Selective reduction of T cells bearing invariant V alpha 24J alpha Q antigen receptor in patients with systemic sclerosis

doi:10.1084/jem.182.4.1163

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Selective reduction of T cells bearing invariant V alpha 24J alpha Q antigen receptor in patients with systemic sclerosis

T Sumida, A Sakamoto, H Murata, Y Makino, H Takahashi, S Yoshida, K Nishioka, I Iwamoto and M Taniguchi
Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.

A novel subset of T cells characterized by the expression of an invariant T cell antigen receptor (TCR) encoded by V alpha 24J alpha Q gene segments was investigated in patients with systemic sclerosis (SSc). Polymerase chain reaction analysis demonstrated that the V alpha 24 TCR repertoire was selectively used in CD4-CD8- double-negative T cells both in patients and in healthy individuals, while almost all families of TCR V alpha were expressed in single-positive T cell fractions. The V alpha 24+ double-negative T cells were increased by approximately fivefold in patients. However, sequence analysis clearly showed significant differences in the V alpha 24 TCR repertoire dominating in patients and healthy donors. In healthy individuals, the invariant V alpha 24J alpha Q was expanded and comprised 20-50% of the total TCR-alpha, while their selective reduction was observed in SSc patients who also showed expansion of invariant V alpha 24 TCR other than V alpha 24J alpha Q. Analogous to murine invariant V alpha 14J alpha 281 TCR, these results suggest that T cells with invariant V alpha 24J alpha Q TCR would function as regulatory T cells, whereas T cells bearing other invariant V alpha 24 TCR in SSc patients could be autoaggressive T cells in nature.
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Hobbs, J. A., Cho, S., Roberts, T. J., Sriram, V., Zhang, J., Xu, M., Brutkiewicz, R. R. (2001). Selective Loss of Natural Killer T Cells by Apoptosis following Infection with Lymphocytic Choriomeningitis Virus. J. Virol. 75: 10746-10754 [Abstract] [Full Text]
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Kadowaki, N., Antonenko, S., Ho, S., Rissoan, M.-C., Soumelis, V., Porcelli, S. A., Lanier, L. L., Liu, Y.-J. (2001). Distinct Cytokine Profiles of Neonatal Natural Killer T Cells after Expansion with Subsets of Dendritic Cells. JEM 193: 1221-1226 [Abstract] [Full Text]
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Yamazaki, K., Ohsawa, Y., Yoshie, H. (2001). Elevated Proportion of Natural Killer T Cells in Periodontitis Lesions : A Common Feature of Chronic Inflammatory Diseases. Am. J. Pathol. 158: 1391-1398 [Abstract] [Full Text]
Seino, K.-i., Fukao, K., Muramoto, K., Yanagisawa, K., Takada, Y., Kakuta, S., Iwakura, Y., Van Kaer, L., Takeda, K., Nakayama, T., Taniguchi, M., Bashuda, H., Yagita, H., Okumura, K. (2001). Requirement for natural killer T (NKT) cells in the induction of allograft tolerance. Proc. Natl. Acad. Sci. USA 10.1073/pnas.041608298v1 [Abstract] [Full Text]
del C. Salamone, M., Rabinovich, G. A., Mendiguren, A. K., Salamone, G. V., Fainboim, L. (2001). Activation-induced expression of CD1d antigen on mature T cells. J. Leukoc. Biol. 69: 207-214 [Abstract] [Full Text]
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Faunce, D. E., Sonoda, K.-H., Stein-Streilein, J. (2001). MIP-2 Recruits NKT Cells to the Spleen During Tolerance Induction. J. Immunol. 166: 313-321 [Abstract] [Full Text]
Yang, O. O., Racke, F. K., Nguyen, P. T., Gausling, R., Severino, M. E., Horton, H. F., Byrne, M. C., Strominger, J. L., Wilson, S. B. (2000). CD1d on Myeloid Dendritic Cells Stimulates Cytokine Secretion from and Cytolytic Activity of V{alpha}24J{alpha}Q T Cells: A Feedback Mechanism for Immune Regulation. J. Immunol. 165: 3756-3762 [Abstract] [Full Text]
Bonish, B., Jullien, D., Dutronc, Y., Huang, B. B., Modlin, R., Spada, F. M., Porcelli, S. A., Nickoloff, B. J. (2000). Overexpression of CD1d by Keratinocytes in Psoriasis and CD1d-Dependent IFN-{gamma} Production by NK-T Cells. J. Immunol. 165: 4076-4085 [Abstract] [Full Text]
Matsuda, J. L., Naidenko, O. V., Gapin, L., Nakayama, T., Taniguchi, M., Wang, C.-R., Koezuka, Y., Kronenberg, M. (2000). Tracking the Response of Natural Killer T Cells to a Glycolipid Antigen Using Cd1d Tetramers. JEM 192: 741-754 [Abstract] [Full Text]
Elewaut, D., Brossay, L., Santee, S. M., Naidenko, O. V., Burdin, N., De Winter, H., Matsuda, J., Ware, C. F., Cheroutre, H., Kronenberg, M. (2000). Membrane Lymphotoxin Is Required for the Development of Different Subpopulations of NK T Cells. J. Immunol. 165: 671-679 [Abstract] [Full Text]
Skold, M., Faizunnessa, N. N., Wang, C.-R., Cardell, S. (2000). CD1d-Specific NK1.1+ T Cells with a Transgenic Variant TCR. J. Immunol. 165: 168-174 [Abstract] [Full Text]
Takahashi, T., Nieda, M., Koezuka, Y., Nicol, A., Porcelli, S. A., Ishikawa, Y., Tadokoro, K., Hirai, H., Juji, T. (2000). Analysis of Human V{alpha}24+ CD4+ NKT Cells Activated by {alpha}-Glycosylceramide-Pulsed Monocyte-Derived Dendritic Cells. J. Immunol. 164: 4458-4464 [Abstract] [Full Text]
Illes, Z., Kondo, T., Newcombe, J., Oka, N., Tabira, T., Yamamura, T. (2000). Differential Expression of NK T Cell V{alpha}24J{alpha}Q Invariant TCR Chain in the Lesions of Multiple Sclerosis and Chronic Inflammatory Demyelinating Polyneuropathy. J. Immunol. 164: 4375-4381 [Abstract] [Full Text]
van der Vliet, H. J. J., Nishi, N., de Gruijl, T. D., von Blomberg, B. M. E., van den Eertwegh, A. J. M., Pinedo, H. M., Giaccone, G., Scheper, R. J. (2000). Human natural killer T cells acquire a memory-activated phenotype before birth. Blood 95: 2440-2442 [Abstract] [Full Text]
Kaneko, Y., Harada, M., Kawano, T., Yamashita, M., Shibata, Y., Gejyo, F., Nakayama, T., Taniguchi, M. (2000). Augmentation of V{alpha}14 Nkt Cell-Mediated Cytotoxicity by Interleukin 4 in an Autocrine Mechanism Resulting in the Development of Concanavalin a-Induced Hepatitis. JEM 191: 105-114 [Abstract] [Full Text]
Yato, H., Matsumoto, Y. (1999). CD56+ T cells in the peripheral blood of uveitis patients. Br J Ophthalmol 83: 1386-1388 [Abstract] [Full Text]
Zeng, D., Gazit, G., Dejbakhsh-Jones, S., Balk, S. P., Snapper, S., Taniguchi, M., Strober, S. (1999). Heterogeneity of NK1.1+ T Cells in the Bone Marrow: Divergence from the Thymus. J. Immunol. 163: 5338-5345 [Abstract] [Full Text]
Sonoda, K.-H., Exley, M., Snapper, S., Balk, S. P., Stein-Streilein, J. (1999). Cd1-Reactive Natural Killer T Cells Are Required for Development of Systemic Tolerance through an Immune-Privileged Site. JEM 190: 1215-1226 [Abstract] [Full Text]
Hong, S., Van Kaer, L. (1999). Immune Privilege: Keeping an Eye on Natural Killer T Cells. JEM 190: 1197-1200 [Full Text]
Gerber, D. J., Azuara, V., Levraud, J.-P., Huang, S. Y., Lembezat, M.-P., Pereira, P. (1999). IL-4-Producing {gamma}{delta} T Cells That Express a Very Restricted TCR Repertoire Are Preferentially Localized in Liver and Spleen. J. Immunol. 163: 3076-3082 [Abstract] [Full Text]
Milner, J. D., Kent, S. C., Ashley, T. A., Wilson, S. B., Strominger, J. L., Hafler, D. A. (1999). Differential Responses of Invariant V{alpha}24J{alpha}Q T Cells and MHC Class II-Restricted CD4+ T Cells to Dexamethasone. J. Immunol. 163: 2522-2529 [Abstract] [Full Text]
Doherty, D. G., Norris, S., Madrigal-Estebas, L., McEntee, G., Traynor, O., Hegarty, J. E., O'Farrelly, C. (1999). The Human Liver Contains Multiple Populations of NK Cells, T Cells, and CD3+CD56+ Natural T Cells with Distinct Cytotoxic Activities and Th1, Th2, and Th0 Cytokine Secretion Patterns. J. Immunol. 163: 2314-2321 [Abstract] [Full Text]
Tomura, M., Yu, W.-G., Ahn, H.-J., Yamashita, M., Yang, Y.-F., Ono, S., Hamaoka, T., Kawano, T., Taniguchi, M., Koezuka, Y., Fujiwara, H. (1999). A Novel Function of V{alpha}14+CD4+NKT Cells: Stimulation of IL-12 Production by Antigen-Presenting Cells in the Innate Immune System. J. Immunol. 163: 93-101 [Abstract] [Full Text]
Tilloy, F., Treiner, E., Park, S.-H., Garcia, C., Lemonnier, F., de la Salle, H., Bendelac, A., Bonneville, M., Lantz, O. (1999). An Invariant T Cell Receptor {alpha} Chain Defines a Novel TAP-independent Major Histocompatibility Complex Class Ib-restricted {alpha}/{beta} T Cell Subpopulation in Mammals. JEM 189: 1907-1921 [Abstract] [Full Text]
Kawano, T., Tanaka, Y., Shimizu, E., Kaneko, Y., Kamata, N., Sato, H., Osada, H., Sekiya, S., Nakayama, T., Taniguchi, M. (1999). A novel recognition motif of human NKT antigen receptor for a glycolipid ligand. Int Immunol 11: 881-887 [Abstract] [Full Text]
Nickoloff, B. J., Wrone-Smith, T., Bonish, B., Porcelli, S. A. (1999). Response of Murine and Normal Human Skin to Injection of Allogeneic Blood-Derived Psoriatic Immunocytes: Detection of T Cells Expressing Receptors Typically Present on Natural Killer Cells, Including CD94, CD158, and CD161. Arch Dermatol 135: 546-552 [Abstract] [Full Text]
Ohteki, T., Maki, C., Koyasu, S., Mak, T. W., Ohashi, P. S. (1999). Cutting Edge: LFA-1 Is Required for Liver NK1.1+TCR{alpha}{beta}+ Cell Development: Evidence That Liver NK1.1+TCR{alpha}{beta}+ Cells Originate from Multiple Pathways. J. Immunol. 162: 3753-3756 [Abstract] [Full Text]
Behar, S. M., Podrebarac, T. A., Roy, C. J., Wang, C. R., Brenner, M. B. (1999). Diverse TCRs Recognize Murine CD1. J. Immunol. 162: 161-167 [Abstract] [Full Text]
Tangri, S., Brossay, L., Burdin, N., Lee, D. J., Corr, M., Kronenberg, M. (1998). Presentation of peptide antigens by mouse CD1 requires endosomal localization and protein antigen processing. Proc. Natl. Acad. Sci. USA 95: 14314-14319 [Abstract] [Full Text]
Van de Keere, F., Tonegawa, S. (1998). CD4+ T Cells Prevent Spontaneous Experimental Autoimmune Encephalomyelitis in Anti-Myelin Basic Protein T Cell Receptor Transgenic Mice. JEM 188: 1875-1882 [Abstract] [Full Text]
Spada, F. M., Koezuka, Y., Porcelli, S. A. (1998). CD1d-restricted Recognition of Synthetic Glycolipid Antigens by Human Natural Killer T Cells. JEM 188: 1529-1534 [Abstract] [Full Text]
Brossay, L., Chioda, M., Burdin, N., Koezuka, Y., Casorati, G., Dellabona, P., Kronenberg, M. (1998). CD1d-mediated Recognition of an {alpha}-Galactosylceramide by Natural Killer T Cells Is Highly Conserved through Mammalian Evolution. JEM 188: 1521-1528 [Abstract] [Full Text]
Sumida, T, Maeda, T, Taniguchi, M, Nishioka, K, Stohl, W (1998). TCR AV24 gene expression in double negative T cells in systemic lupus erythematosus. Lupus 7: 565-568
Burdin, N., Brossay, L., Koezuka, Y., Smiley, S. T., Grusby, M. J., Gui, M., Taniguchi, M., Hayakawa, K., Kronenberg, M. (1998). Selective Ability of Mouse CD1 to Present Glycolipids: {alpha}-Galactosylceramide Specifically Stimulates V{alpha}14+ NK T Lymphocytes. J. Immunol. 161: 3271-3281 [Abstract] [Full Text]
Exley, M., Porcelli, S., Furman, M., Garcia, J., Balk, S. (1998). CD161 (NKR-P1A) Costimulation of CD1d-dependent Activation of Human T Cells Expressing Invariant V{alpha}24J{alpha}Q T Cell Receptor {alpha} Chains. JEM 188: 867-876 [Abstract] [Full Text]
Tamada, K., Harada, M., Abe, K., Li, T., Nomoto, K. (1998). IL-4-Producing NK1.1+ T Cells Are Resistant to Glucocorticoid-Induced Apoptosis: Implications for the Th1/Th2 Balance. J. Immunol. 161: 1239-1247 [Abstract] [Full Text]
Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Sato, H., Kondo, E., Harada, M., Koseki, H., Nakayama, T., Tanaka, Y., Taniguchi, M. (1998). Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Valpha 14 NKT cells. Proc. Natl. Acad. Sci. USA 95: 5690-5693 [Abstract] [Full Text]
Brossay, L., Tangri, S., Bix, M., Cardell, S., Locksley, R., Kronenberg, M. (1998). Mouse CD1-Autoreactive T Cells Have Diverse Patterns of Reactivity to CD1+ Targets. J. Immunol. 160: 3681-3688 [Abstract] [Full Text]
Zhang, B.-n., Yamamura, T., Kondo, T., Fujiwara, M., Tabira, T. (1997). Regulation of Experimental Autoimmune Encephalomyelitis by Natural Killer (NK) Cells. JEM 186: 1677-1687 [Abstract] [Full Text]
Exley, M., Garcia, J., Balk, S. P., Porcelli, S. (1997). Requirements for CD1d Recognition by Human Invariant V{alpha}24+ CD4-CD8- T Cells. JEM 186: 109-120 [Abstract] [Full Text]
Seino, K.-i., Fukao, K., Muramoto, K., Yanagisawa, K., Takada, Y., Kakuta, S., Iwakura, Y., Van Kaer, L., Takeda, K., Nakayama, T., Taniguchi, M., Bashuda, H., Yagita, H., Okumura, K. (2001). Requirement for natural killer T (NKT) cells in the induction of allograft tolerance. Proc. Natl. Acad. Sci. USA 98: 2577-2581 [Abstract] [Full Text]
Matsuda, J. L., Gapin, L., Fazilleau, N., Warren, K., Naidenko, O. V., Kronenberg, M. (2001). Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor beta repertoire and small clone size. Proc. Natl. Acad. Sci. USA 98: 12636-12641 [Abstract] [Full Text]
Motsinger, A., Haas, D. W., Stanic, A. K., Van Kaer, L., Joyce, S., Unutmaz, D. (2002). CD1d-restricted Human Natural Killer T Cells Are Highly Susceptible to Human Immunodeficiency Virus 1 Infection. JEM 195: 869-879 [Abstract] [Full Text]