Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion

doi:10.1084/jem.183.2.693

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Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion

E Stuber, W Strober and M Neurath
Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1890, USA.

The recent finding that CD40L on activated T cells induces interleukin (IL) 12 secretion in human peripheral blood monocytes in vitro suggests that the CD40L-CD40 interaction may be of importance in the priming of T helper (Th) 1-type T cells. We therefore investigated the in vivo relevance of this interaction in an experimental model for a Th1- mediated disease, the hapten reagent (2,4,6-trinitrobenzene sulfonic acid [TNBS])-induced colitis. The administration of anti-gp39 (CD40L) antibodies during the induction phase of the Th1 response prevented interferon gamma production by lamina propria CD4+ T cells and also clinical and histological evidence of disease. In contrast, the secretion of IL-4, a Th2-type cytokine, was increased after anti-gp39 treatment. In further studies we showed that the prevention of disease activity was caused by an inhibition of IL-12 secretion, as demonstrated by immunohistochemistry. In addition, the injection of recombinant IL-12 p70 heterodimer into TNBS + anti-gp39-treated mice reversed the effect of anti-gp39 and resulted in severe disease activity. When anti-gp39 was given after the disease was established, no effect on the disease activity was observed. In conclusion, we demonstrated that the CD40L-CD40 interaction is crucial for the in vivo priming of Th1 T cells via the stimulation of IL-12 secretion by antigen-presenting cells (APC).
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French, L. E., Huard, B., Wysocka, M., Shane, R., Contassot, E., Arrighi, J.-F., Piguet, V., Calderara, S., Rook, A. H. (2005). Impaired CD40L signaling is a cause of defective IL-12 and TNF-{alpha} production in Sezary syndrome: circumvention by hexameric soluble CD40L. Blood 105: 219-225 [Abstract] [Full Text]
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Lee, B. O., Haynes, L., Eaton, S. M., Swain, S. L., Randall, T. D. (2002). The Biological Outcome of CD40 Signaling Is Dependent on the Duration of CD40 Ligand Expression: Reciprocal Regulation by Interleukin (IL)-4 and IL-12. JEM 196: 693-704 [Abstract] [Full Text]
McDowell, M. A., Marovich, M., Lira, R., Braun, M., Sacks, D. (2002). Leishmania Priming of Human Dendritic Cells for CD40 Ligand-Induced Interleukin-12p70 Secretion Is Strain and Species Dependent. Infect. Immun. 70: 3994-4001 [Abstract] [Full Text]
Nierkens, S., van Helden, P., Bol, M., Bleumink, R., van Kooten, P., Ramdien-Murli, S., Boon, L., Pieters, R. (2002). Selective Requirement for CD40-CD154 in Drug-Induced Type 1 Versus Type 2 Responses to Trinitrophenyl-Ovalbumin. J. Immunol. 168: 3747-3754 [Abstract] [Full Text]
Buning, C., Kruger, K., Sieber, T., Schoeler, D., Schriever, F. (2002). Increased Expression of CD40 Ligand on Activated T Cells of Patients with Colon Cancer. Clin. Cancer Res. 8: 1147-1151 [Abstract] [Full Text]
Serbina, N. V., Lazarevic, V., Flynn, J. L. (2001). CD4+ T Cells Are Required for the Development of Cytotoxic CD8+ T Cells During Mycobacterium tuberculosis Infection. J. Immunol. 167: 6991-7000 [Abstract] [Full Text]
Fiorucci, S., Mencarelli, A., Palazzetti, B., Distrutti, E., Vergnolle, N., Hollenberg, M. D., Wallace, J. L., Morelli, A., Cirino, G. (2001). Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. Proc. Natl. Acad. Sci. USA 98: 13936-13941 [Abstract] [Full Text]
Wan, Y., Lu, L., Bramson, J. L., Baral, S., Zhu, Q., Pilon, A., Dayball, K. (2001). Dendritic Cell-Derived IL-12 Is Not Required for the Generation of Cytotoxic, IFN-{gamma}-Secreting, CD8+ CTL In Vivo. J. Immunol. 167: 5027-5033 [Abstract] [Full Text]
Kullberg, M. C., Rothfuchs, A. G., Jankovic, D., Caspar, P., Wynn, T. A., Gorelick, P. L., Cheever, A. W., Sher, A. (2001). Helicobacter hepaticus-Induced Colitis in Interleukin-10-Deficient Mice: Cytokine Requirements for the Induction and Maintenance of Intestinal Inflammation. Infect. Immun. 69: 4232-4241 [Abstract] [Full Text]
Martin, M., Metzger, D. J., Michalek, S. M., Connell, T. D., Russell, M. W. (2001). Distinct Cytokine Regulation by Cholera Toxin and Type II Heat-Labile Toxins Involves Differential Regulation of CD40 Ligand on CD4+ T Cells. Infect. Immun. 69: 4486-4492 [Abstract] [Full Text]
Ahlers, J. D., Belyakov, I. M., Matsui, S., Berzofsky, J. A. (2001). Mechanisms of cytokine synergy essential for vaccine protection against viral challenge. Int Immunol 13: 897-908 [Abstract] [Full Text]
Gorbachev, A. V., DiIulio, N. A., Fairchild, R. L. (2001). IL-12 Augments CD8+ T Cell Development for Contact Hypersensitivity Responses and Circumvents Anti-CD154 Antibody-Mediated Inhibition. J. Immunol. 167: 156-162 [Abstract] [Full Text]
Im, S.-H., Barchan, D., Maiti, P. K., Fuchs, S., Souroujon, M. C. (2001). Blockade of CD40 Ligand Suppresses Chronic Experimental Myasthenia Gravis by Down-Regulation of Th1 Differentiation and Up-Regulation of CTLA-4. J. Immunol. 166: 6893-6898 [Abstract] [Full Text]
Min, B., Legge, K. L., Bell, J. J., Gregg, R. K., Li, L., Caprio, J. C., Zaghouani, H. (2001). Neonatal Exposure to Antigen Induces a Defective CD40 Ligand Expression that Undermines Both IL-12 Production by APC and IL-2 Receptor Up-Regulation on Splenic T Cells and Perpetuates IFN-{{gamma}}-Dependent T Cell Anergy. J. Immunol. 166: 5594-5603 [Abstract] [Full Text]
Green, K. A., Noelle, R. J., Durell, B. G., Green, W. R. (2001). Characterization of the CD154-Positive and CD40-Positive Cellular Subsets Required for Pathogenesis in Retrovirus-Induced Murine Immunodeficiency. J. Virol. 75: 3581-3589 [Abstract] [Full Text]
Hoffmann, J C, Peters, K, Henschke, S, Herrmann, B, Pfister, K, Westermann, J, Zeitz, M (2001). Role of T lymphocytes in rat 2,4,6-trinitrobenzene sulphonic acid (TNBS) induced colitis: increased mortality after {gamma}{delta} T cell depletion and no effect of {alpha}{beta} T cell depletion. Gut 48: 489-495 [Abstract] [Full Text]
Zhang-Hoover, J., Sutton, A., Stein-Streilein, J. (2001). CD40/CD40 Ligand Interactions Are Critical for Elicitation of Autoimmune-Mediated Fibrosis in the Lung. J. Immunol. 166: 3556-3563 [Abstract] [Full Text]
Gorbachev, A. V., Heeger, P. S., Fairchild, R. L. (2001). CD4+ and CD8+ T Cell Priming for Contact Hypersensitivity Occurs Independently of CD40-CD154 Interactions. J. Immunol. 166: 2323-2332 [Abstract] [Full Text]
Howard, L. M., Miller, S. D. (2001). Autoimmune Intervention by CD154 Blockade Prevents T Cell Retention and Effector Function in the Target Organ. J. Immunol. 166: 1547-1553 [Abstract] [Full Text]
Sarukhan, A., Camugli, S., Gjata, B., von Boehmer, H., Danos, O., Jooss, K. (2001). Successful Interference with Cellular Immune Responses to Immunogenic Proteins Encoded by Recombinant Viral Vectors. J. Virol. 75: 269-277 [Abstract] [Full Text]
Tan, J., Town, T., Mori, T., Wu, Y., Saxe, M., Crawford, F., Mullan, M. (2000). CD45 Opposes beta -Amyloid Peptide-Induced Microglial Activation via Inhibition of p44/42 Mitogen-Activated Protein Kinase. J. Neurosci. 20: 7587-7594 [Abstract] [Full Text]
Avice, M.-N., Rubio, M., Sergerie, M., Delespesse, G., Sarfati, M. (2000). CD47 Ligation Selectively Inhibits the Development of Human Naive T Cells into Th1 Effectors. J. Immunol. 165: 4624-4631 [Abstract] [Full Text]
Namba, K., Ogasawara, K., Kitaichi, N., Morohashi, T., Sasamoto, Y., Kotake, S., Matsuda, H., Iwabuchi, K., Iwabuchi, C., Ohno, S., Onoe, K. (2000). Amelioration of Experimental Autoimmune Uveoretinitis by Pretreatment with a Pathogenic Peptide in Liposome and Anti-CD40 Ligand Monoclonal Antibody. J. Immunol. 165: 2962-2969 [Abstract] [Full Text]
Ma, X., Montaner, L. J. (2000). Proinflammatory response and IL-12 expression in HIV-1 infection. J. Leukoc. Biol. 68: 383-390 [Abstract] [Full Text]
Cong, Y., Weaver, C. T., Lazenby, A., Elson, C. O. (2000). Colitis Induced by Enteric Bacterial Antigen-Specific CD4+ T Cells Requires CD40-CD40 Ligand Interactions for a Sustained Increase in Mucosal IL-12. J. Immunol. 165: 2173-2182 [Abstract] [Full Text]
Legge, K. L., Min, B., Bell, J. J., Caprio, J. C., Li, L., Gregg, R. K., Zaghouani, H. (2000). Coupling of Peripheral Tolerance to Endogenous Interleukin 10 Promotes Effective Modulation of Myelin-Activated T Cells and Ameliorates Experimental Allergic Encephalomyelitis. JEM 191: 2039-2052 [Abstract] [Full Text]
Wittig, B. M., Johansson, B., Zoller, M., Schwarzler, C., Gunthert, U. (2000). Abrogation of Experimental Colitis Correlates with Increased Apoptosis in Mice Deficient for Cd44 Variant Exon 7 (Cd44v7). JEM 191: 2053-2064 [Abstract] [Full Text]
Liu, Z., Geboes, K., Colpaert, S., Overbergh, L., Mathieu, C., Heremans, H., de Boer, M., Boon, L., D'Haens, G., Rutgeerts, P., Ceuppens, J. L. (2000). Prevention of Experimental Colitis in SCID Mice Reconstituted with CD45RBhigh CD4+ T Cells by Blocking the CD40-CD154 Interactions. J. Immunol. 164: 6005-6014 [Abstract] [Full Text]
Gjertsson, I., Hultgren, O. H., Stenson, M., Holmdahl, R., Tarkowski, A. (2000). Are B Lymphocytes of Importance in Severe Staphylococcus aureus Infections?. Infect. Immun. 68: 2431-2434 [Abstract] [Full Text]
Samten, B., Thomas, E. K., Gong, J., Barnes, P. F. (2000). Depressed CD40 Ligand Expression Contributes to Reduced Gamma Interferon Production in Human Tuberculosis. Infect. Immun. 68: 3002-3006 [Abstract] [Full Text]
Yamamoto, M., Yoshizaki, K., Kishimoto, T., Ito, H. (2000). IL-6 Is Required for the Development of Th1 Cell-Mediated Murine Colitis. J. Immunol. 164: 4878-4882 [Abstract] [Full Text]
Huang, W.-X., Huang, P., Hillert, J. (2000). Systemic upregulation of CD40 and CD40 ligand mRNA expression in multiple sclerosis. Mult Scler 6: 61-65 [Abstract]
Braun, M. C., Lahey, E., Kelsall, B. L. (2000). Selective Suppression of IL-12 Production by Chemoattractants. J. Immunol. 164: 3009-3017 [Abstract] [Full Text]
Reichmann, G., Walker, W., Villegas, E. N., Craig, L., Cai, G., Alexander, J., Hunter, C. A. (2000). The CD40/CD40 Ligand Interaction Is Required for Resistance to Toxoplasmic Encephalitis. Infect. Immun. 68: 1312-1318 [Abstract] [Full Text]
Martin, D. L., King, C. L., Pearlman, E., Strine, E., Heinzel, F. P. (2000). IFN-{gamma} Is Necessary But Not Sufficient for Anti-CD40 Antibody-Mediated Inhibition of the Th2 Response to Schistosoma mansoni Eggs. J. Immunol. 164: 779-785 [Abstract] [Full Text]
Lefrancois, L., Olson, S., Masopust, D. (1999). A Critical Role for Cd40-Cd40 Ligand Interactions in Amplification of the Mucosal Cd8 T Cell Response. JEM 190: 1275-1284 [Abstract] [Full Text]
Liu, Z., Colpaert, S., D'Haens, G. R., Kasran, A., Boer, M. d., Rutgeerts, P., Geboes, K., Ceuppens, J. L. (1999). Hyperexpression of CD40 Ligand (CD154) in Inflammatory Bowel Disease and Its Contribution to Pathogenic Cytokine Production. J. Immunol. 163: 4049-4057 [Abstract] [Full Text]
Shepherd, D. M., Kerkvliet, N. I. (1999). Disruption of CD154:CD40 Blocks Generation of Allograft Immunity Without Affecting APC Activation. J. Immunol. 163: 2470-2477 [Abstract] [Full Text]
Zeidler, R., Reisbach, G., Wollenberg, B., Lang, S., Chaubal, S., Schmitt, B., Lindhofer, H. (1999). Simultaneous Activation of T Cells and Accessory Cells by a New Class of Intact Bispecific Antibody Results in Efficient Tumor Cell Killing. J. Immunol. 163: 1246-1252 [Abstract] [Full Text]
Subauste, C. S., Wessendarp, M., Sorensen, R. U., Leiva, L. E. (1999). CD40-CD40 Ligand Interaction Is Central to Cell-Mediated Immunity Against Toxoplasma gondii: Patients with Hyper IgM Syndrome Have a Defective Type 1 Immune Response That Can Be Restored by Soluble CD40 Ligand Trimer. J. Immunol. 162: 6690-6700 [Abstract] [Full Text]
Claesson, M. H., Bregenholt, S., Bonhagen, K., Thoma, S., Moller, P., Grusby, M. J., Leithauser, F., Nissen, M. H., Reimann, J. (1999). Colitis-Inducing Potency of CD4+ T Cells in Immunodeficient, Adoptive Hosts Depends on Their State of Activation, IL-12 Responsiveness, and CD45RB Surface Phenotype. J. Immunol. 162: 3702-3710 [Abstract] [Full Text]
Retini, C., Casadevall, A., Pietrella, D., Monari, C., Palazzetti, B., Vecchiarelli, A. (1999). Specific Activated T Cells Regulate IL-12 Production by Human Monocytes Stimulated with Cryptococcus neoformans. J. Immunol. 162: 1618-1623 [Abstract] [Full Text]
ROSSINI, A. A., GREINER, D. L., MORDES, J. P. (1999). Induction of Immunologic Tolerance for Transplantation. Physiol. Rev. 79: 99-141 [Abstract] [Full Text]
Higgins, L. M., McDonald, S. A. C., Whittle, N., Crockett, N., Shields, J. G., MacDonald, T. T. (1999). Regulation of T Cell Activation In Vitro and In Vivo by Targeting the OX40-OX40 Ligand Interaction: Amelioration of Ongoing Inflammatory Bowel Disease with an OX40-IgG Fusion Protein, But Not with an OX40 Ligand-IgG Fusion Protein. J. Immunol. 162: 486-493 [Abstract] [Full Text]
Sharma, M. D., Leite de Moraes, M., Zavala, F., Pontoux, C., Papiernik, M. (1998). Induction and Inhibition of CD40-CD40 Ligand Interactions: A New Strategy Underlying Host-Virus Relationships. J. Immunol. 161: 5357-5365 [Abstract] [Full Text]
Lingnau, K., Hoehn, P., Kerdine, S., Koelsch, S., Neudoerfl, C., Palm, N., Ruede, E., Schmitt, E. (1998). IL-4 in Combination with TGF-{beta} Favors an Alternative Pathway of Th1 Development Independent of IL-12. J. Immunol. 161: 4709-4718 [Abstract] [Full Text]
Ohshima, Y., Yang, L.-P., Uchiyama, T., Tanaka, Y., Baum, P., Sergerie, M., Hermann, P., Delespesse, G. (1998). OX40 Costimulation Enhances Interleukin-4 (IL-4) Expression at Priming and Promotes the Differentiation of Naive Human CD4+ T Cells Into High IL-4-Producing Effectors. Blood 92: 3338-3345 [Abstract] [Full Text]
Mackey, M. F., Gunn, J. R., Maliszewski, C., Kikutani, H., Noelle, R. J., Barth, R. J. Jr. (1998). Cutting Edge: Dendritic Cells Require Maturation via CD40 to Generate Protective Antitumor Immunity. J. Immunol. 161: 2094-2098 [Abstract] [Full Text]
Gans, H. A., Arvin, A. M., Galinus, J., Logan, L., DeHovitz, R., Maldonado, Y. (1998). Deficiency of the Humoral Immune Response to Measles Vaccine in Infants Immunized at Age 6 Months. JAMA 280: 527-532 [Abstract] [Full Text]
Wittig, B., Schwarzler, C., Fohr, N., Gunthert, U., Zoller, M. (1998). Cutting Edge: Curative Treatment of an Experimentally Induced Colitis by a CD44 Variant V7-Specific Antibody. J. Immunol. 161: 1069-1073 [Abstract] [Full Text]
Kornbluth, R. S., Kee, K., Richman, D. D. (1998). CD40 ligand (CD154) stimulation of macrophages to produce HIV-1-suppressive beta -chemokines. Proc. Natl. Acad. Sci. USA 95: 5205-5210 [Abstract] [Full Text]
Zhou, P., Seder, R. A. (1998). CD40 Ligand Is Not Essential for Induction of Type 1 Cytokine Responses or Protective Immunity after Primary or Secondary Infection With Histoplasma capsulatum. JEM 187: 1315-1324 [Abstract] [Full Text]
Kalled, S. L., Cutler, A. H., Datta, S. K., Thomas, D. W. (1998). Anti-CD40 Ligand Antibody Treatment of SNF1 Mice with Established Nephritis: Preservation of Kidney Function. J. Immunol. 160: 2158-2165 [Abstract] [Full Text]
Peng, X., Remacle, J. E., Kasran, A., Huylebroeck, D., Ceuppens, J. L. (1998). IL-12 Up-Regulates CD40 Ligand (CD154) Expression on Human T Cells. J. Immunol. 160: 1166-1172 [Abstract] [Full Text]
Giese, N. A., Gabriele, L., Doherty, T. M., Klinman, D. M., Tadesse-Heath, L., Contursi, C., Epstein, S. L., Morse, H. C. III (1997). Interferon (IFN) Consensus Sequence-binding Protein, a Transcription Factor of the IFN Regulatory Factor Family, Regulates Immune Responses In Vivo through Control of Interleukin 12 Expression. JEM 186: 1535-1546 [Abstract] [Full Text]
Carbone, E., Ruggiero, G., Terrazzano, G., Palomba, C., Manzo, C., Fontana, S., Spits, H., Karre, K., Zappacosta, S. (1997). A New Mechanism of NK Cell Cytotoxicity Activation: The CD40-CD40 Ligand Interaction. JEM 185: 2053-2060 [Abstract] [Full Text]
Meyaard, L., Hovenkamp, E., Pakker, N., van der Pouw Kraan, T. C.T.M., Miedema, F. (1997). Interleukin-12 (IL-12) Production in Whole Blood Cultures From Human Immunodeficiency Virus-Infected Individuals Studied in Relation to IL-10 and Prostaglandin E2 Production. Blood 89: 570-576 [Abstract] [Full Text]
Hancock, W.�W., Sayegh, M.�H., Zheng, X.-G., Peach, R., Linsley, P.�S., Turka, L.�A. (1996). Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft�rejection. Proc. Natl. Acad. Sci. USA 93: 13967-13972 [Abstract] [Full Text]
Grewal, I. S., Foellmer, H. G., Grewal, K. D., Xu, J., Hardardottir, F., Baron, J. L., Janeway Jr., C. A., Flavell, R. A. (1996). Requirement for CD40 Ligand in Costimulation Induction, T Cell Activation, and Experimental Allergic Encephalomyelitis. Science 273: 1864-1867 [Abstract] [Full Text]