Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis

doi:10.1084/jem.183.4.1377

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Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis

C Lagresle, P Mondiere, C Bella, PH Krammer and T Defrance
Institut National de la Sante et de la Recherche Medicale (INSERM) Unit 404, "Immunite et Vaccination," Institut Pasteur de Lyon, France.

Naive and memory B cells were isolated from human tonsils and examined for expression of APO-1/Fas and for their sensitivity to the APO-1- dependent apoptosis. APO-1 was found to be constitutively expressed on memory but not on naive B cells. The susceptibility of both cell types to the APO-1 apoptotic pathway was acquired upon CD40 triggering and was correlated with increased expression of the APO-1 receptor. Both naive and memory B cells were protected from the APO-1-mediated death signal after dual ligation of the Ag receptor adn CD40. Our findings suggest that the APO-1 pathway controls the specificity of B cell responses to T-dependent Ags and that occupancy of the Ag receptor dictates the outcome of APO-1-ligation on B cell survival.
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Craxton, A., Shu, G., Graves, J. D., Saklatvala, J., Krebs, E. G., Clark, E. A. (1998). p38 MAPK Is Required for CD40-Induced Gene Expression and Proliferation in B Lymphocytes. J. Immunol. 161: 3225-3236 [Abstract] [Full Text]
Rathmell, J. C., Fournier, S., Weintraub, B. C., Allison, J. P., Goodnow, C. C. (1998). Repression of B7.2 on Self-reactive B Cells Is Essential to Prevent Proliferation and Allow Fas-mediated Deletion by CD4+ T Cells. JEM 188: 651-659 [Abstract] [Full Text]
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Kuhne, M. R., Robbins, M., Hambor, J. E., Mackey, M. F., Kosaka, Y., Nishimura, T., Gigley, J. P., Noelle, R. J., Calderhead, D. M. (1997). Assembly and Regulation of the CD40 Receptor Complex in Human B Cells. JEM 186: 337-342 [Abstract] [Full Text]
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Reap, E. A., Roof, K., Maynor, K., Borrero, M., Booker, J., Cohen, P. L. (1997). Radiation and stress-induced apoptosis: A role for Fas/Fas ligand�interactions. Proc. Natl. Acad. Sci. USA 94: 5750-5755 [Abstract] [Full Text]
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