Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL- 12

doi:10.1084/jem.181.1.399

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Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL- 12

CM Bacon, DW McVicar, JR Ortaldo, RC Rees, JJ O'Shea and JA Johnston
Laboratory of Experimental Immunology, National Cancer Institute- Frederick Cancer Research and Development Center, MD 21702-1201.

Interleukin (IL-12) has many effects on the function of natural killer and T cells, and is important in the control of cell-mediated immunity. IL-2 and IL-12 display many similar activities, yet each also induces a distinct set of responses. A human IL-12 receptor subunit has recently been cloned and, like the IL-2R beta and IL-2R gamma, is a member of the hematopoietic receptor superfamily; however, the molecular mechanisms of IL-12 action are unknown. In this report we show that IL- 12 and IL-2 induce tyrosine phosphorylation of distinct members of the Janus (JAK) family of protein tyrosine kinases in human T lymphocytes. IL-12, but not IL-2, stimulates the tyrosine phosphorylation of TYK2 and JAK2, whereas JAK1 and JAK3, which are phosphorylated in response to IL-2, are not phosphorylated after IL-12 treatment. The use of distinct but related JAK family tyrosine kinases by IL-12 and IL-2 may provide a biochemical basis for their different biological activities.
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Chiang, P.-H., Wang, L., Bonham, C. A., Liang, X., Fung, J. J., Lu, L., Qian, S. (2004). Mechanistic Insights into Impaired Dendritic Cell Function by Rapamycin: Inhibition of Jak2/Stat4 Signaling Pathway. J. Immunol. 172: 1355-1363 [Abstract] [Full Text]
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Eyles, J. L., Metcalf, D., Grusby, M. J., Hilton, D. J., Starr, R. (2002). Negative Regulation of Interleukin-12 Signaling by Suppressor of Cytokine Signaling-1. J. Biol. Chem. 277: 43735-43740 [Abstract] [Full Text]
Kwang Yoo, J., Ho Cho, J., Woo Lee, S., Chul Sung, Y. (2002). IL-12 Provides Proliferation and Survival Signals to Murine CD4+ T Cells Through Phosphatidylinositol 3-Kinase/Akt Signaling Pathway. J. Immunol. 169: 3637-3643 [Abstract] [Full Text]
Morinobu, A., Gadina, M., Strober, W., Visconti, R., Fornace, A., Montagna, C., Feldman, G. M., Nishikomori, R., O'Shea, J. J. (2002). STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation. Proc. Natl. Acad. Sci. USA 99: 12281-12286 [Abstract] [Full Text]
De Francesco, M. A., Baronio, M., Fiorentini, S., Signorini, C., Bonfanti, C., Poiesi, C., Popovic, M., Grassi, M., Garrafa, E., Bozzo, L., Lewis, G. K., Licenziati, S., Gallo, R. C., Caruso, A. (2002). HIV-1 matrix protein p17 increases the production of proinflammatory cytokines and counteracts IL-4 activity by binding to a cellular receptor. Proc. Natl. Acad. Sci. USA 99: 9972-9977 [Abstract] [Full Text]
Goebel, J., Forrest, K., Morford, L., Roszman, T. L. (2002). Differential localization of IL-2- and -15 receptor chains in membrane rafts of human T cells. J. Leukoc. Biol. 72: 199-206 [Abstract] [Full Text]
Parham, C., Chirica, M., Timans, J., Vaisberg, E., Travis, M., Cheung, J., Pflanz, S., Zhang, R., Singh, K. P., Vega, F., To, W., Wagner, J., O'Farrell, A.-M., McClanahan, T., Zurawski, S., Hannum, C., Gorman, D., Rennick, D. M., Kastelein, R. A., de Waal Malefyt, R., Moore, K. W. (2002). A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12R{beta}1 and a Novel Cytokine Receptor Subunit, IL-23R. J. Immunol. 168: 5699-5708 [Abstract] [Full Text]
Du, C., Guan, Q., Khalil, M. W., Sriram, S. (2001). Stimulation of Th2 Response by High Doses of Dehydroepiandrosterone in KLH-Primed Splenocytes. Exp. Biol. Med. 226: 1051-1060 [Abstract] [Full Text]
Kim, J., Uyemura, K., Van Dyke, M. K., Legaspi, A. J., Rea, T. H., Shuai, K., Modlin, R. L. (2001). A Role for IL-12 Receptor Expression and Signal Transduction in Host Defense in Leprosy. J. Immunol. 167: 779-786 [Abstract] [Full Text]
Grohmann, U., Belladonna, M. L., Vacca, C., Bianchi, R., Fallarino, F., Orabona, C., Fioretti, M. C., Puccetti, P. (2001). Positive Regulatory Role of IL-12 in Macrophages and Modulation by IFN-{{gamma}}. J. Immunol. 167: 221-227 [Abstract] [Full Text]
Wang, K. S., Zorn, E., Ritz, J. (2001). Specific down-regulation of interleukin-12 signaling through induction of phospho-STAT4 protein degradation. Blood 97: 3860-3866 [Abstract] [Full Text]
Ortmann, R., Smeltz, R., Yap, G., Sher, A., Shevach, E. M. (2001). A Heritable Defect in IL-12 Signaling in B10.Q/J Mice. I. In Vitro Analysis. J. Immunol. 166: 5712-5719 [Abstract] [Full Text]
Fukao, T., Frucht, D. M., Yap, G., Gadina, M., O'Shea, J. J., Koyasu, S. (2001). Inducible Expression of Stat4 in Dendritic Cells and Macrophages and Its Critical Role in Innate and Adaptive Immune Responses. J. Immunol. 166: 4446-4455 [Abstract] [Full Text]
Wigginton, J. M., Park, J.-W., Gruys, M. E., Young, H. A., Jorcyk, C. L., Back, T. C., Brunda, M. J., Strieter, R. M., Ward, J., Green, J. E., Wiltrout, R. H. (2001). Complete Regression of Established Spontaneous Mammary Carcinoma and the Therapeutic Prevention of Genetically Programmed Neoplastic Transition by IL-12/Pulse IL-2: Induction of Local T Cell Infiltration, Fas/Fas Ligand Gene Expression, and Mammary Epithelial Apoptosis. J. Immunol. 166: 1156-1168 [Abstract] [Full Text]
Visconti, R., Gadina, M., Chiariello, M., Chen, E. H., Stancato, L. F., Gutkind, J. S., O'Shea, J. J. (2000). Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity. Blood 96: 1844-1852 [Abstract] [Full Text]
Verhagen, C. E., de Boer, T., Smits, H. H., Verreck, F. A.W., Wierenga, E. A., Kurimoto, M., Lammas, D. A., Kumararatne, D. S., Sanal, O., Kroon, F. P., van Dissel, J. T., Sinigaglia, F., Ottenhoff, T. H.M. (2000). Residual Type 1 Immunity in Patients Genetically Deficient for Interleukin 12 Receptor {beta}1 (IL-12R{beta}1): Evidence for an IL-12R{beta}1-Independent Pathway of IL-12 Responsiveness in Human T Cells. JEM 192: 517-528 [Abstract] [Full Text]
Wang, K. S., Frank, D. A., Ritz, J. (2000). Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4. Blood 95: 3183-3190 [Abstract] [Full Text]
Frucht, D. M., Aringer, M., Galon, J., Danning, C., Brown, M., Fan, S., Centola, M., Wu, C.-Y., Yamada, N., El Gabalawy, H., O'Shea, J. J. (2000). Stat4 Is Expressed in Activated Peripheral Blood Monocytes, Dendritic Cells, and Macrophages at Sites of Th1-Mediated Inflammation. J. Immunol. 164: 4659-4664 [Abstract] [Full Text]
Grigorieva, I., Grigoriev, V. G., Rowney, M. K., Hoover, R. G. (2000). Regulation of c-myc Transcription by Interleukin-2 (IL-2). IDENTIFICATION OF A NOVEL IL-2 RESPONSE ELEMENT INTERACTING WITH STAT-4. J. Biol. Chem. 275: 7343-7350 [Abstract] [Full Text]
Franchimont, D., Galon, J., Gadina, M., Visconti, R., Zhou, Y.-J., Aringer, M., Frucht, D. M., Chrousos, G. P., O'Shea, J. J. (2000). Inhibition of Th1 Immune Response by Glucocorticoids: Dexamethasone Selectively Inhibits IL-12-Induced Stat4 Phosphorylation in T Lymphocytes. J. Immunol. 164: 1768-1774 [Abstract] [Full Text]
Farrar, J. D., Smith, J. D., Murphy, T. L., Murphy, K. M. (2000). Recruitment of Stat4 to the Human Interferon-alpha /beta Receptor Requires Activated Stat2. J. Biol. Chem. 275: 2693-2697 [Abstract] [Full Text]
Showe, L. C., Fox, F. E., Williams, D., Au, K., Niu, Z., Rook, A. H. (1999). Depressed IL-12-Mediated Signal Transduction in T Cells from Patients with Sezary Syndrome Is Associated with the Absence of IL-12 Receptor {beta}2 mRNA and Highly Reduced Levels of STAT4. J. Immunol. 163: 4073-4079 [Abstract] [Full Text]
Galon, J., Sudarshan, C., Ito, S., Finbloom, D., O'Shea, J. J. (1999). IL-12 Induces IFN Regulating Factor-1 (IRF-1) Gene Expression in Human NK and T Cells. J. Immunol. 162: 7256-7262 [Abstract] [Full Text]
Bright, J. J., Du, C., Sriram, S. (1999). Tyrphostin B42 Inhibits IL-12-Induced Tyrosine Phosphorylation and Activation of Janus Kinase-2 and Prevents Experimental Allergic Encephalomyelitis. J. Immunol. 162: 6255-6262 [Abstract] [Full Text]
Diefenbach, A., Schindler, H., Röllinghoff, M., Yokoyama, W. M., Bogdan, C. (1999). Requirement for Type 2 NO Synthase for IL-12 Signaling in Innate Immunity. Science 284: 951-955 [Abstract] [Full Text]
Gollob, J. A., Schnipper, C. P., Murphy, E. A., Ritz, J., Frank, D. A. (1999). The Functional Synergy Between IL-12 and IL-2 Involves p38 Mitogen-Activated Protein Kinase and Is Associated with the Augmentation of STAT Serine Phosphorylation. J. Immunol. 162: 4472-4481 [Abstract] [Full Text]
Kanakaraj, P., Ngo, K., Wu, Y., Angulo, A., Ghazal, P., Harris, C. A., Siekierka, J. J., Peterson, P. A., Fung-Leung, W.-P. (1999). Defective Interleukin (IL)-18-mediated Natural Killer and T Helper Cell Type 1 Responses in IL-1 Receptor-associated Kinase (IRAK)-deficient Mice. JEM 189: 1129-1138 [Abstract] [Full Text]
Rogge, L., Papi, A., Presky, D. H., Biffi, M., Minetti, L. J., Miotto, D., Agostini, C., Semenzato, G., Fabbri, L. M., Sinigaglia, F. (1999). Antibodies to the IL-12 Receptor {beta}2 Chain Mark Human Th1 But Not Th2 Cells In Vitro and In Vivo. J. Immunol. 162: 3926-3932 [Abstract] [Full Text]
Sudarshan, C., Galon, J., Zhou, Y.-j., O'Shea, J. J. (1999). TGF-{beta} Does Not Inhibit IL-12- and IL-2-Induced Activation of Janus Kinases and STATs. J. Immunol. 162: 2974-2981 [Abstract] [Full Text]
Begley, C.G., Nicola, N.A. (1999). Resolving Conflicting Signals: Cross Inhibition of Cytokine Signaling Pathways. Blood 93: 1443-1447 [Full Text]
Pardoux, C., Ma, X., Gobert, S., Pellegrini, S., Mayeux, P., Gay, F., Trinchieri, G., Chouaib, S. (1999). Downregulation of Interleukin-12 (IL-12) Responsiveness in Human T Cells by Transforming Growth Factor-beta : Relationship With IL-12 Signaling. Blood 93: 1448-1455 [Abstract] [Full Text]
Gadina, M., Sudarshan, C., O'Shea, J. J. (1999). IL-2, But Not IL-4 and Other Cytokines, Induces Phosphorylation of a 98-kDa Protein Associated with SHP-2, Phosphatidylinositol 3'-Kinase, and Grb2. J. Immunol. 162: 2081-2086 [Abstract] [Full Text]
Naeger, L. K., McKinney, J., Salvekar, A., Hoey, T. (1999). Identification of a STAT4 Binding Site in the Interleukin-12 Receptor Required for Signaling. J. Biol. Chem. 274: 1875-1878 [Abstract] [Full Text]
Ahn, H.-J., Tomura, M., Yu, W.-G., Iwasaki, M., Park, W.-R., Hamaoka, T., Fujiwara, H. (1998). Requirement for Distinct Janus Kinases and STAT Proteins in T Cell Proliferation Versus IFN-{gamma} Production Following IL-12 Stimulation. J. Immunol. 161: 5893-5900 [Abstract] [Full Text]
Fogler, W. E., Volker, K., Watanabe, M., Wigginton, J. M., Roessler, P., Brunda, M. J., Ortaldo, J. R., Wiltrout, R. H. (1998). Recruitment of Hepatic NK Cells by IL-12 Is Dependent on IFN-{gamma} and VCAM-1 and Is Rapidly Down-Regulated by a Mechanism Involving T Cells and Expression of Fas. J. Immunol. 161: 6014-6021 [Abstract] [Full Text]
Collison, K., Saleh, S., Parhar, R., Meyer, B., Kwaasi, A., Al-Hussein, K., Al-Sedairy, S., Al-Mohanna, F. (1998). Evidence for IL-12-Activated Ca2+ and Tyrosine Signaling Pathways in Human Neutrophils. J. Immunol. 161: 3737-3745 [Abstract] [Full Text]
Richter, M. F., Dumenil, G., Uze, G., Fellous, M., Pellegrini, S. (1998). Specific Contribution of Tyk2 JH Regions to the Binding and the Expression of the Interferon alpha /beta Receptor Component IFNAR1. J. Biol. Chem. 273: 24723-24729 [Abstract] [Full Text]
Bright, J. J., Sriram, S. (1998). TGF-{beta} Inhibits IL-12-Induced Activation of Jak-STAT Pathway in T Lymphocytes. J. Immunol. 161: 1772-1777 [Abstract] [Full Text]
Gadina, M., Stancato, L. M., Bacon, C. M., Larner, A. C., O'Shea, J. J. (1998). Cutting Edge: Involvement of SHP-2 in Multiple Aspects of IL-2 Signaling: Evidence for a Positive Regulatory Role. J. Immunol. 160: 4657-4661 [Abstract] [Full Text]
Gollob, J. A., Murphy, E. A., Mahajan, S., Schnipper, C. P., Ritz, J., Frank, D. A. (1998). Altered Interleukin-12 Responsiveness in Th1 and Th2 Cells Is Associated With the Differential Activation of STAT5 and STAT1. Blood 91: 1341-1354 [Abstract] [Full Text]
Piccotti, J. R., Li, K., Chan, S. Y., Ferrante, J., Magram, J., Eichwald, E. J., Bishop, D. K. (1998). Alloantigen-Reactive Th1 Development in IL-12-Deficient Mice. J. Immunol. 160: 1132-1138 [Abstract] [Full Text]
Peng, X., Remacle, J. E., Kasran, A., Huylebroeck, D., Ceuppens, J. L. (1998). IL-12 Up-Regulates CD40 Ligand (CD154) Expression on Human T Cells. J. Immunol. 160: 1166-1172 [Abstract] [Full Text]
Gauzzi, M. C., Barbieri, G., Richter, M. F., Uze, G., Ling, L., Fellous, M., Pellegrini, S. (1997). The amino-terminal region of Tyk2 sustains the level of interferon alpha �receptor 1,�a component of the interferon alpha /beta �receptor. Proc. Natl. Acad. Sci. USA 94: 11839-11844 [Abstract] [Full Text]
Rogge, L., Barberis-Maino, L., Biffi, M., Passini, N., Presky, D. H., Gubler, U., Sinigaglia, F. (1997). Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells. JEM 185: 825-832 [Abstract] [Full Text]
Zou, J., Presky, D. H., Wu, C.-Y., Gubler, U. (1997). Differential Associations between the Cytoplasmic Regions of the Interleukin-12 Receptor Subunits beta 1 and beta 2 and JAK Kinases. J. Biol. Chem. 272: 6073-6077 [Abstract] [Full Text]
Herrada, G, Wolgemuth, D. (1997). The mouse transcription factor Stat4 is expressed in haploid male germ cells and is present in the perinuclear theca of spermatozoa. J. Cell Sci. 110: 1543-1553 [Abstract]
Kotenko, S. V., Izotova, L. S., Pollack, B. P., Muthukumaran, G., Paukku, K., Silvennoinen, O., Ihle, J. N., Pestka, S. (1996). Other Kinases Can Substitute for Jak2 in Signal Transduction by Interferon-gamma. J. Biol. Chem. 271: 17174-17182 [Abstract] [Full Text]
Robertson, M. J., Ritz, J. (1996). Interleukin 12: Basic Biology and Potential Applications in Cancer Treatment. The Oncologist 1: 88-97 [Abstract] [Full Text]
Johnston, J. A., Wang, L.-M., Hanson, E. P., Sun, X.-J., White, M. F., Oakes, S. A., Pierce, J. H., O'Shea, J. J. (1995). Interleukins 2, 4, 7, and 15 Stimulate Tyrosine Phosphorylation of Insulin Receptor Substrates 1 and 2 in T Cells. J. Biol. Chem. 270: 28527-28530 [Abstract] [Full Text]
Taniguchi, T (1995). Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268: 251-255 [Abstract]
Gadina, M., Sudarshan, C., Visconti, R., Zhou, Y.-J., Gu, H., Neel, B. G., O'Shea, J. J. (2000). The Docking Molecule Gab2 Is Induced by Lymphocyte Activation and Is Involved in Signaling by Interleukin-2 and Interleukin-15 but Not Other Common gamma Chain-using Cytokines. J. Biol. Chem. 275: 26959-26966 [Abstract] [Full Text]
Ragimbeau, J., Dondi, E., Vasserot, A., Romero, P., Uze, G., Pellegrini, S. (2001). The Receptor Interaction Region of Tyk2 Contains a Motif Required for Its Nuclear Localization. J. Biol. Chem. 276: 30812-30818 [Abstract] [Full Text]