130-131 [Full Text]
Choi, H.-S., Rai, P. R., Chu, H. W., Cool, C., Chan, E. D. (2002). Analysis of Nitric Oxide Synthase and Nitrotyrosine Expression in Human Pulmonary Tuberculosis. Am. J. Respir. Crit. Care Med. 166: 178-186 [Abstract] [Full Text]
Firmani, M. A., Riley, L. W. (2002). Mycobacterium tuberculosis CDC1551 Is Resistant to Reactive Nitrogen and Oxygen Intermediates In Vitro. Infect. Immun. 70: 3965-3968 [Abstract] [Full Text]
Fang, F. C., Vazquez-Torres, A. (2002). Nitric oxide production by human macrophages: there's NO doubt about it. Am. J. Physiol. Lung Cell. Mol. Physiol. 282: L941-L943 [Full Text]
van Crevel, R., Ottenhoff, T. H. M., van der Meer, J. W. M. (2002). Innate Immunity to Mycobacterium tuberculosis. Clin. Microbiol. Rev. 15: 294-309 [Abstract] [Full Text]
Pechkovsky, D.V., Zissel, G., Stamme, C., Goldmann, T., Ari Jaffe, H., Einhaus, M., Taube, C., Magnussen, H., Schlaak, M., Muller-Quernheim, J. (2002). Human alveolar epithelial cells induce nitric oxide synthase-2 expression in alveolar macrophages. Eur Respir J 19: 672-683 [Abstract] [Full Text]
Portales-Perez, D. P., Baranda, L., Layseca, E., Fierro, N. A., de la Fuente, H., Rosenstein, Y., Gonzalez-Amaro, R. (2002). Comparative and Prospective Study of Different Immune Parameters in Healthy Subjects at Risk for Tuberculosis and in Tuberculosis Patients. CVI 9: 299-307 [Abstract] [Full Text]
Pfister, H., Remer, K. A., Brcic, M., Fatzer, R., Christen, S., Leib, S., Jungi, T. W. (2002). Inducible Nitric Oxide Synthase and Nitrotyrosine in Listeric Encephalitis: A Cross-species Study in Ruminants. Vet Pathol 39: 190-199 [Abstract] [Full Text]
Hart, M. H. (2002). Plasma Nitrate May Be a Marker for Infectious Diarrhea. AAP Grand Rounds 7: 18-18 [Full Text]
Waters, W. R., Nonnecke, B. J., Rahner, T. E., Palmer, M. V., Whipple, D. L., Horst, R. L. (2001). Modulation of Mycobacterium bovis-Specific Responses of Bovine Peripheral Blood Mononuclear Cells by 1,25-Dihydroxyvitamin D3. CVI 8: 1204-1212 [Abstract] [Full Text]
Chan, E. D., Chan, J., Schluger, N. W. (2001). What is the Role of Nitric Oxide in Murine and Human Host Defense against Tuberculosis? . Current Knowledge. Am. J. Respir. Cell Mol. Bio. 25: 606-612 [Abstract] [Full Text]
Springer, B., Master, S., Sander, P., Zahrt, T., McFalone, M., Song, J., Papavinasasundaram, K. G., Colston, M. J., Boettger, E., Deretic, V. (2001). Silencing of Oxidative Stress Response in Mycobacterium tuberculosis: Expression Patterns of ahpC in Virulent and Avirulent Strains and Effect of ahpC Inactivation. Infect. Immun. 69: 5967-5973 [Abstract] [Full Text]
Gantt, K. R., Goldman, T. L., McCormick, M. L., Miller, M. A., Jeronimo, S. M. B., Nascimento, E. T., Britigan, B. E., Wilson, M. E. (2001). Oxidative Responses of Human and Murine Macrophages During Phagocytosis of Leishmania chagasi. J. Immunol. 167: 893-901 [Abstract] [Full Text]
Uetani, K., Thomassen, M. J., Erzurum, S. C. (2001). Nitric oxide synthase 2 through an autocrine loop via respiratory epithelial cell-derived mediator. Am. J. Physiol. Lung Cell. Mol. Physiol. 280: L1179-L1188 [Abstract] [Full Text]
Boechat, N., Bouchonnet, F., Bonay, M., Grodet, A., Pelicic, V., Gicquel, B., Hance, A. J. (2001). Culture at High Density Improves the Ability of Human Macrophages to Control Mycobacterial Growth. J. Immunol. 166: 6203-6211 [Abstract] [Full Text]
Chan, E. D., Morris, K. R., Belisle, J. T., Hill, P., Remigio, L. K., Brennan, P. J., Riches, D. W. H. (2001). Induction of Inducible Nitric Oxide Synthase-NO{middle dot} by Lipoarabinomannan of Mycobacterium tuberculosis Is Mediated by MEK1-ERK, MKK7-JNK, and NF-{kappa}B Signaling Pathways. Infect. Immun. 69: 2001-2010 [Abstract] [Full Text]
Rook, G.A.W., Seah, G., Ustianowski, A. (2001). M. tuberculosis: immunology and vaccination. Eur Respir J 17: 537-557 [Abstract] [Full Text]
Thoma-Uszynski, S., Stenger, S., Takeuchi, O., Ochoa, M. T., Engele, M., Sieling, P. A., Barnes, P. F., Rollinghoff, M., Bolcskei, P. L., Wagner, M., Akira, S., Norgard, M. V., Belisle, J. T., Godowski, P. J., Bloom, B. R., Modlin, R. L. (2001). Induction of Direct Antimicrobial Activity Through Mammalian Toll-Like Receptors. Science 291: 1544-1547 [Abstract] [Full Text]
Mogues, T., Goodrich, M. E., Ryan, L., LaCourse, R., North, R. J. (2001). The Relative Importance of T Cell Subsets in Immunity and Immunopathology of Airborne Mycobacterium tuberculosis Infection in Mice. JEM 193: 271-280 [Abstract] [Full Text]
SITTIPUNT, C., STEINBERG, K. P., RUZINSKI, J. T., MYLES, C., ZHU, S., GOODMAN, R. B., HUDSON, L. D., MATALON, S., MARTIN, T. R. (2001). Nitric Oxide and Nitrotyrosine in the Lungs of Patients with Acute Respiratory Distress Syndrome. Am. J. Respir. Crit. Care Med. 163: 503-510 [Abstract] [Full Text]
Melby, P. C., Chandrasekar, B., Zhao, W., Coe, J. E. (2001). The Hamster as a Model of Human Visceral Leishmaniasis: Progressive Disease and Impaired Generation of Nitric Oxide in the Face of a Prominent Th1-Like Cytokine Response. J. Immunol. 166: 1912-1920 [Abstract] [Full Text]
Feng, H.-M., Walker, D. H. (2000). Mechanisms of Intracellular Killing of Rickettsia conorii in Infected Human Endothelial Cells, Hepatocytes, and Macrophages. Infect. Immun. 68: 6729-6736 [Abstract] [Full Text]
Nathan, C., Shiloh, M. U. (2000). Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proc. Natl. Acad. Sci. USA 97: 8841-8848 [Abstract] [Full Text]
Uetani, K., Der, S. D., Zamanian-Daryoush, M., de la Motte, C., Lieberman, B. Y., Williams, B. R. G., Erzurum, S. C. (2000). Central Role of Double-Stranded RNA-Activated Protein Kinase in Microbial Induction of Nitric Oxide Synthase. J. Immunol. 165: 988-996 [Abstract] [Full Text]
Guo, F. H., Comhair, S. A. A., Zheng, S., Dweik, R. A., Eissa, N. T., Thomassen, M. J., Calhoun, W., Erzurum, S. C. (2000). Molecular Mechanisms of Increased Nitric Oxide (NO) in Asthma: Evidence for Transcriptional and Post-Translational Regulation of NO Synthesis. J. Immunol. 164: 5970-5980 [Abstract] [Full Text]
Tian, Y., Xing, Y., Magliozzo, R., Yu, K., Bloom, B. R., Chan, J. (2000). A Commercial Preparation of Catalase Inhibits Nitric Oxide Production by Activated Murine Macrophages: Role of Arginase. Infect. Immun. 68: 3015-3018 [Abstract] [Full Text]
SINGH, S., WORT, S J., EVANS, T. W (1999). Inducible nitric oxide and pulmonary infection. Thorax 54: 959-960 [Full Text]
Rimmelzwaan, G. F., Baars, M. M. J. W., de Lijster, P., Fouchier, R. A. M., Osterhaus, A. D. M. E. (1999). Inhibition of Influenza Virus Replication by Nitric Oxide. J. Virol. 73: 8880-8883 [Abstract] [Full Text]
Wickremasinghe, M. I., Thomas, L. H., Friedland, J. S. (1999). Pulmonary Epithelial Cells are a Source of IL-8 in the Response to Mycobacterium tuberculosis: Essential Role of IL-1 from Infected Monocytes in a NF-{kappa}B-Dependent Network. J. Immunol. 163: 3936-3947 [Abstract] [Full Text]
Bergeron, Y., Ouellet, N., Simard, M., Olivier, M., Bergeron, M. G. (1999). Immunomodulation of Pneumococcal Pulmonary Infection with NG-Monomethyl-L-Arginine. Antimicrob. Agents Chemother. 43: 2283-2290 [Abstract] [Full Text]
Haddad, I. Y., Panoskaltsis-Mortari, A., Ingbar, D. H., Resnik, E. R., Yang, S., Farrell, C. L., Lacey, D. L., Cornfield, D. N., Blazar, B. R. (1999). Interactions of keratinocyte growth factor with a nitrating species after marrow transplantation in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 277: L391-L400 [Abstract] [Full Text]
Sciorati, C., Rovere, P., Ferrarini, M., Paolucci, C., Heltai, S., Vaiani, R., Clementi, E., Manfredi, A. A. (1999). Generation of Nitric Oxide by the Inducible Nitric Oxide Synthase Protects {gamma}{delta} T Cells from Mycobacterium tuberculosis-Induced Apoptosis. J. Immunol. 163: 1570-1576 [Abstract] [Full Text]
Burgner, D., Rockett, K., Kwiatkowski, D. (1999). Nitric oxide and infectious diseases. Arch. Dis. Child. 81: 185-188 [Full Text]
Ruan, J., St. John, G., Ehrt, S., Riley, L., Nathan, C. (1999). noxR3, a Novel Gene from Mycobacterium tuberculosis, Protects Salmonella typhimurium from Nitrosative and Oxidative Stress. Infect. Immun. 67: 3276-3283 [Abstract] [Full Text]
Murray, P. J., Young, R. A. (1999). Increased Antimycobacterial Immunity in Interleukin-10-Deficient Mice. Infect. Immun. 67: 3087-3095 [Abstract] [Full Text]
Lyall, F., Bulmer, J. N., Kelly, H., Duffie, E., Robson, S. C. (1999). Human Trophoblast Invasion and Spiral Artery Transformation : The Role of Nitric Oxide. Am. J. Pathol. 154: 1105-1114 [Abstract] [Full Text]
Downing, J. F., Kachel, D. L., Pasula, R., Martin, W. J. II (1999). Gamma Interferon Stimulates Rat Alveolar Macrophages To Kill Pneumocystis carinii by L-Arginine- and Tumor Necrosis Factor-Dependent Mechanisms. Infect. Immun. 67: 1347-1352 [Abstract] [Full Text]
Garbe, T. R., Hibler, N. S., Deretic, V. (1999). Response to Reactive Nitrogen Intermediates in Mycobacterium tuberculosis: Induction of the 16-Kilodalton alpha -Crystallin Homolog by Exposure to Nitric Oxide Donors. Infect. Immun. 67: 460-465 [Abstract] [Full Text]
Facchetti, F., Vermi, W., Fiorentini, S., Chilosi, M., Caruso, A., Duse, M., Notarangelo, L. D., Badolato, R. (1999). Expression of Inducible Nitric Oxide Synthase in Human Granulomas and Histiocytic Reactions. Am. J. Pathol. 154: 145-152 [Abstract] [Full Text]
Rockett, K. A., Brookes, R., Udalova, I., Vidal, V., Hill, A. V.�S., Kwiatkowski, D. (1998). 1,25-Dihydroxyvitamin D3 Induces Nitric Oxide Synthase and Suppresses Growth of Mycobacterium tuberculosis in a Human Macrophage-Like Cell Line. Infect. Immun. 66: 5314-5321 [Abstract] [Full Text]
Stenger, S., Hanson, D. A., Teitelbaum, R., Dewan, P., Niazi, K. R., Froelich, C. J., Ganz, T., Thoma-Uszynski, S., Melián, A., Bogdan, C., Porcelli, S. A., Bloom, B. R., Krensky, A. M., Modlin, R. L. (1998). An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin. Science 282: 121-125 [Abstract] [Full Text]
Ravalli, S., Albala, A., Ming, M., Szabolcs, M., Barbone, A., Michler, R. E., Cannon, P. J. (1998). Inducible Nitric Oxide Synthase Expression in Smooth Muscle Cells and Macrophages of Human Transplant Coronary Artery Disease. Circulation 97: 2338-2345 [Abstract] [Full Text]
ASTON, C., ROM, W.�N., TALBOT, A.�T., REIBMAN, J. (1998). Early Inhibition of Mycobacterial Growth by Human Alveolar Macrophages is not Due to Nitric Oxide. Am. J. Respir. Crit. Care Med. 157: 1943-1950 [Abstract] [Full Text]
Bonecini-Almeida, M. G., Chitale, S., Boutsikakis, I., Geng, J., Doo, H., He, S., Ho, J. L. (1998). Induction of In Vitro Human Macrophage Anti-Mycobacterium tuberculosis Activity: Requirement for IFN-{gamma} and Primed Lymphocytes. J. Immunol. 160: 4490-4499 [Abstract] [Full Text]
SCHLUGER, N.�W., ROM, W.�N. (1998). The Host Immune Response to Tuberculosis. Am. J. Respir. Crit. Care Med. 157: 679-691 [Full Text]
FARACI, F. M., HEISTAD, D. D. (1998). Regulation of the Cerebral Circulation: Role of Endothelium and Potassium Channels. Physiol. Rev. 78: 53-97 [Abstract] [Full Text]
Sharara, A. I., Perkins, D. J., Misukonis, M. A., Chan, S. U., Dominitz, J. A., Weinberg, J. B. (1997). Interferon (IFN)-{alpha} Activation of Human Blood Mononuclear Cells In Vitro and In Vivo for Nitric Oxide Synthase (NOS) Type 2 mRNA and Protein Expression: Possible Relationship of Induced NOS2 to the Anti-Hepatitis C Effects of IFN-{alpha} In Vivo. JEM 186: 1495-1502 [Abstract] [Full Text]
Lee, J. W., Beckham, C., Michel, B. R., Rosen, H., Deeg, H. J. (1997). HLA-DR-Mediated Signals for Hematopoiesis and Induction of Apoptosis Involve But Are Not Limited to a Nitric Oxide Pathway. Blood 90: 217-225 [Abstract] [Full Text]
MacMicking, J. D., North, R. J., LaCourse, R., Mudgett, J. S., Shah, S. K., Nathan, C. F. (1997). Identification of nitric oxide synthase as a protective locus against�tuberculosis. Proc. Natl. Acad. Sci. USA 94: 5243-5248 [Abstract] [Full Text]
Adler, H., Beland, J. L., Del-Pan, N. C., Kobzik, L., Brewer, J. P., Martin, T. R., Rimm, I. J. (1997). Suppression of Herpes Simplex Virus Type 1 (HSV-1)-induced Pneumonia in Mice by Inhibition of Inducible Nitric Oxide Synthase (iNOS, NOS2). JEM 185: 1533-1540 [Abstract] [Full Text]
Ding, M., Pierre, B. A.St., Parkinson, J. F., Medberry, P., Wong, J. L., Rogers, N. E., Ignarro, L. J., Merrill, J. E. (1997). Inducible Nitric-oxide Synthase and Nitric Oxide Production in Human Fetal Astrocytes and Microglia. A KINETIC ANALYSIS. J. Biol. Chem. 272: 11327-11335 [Abstract] [Full Text]
Moshage, H. (1997). Nitric Oxide Determinations: Much Ado About NO�-Thing?. Clin. Chem. 43: 553-556 [Full Text]
Pechkovsky, D. V., Zissel, G., Goldmann, T., Einhaus, M., Taube, C., Magnussen, H., Schlaak, M., Muller-Quernheim, J. (2002). Pattern of NOS2 and NOS3 mRNA expression in human A549 cells and primary cultured AEC II. Am. J. Physiol. Lung Cell. Mol. Physiol. 282: L684-L692 [Abstract] [Full Text]