Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage

doi:10.1084/jem.182.5.1223

This Article

	Full Text (PDF, 2067K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Galle, P. R.
	Articles by Runkel, L.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Galle, P. R.
	Articles by Runkel, L.


Social Bookmarking

	What's this?

ARTICLES

Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage

PR Galle, WJ Hofmann, H Walczak, H Schaller, G Otto, W Stremmel, PH Krammer and L Runkel
University Hospital, Department of Gastroenterology, Heidelberg, Germany.

Apoptosis occurs in the normal liver and in various forms of liver disease. The CD95 (APO-1/Fas) (CD95) receptor mediates apoptosis, and liver cells in animal models are acutely sensitive to apoptosis initiated by this receptor. We have used primary human hepatocytes as a model system to investigate CD95-mediated apoptotic liver damage. Treatment of fresh human hepatocytes with low concentrations of agonistic antibodies against CD95 resulted in apoptosis of > 95% of the cultured liver cells within 4 and 7.5 h. Immunohistology of a panel of explanted liver tissues revealed that hepatocytes in normal livers (n = 5) and in alcoholic cirrhosis (n = 13) expressed low constitutive levels of CD95. CD95 receptor expression was highly elevated in hepatocytes in hepatitis B virus-related cirrhosis (n = 9) and in acute liver failure (n = 8). By in situ hybridization CD95 ligand messenger RNA expression was absent in normal liver but detected at high levels in livers with ongoing liver damage. In cases of hepatitis B virus- related cirrhosis and acute hepatic failure, ligand expression was found primarily in areas with lymphocytic infiltration. In contrast, in patients with alcoholic liver damage, high CD95 ligand messenger RNA expression was found in hepatocytes. These findings suggest that liver destruction in hepatitis B may primarily involve killing of hepatocytes by T lymphocytes using the CD95 receptor-ligand system. In alcoholic liver damage, death of hepatocytes might occur by fratricide and paracrine or autocrine mechanisms mediated by the hepatocytes themselves.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Sommerfeld, A., Reinehr, R., Haussinger, D. (2009). Bile Acid-induced Epidermal Growth Factor Receptor Activation in Quiescent Rat Hepatic Stellate Cells Can Trigger Both Proliferation and Apoptosis. J. Biol. Chem. 284: 22173-22183 [Abstract] [Full Text]
Zhou, Z., Liu, J., Song, Z., McClain, C. J., Kang, Y. J. (2008). Zinc Supplementation Inhibits Hepatic Apoptosis in Mice Subjected to a Long-Term Ethanol Exposure. Exp. Biol. Med. 233: 540-548 [Abstract] [Full Text]
Jang, J-H, Moritz, W, Graf, R, Clavien, P-A (2008). Preconditioning with death ligands FasL and TNF-{alpha} protects the cirrhotic mouse liver against ischaemic injury. Gut 57: 492-499 [Abstract] [Full Text]
Tang, W., Lazaro, C. A., Campbell, J. S., Parks, W. T., Katze, M. G., Fausto, N. (2007). Responses of Nontransformed Human Hepatocytes to Conditional Expression of Full-Length Hepatitis C Virus Open Reading Frame. Am. J. Pathol. 171: 1831-1846 [Abstract] [Full Text]
Siegmund, S. V., Qian, T., de Minicis, S., Harvey-White, J., Kunos, G., Vinod, K. Y., Hungund, B., Schwabe, R. F. (2007). The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species. FASEB J. 21: 2798-2806 [Abstract] [Full Text]
Henderson, N. C, Pollock, K. J, Frew, J., Mackinnon, A. C, Flavell, R. A, Davis, R. J, Sethi, T., Simpson, K. J (2007). Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure. Gut 56: 982-990 [Abstract] [Full Text]
Latta, M., Kunstle, G., Lucas, R., Hentze, H., Wendel, A. (2007). ATP-Depleting Carbohydrates Prevent Tumor Necrosis Factor Receptor 1-Dependent Apoptotic and Necrotic Liver Injury in Mice. J. Pharmacol. Exp. Ther. 321: 875-883 [Abstract] [Full Text]
Dunn, C., Brunetto, M., Reynolds, G., Christophides, T., Kennedy, P. T., Lampertico, P., Das, A., Lopes, A. R., Borrow, P., Williams, K., Humphreys, E., Afford, S., Adams, D. H., Bertoletti, A., Maini, M. K. (2007). Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage. JEM 204: 667-680 [Abstract] [Full Text]
Matsutani, T., Kang, S.-C., Miyashita, M., Sasajima, K., Choudhry, M. A., Bland, K. I., Chaudry, I. H. (2007). Liver cytokine production and ICAM-1 expression following bone fracture, tissue trauma, and hemorrhage in middle-aged mice. Am. J. Physiol. Gastrointest. Liver Physiol. 292: G268-G274 [Abstract] [Full Text]
Sutton, A., Nahon, P., Pessayre, D., Rufat, P., Poire, A., Ziol, M., Vidaud, D., Barget, N., Ganne-Carrie, N., Charnaux, N., Trinchet, J.-C., Gattegno, L., Beaugrand, M. (2006). Genetic polymorphisms in antioxidant enzymes modulate hepatic iron accumulation and hepatocellular carcinoma development in patients with alcohol-induced cirrhosis.. Cancer Res. 66: 2844-2852 [Abstract] [Full Text]
Shi, M., Wei, G., Pan, W., Tabel, H. (2005). Impaired Kupffer Cells in Highly Susceptible Mice Infected with Trypanosoma congolense. Infect. Immun. 73: 8393-8396 [Abstract] [Full Text]
Kass, G. E. N. (2005). Response: Comments on "Glycogen Synthase Kinase-3 Mediates Acetaminophen-Induced Apoptosis in Human Hepatoma Cells". J. Pharmacol. Exp. Ther. 314: 1403-1404 [Full Text]
Guicciardi, M E, Gores, G J (2005). Apoptosis: a mechanism of acute and chronic liver injury. Gut 54: 1024-1033 [Full Text]
Nair, J., Strand, S., Frank, N., Knauft, J., Wesch, H., Galle, P. R., Bartsch, H. (2005). Apoptosis and age-dependant induction of nuclear and mitochondrial etheno-DNA adducts in Long-Evans Cinnamon (LEC) rats: enhanced DNA damage by dietary curcumin upon copper accumulation. Carcinogenesis 26: 1307-1315 [Abstract] [Full Text]
Berasain, C., Garcia-Trevijano, E. R., Castillo, J., Erroba, E., Santamaria, M., Lee, D. C., Prieto, J., Avila, M. A. (2005). Novel Role for Amphiregulin in Protection from Liver Injury. J. Biol. Chem. 280: 19012-19020 [Abstract] [Full Text]
Uchikura, K., Wada, T., Hoshino, S., Nagakawa, Y., Aiko, T., Bulkley, G. B., Klein, A. S., Sun, Z. (2004). Lipopolysaccharides induced increases in Fas ligand expression by Kupffer cells via mechanisms dependent on reactive oxygen species. Am. J. Physiol. Gastrointest. Liver Physiol. 287: G620-G626 [Abstract] [Full Text]
Gilbert, S., Loranger, A., Marceau, N. (2004). Keratins Modulate c-Flip/Extracellular Signal-Regulated Kinase 1 and 2 Antiapoptotic Signaling in Simple Epithelial Cells. Mol. Cell. Biol. 24: 7072-7081 [Abstract] [Full Text]
Deeb, D., Jiang, H., Gao, X., Hafner, M. S., Wong, H., Divine, G., Chapman, R. A., Dulchavsky, S. A., Gautam, S. C. (2004). Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-{kappa}B through suppression of I{kappa}B{alpha} phosphorylation. Molecular Cancer Therapeutics 3: 803-812 [Abstract] [Full Text]
Jiang, N., Pisetsky, D. S. (2004). The Effect of Dexamethasone on the Generation of Plasma DNA from Dead and Dying Cells. Am. J. Pathol. 164: 1751-1759 [Abstract] [Full Text]
Finotto, S, Siebler, J, Hausding, M, Schipp, M, Wirtz, S, Klein, S, Protschka, M, Doganci, A, Lehr, H A, Trautwein, C, Khosravi-Fahr, R, Strand, D, Lohse, A, Galle, P R, Blessing, M, Neurath, M F (2004). Severe hepatic injury in interleukin 18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo. Gut 53: 392-400 [Abstract] [Full Text]
Gremion, C., Grabscheid, B., Wolk, B., Moradpour, D., Reichen, J., Pichler, W., Cerny, A. (2004). Cytotoxic T Lymphocytes Derived from Patients with Chronic Hepatitis C Virus Infection Kill Bystander Cells via Fas-FasL Interaction. J. Virol. 78: 2152-2157 [Abstract] [Full Text]
Samel, D., Muller, D., Gerspach, J., Assohou-Luty, C., Sass, G., Tiegs, G., Pfizenmaier, K., Wajant, H. (2003). Generation of a FasL-based Proapoptotic Fusion Protein Devoid of Systemic Toxicity due to Cell-surface Antigen-restricted Activation. J. Biol. Chem. 278: 32077-32082 [Abstract] [Full Text]
Liedtke, C., Groger, N., Manns, M. P., Trautwein, C. (2003). The Human Caspase-8 Promoter Sustains Basal Activity through SP1 and ETS-like Transcription Factors and Can Be Up-regulated by a p53-dependent Mechanism. J. Biol. Chem. 278: 27593-27604 [Abstract] [Full Text]
Ethier, C., Raymond, V.-A., Musallam, L., Houle, R., Bilodeau, M. (2003). Antiapoptotic effect of EGF on mouse hepatocytes associated with downregulation of proapoptotic Bid protein. Am. J. Physiol. Gastrointest. Liver Physiol. 285: G298-G308 [Abstract] [Full Text]
Zender, L., Hutker, S., Liedtke, C., Tillmann, H. L., Zender, S., Mundt, B., Waltemathe, M., Gosling, T., Flemming, P., Malek, N. P., Trautwein, C., Manns, M. P., Kuhnel, F., Kubicka, S. (2003). Caspase 8 small interfering RNA prevents acute liver failure in mice. Proc. Natl. Acad. Sci. USA 100: 7797-7802 [Abstract] [Full Text]
Lambert, J. C., Zhou, Z., Kang, Y. J. (2003). Suppression of Fas-Mediated Signaling Pathway Is Involved in Zinc Inhibition of Ethanol-Induced Liver Apoptosis. Exp. Biol. Med. 228: 406-412 [Abstract] [Full Text]
Choudhury, J. A., Russell, C. L., Randhawa, S., Young, L. S., Adams, D. H., Afford, S. C. (2003). Differential Induction of Nuclear Factor-kappa B and Activator Protein-1 Activity after CD40 Ligation Is Associated with Primary Human Hepatocyte Apoptosis or Intrahepatic Endothelial Cell Proliferation. Mol. Biol. Cell 14: 1334-1345 [Abstract] [Full Text]
Deeb, D., Xu, Y. X., Jiang, H., Gao, X., Janakiraman, N., Chapman, R. A., Gautam, S. C. (2003). Curcumin (Diferuloyl-Methane) Enhances Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis in LNCaP Prostate Cancer Cells. Molecular Cancer Therapeutics 2: 95-103 [Abstract] [Full Text]
Embree-Ku, M., Boekelheide, K. (2002). FasL Deficiency Enhances the Development of Tumors in p53+/- Mice. Toxicol Pathol 30: 705-713 [Abstract]
Zhang, H.-G., Xie, J., Xu, L., Yang, P., Xu, X., Sun, S., Wang, Y., Curiel, D. T., Hsu, H.-C., Mountz, J. D. (2002). Hepatic DR5 Induces Apoptosis and Limits Adenovirus Gene Therapy Product Expression in the Liver. J. Virol. 76: 5692-5700 [Abstract] [Full Text]
Faggioni, R., Cattley, R. C., Guo, J., Flores, S., Brown, H., Qi, M., Yin, S., Hill, D., Scully, S., Chen, C., Brankow, D., Lewis, J., Baikalov, C., Yamane, H., Meng, T., Martin, F., Hu, S., Boone, T., Senaldi, G. (2001). IL-18-Binding Protein Protects Against Lipopolysaccharide- Induced Lethality and Prevents the Development of Fas/Fas Ligand-Mediated Models of Liver Disease in Mice. J. Immunol. 167: 5913-5920 [Abstract] [Full Text]
AFFORD, S. C., AHMED-CHOUDHURY, J., RANDHAWA, S., RUSSELL, C., YOUSTER, J., CROSBY, H. A., ELIOPOULOS, A., HUBSCHER, S. G., YOUNG, L. S., ADAMS, D. H. (2001). CD40 activation-induced, Fas-dependent apoptosis and NF-{kappa}B/AP-1 signaling in human intrahepatic biliary epithelial cells. FASEB J. 15: 2345-2354 [Abstract] [Full Text]
Jodo, S., Xiao, S., Hohlbaum, A., Strehlow, D., Marshak-Rothstein, A., Ju, S.-T. (2001). Apoptosis-inducing Membrane Vesicles. A NOVEL AGENT WITH UNIQUE PROPERTIES. J. Biol. Chem. 276: 39938-39944 [Abstract] [Full Text]
Ghamande, S., Hylander, B. L, Oflazoglu, E., Lele, S., Fanslow, W., Repasky, E. A (2001). Recombinant CD40 Ligand Therapy Has Significant Antitumor Effects on CD40-positive Ovarian Tumor Xenografts Grown in SCID Mice and Demonstrates an Augmented Effect with Cisplatin. Cancer Res. 61: 7556-7562 [Abstract] [Full Text]
Elzey, B. D., Griffith, T. S., Herndon, J. M., Barreiro, R., Tschopp, J., Ferguson, T. A. (2001). Regulation of Fas Ligand-Induced Apoptosis by TNF. J. Immunol. 167: 3049-3056 [Abstract] [Full Text]
Kafrouni, M. I., Brown, G. R., Thiele, D. L. (2001). Virally Infected Hepatocytes Are Resistant to Perforin-Dependent CTL Effector Mechanisms. J. Immunol. 167: 1566-1574 [Abstract] [Full Text]
Zhou, Z., Sun, X., Kang, Y. J. (2001). Ethanol-Induced Apoptosis in Mouse Liver : Fas- and Cytochrome c-Mediated Caspase-3 Activation Pathway. Am. J. Pathol. 159: 329-338 [Abstract] [Full Text]
Waters, E., Wang, J. H., Redmond, H. P., Wu, Q. D., Kay, E., Bouchier-Hayes, D. (2001). Role of taurine in preventing acetaminophen-induced hepatic injury in the rat. Am. J. Physiol. Gastrointest. Liver Physiol. 280: G1274-G1279 [Abstract] [Full Text]
Kiba, T., Saito, S., Numata, K., Kon, Y., Mizutani, T., Sekihara, H. (2001). Expression of apoptosis on rat liver by hepatic vagus hyperactivity after ventromedial hypothalamic lesioning. Am. J. Physiol. Gastrointest. Liver Physiol. 280: G958-G967 [Abstract] [Full Text]
Hoglen, N. C., Hirakawa, B. P., Fisher, C. D., Weeks, S., Srinivasan, A., Wong, A. M., Valentino, K. L., Tomaselli, K. J., Bai, X., Karanewsky, D. S., Contreras, P. C. (2001). Characterization of the Caspase Inhibitor IDN-1965 in a Model of Apoptosis-Associated Liver Injury. J. Pharmacol. Exp. Ther. 297: 811-818 [Abstract] [Full Text]
Liu, Z.-X., Govindarajan, S., Okamoto, S., Dennert, G. (2001). Fas-Mediated Apoptosis Causes Elimination of Virus-Specific Cytotoxic T Cells in the Virus-Infected Liver. J. Immunol. 166: 3035-3041 [Abstract] [Full Text]
Seol, D.-W., Li, J., Seol, M.-H., Park, S.-Y., Talanian, R. V., Billiar, T. R. (2001). Signaling Events Triggered by Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL): Caspase-8 Is Required for TRAIL-induced Apoptosis. Cancer Res. 61: 1138-1143 [Abstract] [Full Text]
Pan, J., Duan, L.-X., Sun, B. S., Feitelson, M. A. (2001). Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-{{kappa}}B. J. Gen. Virol. 82: 171-182 [Abstract] [Full Text]
Bajt, M. L., Lawson, J. A., Vonderfecht, S. L., Gujral, J. S., Jaeschke, H. (2000). Protection against Fas Receptor-Mediated Apoptosis in Hepatocytes and Nonparenchymal Cells by a Caspase-8 Inhibitor in Vivo: Evidence for a Postmitochondrial Processing of Caspase-8. Toxicol Sci 58: 109-117 [Abstract] [Full Text]
van Oosten, M., Rebel, H., Friedberg, E. C., van Steeg, H., van der Horst, G. T. J., van Kranen, H. J., Westerman, A., van Zeeland, A. A., Mullenders, L. H. F., de Gruijl, F. R. (2000). Differential role of transcription-coupled repair in UVB-induced G2 arrest and apoptosis in mouse epidermis. Proc. Natl. Acad. Sci. USA 10.1073/pnas.200226697v1 [Abstract] [Full Text]
Chen, M., Sällberg, M., Thung, S. N., Hughes, J., Jones, J., Milich, D. R. (2000). Nondeletional T-Cell Receptor Transgenic Mice: Model for the CD4+ T-Cell Repertoire in Chronic Hepatitis B Virus Infection. J. Virol. 74: 7587-7599 [Abstract] [Full Text]
Seol, D.-W., Billiar, T. R. (2000). Cysteine 230 Modulates Tumor Necrosis Factor-related Apoptosis-inducing Ligand Activity. Cancer Res. 60: 3152-3154 [Abstract] [Full Text]
Hentze, H., Gantner, F., Kolb, S. A., Wendel, A. (2000). Depletion of Hepatic Glutathione Prevents Death Receptor-Dependent Apoptotic and Necrotic Liver Injury in Mice. Am. J. Pathol. 156: 2045-2056 [Abstract] [Full Text]
Schmitz, J. E., Kuroda, M. J., Veazey, R. S., Seth, A., Taylor, W. M., Nickerson, C. E., Lifton, M. A., Dailey, P. J., Forman, M. A., Racz, P., Tenner-Racz, K., Letvin, N. L. (2000). Simian Immunodeficiency Virus (SIV)-Specific CTL Are Present in Large Numbers in Livers of SIV-Infected Rhesus Monkeys. J. Immunol. 164: 6015-6019 [Abstract] [Full Text]
Liu, J. H., Wei, S., Lamy, T., Epling-Burnette, P. K., Starkebaum, G., Djeu, J. Y., Loughran, T. P. Jr (2000). Chronic neutropenia mediated by Fas ligand. Blood 95: 3219-3222 [Abstract] [Full Text]
Josephs, M. D., Bahjat, F. R., Fukuzuka, K., Ksontini, R., Solorzano, C. C., Edwards, C. K. III, Tannahill, C. L., MacKay, S. L. D., Copeland, E. M. III, Moldawer, L. L. (2000). Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-alpha and not by Fas ligand. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278: R1196-R1201 [Abstract] [Full Text]
Chisari, F. V. (2000). Viruses, Immunity, and Cancer: Lessons from Hepatitis B. Am. J. Pathol. 156: 1117-1132 [Full Text]
Trim, N., Morgan, S., Evans, M., Issa, R., Fine, D., Afford, S., Wilkins, B., Iredale, J. (2000). Hepatic Stellate Cells Express the Low Affinity Nerve Growth Factor Receptor p75 and Undergo Apoptosis in Response to Nerve Growth Factor Stimulation. Am. J. Pathol. 156: 1235-1243 [Abstract] [Full Text]
Zeytun, A., Nagarkatti, M., Nagarkatti, P. S. (2000). Growth of FasL-bearing tumor cells in syngeneic murine host induces apoptosis and toxicity in Fas+ organs. Blood 95: 2111-2117 [Abstract] [Full Text]
Pinkoski, M. J., Brunner, T., Green, D. R., Lin, T. (2000). Fas and Fas ligand in gut and liver. Am. J. Physiol. Gastrointest. Liver Physiol. 278: G354-G366 [Abstract] [Full Text]
Su, X., Hu, Q., Kristan, J. M., Costa, C., Shen, Y., Gero, D., Matis, L. A., Wang, Y. (2000). Significant Role for Fas in the Pathogenesis of Autoimmune Diabetes. J. Immunol. 164: 2523-2532 [Abstract] [Full Text]
Kuhnel, F., Zender, L., Paul, Y., Tietze, M. K., Trautwein, C., Manns, M., Kubicka, S. (2000). NFkappa B Mediates Apoptosis through Transcriptional Activation of Fas (CD95) in Adenoviral Hepatitis. J. Biol. Chem. 275: 6421-6427 [Abstract] [Full Text]
Papoff, G., Hausler, P., Eramo, A., Pagano, M. G., Di Leve, G., Signore, A., Ruberti, G. (1999). Identification and Characterization of a Ligand-independent Oligomerization Domain in the Extracellular Region of the CD95 Death Receptor. J. Biol. Chem. 274: 38241-38250 [Abstract] [Full Text]
Van Molle, W., Denecker, G., Rodriguez, I., Brouckaert, P., Vandenabeele, P., Libert, C. (1999). Activation of Caspases in Lethal Experimental Hepatitis and Prevention by Acute Phase Proteins. J. Immunol. 163: 5235-5241 [Abstract] [Full Text]
CARDIER, J. E., SCHULTE, T., KAMMER, H., KWAK, J., CARDIER, M. (1999). Fas (CD95, APO-1) antigen expression and function in murine liver endothelial cells: implications for the regulation of apoptosis in liver endothelial cells. FASEB J. 13: 1950-1960 [Abstract] [Full Text]
Woo, M., Hakem, A., Elia, A. J., Hakem, R., Duncan, G. S., Patterson, B. J., Mak, T. W. (1999). In Vivo Evidence That Caspase-3 Is Required for Fas-Mediated Apoptosis of Hepatocytes. J. Immunol. 163: 4909-4916 [Abstract] [Full Text]
Shankar, P., Xu, Z., Lieberman, J. (1999). Viral-Specific Cytotoxic T Lymphocytes Lyse Human Immunodeficiency Virus-Infected Primary T Lymphocytes by the Granule Exocytosis Pathway. Blood 94: 3084-3093 [Abstract] [Full Text]
Hill, L. L., Ouhtit, A., Loughlin, S. M., Kripke, M. L., Ananthaswamy, H. N., Owen-Schaub, L. B. (1999). Fas Ligand: A Sensor for DNA Damage Critical in Skin Cancer Etiology. Science 285: 898-900 [Abstract] [Full Text]
Marusawa, H., Hijikata, M., Chiba, T., Shimotohno, K. (1999). Hepatitis C Virus Core Protein Inhibits Fas- and Tumor Necrosis Factor Alpha-Mediated Apoptosis via NF-kappa B Activation. J. Virol. 73: 4713-4720 [Abstract] [Full Text]
Peng, Y., Trevejo, J., Zhou, J., Marino, M. W., Crystal, R. G., Falck-Pedersen, E., Elkon, K. B. (1999). Inhibition of Tumor Necrosis Factor Alpha by an Adenovirus-Encoded Soluble Fusion Protein Extends Transgene Expression in the Liver and Lung. J. Virol. 73: 5098-5109 [Abstract] [Full Text]
Gagnon, S. J., Ennis, F. A., Rothman, A. L. (1999). Bystander Target Cell Lysis and Cytokine Production by Dengue Virus-Specific Human CD4+ Cytotoxic T-Lymphocyte Clones. J. Virol. 73: 3623-3629 [Abstract] [Full Text]
Liu, A. N., Mohammed, A. Z., Rice, W. R., Fiedeldey, D. T., Liebermann, J. S., Whitsett, J. A., Braciale, T. J., Enelow, R. I. (1999). Perforin-Independent CD8+ T-Cell-Mediated Cytotoxicity of Alveolar Epithelial Cells Is Preferentially Mediated by Tumor Necrosis Factor-alpha . Relative Insensitivity to Fas Ligand. Am. J. Respir. Cell Mol. Bio. 20: 849-858 [Abstract] [Full Text]
Griffith, T. S., Wiley, S. R., Kubin, M. Z., Sedger, L. M., Maliszewski, C. R., Fanger, N. A. (1999). Monocyte-mediated Tumoricidal Activity via the Tumor Necrosis Factor-related Cytokine, TRAIL. JEM 189: 1343-1354 [Abstract] [Full Text]
MIGNON, A., ROUQUET, N., FABRE, M., MARTIN, S., PAGES, J.�C., DHAINAUT, J.�F., KAHN, A., BRIAND, P., JOULIN, V. (1999). LPS Challenge in D-galactosamine-Sensitized Mice Accounts for Caspase-dependent Fulminant Hepatitis, not for Septic Shock. Am. J. Respir. Crit. Care Med. 159: 1308-1315 [Abstract] [Full Text]
McClure, R. F., Heppelmann, C. J., Paya, C. V. (1999). Constitutive Fas Ligand Gene Transcription in Sertoli Cells Is Regulated By Sp1. J. Biol. Chem. 274: 7756-7762 [Abstract] [Full Text]
Yoong, K. F., Afford, S. C., Randhawa, S., Hubscher, S. G., Adams, D. H. (1999). Fas/Fas Ligand Interaction in Human Colorectal Hepatic Metastases : A Mechanism of Hepatocyte Destruction to Facilitate Local Tumor Invasion. Am. J. Pathol. 154: 693-703 [Abstract] [Full Text]
Bennett, M W, O'Connell, J, O'Sullivan, G C, Roche, D, Brady, C, Kelly, J, Collins, J K, Shanahan, F (1999). Expression of Fas ligand by human gastric adenocarcinomas: a potential mechanism of immune escape in stomach cancer. Gut 44: 156-162 [Abstract] [Full Text]
Afford, S. C., Randhawa, S., Eliopoulos, A. G., Hubscher, S. G., Young, L. S., Adams, D. H. (1999). CD40 Activation Induces Apoptosis in Cultured Human Hepatocytes via Induction of Cell Surface Fas Ligand Expression and Amplifies Fas-mediated Hepatocyte Death during Allograft Rejection. JEM 189: 441-446 [Abstract] [Full Text]
Jones, B. E., Czaja, M. J. (1998). III. Intracellular signaling in response to toxic liver injury. Am. J. Physiol. Gastrointest. Liver Physiol. 275: G874-G878 [Abstract] [Full Text]
Angermüller, S., Künstle, G., Tiegs, G. (1998). Pre-apoptotic Alterations in Hepatocytes of TNF{alpha}-treated Galactosamine-sensitized Mice. J. Histochem. Cytochem. 46: 1175-1184 [Abstract] [Full Text]
Dollinger, M. M., M. howie, S. E., Plevris, J. N., Graham, A. M., Hayes, P. C., Harrison, D. J. (1998). Intrahepatic proliferation of `naive' and `memory' T cells during liver allograft rejection: primary immune response within the allograft. FASEB J. 12: 939-947 [Abstract] [Full Text]
Ueyama, H, Kiyohara, T, Sawada, N, Isozaki, K, Kitamura, S, Kondo, S, Miyagawa, J, Kanayama, S, Shinomura, Y, Ishikawa, H, Ohtani, T, Nezu, R, Nagata, S, Matsuzawa, Y (1998). High Fas ligand expression on lymphocytes in lesions of ulcerative colitis. Gut 43: 48-55 [Abstract] [Full Text]
Seydel, K. B., Stanley, S. L. Jr. (1998). Entamoeba histolytica Induces Host Cell Death in Amebic Liver Abscess by a Non-Fas-Dependent, Non-Tumor Necrosis Factor Alpha-Dependent Pathway of Apoptosis. Infect. Immun. 66: 2980-2983 [Abstract] [Full Text]
Yoshimoto, T., Takahama, Y., Wang, C.-R., Yoneto, T., Waki, S., Nariuchi, H. (1998). A Pathogenic Role of IL-12 in Blood-Stage Murine Malaria Lethal Strain Plasmodium berghei NK65 Infection. J. Immunol. 160: 5500-5505 [Abstract] [Full Text]
Schneider, P., Holler, N., Bodmer, J.-L., Hahne, M., Frei, K., Fontana, A., Tschopp, J. (1998). Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity. JEM 187: 1205-1213 [Abstract] [Full Text]
Ksontini, R., Colagiovanni, D. B., Josephs, M. D., Edwards, C. K. III, Tannahill, C. L., Solorzano, C. C., Norman, J., Denham, W., Clare-Salzler, M., MacKay, S. L. D., Moldawer, L. L. (1998). Disparate Roles for TNF-{alpha} and Fas Ligand in Concanavalin A-Induced Hepatitis. J. Immunol. 160: 4082-4089 [Abstract] [Full Text]
Hasegawa, D., Kojima, S., Tatsumi, E., Hayakawa, A., Kosaka, Y., Nakamura, H., Sako, M., Osugi, Y., Nagata, S., Sano, K. (1998). Elevation of the Serum Fas Ligand in Patients With Hemophagocytic Syndrome and Diamond-Blackfan Anemia. Blood 91: 2793-2799 [Abstract] [Full Text]
Jones, B. A., Gores, G. J. (1997). Physiology and pathophysiology of apoptosis in epithelial cells of the liver, pancreas, and intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 273: G1174-G1188 [Abstract] [Full Text]
Hug, H., Strand, S., Grambihler, A., Galle, J., Hack, V., Stremmel, W., Krammer, P. H., Galle, P. R. (1997). Reactive Oxygen Intermediates Are Involved in the Induction of CD95 Ligand mRNA Expression by Cytostatic Drugs in Hepatoma Cells. J. Biol. Chem. 272: 28191-28193 [Abstract] [Full Text]
Dybedal, I., Guan, F., Borge, O. J., Veiby, O. P., Ramsfjell, V., Nagata, S., Jacobsen, S. E. W. (1997). Transforming Growth Factor-beta 1 Abrogates Fas-Induced Growth Suppression and Apoptosis of Murine Bone Marrow Progenitor Cells. Blood 90: 3395-3403 [Abstract] [Full Text]
Elkon, K. B., Liu, C.-C., Gall, J. G., Trevejo, J., Marino, M. W., Abrahamsen, K. A., Song, X., Zhou, J.-L., Old, L. J., Crystal, R. G., Falck-Pedersen, E. (1997). Tumor necrosis factor alpha �plays a central role in immune-mediated clearance of adenoviral�vectors. Proc. Natl. Acad. Sci. USA 94: 9814-9819 [Abstract] [Full Text]
Shiraki, K., Tsuji, N., Shioda, T., Isselbacher, K. J., Takahashi, H. (1997). Expression of Fas ligand in liver metastases of human�colonic�adenocarcinomas. Proc. Natl. Acad. Sci. USA 94: 6420-6425 [Abstract] [Full Text]
Starling, G. C., Bajorath, J., Emswiler, J., Ledbetter, J. A., Aruffo, A., Kiener, P. A. (1997). Identification of Amino Acid Residues Important for Ligand Binding to Fas. JEM 185: 1487-1492 [Abstract] [Full Text]
Mariani, S. M., Matiba, B., Armandola, E. A., Krammer, P. H. (1997). Interleukin 1{beta}-converting Enzyme Related Proteases/Caspases Are Involved in TRAIL-induced Apoptosis of Myeloma and Leukemia Cells. JCB 137: 221-229 [Abstract] [Full Text]
Truman, J.-P., Choqueux, C., Tschopp, J., Vedrenne, J., Le Deist, F., Charron, D., Mooney, N. (1997). HLA Class II-Mediated Death Is Induced Via Fas/Fas Ligand Interactions in Human Splenic B Lymphocytes. Blood 89: 1996-2007 [Abstract] [Full Text]
Giordano, C., Stassi, G., De Maria, R., Todaro, M., Richiusa, P., Papoff, G., Ruberti, G., Bagnasco, M., Testi, R., Galluzzo, A. (1997). Potential Involvement of Fas and Its Ligand in the Pathogenesis of Hashimoto's Thyroiditis. Science 275: 960-963 [Abstract] [Full Text]
Drappa, J., Vaishnaw, A. K., Sullivan, K. E., Chu, J.-L., Elkon, K. B. (1996). Fas Gene Mutations in the Canale-Smith Syndrome, an Inherited Lymphoproliferative Disorder Associated with Autoimmunity. NEJM 335: 1643-1649 [Abstract] [Full Text]
Diao, J., Khine, A. A., Sarangi, F., Hsu, E., Iorio, C., Tibbles, L. A., Woodgett, J. R., Penninger, J., Richardson, C. D. (2001). X Protein of Hepatitis B Virus Inhibits Fas-mediated Apoptosis and Is Associated with Up-regulation of the SAPK/JNK Pathway. J. Biol. Chem. 276: 8328-8340 [Abstract] [Full Text]
van Oosten, M., Rebel, H., Friedberg, E. C., van Steeg, H., van der Horst, G. T. J., van Kranen, H. J., Westerman, A., van Zeeland, A. A., Mullenders, L. H. F., de Gruijl, F. R. (2000). Differential role of transcription-coupled repair in UVB-induced G2 arrest and apoptosis in mouse epidermis. Proc. Natl. Acad. Sci. USA 97: 11268-11273 [Abstract] [Full Text]