Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1

doi:10.1084/jem.183.2.393

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Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1

AM Reimold, PD Ponath, YS Li, RR Hardy, CS David, JL Strominger and LH Glimcher
Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

The transcription factor human X-box binding protein 1 (hXBP-1) is a basic region-leucine zipper protein implicated in the regulation of major histocompatibility complex class II gene expression as well as in exocrine gland and skeletal development. Multiple regulatory elements in the hXBP-1 promoter lie 3' to the transcription start site, including the hX2 site, whose core sequence is an AP-1-like element identical to the hXBP-1 target sequence in the HLA-DRA promoter. One complex identified by electrophoretic mobility shift assay (EMSA), complex 3, was previously shown to protect the hX2 site and more 3' bases. Sequence analysis now shows that this region contains a consensus binding site for transcription factor BSAP (B cell lineage- specific activator protein). Complex 3 and BSAP have identical cell- type specificities, as they are found only in pre-B and mature B cell lines. In EMSAs, BSAP antibody specifically recognized complex 3, and in vitro translated BSAP could bind to an hXBP promoter fragment. Cotransfections using an hXBP-1 reporter construct indicated that BSAP downregulates the hXBP-1 promoter. The highest levels of hXBP-1 mRNA were found when BSAP was not expressed, in pre-Pro-B cells and in plasma cell lines. In addition, hXBP-1 and BSAP levels were inversely correlated along the early stages of B cell development. In the regulation of the hXBP-1 promoter, a strong positive transcriptional influence at the hX2 site is opposed by the downregulatory actions of BSAP.
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Mora-Lopez, F., Reales, E., Brieva, J. A., Campos-Caro, A. (2007). Human BSAP and BLIMP1 conform an autoregulatory feedback loop. Blood 110: 3150-3157 [Abstract] [Full Text]
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Lee, K., Tirasophon, W., Shen, X., Michalak, M., Prywes, R., Okada, T., Yoshida, H., Mori, K., Kaufman, R. J. (2002). IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev. 16: 452-466 [Abstract] [Full Text]
Tierney, R., Kirby, H., Nagra, J., Rickinson, A., Bell, A. (2000). The Epstein-Barr Virus Promoter Initiating B-Cell Transformation Is Activated by RFX Proteins and the B-Cell-Specific Activator Protein BSAP/Pax5. J. Virol. 74: 10458-10467 [Abstract] [Full Text]
Maitra, S., Atchison, M. (2000). BSAP Can Repress Enhancer Activity by Targeting PU.1 Function. Mol. Cell. Biol. 20: 1911-1922 [Abstract] [Full Text]
Reimold, A. M., Etkin, A., Clauss, I., Perkins, A., Friend, D. S., Zhang, J., Horton, H. F., Scott, A., Orkin, S. H., Byrne, M. C., Grusby, M. J., Glimcher, L. H. (2000). An essential role in liver development for transcription factor XBP-1. Genes Dev. 14: 152-157 [Abstract] [Full Text]
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Lauring, J., Schlissel, M. S. (1999). Distinct Factors Regulate the Murine RAG-2 Promoter in B- and T-Cell Lines. Mol. Cell. Biol. 19: 2601-2612 [Abstract] [Full Text]
Ying, H., Healy, J. I., Goodnow, C. C., Parnes, J. R. (1998). Regulation of Mouse CD72 Gene Expression During B Lymphocyte Development. J. Immunol. 161: 4760-4767 [Abstract] [Full Text]
Qiu, G., Stavnezer, J. (1998). Overexpression of BSAP/Pax-5 Inhibits Switching to IgA and Enhances Switching to IgE in the I.29{micro} B Cell Line. J. Immunol. 161: 2906-2918 [Abstract] [Full Text]
Nutt, S L, Urbanek, P, Rolink, A, Busslinger, M (1997). Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.. Genes Dev. 11: 476-491 [Abstract]