T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice

doi:10.1084/jem.182.5.1567

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T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice

A Ma, M Datta, E Margosian, J Chen and I Horak
Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115, USA.

Interleukin-2 (IL-2)-deficient (IL-2-/-) mice develop anemia and colonic inflammatory bowel disease. To elucidate the mechanism of this disease, we have bred IL-2-/- mice to two strains of immunodeficient mice, RAG-2-deficient (RAG-2-/-, lacking B and T cells) and JH- deficient mice (JH-/-, lacking B cells). IL-2-/-, RAG-2-/- double- mutant mice are disease free, while IL-2-/-, JH-/- double-mutant mice succumb to bowel disease at the same rate as IL-2-/- littermates. IL-2- /-, JH-/- mice do not, however, succumb to anemia. Thus, spontaneous intestinal inflammation in IL-2-/- mice requires mature T cells, not B cells, while anemia is dependent on B cells.
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