CD44 and its ligand hyaluronate mediate rolling under physiologic flow: a novel lymphocyte-endothelial cell primary adhesion pathway

doi:10.1084/jem.183.3.1119

This Article

	Full Text (PDF, 1216K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by DeGrendele, H. C.
	Articles by Siegelman, M. H.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by DeGrendele, H. C.
	Articles by Siegelman, M. H.


Social Bookmarking

	What's this?

ARTICLES

CD44 and its ligand hyaluronate mediate rolling under physiologic flow: a novel lymphocyte-endothelial cell primary adhesion pathway

HC DeGrendele, P Estess, LJ Picker and MH Siegelman
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, 75235-9072, USA.

The extravasation of leukocytes from the blood into tissues occurs as a multistep process: an initial transient interaction ("rolling"), generally thought to be mediated by the selectin family of adhesion molecules, followed by firm adhesion, usually mediated by integrins. Using a parallel plate flow chamber designed to approximate physiologic flow in postcapillary venules, we have characterized a rolling interaction between lymphoid cells and adherent primary and cultured endothelial cells that is not selectin mediated. Studies using blocking monoclonal antibodies indicate that this novel interaction is mediated by CD44. Abrogation of the rolling interaction could be specifically achieved using both soluble hyaluronate (HA) and treatment of the adherent cells with HA-reactive substances, indicating that HA is the ligand supporting this rolling interaction. Some B and T cell lines, as well as normal lymphocytes, either constitutively exhibit rolling or can be induced to do so by phorbol ester or in vivo antigen activation. These studies indicate that CD44 and its principal ligand hyaluronate represent another receptor/carbohydrate ligand pair mediating a novel activation-dependent pathway of lymphocyte/endothelial cell adhesion.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Norling, L. V, Perretti, M., Cooper, D. (2009). Endogenous galectins and the control of the host inflammatory response. J Endocrinol 201: 169-184 [Abstract] [Full Text]
Piconi, S., Trabattoni, D., Luraghi, C., Perilli, E., Borelli, M., Pacei, M., Rizzardini, G., Lattuada, A., Bray, D. H., Catalano, M., Sparaco, A., Clerici, M. (2009). Treatment of periodontal disease results in improvements in endothelial dysfunction and reduction of the carotid intima-media thickness. FASEB J. 23: 1196-1204 [Abstract] [Full Text]
Nightingale, T. D., Frayne, M. E. F., Clasper, S., Banerji, S., Jackson, D. G. (2009). A Mechanism of Sialylation Functionally Silences the Hyaluronan Receptor LYVE-1 in Lymphatic Endothelium. J. Biol. Chem. 284: 3935-3945 [Abstract] [Full Text]
Zen, K., Liu, D.-Q., Li, L.-M., Chen, C. X.-J., Guo, Y.-L., Ha, B., Chen, X., Zhang, C.-Y., Liu, Y. (2009). The Heparan Sulfate Proteoglycan Form of Epithelial CD44v3 Serves as a CD11b/CD18 Counter-receptor during Polymorphonuclear Leukocyte Transepithelial Migration. J. Biol. Chem. 284: 3768-3776 [Abstract] [Full Text]
Colon, E., Shytuhina, A., Cowman, M. K., Band, P. A., Sanggaard, K. W., Enghild, J. J., Wisniewski, H.-G. (2009). Transfer of Inter-{alpha}-inhibitor Heavy Chains to Hyaluronan by Surface-linked Hyaluronan-TSG-6 Complexes. J. Biol. Chem. 284: 2320-2331 [Abstract] [Full Text]
Hutas, G., Bajnok, E., Gal, I., Finnegan, A., Glant, T. T., Mikecz, K. (2008). CD44-specific antibody treatment and CD44 deficiency exert distinct effects on leukocyte recruitment in experimental arthritis. Blood 112: 4999-5006 [Abstract] [Full Text]
Wong, N. K. Y., Lai, J. C. Y., Birkenhead, D., Shaw, A. S., Johnson, P. (2008). CD45 Down-Regulates Lck-Mediated CD44 Signaling and Modulates Actin Rearrangement in T Cells. J. Immunol. 181: 7033-7043 [Abstract] [Full Text]
Ruffell, B., Johnson, P. (2008). Hyaluronan Induces Cell Death in Activated T Cells through CD44. J. Immunol. 181: 7044-7054 [Abstract] [Full Text]
Petri, B., Phillipson, M., Kubes, P. (2008). The Physiology of Leukocyte Recruitment: An In Vivo Perspective. J. Immunol. 180: 6439-6446 [Abstract] [Full Text]
Anderson, B. E., Taylor, P. A., McNiff, J. M., Jain, D., Demetris, A. J., Panoskaltsis-Mortari, A., Ager, A., Blazar, B. R., Shlomchik, W. D., Shlomchik, M. J. (2008). Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells. Blood 111: 5242-5251 [Abstract] [Full Text]
Gao, F., Koenitzer, J. R., Tobolewski, J. M., Jiang, D., Liang, J., Noble, P. W., Oury, T. D. (2008). Extracellular Superoxide Dismutase Inhibits Inflammation by Preventing Oxidative Fragmentation of Hyaluronan. J. Biol. Chem. 283: 6058-6066 [Abstract] [Full Text]
Mahaffey, C. L., Mummert, M. E. (2007). Hyaluronan Synthesis Is Required for IL-2-Mediated T Cell Proliferation. J. Immunol. 179: 8191-8199 [Abstract] [Full Text]
Pals, S. T., de Gorter, D. J. J., Spaargaren, M. (2007). Lymphoma dissemination: the other face of lymphocyte homing. Blood 110: 3102-3111 [Abstract] [Full Text]
Zoller, M., Gupta, P., Marhaba, R., Vitacolonna, M., Freyschmidt-Paul, P. (2007). Anti-CD44-mediated blockade of leukocyte migration in skin-associated immune diseases. J. Leukoc. Biol. 82: 57-71 [Abstract] [Full Text]
Taylor, K. R., Yamasaki, K., Radek, K. A., Nardo, A. D., Goodarzi, H., Golenbock, D., Beutler, B., Gallo, R. L. (2007). Recognition of Hyaluronan Released in Sterile Injury Involves a Unique Receptor Complex Dependent on Toll-like Receptor 4, CD44, and MD-2. J. Biol. Chem. 282: 18265-18275 [Abstract] [Full Text]
Hossain, M. S., Roback, J. D., Pollack, B. P., Jaye, D. L., Langston, A., Waller, E. K. (2007). Chronic GvHD decreases antiviral immune responses in allogeneic BMT. Blood 109: 4548-4556 [Abstract] [Full Text]
Zhao, L., A. Hall, J., Levenkova, N., Lee, E., Middleton, M. K., Zukas, A. M., Rader, D. J., Rux, J. J., Pure, E. (2007). CD44 Regulates Vascular Gene Expression in a Proatherogenic Environment. Arterioscler. Thromb. Vasc. Bio. 27: 886-892 [Abstract] [Full Text]
Rouschop, K. M. A., Sylva, M., Teske, G. J. D., Hoedemaeker, I., Pals, S. T., Weening, J. J., van der Poll, T., Florquin, S. (2006). Urothelial CD44 Facilitates Escherichia coli Infection of the Murine Urinary Tract. J. Immunol. 177: 7225-7232 [Abstract] [Full Text]
Sarraj, B., Ludanyi, K., Glant, T. T., Finnegan, A., Mikecz, K. (2006). Expression of CD44 and L-Selectin in the Innate Immune System Is Required for Severe Joint Inflammation in the Proteoglycan-Induced Murine Model of Rheumatoid Arthritis. J. Immunol. 177: 1932-1940 [Abstract] [Full Text]
Zhuo, L., Kanamori, A., Kannagi, R., Itano, N., Wu, J., Hamaguchi, M., Ishiguro, N., Kimata, K. (2006). SHAP Potentiates the CD44-mediated Leukocyte Adhesion to the Hyaluronan Substratum. J. Biol. Chem. 281: 20303-20314 [Abstract] [Full Text]
Larkin, J., Renukaradhya, G. J., Sriram, V., Du, W., Gervay-Hague, J., Brutkiewicz, R. R. (2006). CD44 Differentially Activates Mouse NK T Cells and Conventional T Cells. J. Immunol. 177: 268-279 [Abstract] [Full Text]
Bonder, C. S., Clark, S. R., Norman, M. U., Johnson, P., Kubes, P. (2006). Use of CD44 by CD4+ Th1 and Th2 lymphocytes to roll and adhere. Blood 107: 4798-4806 [Abstract] [Full Text]
Garton, K. J., Gough, P. J., Raines, E. W. (2006). Emerging roles for ectodomain shedding in the regulation of inflammatory responses. J. Leukoc. Biol. 79: 1105-1116 [Abstract] [Full Text]
Firan, M., Dhillon, S., Estess, P., Siegelman, M. H. (2006). Suppressor activity and potency among regulatory T cells is discriminated by functionally active CD44. Blood 107: 619-627 [Abstract] [Full Text]
Zaman, A., Cui, Z., Foley, J. P., Zhao, H., Grimm, P. C., DeLisser, H. M., Savani, R. C. (2005). Expression and Role of the Hyaluronan Receptor RHAMM in Inflammation after Bleomycin Injury. Am. J. Respir. Cell Mol. Bio. 33: 447-454 [Abstract] [Full Text]
Rouschop, K. M. A., Roelofs, J. J.T.H., Claessen, N., Martins, P. d. C., Zwaginga, J.-J., Pals, S. T., Weening, J. J., Florquin, S. (2005). Protection against Renal Ischemia Reperfusion Injury by CD44 Disruption. J. Am. Soc. Nephrol. 16: 2034-2043 [Abstract] [Full Text]
Song, L., Zlobin, A., Ghoshal, P., Zhang, Q., Houde, C., Weijzen, S., Jiang, Q., Nacheva, E., Yagan, D., Davis, E., Galiegue-Zouitina, S., Catovsky, D., Grogan, T., Fisher, R. I., Miele, L., Coignet, L. J. (2005). Alteration of SMRT Tumor Suppressor Function in Transformed Non-Hodgkin Lymphomas. Cancer Res. 65: 4554-4561 [Abstract] [Full Text]
Guazzone, V A, Denduchis, B, Lustig, L (2005). Involvement of CD44 in leukocyte recruitment to the rat testis in experimental autoimmune orchitis. Reproduction 129: 603-609 [Abstract] [Full Text]
Wisniewski, H.-G., Snitkin, E. S., Mindrescu, C., Sweet, M. H., Vilcek, J. (2005). TSG-6 Protein Binding to Glycosaminoglycans: FORMATION OF STABLE COMPLEXES WITH HYALURONAN AND BINDING TO CHONDROITIN SULFATES. J. Biol. Chem. 280: 14476-14484 [Abstract] [Full Text]
Yonekawa, K., Harlan, J. M. (2005). Targeting leukocyte integrins in human diseases. J. Leukoc. Biol. 77: 129-140 [Abstract] [Full Text]
Khan, A. I., Kerfoot, S. M., Heit, B., Liu, L., Andonegui, G., Ruffell, B., Johnson, P., Kubes, P. (2004). Role of CD44 and Hyaluronan in Neutrophil Recruitment. J. Immunol. 173: 7594-7601 [Abstract] [Full Text]
Salmi, M., Koskinen, K., Henttinen, T., Elima, K., Jalkanen, S. (2004). CLEVER-1 mediates lymphocyte transmigration through vascular and lymphatic endothelium. Blood 104: 3849-3857 [Abstract] [Full Text]
Draffin, J. E., McFarlane, S., Hill, A., Johnston, P. G., Waugh, D. J. J. (2004). CD44 Potentiates the Adherence of Metastatic Prostate and Breast Cancer Cells to Bone Marrow Endothelial Cells. Cancer Res. 64: 5702-5711 [Abstract] [Full Text]
Lesley, J., Gal, I., Mahoney, D. J., Cordell, M. R., Rugg, M. S., Hyman, R., Day, A. J., Mikecz, K. (2004). TSG-6 Modulates the Interaction between Hyaluronan and Cell Surface CD44. J. Biol. Chem. 279: 25745-25754 [Abstract] [Full Text]
Szanto, S., Gal, I., Gonda, A., Glant, T. T., Mikecz, K. (2004). Expression of L-Selectin, but Not CD44, Is Required for Early Neutrophil Extravasation in Antigen-Induced Arthritis. J. Immunol. 172: 6723-6734 [Abstract] [Full Text]
Avigdor, A., Goichberg, P., Shivtiel, S., Dar, A., Peled, A., Samira, S., Kollet, O., Hershkoviz, R., Alon, R., Hardan, I., Ben-Hur, H., Naor, D., Nagler, A., Lapidot, T. (2004). CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow. Blood 103: 2981-2989 [Abstract] [Full Text]
Sussmann, M., Sarbia, M., Meyer-Kirchrath, J., Nusing, R.M., Schror, K., Fischer, J.W. (2004). Induction of Hyaluronic Acid Synthase 2 (HAS2) in Human Vascular Smooth Muscle Cells by Vasodilatory Prostaglandins. Circ. Res. 94: 592-600 [Abstract] [Full Text]
Sumoza-Toledo, A., Santos-Argumedo, L. (2004). The spreading of B lymphocytes induced by CD44 cross-linking requires actin, tubulin, and vimentin rearrangements. J. Leukoc. Biol. 75: 233-239 [Abstract] [Full Text]
Milinkovic, M., Antin, J. H., Hergrueter, C. A., Underhill, C. B., Sackstein, R. (2004). CD44-hyaluronic acid interactions mediate shear-resistant binding of lymphocytes to dermal endothelium in acute cutaneous GVHD. Blood 103: 740-742 [Abstract] [Full Text]
Zaph, C., Scott, P. (2003). Th1 Cell-Mediated Resistance to Cutaneous Infection with Leishmania major Is Independent of P- and E-Selectins. J. Immunol. 171: 4726-4732 [Abstract] [Full Text]
Mohan, K., Pinto, D., Issekutz, T. B. (2003). Identification of Tissue Transglutaminase as a Novel Molecule Involved In Human CD8+ T Cell Transendothelial Migration. J. Immunol. 171: 3179-3186 [Abstract] [Full Text]
Gal, I., Lesley, J., Ko, W., Gonda, A., Stoop, R., Hyman, R., Mikecz, K. (2003). Role of the Extracellular and Cytoplasmic Domains of CD44 in the Rolling Interaction of Lymphoid Cells with Hyaluronan under Physiologic Flow. J. Biol. Chem. 278: 11150-11158 [Abstract] [Full Text]
Honjo, M., Nakamura, K., Yamashiro, K., Kiryu, J., Tanihara, H., McEvoy, L. M., Honda, Y., Butcher, E. C., Masaki, T., Sawamura, T. (2003). Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation. Proc. Natl. Acad. Sci. USA 100: 1274-1279 [Abstract] [Full Text]
Xu, H., Manivannan, A., Liversidge, J., Sharp, P. F., Forrester, J. V., Crane, I. J. (2002). Involvement of CD44 in leukocyte trafficking at the blood-retinal barrier. J. Leukoc. Biol. 72: 1133-1141 [Abstract] [Full Text]
Wols, H. A. M., Underhill, G. H., Kansas, G. S., Witte, P. L. (2002). The Role of Bone Marrow-Derived Stromal Cells in the Maintenance of Plasma Cell Longevity. J. Immunol. 169: 4213-4221 [Abstract] [Full Text]
Lesley, J., English, N. M., Gal, I., Mikecz, K., Day, A. J., Hyman, R. (2002). Hyaluronan Binding Properties of a CD44 Chimera Containing the Link Module of TSG-6. J. Biol. Chem. 277: 26600-26608 [Abstract] [Full Text]
Mazo, I. B., Quackenbush, E. J., Lowe, J. B., von Andrian, U. H. (2002). Total body irradiation causes profound changes in endothelial traffic molecules for hematopoietic progenitor cell recruitment to bone marrow. Blood 99: 4182-4191 [Abstract] [Full Text]
Underhill, G. H., Minges-Wols, H. A., Fornek, J. L., Witte, P. L., Kansas, G. S. (2002). IgG plasma cells display a unique spectrum of leukocyte adhesion and homing molecules. Blood 99: 2905-2912 [Abstract] [Full Text]
Berg, L.-P., James, M. J., Alvarez-Iglesias, M., Glennie, S., Lechler, R. I., Marelli-Berg, F. M. (2002). Functional Consequences of Noncognate Interactions Between CD4+ Memory T Lymphocytes and the Endothelium. J. Immunol. 168: 3227-3234 [Abstract] [Full Text]
Toole, B. P., Wight, T. N., Tammi, M. I. (2002). Hyaluronan-Cell Interactions in Cancer and Vascular Disease. J. Biol. Chem. 277: 4593-4596 [Full Text]
Fiorucci, S., Mencarelli, A., Palazzetti, B., Distrutti, E., Vergnolle, N., Hollenberg, M. D., Wallace, J. L., Morelli, A., Cirino, G. (2001). Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. Proc. Natl. Acad. Sci. USA 98: 13936-13941 [Abstract] [Full Text]
Brown, K. L., Maiti, A., Johnson, P. (2001). Role of Sulfation in CD44-Mediated Hyaluronan Binding Induced by Inflammatory Mediators in Human CD14+ Peripheral Blood Monocytes. J. Immunol. 167: 5367-5374 [Abstract] [Full Text]
Tanigawa, K., Takeshita, N., Craig, R. A., Phillips, K., Knibbs, R. N., Chang, A. E., Stoolman, L. M. (2001). Tumor-Specific Responses in Lymph Nodes Draining Murine Sarcomas Are Concentrated in Cells Expressing P-Selectin Binding Sites. J. Immunol. 167: 3089-3098 [Abstract] [Full Text]
Shi, M., Dennis, K., Peschon, J. J., Chandrasekaran, R., Mikecz, K. (2001). Antibody-Induced Shedding of CD44 from Adherent Cells Is Linked to the Assembly of the Cytoskeleton. J. Immunol. 167: 123-131 [Abstract] [Full Text]
Dimitroff, C. J., Lee, J. Y., Rafii, S., Fuhlbrigge, R. C., Sackstein, R. (2001). Cd44 Is a Major E-Selectin Ligand on Human Hematopoietic Progenitor Cells. JCB 153: 1277-1286 [Abstract] [Full Text]
Blass, S. L., Pure, E., Hunter, C. A. (2001). A Role for CD44 in the Production of IFN-{{gamma}} and Immunopathology During Infection with Toxoplasma gondii. J. Immunol. 166: 5726-5732 [Abstract] [Full Text]
Salmi, M., Jalkanen, S. (2001). Human Leukocyte Subpopulations from Inflamed Gut Bind to Joint Vasculature Using Distinct Sets of Adhesion Molecules. J. Immunol. 166: 4650-4657 [Abstract] [Full Text]
Bono, P., Rubin, K., Higgins, J. M. G., Hynes, R. O. (2001). Layilin, a Novel Integral Membrane Protein, Is a Hyaluronan Receptor. Mol. Biol. Cell 12: 891-900 [Abstract] [Full Text]
Fujimoto, T., Kawashima, H., Tanaka, T., Hirose, M., Toyama-Sorimachi, N., Matsuzawa, Y., Miyasaka, M. (2001). CD44 binds a chondroitin sulfate proteoglycan, aggrecan. Int Immunol 13: 359-366 [Abstract] [Full Text]
Wallach-Dayan, S. B., Grabovsky, V., Moll, J., Sleeman, J., Herrlich, P., Alon, R., Naor, D. (2001). CD44-dependent lymphoma cell dissemination: a cell surface CD44 variant, rather than standard CD44, supports in vitro lymphoma cell rolling on hyaluronic acid substrate and its in vivo accumulation in the peripheral lymph nodes. J. Cell Sci. 114: 3463-3477 [Abstract] [Full Text]
Levesque, M. C., Haynes, B. F. (2001). Activated T Lymphocytes Regulate Hyaluronan Binding to Monocyte CD44 Via Production of IL-2 and IFN-{{gamma}}. J. Immunol. 166: 188-196 [Abstract] [Full Text]
Savani, R. C., Hou, G., Liu, P., Wang, C., Simons, E., Grimm, P. C., Stern, R., Greenberg, A. H., DeLisser, H. M., Khalil, N. (2000). A Role for Hyaluronan in Macrophage Accumulation and Collagen Deposition after Bleomycin-Induced Lung Injury. Am. J. Respir. Cell Mol. Bio. 23: 475-484 [Abstract] [Full Text]
Mummert, M. E., Mohamadzadeh, M., Mummert, D. I., Mizumoto, N., Takashima, A. (2000). Development of a Peptide Inhibitor of Hyaluronan-Mediated Leukocyte Trafficking. JEM 192: 769-780 [Abstract] [Full Text]
Nandi, A., Estess, P., Siegelman, M. H. (2000). Hyaluronan Anchoring and Regulation on the Surface of Vascular Endothelial Cells Is Mediated through the Functionally Active Form of CD44. J. Biol. Chem. 275: 14939-14948 [Abstract] [Full Text]
Drillenburg, P., Pals, S. T. (2000). Cell adhesion receptors in lymphoma dissemination. Blood 95: 1900-1910 [Abstract] [Full Text]
de la Motte, C. A., Hascall, V. C., Calabro, A., Yen-Lieberman, B., Strong, S. A. (1999). Mononuclear Leukocytes Preferentially Bind via CD44 to Hyaluronan on Human Intestinal Mucosal Smooth Muscle Cells after Virus Infection or Treatment with Poly(I{middle dot}C). J. Biol. Chem. 274: 30747-30755 [Abstract] [Full Text]
Hengel, R. L., Jones, B. M., Kennedy, M. S., Hubbard, M. R., McDougal, J. S. (1999). Markers of Lymphocyte Homing Distinguish CD4 T Cell Subsets That Turn Over in Response to HIV-1 Infection in Humans. J. Immunol. 163: 3539-3548 [Abstract] [Full Text]
Estess, P., Nandi, A., Mohamadzadeh, M., Siegelman, M. H. (1999). Interleukin 15 Induces Endothelial Hyaluronan Expression in Vitro and Promotes Activated T Cell Extravasation through a Cd44-Dependent Pathway in Vivo. JEM 190: 9-20 [Abstract] [Full Text]
SALMI, M, JALKANEN, S (1999). Molecules controlling lymphocyte migration to the gut. Gut 45: 148-153 [Full Text]
Brocke, S., Piercy, C., Steinman, L., Weissman, I. L., Veromaa, T. (1999). Antibodies to CD44 and integrin alpha 4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment. Proc. Natl. Acad. Sci. USA 96: 6896-6901 [Abstract] [Full Text]
Giembycz, M. A., Lindsay, M. A. (1999). Pharmacology of the Eosinophil. Pharmacol. Rev. 51: 213-340 [Abstract] [Full Text]
Banerji, S., Ni, J., Wang, S.-X., Clasper, S., Su, J., Tammi, R., Jones, M., Jackson, D. G. (1999). LYVE-1, a New Homologue of the CD44 Glycoprotein, Is a Lymph-specific Receptor for Hyaluronan. JCB 144: 789-801 [Abstract] [Full Text]
Catalina, M. D., Estess, P., Siegelman, M. H. (1999). Selective Requirements for Leukocyte Adhesion Molecules in Models of Acute and Chronic Cutaneous Inflammation: Participation of E- and P- But Not L-Selectin. Blood 93: 580-589 [Abstract] [Full Text]
Stein, J. V., Cheng, G., Stockton, B. M., Fors, B. P., Butcher, E. C., von Andrian, U. H. (1999). L-selectin-mediated Leukocyte Adhesion In Vivo: Microvillous Distribution Determines Tethering Efficiency, But Not Rolling Velocity. JEM 189: 37-50 [Abstract] [Full Text]
Maiti, A., Maki, G., Johnson, P. (1998). TNF- Induction of CD44-Mediated Leukocyte Adhesion by Sulfation. Science 282: 941-943 [Abstract] [Full Text]
DeLisser, H. M., Albelda, S. M. (1998). The Function of Cell Adhesion Molecules in Lung Inflammation: More Questions Than Answers. Am. J. Respir. Cell Mol. Bio. 19: 533-536 [Full Text]
Steeber, D. A., Campbell, M. A., Basit, A., Ley, K., Tedder, T. F. (1998). Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expression. Proc. Natl. Acad. Sci. USA 95: 7562-7567 [Abstract] [Full Text]
Matsumoto, K., Appiah-Pippim, J., Schleimer, R. P., Bickel, C. A., Beck, L. A., Bochner, B. S. (1998). CD44 and CD69 Represent Different Types of Cell-surface Activation Markers for Human Eosinophils. Am. J. Respir. Cell Mol. Bio. 18: 860-866 [Abstract] [Full Text]
Cines, D. B., Pollak, E. S., Buck, C. A., Loscalzo, J., Zimmerman, G. A., McEver, R. P., Pober, J. S., Wick, T. M., Konkle, B. A., Schwartz, B. S., Barnathan, E. S., McCrae, K. R., Hug, B. A., Schmidt, A.-M., Stern, D. M. (1998). Endothelial Cells in Physiology and in the Pathophysiology of Vascular Disorders. Blood 91: 3527-3561 [Full Text]
Sherman, L., Wainwright, D., Ponta, H., Herrlich, P. (1998). A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb�outgrowth. Genes Dev. 12: 1058-1071 [Abstract] [Full Text]
Esford, L., Maiti, A, Bader, S., Tufaro, F, Johnson, P (1998). Analysis of CD44 interactions with hyaluronan in murine L cell fibroblasts deficient in glycosaminoglycan synthesis: a role for chondroitin sulfate. J. Cell Sci. 111: 1021-1029 [Abstract]
Bajorath, J., Greenfield, B., Munro, S. B., Day, A. J., Aruffo, A. (1998). Identification of CD44 Residues Important for Hyaluronan Binding and Delineation of the Binding Site. J. Biol. Chem. 273: 338-343 [Abstract] [Full Text]
Kogerman, P., Sy, M.-S., Culp, L. A. (1997). Overexpressed human CD44s promotes lung colonization during micrometastasis of murine fibrosarcoma cells: Facilitated retention in the lung�vasculature. Proc. Natl. Acad. Sci. USA 94: 13233-13238 [Abstract] [Full Text]
DeGrendele, H. C., Estess, P., Siegelman, M. H. (1997). Requirement for CD44 in Activated T Cell Extravasation into an Inflammatory Site. Science 278: 672-675 [Abstract] [Full Text]
Schmits, R., Filmus, J., Gerwin, N., Senaldi, G., Kiefer, F., Kundig, T., Wakeham, A., Shahinian, A., Catzavelos, C., Rak, J., Furlonger, C., Zakarian, A., Simard, J. J.L., Ohashi, P. S., Paige, C. J., Gutierrez-Ramos, J. C., Mak, T. W. (1997). CD44 Regulates Hematopoietic Progenitor Distribution, Granuloma Formation, and Tumorigenicity. Blood 90: 2217-2233 [Abstract] [Full Text]
Todderud, G., Nair, X., Lee, D., Alford, J., Davern, L., Stanley, P., Bachand, C., Lapointe, P., Marinier, A., Martel, A., Menard, M., Wright, J. J., Bajorath, J., Hollenbaugh, D., Aruffo, A., Tramposch, K. M. (1997). BMS-190394, a Selectin Inhibitor, Prevents Rat Cutaneous Inflammatory Reactions. J. Pharmacol. Exp. Ther. 282: 1298-1304 [Abstract] [Full Text]
Griffioen, A. W., Coenen, M. J.H., Damen, C. A., Hellwig, S. M.M., H.J. van Weering, D., Vooys, W., Blijham, G. H., Groenewegen, G. (1997). CD44 Is Involved in Tumor Angiogenesis; an Activation Antigen on Human Endothelial Cells. Blood 90: 1150-1159 [Abstract] [Full Text]
Clark, R. A., Erickson, H. P., Springer, T. A. (1997). Tenascin Supports Lymphocyte Rolling. JCB 137: 755-765 [Abstract] [Full Text]
Chen, S., Alon, R., Fuhlbrigge, R. C., Springer, T. A. (1997). Rolling and transient tethering of leukocytes on antibodies reveal specializations of�selectins. Proc. Natl. Acad. Sci. USA 94: 3172-3177 [Abstract] [Full Text]
Prevo, R., Banerji, S., Ferguson, D. J. P., Clasper, S., Jackson, D. G. (2001). Mouse LYVE-1 Is an Endocytic Receptor for Hyaluronan in Lymphatic Endothelium. J. Biol. Chem. 276: 19420-19430 [Abstract] [Full Text]