Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death

doi:10.1084/jem.183.5.1957

This Article

Full Text (PDF, 1018K)

Alert me when this article is cited

Citation Map

Services

Email this article

Similar articles in this journal

Similar articles in PubMed

Alert me to new content in the JEM

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via CrossRef

Citing Articles via Google Scholar

Google Scholar

Articles by Casciola-Rosen, L.

Articles by Rosen, A.

Search for Related Content

PubMed

PubMed Citation

Articles by Casciola-Rosen, L.

Articles by Rosen, A.

Pubmed/NCBI databases

Compound via MeSH
Substance via MeSH

Social Bookmarking

What's this?

ARTICLES

Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death

L Casciola-Rosen, DW Nicholson, T Chong, KR Rowan, NA Thornberry, DK Miller and A Rosen
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Proteolysis mediated by the interleukin 1 beta-converting enzyme (ICE) homologues is an important mechanism of the apoptotic process. The ICE homologue apopain/CPP-32/Yama (subsequently referred to as apopain) cleaves poly(ADP-ribose)polymerase (PARP) early during apoptosis. Additional apoptosis-specific protein cleavages have been observed in which the direct involvement of ICE-like proteases has been postulated. These substrates include the 70-kD protein component of the U1- ribonucleoprotein (U1-70kD), and the catalytic subunit of the DNA- dependent protein kinase (DNA-PKcs). The present studies demonstrate that U1-70kD and DNA-PKcs are excellent substrates for apopain, with cleavage occurring at sites that are highly similar to the cleavage site within PARP. The fragments generated from isolated protein substrates by apopain are identical to those observed in intact apoptotic cells, in apoptotic cell extracts, and in normal cell extracts to which apopain has been added. Like PARP, cleavage of these substrates in apoptotic cell extracts is abolished by nanomolar concentrations of Ac-DEVD-CHO and micromolar amounts of Ac-YVAD-CHO, confirming the involvement of apopain or an apopain-like activity. We propose that a central function of apopain or similar homologues in apoptosis is the cleavage of nuclear repair proteins, thereby abolishing their critical homeostatic functions.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Kato, K., Yamanouchi, D., Esbona, K., Kamiya, K., Zhang, F., Kent, K. C., Liu, B. (2009). Caspase-mediated protein kinase C-{delta} cleavage is necessary for apoptosis of vascular smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 297: H2253-H2261 [Abstract] [Full Text]
Zhu, P., Martinvalet, D., Chowdhury, D., Zhang, D., Schlesinger, A., Lieberman, J. (2009). The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1. Blood 114: 1205-1216 [Abstract] [Full Text]
Wann, B., Bah, T., Kaloustian, S, Boucher, M, Dufort, A., Le Marec, N, Godbout, R, Rousseau, G (2009). Behavioural signs of depression and apoptosis in the limbic system following myocardial infarction: effects of sertraline. J Psychopharmacol 23: 451-459 [Abstract]
Jeong, W., Lee, D.-Y., Park, S., Rhee, S. G. (2008). ERp16, an Endoplasmic Reticulum-resident Thiol-disulfide Oxidoreductase: BIOCHEMICAL PROPERTIES AND ROLE IN APOPTOSIS INDUCED BY ENDOPLASMIC RETICULUM STRESS. J. Biol. Chem. 283: 25557-25566 [Abstract] [Full Text]
Butkinaree, C., Cheung, W. D., Park, S., Park, K., Barber, M., Hart, G. W. (2008). Characterization of {beta}-N-Acetylglucosaminidase Cleavage by Caspase-3 during Apoptosis. J. Biol. Chem. 283: 23557-23566 [Abstract] [Full Text]
Eggleton, P., Haigh, R., Winyard, P. G. (2008). Consequence of neo-antigenicity of the 'altered self'. Rheumatology (Oxford) 47: 567-571 [Abstract] [Full Text]
Frisoni, L., McPhie, L., Kang, S.-A., Monestier, M., Madaio, M., Satoh, M., Caricchio, R. (2007). Lack of Chromatin and Nuclear Fragmentation In Vivo Impairs the Production of Lupus Anti-Nuclear Antibodies. J. Immunol. 179: 7959-7966 [Abstract] [Full Text]
Chen, Z.-Y., Feng, G.-G., Nishiwaki, K., Shimada, Y., Fujiwara, Y., Komatsu, T., Ishikawa, N. (2007). Possible roles of neuropeptide Y Y3-receptor subtype in rat aortic endothelial cell proliferation under hypoxia, and its specific signal transduction. Am. J. Physiol. Heart Circ. Physiol. 293: H959-H967 [Abstract] [Full Text]
Kitagawa, A, Miura, Y, Saura, R, Mitani, M, Ishikawa, H, Hashiramoto, A, Yoshiya, S, Shiozawa, S, Kurosaka, M (2006). Anchorage on fibronectin via VLA-5 ({alpha}5{beta}1 integrin) protects rheumatoid synovial cells from Fas-induced apoptosis. Ann Rheum Dis 65: 721-727 [Abstract] [Full Text]
Clarke, C. A. L., Bennett, L. N., Clarke, P. R. (2005). Cleavage of Claspin by Caspase-7 during Apoptosis Inhibits the Chk1 Pathway. J. Biol. Chem. 280: 35337-35345 [Abstract] [Full Text]
Kaul, S., Anantharam, V., Yang, Y., Choi, C. J., Kanthasamy, A., Kanthasamy, A. G. (2005). Tyrosine Phosphorylation Regulates the Proteolytic Activation of Protein Kinase C{delta} in Dopaminergic Neuronal Cells. J. Biol. Chem. 280: 28721-28730 [Abstract] [Full Text]
Weber, G. F., Menko, A. S. (2005). The Canonical Intrinsic Mitochondrial Death Pathway Has a Non-apoptotic Role in Signaling Lens Cell Differentiation. J. Biol. Chem. 280: 22135-22145 [Abstract] [Full Text]
West, J. D., Ji, C., Marnett, L. J. (2005). Modulation of DNA Fragmentation Factor 40 Nuclease Activity by Poly(ADP-ribose) Polymerase-1. J. Biol. Chem. 280: 15141-15147 [Abstract] [Full Text]
Muris, J. J. F., Cillessen, S. A. G. M., Vos, W., van Houdt, I. S., Kummer, J. A., van Krieken, J. H. J. M., Jiwa, N. M., Jansen, P. M., Kluin-Nelemans, H. C., Ossenkoppele, G. J., Gundy, C., Meijer, C. J. L. M., Oudejans, J. J. (2005). Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas. Blood 105: 2916-2923 [Abstract] [Full Text]
Newton, C. J., Bilko, D., Tichomirowa, M., Renner, U., Stalla, G. K. (2005). The Role of Poly (Adenosine 5'-Diphosphate-Ribose) Polymerase in the Response of Pituitary Tumor Cells to Reactive Oxygen Species. Endocrinology 146: 1119-1127 [Abstract] [Full Text]
Matarrese, P., Tinari, A., Mormone, E., Bianco, G. A., Toscano, M. A., Ascione, B., Rabinovich, G. A., Malorni, W. (2005). Galectin-1 Sensitizes Resting Human T Lymphocytes to Fas (CD95)-mediated Cell Death via Mitochondrial Hyperpolarization, Budding, and Fission. J. Biol. Chem. 280: 6969-6985 [Abstract] [Full Text]
Sarkar, S., Chawla-Sarkar, M., Young, D., Nishiyama, K., Rayborn, M. E., Hollyfield, J. G., Sen, S. (2004). Myocardial Cell Death and Regeneration during Progression of Cardiac Hypertrophy to Heart Failure. J. Biol. Chem. 279: 52630-52642 [Abstract] [Full Text]
Iwatsubo, K., Minamisawa, S., Tsunematsu, T., Nakagome, M., Toya, Y., Tomlinson, J. E., Umemura, S., Scarborough, R. M., Levy, D. E., Ishikawa, Y. (2004). Direct Inhibition of Type 5 Adenylyl Cyclase Prevents Myocardial Apoptosis without Functional Deterioration. J. Biol. Chem. 279: 40938-40945 [Abstract] [Full Text]
Mano, A., Tatsumi, T., Shiraishi, J., Keira, N., Nomura, T., Takeda, M., Nishikawa, S., Yamanaka, S., Matoba, S., Kobara, M., Tanaka, H., Shirayama, T., Takamatsu, T., Nozawa, Y., Matsubara, H. (2004). Aldosterone Directly Induces Myocyte Apoptosis Through Calcineurin-Dependent Pathways. Circulation 110: 317-323 [Abstract] [Full Text]
Chen, F., Arseven, O. K., Cryns, V. L. (2004). Proteolysis of the Mismatch Repair Protein MLH1 by Caspase-3 Promotes DNA Damage-induced Apoptosis. J. Biol. Chem. 279: 27542-27548 [Abstract] [Full Text]
Graham, K. L., Gustin, K. E., Rivera, C., Kuyumcu-Martinez, N. M., Choe, S. S., Lloyd, R. E., Sarnow, P., Utz, P. J. (2004). Proteolytic Cleavage of the Catalytic Subunit of DNA-Dependent Protein Kinase during Poliovirus Infection. J. Virol. 78: 6313-6321 [Abstract] [Full Text]
Chen, A.-C., Donovan, S. M. (2004). Genistein at a Concentration Present in Soy Infant Formula Inhibits Caco-2BBe Cell Proliferation by Causing G2/M Cell Cycle Arrest. J. Nutr. 134: 1303-1308 [Abstract] [Full Text]
Rosen, A., Casciola-Rosen, L. (2004). ALTERED AUTOANTIGEN STRUCTURE IN SJoGREN'S SYNDROME: IMPLICATIONS FOR THE PATHOGENESIS OF AUTOIMMUNE TISSUE DAMAGE. CROBM 15: 156-164 [Abstract] [Full Text]
Tokudome, T., Horio, T., Fukunaga, M., Okumura, H., Hino, J., Mori, K., Yoshihara, F., Suga, S.-I., Kawano, Y., Kohno, M., Kangawa, K. (2004). Ventricular Nonmyocytes Inhibit Doxorubicin-Induced Myocyte Apoptosis: Involvement of Endogenous Endothelin-1 as a Paracrine Factor. Endocrinology 145: 2458-2466 [Abstract] [Full Text]
Lee, Y. J., Froelich, C. J., Fujita, N., Tsuruo, T., Kim, J. H. (2004). Reconstitution of Caspase-3 Confers Low Glucose-Enhanced Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Cytotoxicity and Akt Cleavage. Clin. Cancer Res. 10: 1894-1900 [Abstract] [Full Text]
Jackson, S. J. T., Singletary, K. W. (2004). Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization. Carcinogenesis 25: 219-227 [Abstract] [Full Text]
Jeong, W., Chang, T.-S., Boja, E. S., Fales, H. M., Rhee, S. G. (2004). Roles of TRP14, a Thioredoxin-related Protein in Tumor Necrosis Factor-{alpha} Signaling Pathways. J. Biol. Chem. 279: 3151-3159 [Abstract] [Full Text]
Cappello, P., Caorsi, C., Bosticardo, M., De Angelis, S., Novelli, F., Forni, G., Giovarelli, M. (2004). CCL16/LEC powerfully triggers effector and antigen-presenting functions of macrophages and enhances T cell cytotoxicity. J. Leukoc. Biol. 75: 135-142 [Abstract] [Full Text]
Chu, J. J. H., Ng, M. L. (2003). The mechanism of cell death during West Nile virus infection is dependent on initial infectious dose. J. Gen. Virol. 84: 3305-3314 [Abstract] [Full Text]
Koshizuka, Y., Yamada, T., Hoshi, K., Ogasawara, T., Chung, U.-i., Kawano, H., Nakamura, Y., Nakamura, K., Ikegawa, S., Kawaguchi, H. (2003). Cystatin 10, a Novel Chondrocyte-specific Protein, May Promote the Last Steps of the Chondrocyte Differentiation Pathway. J. Biol. Chem. 278: 48259-48266 [Abstract] [Full Text]
Li, S., Takeda, Y., Wragg, S., Barrett, J., Phillips, A., Dynan, W. S. (2003). Modification of the ionizing radiation response in living cells by an scFv against the DNA-dependent protein kinase. Nucleic Acids Res 31: 5848-5857 [Abstract] [Full Text]
Saito, Y., Yoshida, Y., Akazawa, T., Takahashi, K., Niki, E. (2003). Cell Death Caused by Selenium Deficiency and Protective Effect of Antioxidants. J. Biol. Chem. 278: 39428-39434 [Abstract] [Full Text]
Ishimaru, N., Arakaki, R., Watanabe, M., Kobayashi, M., Miyazaki, K., Hayashi, Y. (2003). Development of Autoimmune Exocrinopathy Resembling Sjogren's Syndrome in Estrogen-Deficient Mice of Healthy Background. Am. J. Pathol. 163: 1481-1490 [Abstract] [Full Text]
Gu, X., El-Remessy, A. B., Brooks, S. E., Al-Shabrawey, M., Tsai, N.-T., Caldwell, R. B. (2003). Hyperoxia induces retinal vascular endothelial cell apoptosis through formation of peroxynitrite. Am. J. Physiol. Cell Physiol. 285: C546-C554 [Abstract] [Full Text]
Tatsumi, T., Shiraishi, J., Keira, N., Akashi, K., Mano, A., Yamanaka, S., Matoba, S., Fushiki, S., Fliss, H., Nakagawa, M. (2003). Intracellular ATP is required for mitochondrial apoptotic pathways in isolated hypoxic rat cardiac myocytes. Cardiovasc Res 59: 428-440 [Abstract] [Full Text]
Matarrese, P., Gambardella, L., Cassone, A., Vella, S., Cauda, R., Malorni, W. (2003). Mitochondrial Membrane Hyperpolarization Hijacks Activated T Lymphocytes Toward the Apoptotic-Prone Phenotype: Homeostatic Mechanisms of HIV Protease Inhibitors. J. Immunol. 170: 6006-6015 [Abstract] [Full Text]
Yamanaka, S., Tatsumi, T., Shiraishi, J., Mano, A., Keira, N., Matoba, S., Asayama, J., Fushiki, S., Fliss, H., Nakagawa, M. (2003). Amlodipine inhibits doxorubicin-induced apoptosis in neonatal rat cardiac myocytes. J Am Coll Cardiol 41: 870-878 [Abstract] [Full Text]
Rosenthal, D. S., Velena, A., Chou, F.-P., Schlegel, R., Ray, R., Benton, B., Anderson, D., Smith, W. J., Simbulan-Rosenthal, C. M. (2003). Expression of Dominant-negative Fas-associated Death Domain Blocks Human Keratinocyte Apoptosis and Vesication Induced by Sulfur Mustard. J. Biol. Chem. 278: 8531-8540 [Abstract] [Full Text]
Lee, K.-J., Dong, X., Wang, J., Takeda, Y., Dynan, W. S. (2002). Identification of Human Autoantibodies to the DNA Ligase IV/XRCC4 Complex and Mapping of an Autoimmune Epitope to a Potential Regulatory Region. J. Immunol. 169: 3413-3421 [Abstract] [Full Text]
Tokudome, T., Horio, T., Yoshihara, F., Suga, S.-i., Kawano, Y., Kohno, M., Kangawa, K. (2002). Adrenomedullin Inhibits Doxorubicin-Induced Cultured Rat Cardiac Myocyte Apoptosis via a cAMP-Dependent Mechanism. Endocrinology 143: 3515-3521 [Abstract] [Full Text]
Saegusa, K., Ishimaru, N., Yanagi, K., Mishima, K., Arakaki, R., Suda, T., Saito, I., Hayashi, Y. (2002). Prevention and Induction of Autoimmune Exocrinopathy Is Dependent on Pathogenic Autoantigen Cleavage in Murine Sjogren's Syndrome. J. Immunol. 169: 1050-1057 [Abstract] [Full Text]
Rehm, M., Dussmann, H., Janicke, R. U., Tavare, J. M., Kogel, D., Prehn, J. H. M. (2002). Single-cell Fluorescence Resonance Energy Transfer Analysis Demonstrates That Caspase Activation during Apoptosis Is a Rapid Process. ROLE OF CASPASE-3. J. Biol. Chem. 277: 24506-24514 [Abstract] [Full Text]
Dukers, D. F., Meijer, C. J. L. M., ten Berge, R. L., Vos, W., Ossenkoppele, G. J., Oudejans, J. J. (2002). High numbers of active caspase 3-positive Reed-Sternberg cells in pretreatment biopsy specimens of patients with Hodgkin disease predict favorable clinical outcome. Blood 100: 36-42 [Abstract] [Full Text]
Preaudat, M., Ouled-Diaf, J., Alpha-Bazin, B., Mathis, G., Mitsugi, T., Aono, Y., Takahashi, K., Takemoto, H. (2002). A Homogeneous Caspase-3 Activity Assay Using HTRF(R) Technology. J Biomol Screen 7: 267-274 [Abstract]
ten Berge, R. L., Meijer, C. J. L. M., Dukers, D. F., Kummer, J. A., Bladergroen, B. A., Vos, W., Hack, C. E., Ossenkoppele, G. J., Oudejans, J. J. (2002). Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma. Blood 99: 4540-4546 [Abstract] [Full Text]
Matarrese, P., Di Biase, L., Santodonato, L., Straface, E., Mecchia, M., Ascione, B., Parmiani, G., Belardelli, F., Ferrantini, M., Malorni, W. (2002). Type I Interferon Gene Transfer Sensitizes Melanoma Cells to Apoptosis via a Target Activity on Mitochondrial Function. Am. J. Pathol. 160: 1507-1520 [Abstract] [Full Text]
Laprise, P., Chailler, P., Houde, M., Beaulieu, J.-F., Boucher, M.-J., Rivard, N. (2002). Phosphatidylinositol 3-Kinase Controls Human Intestinal Epithelial Cell Differentiation by Promoting Adherens Junction Assembly and p38 MAPK Activation. J. Biol. Chem. 277: 8226-8234 [Abstract] [Full Text]
Jimenez, F., Aiba-Masago, S., Al Hashimi, I., Vela-Roch, N., Fernandes, G., Yeh, C.-K., Talal, N., Dang, H. (2002). Activated caspase 3 and cleaved poly(ADP-ribose)polymerase in salivary epithelium suggest a pathogenetic mechanism for Sjogren's syndrome. Rheumatology (Oxford) 41: 338-342 [Abstract] [Full Text]
Kunisada, K., Tone, E., Negoro, S., Nakaoka, Y., Oshima, Y., Osugi, T., Funamoto, M., Izumi, M., Fujio, Y., Hirota, H., Yamauchi-Takihara, K. (2002). Bcl-xl reduces doxorubicin-induced myocardial damage but fails to control cardiac gene downregulation. Cardiovasc Res 53: 936-943 [Abstract] [Full Text]
Park, J.-W., Choi, Y.-J., Suh, S.-I., Baek, W.-K., Suh, M.-H., Jin, I.-N., Min, D. S., Woo, J.-H., Chang, J.-S., Passaniti, A., Lee, Y. H., Kwon, T. K. (2001). Bcl-2 overexpression attenuates resveratrol-induced apoptosis in U937 cells by inhibition of caspase-3 activity. Carcinogenesis 22: 1633-1639 [Abstract] [Full Text]
Shiraishi, J., Tatsumi, T., Keira, N., Akashi, K., Mano, A., Yamanaka, S., Matoba, S., Asayama, J., Yaoi, T., Fushiki, S., Fliss, H., Nakagawa, M. (2001). Important role of energy-dependent mitochondrial pathways in cultured rat cardiac myocyte apoptosis. Am. J. Physiol. Heart Circ. Physiol. 281: H1637-H1647 [Abstract] [Full Text]
Alscher, K. T., Phang, P. T., McDonald, T. E., Walley, K. R. (2001). Enteral feeding decreases gut apoptosis, permeability, and lung inflammation during murine endotoxemia. Am. J. Physiol. Gastrointest. Liver Physiol. 281: G569-G576 [Abstract] [Full Text]
Yamamoto, K., Morishita, R., Hayashi, S.-i., Matsushita, H., Nakagami, H., Moriguchi, A., Matsumoto, K., Nakamura, T., Kaneda, Y., Ogihara, T. (2001). Contribution of Bcl-2, but Not Bcl-xL and Bax, to Antiapoptotic Actions of Hepatocyte Growth Factor in Hypoxia-Conditioned Human Endothelial Cells. Hypertension 37: 1341-1348 [Abstract] [Full Text]
Navratil, J. S., Watkins, S. C., Wisnieski, J. J., Ahearn, J. M. (2001). The Globular Heads of C1q Specifically Recognize Surface Blebs of Apoptotic Vascular Endothelial Cells. J. Immunol. 166: 3231-3239 [Abstract] [Full Text]
Williams, C. J., Grandal, I., Vesprini, D. J., Wojtyra, U., Danska, J. S., Guidos, C. J. (2001). Irradiation Promotes V(D)J Joining and RAG-Dependent Neoplastic Transformation in SCID T-Cell Precursors. Mol. Cell. Biol. 21: 400-413 [Abstract] [Full Text]
Charland, S., Boucher, M.-J., Houde, M., Rivard, N. (2001). Somatostatin Inhibits Akt Phosphorylation and Cell Cycle Entry, But Not p42/p44 Mitogen-Activated Protein (MAP) Kinase Activation in Normal and Tumoral Pancreatic Acinar Cells. Endocrinology 142: 121-128 [Abstract] [Full Text]
Yang, X.-H., Sladek, T. L., Liu, X., Butler, B. R., Froelich, C. J., Thor, A. D. (2001). Reconstitution of Caspase 3 Sensitizes MCF-7 Breast Cancer Cells to Doxorubicin- and Etoposide-induced Apoptosis. Cancer Res. 61: 348-354 [Abstract] [Full Text]
Heinke, M. Y, Yao, M., Chang, D., Einstein, R., dos Remedios, C. G (2001). Apoptosis of ventricular and atrial myocytes from pacing-induced canine heart failure. Cardiovasc Res 49: 127-134 [Abstract] [Full Text]
Patel, C. A., Mukhtar, M., Pomerantz, R. J. (2000). Human Immunodeficiency Virus Type 1 Vpr Induces Apoptosis in Human Neuronal Cells. J. Virol. 74: 9717-9726 [Abstract] [Full Text]
Negoro, S., Kunisada, K., Tone, E., Funamoto, M., Oh, H., Kishimoto, T., Yamauchi-Takihara, K. (2000). Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction. Cardiovasc Res 47: 797-805 [Abstract] [Full Text]
Law, S. F., O'Neill, G. M., Fashena, S. J., Einarson, M. B., Golemis, E. A. (2000). The Docking Protein HEF1 Is an Apoptotic Mediator at Focal Adhesion Sites. Mol. Cell. Biol. 20: 5184-5195 [Abstract] [Full Text]
Stiewe, T., Parssanedjad, K., Esche, H., Opalka, B., Pützer, B. M. (2000). E1A Overcomes the Apoptosis Block in BCR-ABL+ Leukemia Cells and Renders Cells Susceptible to Induction of Apoptosis by Chemotherapeutic Agents. Cancer Res. 60: 3957-3964 [Abstract] [Full Text]
Sam, F., Sawyer, D. B., Chang, D. L.-F., Eberli, F. R., Ngoy, S., Jain, M., Amin, J., Apstein, C. S., Colucci, W. S. (2000). Progressive left ventricular remodeling and apoptosis late after myocardial infarction in mouse heart. Am. J. Physiol. Heart Circ. Physiol. 279: H422-H428 [Abstract] [Full Text]
Koya, R. C., Fujita, H., Shimizu, S., Ohtsu, M., Takimoto, M., Tsujimoto, Y., Kuzumaki, N. (2000). Gelsolin Inhibits Apoptosis by Blocking Mitochondrial Membrane Potential Loss and Cytochrome c Release. J. Biol. Chem. 275: 15343-15349 [Abstract] [Full Text]
Matsushita, H., Morishita, R., Nata, T., Aoki, M., Nakagami, H., Taniyama, Y., Yamamoto, K., Higaki, J., Yasufumi, K., Ogihara, T. (2000). Hypoxia-Induced Endothelial Apoptosis Through Nuclear Factor-{kappa}B (NF-{kappa}B)-Mediated bcl-2 Suppression : In Vivo Evidence of the Importance of NF-{kappa}B in Endothelial Cell Regulation. Circ. Res. 86: 974-981 [Abstract] [Full Text]
Mancini, M., Machamer, C. E., Roy, S., Nicholson, D. W., Thornberry, N. A., Casciola-Rosen, L. A., Rosen, A. (2000). Caspase-2 Is Localized at the Golgi Complex and Cleaves Golgin-160 during Apoptosis. JCB 149: 603-612 [Abstract] [Full Text]
Hingorani, R., Bi, B., Dao, T., Bae, Y., Matsuzawa, A., Crispe, I. N. (2000). CD95/Fas Signaling in T Lymphocytes Induces the Cell Cycle Control Protein p21cip-1/WAF-1, Which Promotes Apoptosis. J. Immunol. 164: 4032-4036 [Abstract] [Full Text]
Kim, Y.-M., Chung, H.-T., Simmons, R. L., Billiar, T. R. (2000). Cellular Non-heme Iron Content Is a Determinant of Nitric Oxide-mediated Apoptosis, Necrosis, and Caspase Inhibition. J. Biol. Chem. 275: 10954-10961 [Abstract] [Full Text]
Nakashima, T., Miura, M., Hara, M. (2000). Tetrocarcin A Inhibits Mitochondrial Functions of Bcl-2 and Suppresses Its Anti-apoptotic Activity. Cancer Res. 60: 1229-1235 [Abstract] [Full Text]
Wade, M., Allday, M. J. (2000). Epstein-Barr Virus Suppresses a G2/M Checkpoint Activated by Genotoxins. Mol. Cell. Biol. 20: 1344-1360 [Abstract] [Full Text]
Liu, W, Kato, M, Akhand, A., Hayakawa, A, Suzuki, H, Miyata, T, Kurokawa, K, Hotta, Y, Ishikawa, N, Nakashima, I (2000). 4-hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death. J. Cell Sci. 113: 635-641 [Abstract]
Granville, D. J., Carthy, C. M., Jiang, H., Levy, J. G., McManus, B. M., Matroule, J.-Y., Piette, J., Hunt, D. W. C. (2000). Nuclear factor-kappa B activation by the photochemotherapeutic agent verteporfin. Blood 95: 256-262 [Abstract] [Full Text]
Swanton, E., Bishop, N., Woodman, P. (1999). Human Rabaptin-5 Is Selectively Cleaved by Caspase-3 during Apoptosis. J. Biol. Chem. 274: 37583-37590 [Abstract] [Full Text]
Takeda, Y., Caudell, P., Grady, G., Wang, G., Suwa, A., Sharp, G. C., Dynan, W. S., Hardin, J. A. (1999). Human RNA Helicase A Is a Lupus Autoantigen That Is Cleaved During Apoptosis. J. Immunol. 163: 6269-6274 [Abstract] [Full Text]
Tezel, G., Wax, M. B. (1999). Inhibition of Caspase Activity in Retinal Cell Apoptosis Induced by Various Stimuli In Vitro. IOVS 40: 2660-2667 [Abstract] [Full Text]
Germain, M., Affar, E. B., D'Amours, D., Dixit, V. M., Salvesen, G. S., Poirier, G. G. (1999). Cleavage of Automodified Poly(ADP-ribose) Polymerase during Apoptosis. EVIDENCE FOR INVOLVEMENT OF CASPASE-7. J. Biol. Chem. 274: 28379-28384 [Abstract] [Full Text]
Donoghue, S., Baden, H. S., Lauder, I., Sobolewski, S., Pringle, J. H. (1999). Immunohistochemical Localization of Caspase-3 Correlates with Clinical Outcome in B-Cell Diffuse Large-Cell Lymphoma. Cancer Res. 59: 5386-5391 [Abstract] [Full Text]
Casciola-Rosen, L., Andrade, F., Ulanet, D., Wong, W. B., Rosen, A. (1999). Cleavage by Granzyme B Is Strongly Predictive of Autoantigen Status: Implications for Initiation of Autoimmunity. JEM 190: 815-826 [Abstract] [Full Text]
Rutjes, S. A., van der Heijden, A., Utz, P. J., van Venrooij, W. J., Pruijn, G. J. M. (1999). Rapid Nucleolytic Degradation of the Small Cytoplasmic Y RNAs during Apoptosis. J. Biol. Chem. 274: 24799-24807 [Abstract] [Full Text]
Morrow, T. A., Muljo, S. A., Zhang, J., Hardwick, J. M., Schlissel, M. S. (1999). Pro-B-Cell-Specific Transcription and Proapoptotic Function of Protein Kinase Ceta. Mol. Cell. Biol. 19: 5608-5618 [Abstract] [Full Text]
Mendonca, M. S., Howard, K. L., Farrington, D. L., Desmond, L. A., Temples, T. M., Mayhugh, B. M., Pink, J. J., Boothman, D. A. (1999). Delayed Apoptotic Responses Associated with Radiation-induced Neoplastic Transformation of Human Hybrid Cells. Cancer Res. 59: 3972-3979 [Abstract] [Full Text]
Gurr, J.-R., Bau, D.-T., Liu, F., Lynn, S., Jan, K.-Y. (1999). Dithiothreitol Enhances Arsenic Trioxide-Induced Apoptosis in NB4 Cells. Mol. Pharmacol. 56: 102-109 [Abstract] [Full Text]
Rueda, B. R., Hendry, I. R., Tilly, J. L., Hamernik, D. L. (1999). Accumulation of Caspase-3 Messenger Ribonucleic Acid and Induction of Caspase Activity in the Ovine Corpus Luteum Following Prostaglandin F2{alpha} Treatment In Vivo. Biol. Reprod. 60: 1087-1092 [Abstract] [Full Text]
Dhanabal, M., Ramchandran, R., Waterman, M. J.�F., Lu, H., Knebelmann, B., Segal, M., Sukhatme, V. P. (1999). Endostatin Induces Endothelial Cell Apoptosis. J. Biol. Chem. 274: 11721-11726 [Abstract] [Full Text]
Huang, Y., Nakada, S., Ishiko, T., Utsugisawa, T., Datta, R., Kharbanda, S., Yoshida, K., Talanian, R. V., Weichselbaum, R., Kufe, D., Yuan, Z.-M. (1999). Role for Caspase-Mediated Cleavage of Rad51 in Induction of Apoptosis by DNA Damage. Mol. Cell. Biol. 19: 2986-2997 [Abstract] [Full Text]
Matsuda, S., Minowa, A., Suzuki, S., Koyasu, S. (1999). Differential Activation of c-Jun NH2-Terminal Kinase and p38 Pathways During FTY720-Induced Apoptosis of T Lymphocytes That Is Suppressed by the Extracellular Signal-Regulated Kinase Pathway. J. Immunol. 162: 3321-3326 [Abstract] [Full Text]
Ozawa, K., Kuwabara, K., Tamatani, M., Takatsuji, K., Tsukamoto, Y., Kaneda, S., Yanagi, H., Stern, D. M., Eguchi, Y., Tsujimoto, Y., Ogawa, S., Tohyama, M. (1999). 150-kDa Oxygen-regulated Protein (ORP150) Suppresses Hypoxia-induced Apoptotic Cell Death. J. Biol. Chem. 274: 6397-6404 [Abstract] [Full Text]
Du, Q., Lehavi, D., Faktor, O., Qi, Y., Chejanovsky, N. (1999). Isolation of an Apoptosis Suppressor Gene of the Spodoptera littoralis Nucleopolyhedrovirus. J. Virol. 73: 1278-1285 [Abstract] [Full Text]
Pentikainen, V., Erkkila, K., Dunkel, L. (1999). Fas regulates germ cell apoptosis in the human testis in vitro. Am. J. Physiol. Endocrinol. Metab. 276: E310-E316 [Abstract] [Full Text]
Banki, K., Hutter, E., Gonchoroff, N. J., Perl, A. (1999). Elevation of Mitochondrial Transmembrane Potential and Reactive Oxygen Intermediate Levels Are Early Events and Occur Independently from Activation of Caspases in Fas Signaling. J. Immunol. 162: 1466-1479 [Abstract] [Full Text]
Bello, B. D., Paolicchi, A., Comporti, M., Pompella, A., Maellaro, E. (1999). Hydrogen peroxide produced during {gamma}-glutamyl transpeptidase activity is involved in prevention of apoptosis and maintainance of proliferation in U937 cells. FASEB J. 13: 69-79 [Abstract] [Full Text]
Oliver, F. J., de la Rubia, G., Rolli, V., Ruiz-Ruiz, M. C., de Murcia, G., Murcia, J. M.-d. (1998). Importance of Poly(ADP-ribose) Polymerase and Its Cleavage in Apoptosis. LESSON FROM AN UNCLEAVABLE MUTANT. J. Biol. Chem. 273: 33533-33539 [Abstract] [Full Text]
Knepper-Nicolai, B., Savill, J., Brown, S. B. (1998). Constitutive Apoptosis in Human Neutrophils Requires Synergy between Calpains and the Proteasome Downstream of Caspases. J. Biol. Chem. 273: 30530-30536 [Abstract] [Full Text]
Rai, R. M., Lee, F. Y. J., Rosen, A., Yang, S. Q., Lin, H. Z., Koteish, A., Liew, F. Y., Zaragoza, C., Lowenstein, C., Diehl, A. M. (1998). Impaired liver regeneration in inducible nitric oxide synthasedeficient mice. Proc. Natl. Acad. Sci. USA 95: 13829-13834 [Abstract] [Full Text]
Bharti, A., Kraeft, S.-K., Gounder, M., Pandey, P., Jin, S., Yuan, Z.-M., Lees-Miller, S. P., Weichselbaum, R., Weaver, D., Chen, L. B., Kufe, D., Kharbanda, S. (1998). Inactivation of DNA-Dependent Protein Kinase by Protein Kinase Cdelta : Implications for Apoptosis. Mol. Cell. Biol. 18: 6719-6728 [Abstract] [Full Text]
Wang, L., Ma, W., Markovich, R., Chen, J.-W., Wang, P. H. (1998). Regulation of Cardiomyocyte Apoptotic Signaling by Insulin-like Growth Factor I. Circ. Res. 83: 516-522 [Abstract] [Full Text]
McGinnis, K. M., Whitton, M. M., Gnegy, M. E., Wang, K. K.�W. (1998). Calcium/Calmodulin-dependent Protein Kinase IV Is Cleaved by Caspase-3 and Calpain in SH-SY5Y Human Neuroblastoma Cells Undergoing Apoptosis. J. Biol. Chem. 273: 19993-20000 [Abstract] [Full Text]
He, H., Hershberger, P. A., McCarthy, S. A. (1998). Characterization of a Novel Bax-Associated Protein Expressed in Hemopoietic Tissues and Regulated During Thymocyte Apoptosis. J. Immunol. 161: 1169-1175 [Abstract] [Full Text]