The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells

doi:10.1084/jem.183.5.2185

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The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells

A Imura, T Hori, K Imada, T Ishikawa, Y Tanaka, M Maeda, S Imamura and T Uchiyama
Laboratory of AIDS Immunology, Kyoto University, Japan.

Fresh leukemic cells from patients with adult T cell leukemia (ATL) and some ATL-derived T cell lines show adhesion to human umbilical vein endothelial cells (HUVECs) mainly through E-selectin, but a proportion of this binding remains unaffected by the addition of combinations of antibodies against known adhesion molecules. By immunizing mice with one of such cell lines, we established monoclonal antibodies (mAbs), termed 131 and 315, that recognize a single cell surface antigen (Ag) and inhibit the remaining pathway of the adhesion. These mAbs did not react with normal resting peripheral blood mononuclear cells (PBMC) or most of the cell lines tested except for two other human T cell leukemia virus type I (HTLV-I)-infected T cell lines. After stimulation with phytohemagglutinin (PHA), PBMC expressed Ag 131/315 transiently, indicating that these mAbs define a T cell activation Ag. Western blotting and immunoprecipitation revealed that Ag 131/315 has an apparent molecular mass of 50 kD. Expression cloning was done by transient expression in COS-7 cells and immunological selection to isolate a cDNA clone encoding Ag 131/315. Sequence analysis of the cDNA indicated that it is identical to human OX40, a member of the tumor necrosis factor/nerve growth factor receptor family. We then found that gp34, the ligand of OX40, was expressed on HUVECs and other types of vascular endothelial cells. Furthermore, it was shown that the adhesion of CD4+ cells of PHA-stimulated PBMC to unstimulated HUVECs was considerably inhibited by either 131 or 315. Finally, OX40 transfectants of Kit 225, a human interleukin 2-dependent T cell line, were bound specifically to gp34 transfectants of MMCE, a mouse epithelial cell line, and this binding was blocked by either 315 or 5A8, an anti-gp34 mAb. These results indicate that the OX40/gp34 system directly mediates adhesion of activated T cells or OX40+-transformed T cells to vascular endothelial cells.
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Baba, E., Takahashi, Y., Lichtenfeld, J., Tanaka, R., Yoshida, A., Sugamura, K., Yamamoto, N., Tanaka, Y. (2001). Functional CD4 T Cells after Intercellular Molecular Transfer of OX40 Ligand. J. Immunol. 167: 875-883 [Abstract] [Full Text]
Malmstrom, V., Shipton, D., Singh, B., Al-Shamkhani, A., Puklavec, M. J., Barclay, A. N., Powrie, F. (2001). CD134L Expression on Dendritic Cells in the Mesenteric Lymph Nodes Drives Colitis in T Cell-Restored SCID Mice. J. Immunol. 166: 6972-6981 [Abstract] [Full Text]
Nohara, C., Akiba, H., Nakajima, A., Inoue, A., Koh, C.-S., Ohshima, H., Yagita, H., Mizuno, Y., Okumura, K. (2001). Amelioration of Experimental Autoimmune Encephalomyelitis with Anti-OX40 Ligand Monoclonal Antibody: A Critical Role for OX40 Ligand in Migration, But Not Development, of Pathogenic T Cells. J. Immunol. 166: 2108-2115 [Abstract] [Full Text]
Gramaglia, I., Jember, A., Pippig, S. D., Weinberg, A. D., Killeen, N., Croft, M. (2000). The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion. J. Immunol. 165: 3043-3050 [Abstract] [Full Text]
ATEN, J., ROOS, A., CLAESSEN, N., SCHILDER-TOL, E. J. M., TEN BERGE, I. J. M., WEENING, J. J. (2000). Strong and Selective Glomerular Localization of CD134 Ligand and TNF Receptor-1 in Proliferative Lupus Nephritis. J. Am. Soc. Nephrol. 11: 1426-1438 [Abstract] [Full Text]
Kunitomi, A., Hori, T., Imura, A., Uchiyama, T. (2000). Vascular endothelial cells provide T cells with costimulatory signals via the OX40/gp34 system. J. Leukoc. Biol. 68: 111-118 [Abstract] [Full Text]
Pankow, R., Durkop, H., Latza, U., Krause, H., Kunzendorf, U., Pohl, T., Bulfone-Paus, S. (2000). The HTLV-I Tax Protein Transcriptionally Modulates OX40 Antigen Expression. J. Immunol. 165: 263-270 [Abstract] [Full Text]
Kahn, J., Mehraban, F., Ingle, G., Xin, X., Bryant, J. E., Vehar, G., Schoenfeld, J., Grimaldi, C. J., Peale, F., Draksharapu, A., Lewin, D. A., Gerritsen, M. E. (2000). Gene Expression Profiling in an in Vitro Model of Angiogenesis. Am. J. Pathol. 156: 1887-1900 [Abstract] [Full Text]
Morimoto, S., Kanno, Y., Tanaka, Y., Tokano, Y., Hashimoto, H., Jacquot, S., Morimoto, C., Schlossman, S. F., Yagita, H., Okumura, K., Kobata, T. (2000). CD134L Engagement Enhances Human B Cell Ig Production: CD154/CD40, CD70/CD27, and CD134/CD134L Interactions Coordinately Regulate T Cell-Dependent B Cell Responses. J. Immunol. 164: 4097-4104 [Abstract] [Full Text]
Faveeuw, C., Di Mauro, M. E., Price, A. A., Ager, A. (2000). Roles of {alpha}4 integrins/VCAM-1 and LFA-1/ICAM-1 in the binding and transendothelial migration of T lymphocytes and T lymphoblasts across high endothelial venules. Int Immunol 12: 241-251 [Abstract] [Full Text]
Weinberg, A. D., Rivera, M.-M., Prell, R., Morris, A., Ramstad, T., Vetto, J. T., Urba, W. J., Alvord, G., Bunce, C., Shields, J. (2000). Engagement of the OX-40 Receptor In Vivo Enhances Antitumor Immunity. J. Immunol. 164: 2160-2169 [Abstract] [Full Text]
Murata, K., Ishii, N., Takano, H., Miura, S., Ndhlovu, L. C., Nose, M., Noda, T., Sugamura, K. (2000). Impairment of Antigen-Presenting Cell Function in Mice Lacking Expression of Ox40 Ligand. JEM 191: 365-374 [Abstract] [Full Text]
Lane, P. (2000). Role of Ox40 Signals in Coordinating Cd4 T Cell Selection, Migration, and Cytokine Differentiation in T Helper (Th)1 and Th2 Cells. JEM 191: 201-206 [Full Text]
Pippig, S. D., Pena-Rossi, C., Long, J., Godfrey, W. R., Fowell, D. J., Reiner, S. L., Birkeland, M. L., Locksley, R. M., Barclay, A. N., Killeen, N. (1999). Robust B Cell Immunity but Impaired T Cell Proliferation in the Absence of CD134 (OX40). J. Immunol. 163: 6520-6529 [Abstract] [Full Text]
Souza, H S, Elia, C C S, Spencer, J, MacDonald, T T (1999). Expression of lymphocyte-endothelial receptor-ligand pairs, alpha 4beta 7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease. Gut 45: 856-863 [Abstract] [Full Text]
Walker, L. S.K., Gulbranson-Judge, A., Flynn, S., Brocker, T., Raykundalia, C., Goodall, M., Forster, R., Lipp, M., Lane, P. (1999). Compromised Ox40 Function in Cd28-Deficient Mice Is Linked with Failure to Develop Cxc Chemokine Receptor 5-Positive Cd4 Cells and Germinal Centers. JEM 190: 1115-1122 [Abstract] [Full Text]
Matsumura, Y., Hori, T., Kawamata, S., Imura, A., Uchiyama, T. (1999). Intracellular Signaling of gp34, the OX40 Ligand: Induction of c-jun and c-fos mRNA Expression Through gp34 upon Binding of Its Receptor, OX40. J. Immunol. 163: 3007-3011 [Abstract] [Full Text]
Akiba, H., Oshima, H., Takeda, K., Atsuta, M., Nakano, H., Nakajima, A., Nohara, C., Yagita, H., Okumura, K. (1999). CD28-Independent Costimulation of T Cells by OX40 Ligand and CD70 on Activated B Cells. J. Immunol. 162: 7058-7066 [Abstract] [Full Text]
Hollsberg, P. (1999). Mechanisms of T-Cell Activation by Human T-Cell Lymphotropic Virus Type I. Microbiol. Mol. Biol. Rev. 63: 308-333 [Abstract] [Full Text]
Jones, D., Fletcher, C. D.M., Pulford, K., Shahsafaei, A., Dorfman, D. M. (1999). The T-Cell Activation Markers CD30 and OX40/CD134 Are Expressed in Nonoverlapping Subsets of Peripheral T-Cell Lymphoma. Blood 93: 3487-3493 [Abstract] [Full Text]
Weinberg, A. D., Wegmann3, K. W., Funatake, C., Whitham, R. H. (1999). Blocking OX-40/OX-40 Ligand Interaction In Vitro and In Vivo Leads to Decreased T Cell Function and Amelioration of Experimental Allergic Encephalomyelitis. J. Immunol. 162: 1818-1826 [Abstract] [Full Text]
Higgins, L. M., McDonald, S. A. C., Whittle, N., Crockett, N., Shields, J. G., MacDonald, T. T. (1999). Regulation of T Cell Activation In Vitro and In Vivo by Targeting the OX40-OX40 Ligand Interaction: Amelioration of Ongoing Inflammatory Bowel Disease with an OX40-IgG Fusion Protein, But Not with an OX40 Ligand-IgG Fusion Protein. J. Immunol. 162: 486-493 [Abstract] [Full Text]
Ohshima, Y., Yang, L.-P., Uchiyama, T., Tanaka, Y., Baum, P., Sergerie, M., Hermann, P., Delespesse, G. (1998). OX40 Costimulation Enhances Interleukin-4 (IL-4) Expression at Priming and Promotes the Differentiation of Naive Human CD4+ T Cells Into High IL-4-Producing Effectors. Blood 92: 3338-3345 [Abstract] [Full Text]
Kawamata, S., Hori, T., Imura, A., Takaori-Kondo, A., Uchiyama, T. (1998). Activation of OX40 Signal Transduction Pathways Leads to Tumor Necrosis Factor Receptor-associated Factor (TRAF) 2-�and TRAF5-mediated NF-kappa B Activation. J. Biol. Chem. 273: 5808-5814 [Abstract] [Full Text]
Thompson, R. H.�A. a. C. B. (1998). 4-1BB and Ox40 Are Members of a Tumor Necrosis Factor (TNF)-Nerve Growth Factor Receptor Subfamily That Bind TNF Receptor-Associated Factors and Activate Nuclear Factor kappa B. Mol. Cell. Biol. 18: 558-565 [Abstract] [Full Text]
Hori, T., Sakaida, H., Sato, A., Nakajima, T., Shida, H., Yoshie, O., Uchiyama, T. (1998). Detection and Delineation of CXCR-4 (Fusin) as an Entry and Fusion Cofactor for T Cell-Tropic HIV-1 by Three Different Monoclonal Antibodies. J. Immunol. 160: 180-188 [Abstract] [Full Text]
Imura, A., Hori, T., Imada, K., Kawamata, S., Tanaka, Y., Imamura, S., Uchiyama, T. (1997). OX40 Expressed on Fresh Leukemic Cells From Adult T-Cell Leukemia Patients Mediates Cell Adhesion to Vascular Endothelial Cells: Implication for the Possible Involvement of OX40 in Leukemic Cell Infiltration. Blood 89: 2951-2958 [Abstract] [Full Text]
Al-Shamkhani, A., Mallett, S., Brown, M. H., James, W., Barclay, A. N. (1997). Affinity and Kinetics of the Interaction between Soluble Trimeric OX40 Ligand, a Member of the Tumor Necrosis Factor Superfamily, and Its Receptor OX40 on Activated T Cells. J. Biol. Chem. 272: 5275-5282 [Abstract] [Full Text]