Penetration of the blood-brain barrier: enhancement of drug delivery and imaging by bacterial glycopeptides

doi:10.1084/jem.182.4.1037

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Penetration of the blood-brain barrier: enhancement of drug delivery and imaging by bacterial glycopeptides

B Spellerberg, S Prasad, C Cabellos, M Burroughs, P Cahill and E Tuomanen
Laboratory of Molecular Infectious Diseases, Rockefeller University, New York 10021, USA.

The blood-brain barrier restricts the passage of many pharmacological agents into the brain parenchyma. Bacterial glycopeptides induce enhanced blood-brain barrier permeability when they are present in the subarachnoid space during meningitis. By presenting such glycopeptides intravenously, blood-brain barrier permeability in rabbits was enhanced in a reversible time- and dose-dependent manner to agents < or = 20 kD in size. Therapeutic application of this bioactivity was evident as enhanced penetration of the antibiotic penicillin and the magnetic resonance imaging contrast agent gadolinium-diethylene-triamine- pentaacetic acid into the brain parenchyma.
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