The antigen-presenting activities of Ia+ dendritic cells shift dynamically from lung to lymph node after an airway challenge with soluble antigen

doi:10.1084/jem.181.4.1275

This Article

	Full Text (PDF, 1417K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Xia, W.
	Articles by Kradin, R. L.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Xia, W.
	Articles by Kradin, R. L.


Social Bookmarking

	What's this?

ARTICLES

The antigen-presenting activities of Ia+ dendritic cells shift dynamically from lung to lymph node after an airway challenge with soluble antigen

W Xia, CE Pinto and RL Kradin
Department of Pathology, Massachusetts General Hospital, Boston 02114, USA.

Dendritic cells (DC) are widely distributed in the lung where they are distinguished by their morphology and class II major histocompatibility complex (Ia) antigen expression. Although a role for DC as pulmonary antigen-presenting cell (APC) has been suggested, little is currently known concerning how these cells respond to inhaled antigens in vivo. Hen-egg lysozyme (HEL) was injected intratracheally into Lewis rats; DC were subsequently purified from the lung and regional lymph nodes (LN) at intervals of up to 14 d and examined for their ability to stimulate the proliferation of HEL-immune T cells in vitro in the absence of added HEL. Pulmonary DC displayed APC activities at 3 h and for up to 7 d after the injection of antigen. Dendritic cells in the draining hilar LN showed APC activities that appeared at 24 h, peaked at day 3, and then diminished progressively. After the primary sensitization, HEL- immune T cells were detected in hilar LN but not in the lung. A second airway challenge with HEL at day 14 yielded an antigen-specific pulmonary immune response, characterized histologically by the accumulation of mononuclear cells around lung venules. We conclude that APC activities shift from lung to lymph node during the response to inhaled antigen.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

McGill, J., Heusel, J. W., Legge, K. L. (2009). Innate immune control and regulation of influenza virus infections. J. Leukoc. Biol. 86: 803-812 [Abstract] [Full Text]
McGill, J., Van Rooijen, N., Legge, K. L. (2008). Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs. JEM 205: 1635-1646 [Abstract] [Full Text]
Anis, M. M., Fulton, S. A., Reba, S. M., Harding, C. V., Boom, W. H. (2007). Modulation of Naive CD4+ T-Cell Responses to an Airway Antigen during Pulmonary Mycobacterial Infection. Infect. Immun. 75: 2260-2268 [Abstract] [Full Text]
Matthews, K. E., Karabeg, A., Roberts, J. M., Saeland, S., Dekan, G., Epstein, M. M., Ronchese, F. (2007). Long-Term Deposition of Inhaled Antigen in Lung Resident CD11b-CD11c+ Cells. Am. J. Respir. Cell Mol. Bio. 36: 435-441 [Abstract] [Full Text]
Beaty, S. R., Rose, C. E. Jr., Sung, S.-s. J. (2007). Diverse and Potent Chemokine Production by Lung CD11bhigh Dendritic Cells in Homeostasis and in Allergic Lung Inflammation. J. Immunol. 178: 1882-1895 [Abstract] [Full Text]
Klinke, D. J. II (2006). An age-structured model of dendritic cell trafficking in the lung.. Am. J. Physiol. Lung Cell. Mol. Physiol. 291: L1038-L1049 [Abstract] [Full Text]
Wikstrom, M. E., Batanero, E., Smith, M., Thomas, J. A., von Garnier, C., Holt, P. G., Stumbles, P. A. (2006). Influence of Mucosal Adjuvants on Antigen Passage and CD4+ T Cell Activation during the Primary Response to Airborne Allergen. J. Immunol. 177: 913-924 [Abstract] [Full Text]
Ettmayer, P., Mayer, P., Kalthoff, F., Neruda, W., Harrer, N., Hartmann, G., Epstein, M. M., Brinkmann, V., Heusser, C., Woisetschlager, M. (2006). A Novel Low Molecular Weight Inhibitor of Dendritic Cells and B Cells Blocks Allergic Inflammation. Am. J. Respir. Crit. Care Med. 173: 599-606 [Abstract] [Full Text]
Sung, S.-S. J., Fu, S. M., Rose, C. E. Jr., Gaskin, F., Ju, S.-T., Beaty, S. R. (2006). A Major Lung CD103 ({alpha}E)-beta7 Integrin-Positive Epithelial Dendritic Cell Population Expressing Langerin and Tight Junction Proteins. J. Immunol. 176: 2161-2172 [Abstract] [Full Text]
Vermaelen, K., Pauwels, R. (2005). Pulmonary Dendritic Cells. Am. J. Respir. Crit. Care Med. 172: 530-551 [Abstract] [Full Text]
Osterholzer, J. J., Ames, T., Polak, T., Sonstein, J., Moore, B. B., Chensue, S. W., Toews, G. B., Curtis, J. L. (2005). CCR2 and CCR6, but Not Endothelial Selectins, Mediate the Accumulation of Immature Dendritic Cells within the Lungs of Mice in Response to Particulate Antigen. J. Immunol. 175: 874-883 [Abstract] [Full Text]
Padilla, J., Daley, E., Chow, A., Robinson, K., Parthasarathi, K., McKenzie, A. N. J., Tschernig, T., Kurup, V. P., Donaldson, D. D., Grunig, G. (2005). IL-13 Regulates the Immune Response to Inhaled Antigens. J. Immunol. 174: 8097-8105 [Abstract] [Full Text]
Shi, H.-Z. (2004). Eosinophils function as antigen-presenting cells. J. Leukoc. Biol. 76: 520-527 [Abstract] [Full Text]
Belz, G. T., Smith, C. M., Kleinert, L., Reading, P., Brooks, A., Shortman, K., Carbone, F. R., Heath, W. R. (2004). Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus. Proc. Natl. Acad. Sci. USA 101: 8670-8675 [Abstract] [Full Text]
Masten, B. J., Olson, G. K., Kusewitt, D. F., Lipscomb, M. F. (2004). Flt3 Ligand Preferentially Increases the Number of Functionally Active Myeloid Dendritic Cells in the Lungs of Mice. J. Immunol. 172: 4077-4083 [Abstract] [Full Text]
Huh, J. C., Strickland, D. H., Jahnsen, F. L., Turner, D. J., Thomas, J. A., Napoli, S., Tobagus, I., Stumbles, P. A., Sly, P. D., Holt, P. G. (2003). Bidirectional Interactions between Antigen-bearing Respiratory Tract Dendritic Cells (DCs) and T Cells Precede the Late Phase Reaction in Experimental Asthma: DC Activation Occurs in the Airway Mucosa but Not in the Lung Parenchyma. JEM 198: 19-30 [Abstract] [Full Text]
Brimnes, M. K., Bonifaz, L., Steinman, R. M., Moran, T. M. (2003). Influenza Virus-induced Dendritic Cell Maturation Is Associated with the Induction of Strong T Cell Immunity to a Coadministered, Normally Nonimmunogenic Protein. JEM 198: 133-144 [Abstract] [Full Text]
Dodge, I. L., Carr, M. W., Cernadas, M., Brenner, M. B. (2003). IL-6 Production by Pulmonary Dendritic Cells Impedes Th1 Immune Responses. J. Immunol. 170: 4457-4464 [Abstract] [Full Text]
van Rijt, L. S., Prins, J.-B., Leenen, P. J. M., Thielemans, K., de Vries, V. C., Hoogsteden, H. C., Lambrecht, B. N. (2002). Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31hiLy-6Cneg bone marrow precursors in a mouse model of asthma. Blood 100: 3663-3671 [Abstract] [Full Text]
Balmelli, C., Demotz, S., Acha-Orbea, H., De Grandi, P., Nardelli-Haefliger, D. (2002). Trachea, Lung, and Tracheobronchial Lymph Nodes Are the Major Sites Where Antigen-Presenting Cells Are Detected after Nasal Vaccination of Mice with Human Papillomavirus Type 16 Virus-Like Particles. J. Virol. 76: 12596-12602 [Abstract] [Full Text]
Omata, N., Yasutomi, M., Yamada, A., Iwasaki, H., Mayumi, M., Ohshima, Y. (2002). Monocyte Chemoattractant Protein-1 Selectively Inhibits the Acquisition of CD40 Ligand-Dependent IL-12-Producing Capacity of Monocyte-Derived Dendritic Cells and Modulates Th1 Immune Response. J. Immunol. 169: 4861-4866 [Abstract] [Full Text]
Hammad, H., Lambrecht, B. N., Pochard, P., Gosset, P., Marquillies, P., Tonnel, A.-B., Pestel, J. (2002). Monocyte-Derived Dendritic Cells Induce a House Dust Mite-Specific Th2 Allergic Inflammation in the Lung of Humanized SCID Mice: Involvement of CCR7. J. Immunol. 169: 1524-1534 [Abstract] [Full Text]
Iyonaga, K., McCarthy, K. M., Schneeberger, E. E. (2002). Dendritic Cells and the Regulation of a Granulomatous Immune Response in the Lung. Am. J. Respir. Cell Mol. Bio. 26: 671-679 [Abstract] [Full Text]
Bozza, S., Gaziano, R., Spreca, A., Bacci, A., Montagnoli, C., di Francesco, P., Romani, L. (2002). Dendritic Cells Transport Conidia and Hyphae of Aspergillus fumigatus from the Airways to the Draining Lymph Nodes and Initiate Disparate Th Responses to the Fungus. J. Immunol. 168: 1362-1371 [Abstract] [Full Text]
Byersdorfer, C. A., Chaplin, D. D. (2001). Visualization of Early APC/T Cell Interactions in the Mouse Lung Following Intranasal Challenge. J. Immunol. 167: 6756-6764 [Abstract] [Full Text]
Jahnsen, F L, Moloney, E D, Hogan, T, Upham, J W, Burke, C M, Holt, P G (2001). Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge. Thorax 56: 823-826 [Abstract] [Full Text]
Lambrecht, B.N., Prins, J-;B., Hoogsteden, H.C. (2001). Lung dendritic cells and host immunity to infection. Eur Respir J 18: 692-704 [Abstract] [Full Text]
Gajewska, B. U., Swirski, F. K., Alvarez, D., Ritz, S. A., Goncharova, S., Cundall, M., Snider, D. P., Coyle, A. J., Gutierrez-Ramos, J.-C., Stampfli, M. R., Jordana, M. (2001). Temporal-Spatial Analysis of the Immune Response in a Murine Model of Ovalbumin-Induced Airways Inflammation. Am. J. Respir. Cell Mol. Bio. 25: 326-334 [Abstract] [Full Text]
Bodnar, K. A., Serbina, N. V., Flynn, J. L. (2001). Fate of Mycobacterium tuberculosis within Murine Dendritic Cells. Infect. Immun. 69: 800-809 [Abstract] [Full Text]
Gonzalez-Juarrero, M., Orme, I. M. (2001). Characterization of Murine Lung Dendritic Cells Infected with Mycobacterium tuberculosis. Infect. Immun. 69: 1127-1133 [Abstract] [Full Text]
Sung, S.-s. J., Rose, C. E. Jr., Fu, S. M. (2001). Intratracheal Priming with Ovalbumin- and Ovalbumin 323-339 Peptide-Pulsed Dendritic Cells Induces Airway Hyperresponsiveness, Lung Eosinophilia, Goblet Cell Hyperplasia, and Inflammation. J. Immunol. 166: 1261-1271 [Abstract] [Full Text]
Yamamoto, N., Suzuki, S., Suzuki, Y., Shirai, A., Nakazawa, M., Suzuki, M., Takamasu, T., Nagashima, Y., Minami, M., Ishigatsubo, Y. (2001). Immune Response Induced by Airway Sensitization after Influenza A Virus Infection Depends on Timing of Antigen Exposure in Mice. J. Virol. 75: 499-505 [Abstract] [Full Text]
Vermaelen, K. Y., Carro-Muino, I., Lambrecht, B. N., Pauwels, R. A. (2001). Specific Migratory Dendritic Cells Rapidly Transport Antigen from the Airways to the Thoracic Lymph Nodes. JEM 193: 51-60 [Abstract] [Full Text]
HOLT, P. G. (2000). Antigen Presentation in the Lung. Am. J. Respir. Crit. Care Med. 162: S151-156 [Abstract] [Full Text]
Tazi, A., Soler, P., Hance, A. J (2000). Rare diseases bullet 9: Adult pulmonary Langerhans' cell histiocytosis. Thorax 55: 405-416 [Full Text]
Lambrecht, B. N., Pauwels, R. A., Fazekas de St. Groth, B. (2000). Induction of Rapid T Cell Activation, Division, and Recirculation by Intratracheal Injection of Dendritic Cells in a TCR Transgenic Model. J. Immunol. 164: 2937-2946 [Abstract] [Full Text]
KRADIN, R.�L., LIU, H.-W., van ROOIJEN, N., SPRINGER, K., ZHAO, L.-H., LEARY, C.�P. (1999). Pulmonary Immunity to Listeria Is Enhanced by Elimination of Alveolar Macrophages. Am. J. Respir. Crit. Care Med. 159: 1967-1974 [Abstract] [Full Text]
Burastero, S. E, Rossi, G. A (1999). Immunomodulation by interference with co-stimulatory molecules: therapeutic perspectives in asthma. Thorax 54: 554-557 [Full Text]
Masten, B. J., Lipscomb, M. F. (1999). Comparison of Lung Dendritic Cells and B Cells in Stimulating Naive Antigen-Specific T Cells. J. Immunol. 162: 1310-1317 [Abstract] [Full Text]
Sozzani, S., Allavena, P., D'Amico, G., Luini, W., Bianchi, G., Kataura, M., Imai, T., Yoshie, O., Bonecchi, R., Mantovani, A. (1998). Cutting Edge: Differential Regulation of Chemokine Receptors During Dendritic Cell Maturation: A Model for Their Trafficking Properties. J. Immunol. 161: 1083-1086 [Abstract] [Full Text]
D'Amico, G., Bianchi, G., Bernasconi, S., Bersani, L., Piemonti, L., Sozzani, S., Mantovani, A., Allavena, P. (1998). Adhesion, Transendothelial Migration, and Reverse Transmigration of In Vitro Cultured Dendritic Cells. Blood 92: 207-214 [Abstract] [Full Text]
Lambrecht, B. N., Salomon, B., Klatzmann, D., Pauwels, R. A. (1998). Dendritic Cells Are Required for the Development of Chronic Eosinophilic Airway Inflammation in Response to Inhaled Antigen in Sensitized Mice. J. Immunol. 160: 4090-4097 [Abstract] [Full Text]
Grosjean, I., Caux, C., Bella, C., Berger, I., Wild, F., Banchereau, J., Kaiserlian, D. (1997). Measles Virus Infects Human Dendritic Cells and Blocks Their Allostimulatory Properties for CD4+ T Cells. JEM 186: 801-812 [Abstract] [Full Text]