Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors

doi:10.1084/jem.183.2.639

This Article

	Full Text (PDF, 555K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Li, Y.
	Articles by Chen, L.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Li, Y.
	Articles by Chen, L.


Social Bookmarking

	What's this?

ARTICLES

Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors

Y Li, KE Hellstrom, SA Newby and L Chen
Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121, USA.

Genetic modification of many types of mouse tumors to express the B7-1 or B7-2 molecules, natural ligands for the T cell-costimulatory molecule CD28, increases their immunogenicity. However, even after transfection with the B7-1 and/or B7-2 genes, poorly immunogenic tumors fail to elicit and efficient immune response. We report here that two such tumors, the Ag104A sarcoma and the K1735-M2 melanoma, become immunogenic after transfection of the genes encoding murine B7-1 together with CD48, which is the natural ligand for CD2. Tumor-specific CD8+ cytotoxic T lymphocytes were readily generated and were effective for adoptive immunotherapy of metastasis induced by wild-type Ag104A sarcoma cells. A similar approach may be useful for developing therapy for other poorly immunogenic tumors, including those in humans.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Yang, S., Yang, Y., Raycraft, J., Zhang, H., Kanan, S., Guo, Y., Ronai, Z., Hellstrom, I., Hellstrom, K. E. (2004). Melanoma cells transfected to express CD83 induce antitumor immunity that can be increased by also engaging CD137. Proc. Natl. Acad. Sci. USA 101: 4990-4995 [Abstract] [Full Text]
Flynn, S., Stockinger, B. (2003). Tumor and CD4 T-cell interactions: tumor escape as result of reciprocal inactivation. Blood 101: 4472-4478 [Abstract] [Full Text]
LaBelle, J. L., Hanke, C. A., Blazar, B. R., Truitt, R. L. (2002). Negative effect of CTLA-4 on induction of T-cell immunity in vivo to B7-1+, but not B7-2+, murine myelogenous leukemia. Blood 99: 2146-2153 [Abstract] [Full Text]
Zheng, G., Chen, A., Sterner, R. E., Zhang, P. J., Pan, T., Kiyatkin, N., Tykocinski, M. L. (2001). Induction of Antitumor Immunity via Intratumoral Tetra-Costimulator Protein Transfer. Cancer Res. 61: 8127-8134 [Abstract] [Full Text]
Tamura, H., Dong, H., Zhu, G., Sica, G. L., Flies, D. B., Tamada, K., Chen, L. (2001). B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood 97: 1809-1816 [Abstract] [Full Text]
Todo, T., Martuza, R. L., Dallman, M. J., Rabkin, S. D. (2001). In Situ Expression of Soluble B7-1 in the Context of Oncolytic Herpes Simplex Virus Induces Potent Antitumor Immunity. Cancer Res. 61: 153-161 [Abstract] [Full Text]
Nishimura, T., Iwakabe, K., Sekimoto, M., Ohmi, Y., Yahata, T., Nakui, M., Sato, T., Habu, S., Tashiro, H., Sato, M., Ohta, A. (1999). Distinct Role of Antigen-Specific T Helper Type 1 (Th1) and Th2 Cells in Tumor Eradication in Vivo. JEM 190: 617-628 [Abstract] [Full Text]
Sembries, S., Pahl, H., Stilgenbauer, S., Dohner, H., Schriever, F. (1999). Reduced Expression of Adhesion Molecules and Cell Signaling Receptors by Chronic Lymphocytic Leukemia Cells With 11q Deletion. Blood 93: 624-631 [Abstract] [Full Text]
Mutis, T., Schrama, E., Melief, C. J.M., Goulmy, E. (1998). CD80-Transfected Acute Myeloid Leukemia Cells Induce Primary Allogeneic T-Cell Responses Directed at Patient Specific Minor Histocompatibility Antigens and Leukemia-Associated Antigens. Blood 92: 1677-1684 [Abstract] [Full Text]
Wu, Y., Zhou, Q., Zheng, P., Liu, Y. (1998). CD28-independent Induction of T Helper Cells and Immunoglobulin Class Switches Requires Costimulation by the Heat-stable Antigen. JEM 187: 1151-1156 [Abstract] [Full Text]
Wick, M., Dubey, P., Koeppen, H., Siegel, C. T., Fields, P. E., Chen, L., Bluestone, J. A., Schreiber, H. (1997). Antigenic Cancer Cells Grow Progressively in Immune Hosts without Evidence for T Cell Exhaustion or Systemic Anergy. JEM 186: 229-238 [Abstract] [Full Text]