Activation of human dendritic cells through CD40 cross-linking

doi:10.1084/jem.180.4.1263

This Article

Full Text (PDF, 3076K)

Alert me when this article is cited

Citation Map

Services

Email this article

Similar articles in this journal

Similar articles in PubMed

Alert me to new content in the JEM

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via CrossRef

Citing Articles via Google Scholar

Google Scholar

Articles by Caux, C.

Articles by Banchereau, J.

Search for Related Content

PubMed

PubMed Citation

Articles by Caux, C.

Articles by Banchereau, J.

Pubmed/NCBI databases

Substance via MeSH

Social Bookmarking

What's this?

ARTICLES

Activation of human dendritic cells through CD40 cross-linking

C Caux, C Massacrier, B Vanbervliet, B Dubois, C Van Kooten, I Durand and J Banchereau
Schering-Plough, Laboratory for Immunological Research, Dardilly, France.

Dendritic cells, the professional antigen-presenting cells (APC) involved in T cell priming, express CD40, a molecule which triggering plays a key role in B cell growth and differentiation as well as monocyte activation. Herein we demonstrate that dendritic Langerhans cells (D-Lc) generated by culturing cord blood CD34+ progenitor cells with granulocyte/macrophage colony-stimulating and tumor necrosis factor alpha (TNF-alpha) express functional CD40 at a density higher than that found on B cells. Culturing D-Lc on CD40-ligand (CD40L) transfected L cells allowed D-Lc survival as 50 +/- 15% of seeded cells were recovered after 4 d while only 5% survived over control L cells. CD40 activation induced important morphological changes with a reduction of cytoplasmic content and a remarkable increase of dendrite development as well as an altered phenotype. In particular, CD40 triggering induced maintenance of high levels of major histocompatibility complex class II antigens and upregulation of accessory molecules such as CD58, CD80 (B7-1) and CD86 (B7-2). CD40 engagement also seems to turn on D-Lc maturation as illustrated by upregulation of CD25, a molecule usually expressed on interdigitating dendritic cells of secondary lymphoid organs. Finally, CD40 activated D- Lc secreted a limited set of cytokines (TNF-alpha, IL-8, and macrophage inflammatory protein 1 alpha [MIP-1 alpha]) whereas a similar activation induced elutriated monocytes to secrete IL-1 alpha, IL-1 beta, IL-6, IL-8, IL-10, TNF-alpha, and MIP-1 alpha. As D-Lc activated T cells upregulated CD40L, it is likely that CD40 activation of D-Lc observed herein with a fibroblast cell line stably expressing CD40L, mimics physiological interactions between dendritic cells and T cells.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Chino, T., Draves, K. E., Clark, E. A. (2009). Regulation of dendritic cell survival and cytokine production by osteoprotegerin. J. Leukoc. Biol. 86: 933-940 [Abstract] [Full Text]
Jin, J.-O, Park, H.-Y., Xu, Q., Park, J.-I., Zvyagintseva, T., Stonik, V. A., Kwak, J.-Y. (2009). Ligand of scavenger receptor class A indirectly induces maturation of human blood dendritic cells via production of tumor necrosis factor-{alpha}. Blood 113: 5839-5847 [Abstract] [Full Text]
Baruah, P., Dumitriu, I. E., Malik, T. H., Cook, H. T., Dyson, J., Scott, D., Simpson, E., Botto, M. (2009). C1q enhances IFN-{gamma} production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells. Blood 113: 3485-3493 [Abstract] [Full Text]
Choi, B. K., Kim, Y. H., Kwon, P. M., Lee, S. C., Kang, S. W., Kim, M. S., Lee, M. J., Kwon, B. S. (2009). 4-1BB Functions As a Survival Factor in Dendritic Cells. J. Immunol. 182: 4107-4115 [Abstract] [Full Text]
Janelsins, B. M., Mathers, A. R., Tkacheva, O. A., Erdos, G., Shufesky, W. J., Morelli, A. E., Larregina, A. T. (2009). Proinflammatory tachykinins that signal through the neurokinin 1 receptor promote survival of dendritic cells and potent cellular immunity. Blood 113: 3017-3026 [Abstract] [Full Text]
Li, K., Anderson, K. J., Peng, Q., Noble, A., Lu, B., Kelly, A. P., Wang, N., Sacks, S. H., Zhou, W. (2008). Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation. Blood 112: 5084-5094 [Abstract] [Full Text]
Mukherjee, P., Chauhan, V. S. (2008). Plasmodium falciparum-free merozoites and infected RBCs distinctly affect soluble CD40 ligand-mediated maturation of immature monocyte-derived dendritic cells. J. Leukoc. Biol. 84: 244-254 [Abstract] [Full Text]
Suzuki, M., Zheng, X., Zhang, X., Li, M., Vladau, C., Ichim, T. E., Sun, H., Min, L. R., Garcia, B., Min, W.-P. (2008). Novel Vaccination for Allergy through Gene Silencing of CD40 Using Small Interfering RNA. J. Immunol. 180: 8461-8469 [Abstract] [Full Text]
Sprague, D. L., Elzey, B. D., Crist, S. A., Waldschmidt, T. J., Jensen, R. J., Ratliff, T. L. (2008). Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles. Blood 111: 5028-5036 [Abstract] [Full Text]
Peiser, M., Koeck, J., Kirschning, C. J., Wittig, B., Wanner, R. (2008). Human Langerhans cells selectively activated via Toll-like receptor 2 agonists acquire migratory and CD4+T cell stimulatory capacity. J. Leukoc. Biol. 83: 1118-1127 [Abstract] [Full Text]
Nobile, C., Lind, M., Miro, F., Chemin, K., Tourret, M., Occhipinti, G., Dogniaux, S., Amigorena, S., Hivroz, C. (2008). Cognate CD4+ T-cell-dendritic cell interactions induce migration of immature dendritic cells through dissolution of their podosomes. Blood 111: 3579-3590 [Abstract] [Full Text]
Mollah, Z. U. A., Pai, S., Moore, C., O'Sullivan, B. J., Harrison, M. J., Peng, J., Phillips, K., Prins, J. B., Cardinal, J., Thomas, R. (2008). Abnormal NF-{kappa}B Function Characterizes Human Type 1 Diabetes Dendritic Cells and Monocytes. J. Immunol. 180: 3166-3175 [Abstract] [Full Text]
Kawasaki, T., Choudhry, M. A., Schwacha, M. G., Fujimi, S., Lederer, J. A., Bland, K. I., Chaudry, I. H. (2008). Trauma-hemorrhage inhibits splenic dendritic cell proinflammatory cytokine production via a mitogen-activated protein kinase process. Am. J. Physiol. Cell Physiol. 294: C754-C764 [Abstract] [Full Text]
Robson, N. C., Phillips, D. J., McAlpine, T., Shin, A., Svobodova, S., Toy, T., Pillay, V., Kirkpatrick, N., Zanker, D., Wilson, K., Helling, I., Wei, H., Chen, W., Cebon, J., Maraskovsky, E. (2008). Activin-A: a novel dendritic cell-derived cytokine that potently attenuates CD40 ligand-specific cytokine and chemokine production. Blood 111: 2733-2743 [Abstract] [Full Text]
Hanig, J., Lutz, M. B. (2008). Suppression of Mature Dendritic Cell Function by Regulatory T Cells In Vivo Is Abrogated by CD40 Licensing. J. Immunol. 180: 1405-1413 [Abstract] [Full Text]
Spence, P. J., Green, E. A. (2008). Foxp3+ regulatory T cells promiscuously accept thymic signals critical for their development. Proc. Natl. Acad. Sci. USA 105: 973-978 [Abstract] [Full Text]
Lin, Y.-L., Liang, Y.-C., Chiang, B.-L. (2007). Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells. J. Leukoc. Biol. 82: 1473-1480 [Abstract] [Full Text]
Hwang, M. L., Lukens, J. R., Bullock, T. N. J. (2007). Cognate Memory CD4+ T Cells Generated with Dendritic Cell Priming Influence the Expansion, Trafficking, and Differentiation of Secondary CD8+ T Cells and Enhance Tumor Control. J. Immunol. 179: 5829-5838 [Abstract] [Full Text]
Martinez, D., Vermeulen, M., von Euw, E., Sabatte, J., Maggini, J., Ceballos, A., Trevani, A., Nahmod, K., Salamone, G., Barrio, M., Giordano, M., Amigorena, S., Geffner, J. (2007). Extracellular Acidosis Triggers the Maturation of Human Dendritic Cells and the Production of IL-12. J. Immunol. 179: 1950-1959 [Abstract] [Full Text]
Hewitson, J. P., Hamblin, P. A., Mountford, A. P. (2007). In the Absence of CD154, Administration of Interleukin-12 Restores Th1 Responses but Not Protective Immunity to Schistosoma mansoni. Infect. Immun. 75: 3539-3547 [Abstract] [Full Text]
Chang, W. L. W., Baumgarth, N., Eberhardt, M. K., Lee, C. Y. D., Baron, C. A., Gregg, J. P., Barry, P. A. (2007). Exposure of Myeloid Dendritic Cells to Exogenous or Endogenous IL-10 during Maturation Determines Their Longevity. J. Immunol. 178: 7794-7804 [Abstract] [Full Text]
Turnquist, H. R., Raimondi, G., Zahorchak, A. F., Fischer, R. T., Wang, Z., Thomson, A. W. (2007). Rapamycin-Conditioned Dendritic Cells Are Poor Stimulators of Allogeneic CD4+ T Cells, but Enrich for Antigen-Specific Foxp3+ T Regulatory Cells and Promote Organ Transplant Tolerance. J. Immunol. 178: 7018-7031 [Abstract] [Full Text]
Srivastava, R. M., Varalakshmi, Ch., Khar, A. (2007). Cross-linking a mAb to NKR-P2/NKG2D on dendritic cells induces their activation and maturation leading to enhanced anti-tumor immune response. Int Immunol 19: 591-607 [Abstract] [Full Text]
Sanderson, J. P., Naisbitt, D. J., Farrell, J., Ashby, C. A., Tucker, M. J., Rieder, M. J., Pirmohamed, M., Clarke, S. E., Park, B. K. (2007). Sulfamethoxazole and Its Metabolite Nitroso Sulfamethoxazole Stimulate Dendritic Cell Costimulatory Signaling. J. Immunol. 178: 5533-5542 [Abstract] [Full Text]
Bayry, J., Triebel, F., Kaveri, S. V., Tough, D. F. (2007). Human Dendritic Cells Acquire a Semimature Phenotype and Lymph Node Homing Potential through Interaction with CD4+CD25+ Regulatory T Cells. J. Immunol. 178: 4184-4193 [Abstract] [Full Text]
Radhakrishnan, S., Nguyen, L. T., Ciric, B., Van Keulen, V. P., Pease, L. R. (2007). B7-DC/PD-L2 Cross-Linking Induces NF-{kappa}B-Dependent Protection of Dendritic Cells from Cell Death. J. Immunol. 178: 1426-1432 [Abstract] [Full Text]
Remoli, M. E., Ragimbeau, J., Giacomini, E., Gafa, V., Severa, M., Lande, R., Pellegrini, S., Coccia, E. M. (2007). NF-{kappa}B is required for STAT-4 expression during dendritic cell maturation. J. Leukoc. Biol. 81: 355-363 [Abstract] [Full Text]
Nayak, J. V., Hokey, D. A., Larregina, A., He, Y., Salter, R. D., Watkins, S. C., Falo, L. D. Jr (2006). Phagocytosis Induces Lysosome Remodeling and Regulated Presentation of Particulate Antigens by Activated Dendritic Cells. J. Immunol. 177: 8493-8503 [Abstract] [Full Text]
Kornbluth, R. S., Stone, G. W. (2006). Immunostimulatory combinations: designing the next generation of vaccine adjuvants. J. Leukoc. Biol. 80: 1084-1102 [Abstract] [Full Text]
Hellings, P. W., Kasran, A., Bullens, D., Overbergh, L., Mathieu, C., Heremans, H., Matthys, P., Boon, L., Jorissen, M., Ceuppens, J. L. (2006). IL-10- and IL-12-Independent Down-Regulation of Allergic Sensitization by Stimulation of CD40 Signaling. J. Immunol. 177: 5138-5144 [Abstract] [Full Text]
Temmerman, S. T., Ma, C. A., Borges, L., Kubin, M., Liu, S., Derry, J. M. J., Jain, A. (2006). Impaired dendritic-cell function in ectodermal dysplasia with immune deficiency is linked to defective NEMO ubiquitination. Blood 108: 2324-2331 [Abstract] [Full Text]
Miro, F., Nobile, C., Blanchard, N., Lind, M., Filipe-Santos, O., Fieschi, C., Chapgier, A., Vogt, G., de Beaucoudrey, L., Kumararatne, D. S., Le Deist, F., Casanova, J.-L., Amigorena, S., Hivroz, C. (2006). T Cell-Dependent Activation of Dendritic Cells Requires IL-12 and IFN-{gamma} Signaling in T Cells. J. Immunol. 177: 3625-3634 [Abstract] [Full Text]
Hewitson, J. P., Jenkins, G. R., Hamblin, P. A., Mountford, A. P. (2006). CD40/CD154 Interactions Are Required for the Optimal Maturation of Skin-Derived APCs and the Induction of Helminth-Specific IFN-{gamma} but Not IL-4.. J. Immunol. 177: 3209-3217 [Abstract] [Full Text]
Dauer, M., Schad, K., Junkmann, J., Bauer, C., Herten, J., Kiefl, R., Schnurr, M., Endres, S., Eigler, A. (2006). IFN-{alpha} promotes definitive maturation of dendritic cells generated by short-term culture of monocytes with GM-CSF and IL-4. J. Leukoc. Biol. 80: 278-286 [Abstract] [Full Text]
Beuneu, H., Garcia, Z., Bousso, P. (2006). Cutting Edge: Cognate CD4 Help Promotes Recruitment of Antigen-Specific CD8 T Cells around Dendritic Cells. J. Immunol. 177: 1406-1410 [Abstract] [Full Text]
Schiavo, R., Baatar, D., Olkhanud, P., Indig, F. E., Restifo, N., Taub, D., Biragyn, A. (2006). Chemokine receptor targeting efficiently directs antigens to MHC class I pathways and elicits antigen-specific CD8+ T-cell responses. Blood 107: 4597-4605 [Abstract] [Full Text]
Lum, H. D., Buhtoiarov, I. N., Schmidt, B. E., Berke, G., Paulnock, D. M., Sondel, P. M., Rakhmilevich, A. L. (2006). In vivo CD40 ligation can induce T cell-independent antitumor effects that involve macrophages. J. Leukoc. Biol. 79: 1181-1192 [Abstract] [Full Text]
Zhou, Q., Gault, R. A., Kozel, T. R., Murphy, W. J. (2006). Immunomodulation with CD40 Stimulation and Interleukin-2 Protects Mice from Disseminated Cryptococcosis. Infect. Immun. 74: 2161-2168 [Abstract] [Full Text]
Rivollier, A., Perrin-Cocon, L., Luche, S., Diemer, H., Strub, J.-M., Hanau, D., van Dorsselaer, A., Lotteau, V., Rabourdin-Combe, C., Rabilloud, T., Servet-Delprat, C. (2006). High Expression of Antioxidant Proteins in Dendritic Cells: Possible Implications in Atherosclerosis. Mol. Cell. Proteomics 5: 726-736 [Abstract] [Full Text]
Jiang, H., Chess, L. (2006). Regulation of immune responses by T cells.. NEJM 354: 1166-1176 [Full Text]
Wang, H., Arp, J., Huang, X., Liu, W., Ramcharran, S., Jiang, J., Garcia, B., Kanai, N., Min, W., O'Connell, P. J., Zhong, R. (2006). Distinct Subsets of Dendritic Cells Regulate the Pattern of Acute Xenograft Rejection and Susceptibility to Cyclosporine Therapy. J. Immunol. 176: 3525-3535 [Abstract] [Full Text]
Cavrois, M., Neidleman, J., Kreisberg, J. F., Fenard, D., Callebaut, C., Greene, W. C. (2006). Human Immunodeficiency Virus Fusion to Dendritic Cells Declines as Cells Mature. J. Virol. 80: 1992-1999 [Abstract] [Full Text]
Barchet, W., Price, J. D., Cella, M., Colonna, M., MacMillan, S. K., Cobb, J. P., Thompson, P. A., Murphy, K. M., Atkinson, J. P., Kemper, C. (2006). Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation. Blood 107: 1497-1504 [Abstract] [Full Text]
Rousseau, R. F., Biagi, E., Dutour, A., Yvon, E. S., Brown, M. P., Lin, T., Mei, Z., Grilley, B., Popek, E., Heslop, H. E., Gee, A. P., Krance, R. A., Popat, U., Carrum, G., Margolin, J. F., Brenner, M. K. (2006). Immunotherapy of high-risk acute leukemia with a recipient (autologous) vaccine expressing transgenic human CD40L and IL-2 after chemotherapy and allogeneic stem cell transplantation. Blood 107: 1332-1341 [Abstract] [Full Text]
Triantis, V., Trancikova, D. E., Looman, M. W. G., Hartgers, F. C., Janssen, R. A. J., Adema, G. J. (2006). Identification and Characterization of DC-SCRIPT, a Novel Dendritic Cell-Expressed Member of the Zinc Finger Family of Transcriptional Regulators. J. Immunol. 176: 1081-1089 [Abstract] [Full Text]
Lin, Y.-L., Liang, Y.-C., Lee, S.-S., Chiang, B.-L. (2005). Polysaccharide purified from Ganoderma lucidum induced activation and maturation of human monocyte-derived dendritic cells by the NF-{kappa}B and p38 mitogen-activated protein kinase pathways. J. Leukoc. Biol. 78: 533-543 [Abstract] [Full Text]
Rossi, M., Young, J. W. (2005). Human Dendritic Cells: Potent Antigen-Presenting Cells at the Crossroads of Innate and Adaptive Immunity. J. Immunol. 175: 1373-1381 [Abstract] [Full Text]
Kang, H. K., Lee, H.-Y., Kim, M.-K., Park, K. S., Park, Y. M., Kwak, J.-Y., Bae, Y.-S. (2005). The Synthetic Peptide Trp-Lys-Tyr-Met-Val-D-Met Inhibits Human Monocyte-Derived Dendritic Cell Maturation via Formyl Peptide Receptor and Formyl Peptide Receptor-Like 2. J. Immunol. 175: 685-692 [Abstract] [Full Text]
Kriehuber, E., Bauer, W., Charbonnier, A.-S., Winter, D., Amatschek, S., Tamandl, D., Schweifer, N., Stingl, G., Maurer, D. (2005). Balance between NF-{kappa}B and JNK/AP-1 activity controls dendritic cell life and death. Blood 106: 175-183 [Abstract] [Full Text]
Pejawar, S. S., Parks, G. D., Alexander-Miller, M. A. (2005). Abortive versus Productive Viral Infection of Dendritic Cells with a Paramyxovirus Results in Differential Upregulation of Select Costimulatory Molecules. J. Virol. 79: 7544-7557 [Abstract] [Full Text]
Efron, P. A., Tsujimoto, H., Bahjat, F. R., Ungaro, R., Debernardis, J., Tannahill, C., Baker, H. V., Edwards, C. K., Moldawer, L. L. (2005). Differential maturation of murine bone-marrow derived dendritic cells with lipopolysaccharide and tumor necrosis factor-{alpha}. Innate Immunity 11: 145-160 [Abstract]
Dudziak, D., Nimmerjahn, F., Bornkamm, G. W., Laux, G. (2005). Alternative Splicing Generates Putative Soluble CD83 Proteins That Inhibit T Cell Proliferation. J. Immunol. 174: 6672-6676 [Abstract] [Full Text]
van Gisbergen, K. P.J.M., Sanchez-Hernandez, M., Geijtenbeek, T. B.H., van Kooyk, Y. (2005). Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN. JEM 201: 1281-1292 [Abstract] [Full Text]
Li, G., Kim, Y.-J., Broxmeyer, H. E. (2005). Macrophage Colony-Stimulating Factor Drives Cord Blood Monocyte Differentiation into IL-10highIL-12absent Dendritic Cells with Tolerogenic Potential. J. Immunol. 174: 4706-4717 [Abstract] [Full Text]
Iizasa, H., Yoneyama, H., Mukaida, N., Katakoka, Y., Naito, M., Yoshida, N., Nakashima, E., Matsushima, K. (2005). Exacerbation of Granuloma Formation in IL-1 Receptor Antagonist-Deficient Mice with Impaired Dendritic Cell Maturation Associated with Th2 Cytokine Production. J. Immunol. 174: 3273-3280 [Abstract] [Full Text]
Wang, Y., Whittall, T., McGowan, E., Younson, J., Kelly, C., Bergmeier, L. A., Singh, M., Lehner, T. (2005). Identification of Stimulating and Inhibitory Epitopes within the Heat Shock Protein 70 Molecule That Modulate Cytokine Production and Maturation of Dendritic Cells. J. Immunol. 174: 3306-3316 [Abstract] [Full Text]
Anderson, B. E., McNiff, J. M., Jain, D., Blazar, B. R., Shlomchik, W. D., Shlomchik, M. J. (2005). Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ. Blood 105: 2227-2234 [Abstract] [Full Text]
Mukundan, L., Bishop, G. A., Head, K. Z., Zhang, L., Wahl, L. M., Suttles, J. (2005). TNF Receptor-Associated Factor 6 Is an Essential Mediator of CD40-Activated Proinflammatory Pathways in Monocytes and Macrophages. J. Immunol. 174: 1081-1090 [Abstract] [Full Text]
Nakahara, T., Uchi, H., Urabe, K., Chen, Q., Furue, M., Moroi, Y. (2004). Role of c-Jun N-terminal kinase on lipopolysaccharide induced maturation of human monocyte-derived dendritic cells. Int Immunol 16: 1701-1709 [Abstract] [Full Text]
Haase, C., Skak, K., Michelsen, B. K., Markholst, H. (2004). Local Activation of Dendritic Cells Leads to Insulitis and Development of Insulin-Dependent Diabetes in Transgenic Mice Expressing CD154 on the Pancreatic {beta}-Cells. Diabetes 53: 2588-2595 [Abstract] [Full Text]
Bayry, J., Lacroix-Desmazes, S., Donkova-Petrini, V., Carbonneil, C., Misra, N., Lepelletier, Y., Delignat, S., Varambally, S., Oksenhendler, E., Levy, Y., Debre, M., Kazatchkine, M. D., Hermine, O., Kaveri, S. V. (2004). Natural antibodies sustain differentiation and maturation of human dendritic cells. Proc. Natl. Acad. Sci. USA 101: 14210-14215 [Abstract] [Full Text]
Do, Y., Hegde, V. L., Nagarkatti, P. S., Nagarkatti, M. (2004). Bryostatin-1 Enhances the Maturation and Antigen-Presenting Ability of Murine and Human Dendritic Cells. Cancer Res. 64: 6756-6765 [Abstract] [Full Text]
Peiser, M., Wanner, R., Kolde, G. (2004). Human epidermal Langerhans cells differ from monocyte-derived Langerhans cells in CD80 expression and in secretion of IL-12 after CD40 cross-linking. J. Leukoc. Biol. 76: 616-622 [Abstract] [Full Text]
Shi, H.-Z. (2004). Eosinophils function as antigen-presenting cells. J. Leukoc. Biol. 76: 520-527 [Abstract] [Full Text]
Gorbachev, A. V., Fairchild, R. L. (2004). CD40 Engagement Enhances Antigen-Presenting Langerhans Cell Priming of IFN-{gamma}-Producing CD4+ and CD8+ T Cells Independently of IL-12. J. Immunol. 173: 2443-2452 [Abstract] [Full Text]
McKee, A. S., Dzierszinski, F., Boes, M., Roos, D. S., Pearce, E. J. (2004). Functional Inactivation of Immature Dendritic Cells by the Intracellular Parasite Toxoplasma gondii. J. Immunol. 173: 2632-2640 [Abstract] [Full Text]
Brzoza, K. L., Rockel, A. B., Hiltbold, E. M. (2004). Cytoplasmic Entry of Listeria monocytogenes Enhances Dendritic Cell Maturation and T Cell Differentiation and Function. J. Immunol. 173: 2641-2651 [Abstract] [Full Text]
Ratzinger, G., Baggers, J., de Cos, M. A., Yuan, J., Dao, T., Reagan, J. L., Munz, C., Heller, G., Young, J. W. (2004). Mature Human Langerhans Cells Derived from CD34+ Hematopoietic Progenitors Stimulate Greater Cytolytic T Lymphocyte Activity in the Absence of Bioactive IL-12p70, by Either Single Peptide Presentation or Cross-Priming, Than Do Dermal-Interstitial or Monocyte-Derived Dendritic Cells. J. Immunol. 173: 2780-2791 [Abstract] [Full Text]
Jaksits, S., Bauer, W., Kriehuber, E., Zeyda, M., Stulnig, T. M., Stingl, G., Fiebiger, E., Maurer, D. (2004). Lipid Raft-Associated GTPase Signaling Controls Morphology and CD8+ T Cell Stimulatory Capacity of Human Dendritic Cells. J. Immunol. 173: 1628-1639 [Abstract] [Full Text]
Radhakrishnan, S., Nguyen, L. T., Ciric, B., Flies, D., Keulen, V. P. V., Tamada, K., Chen, L., Rodriguez, M., Pease, L. R. (2004). Immunotherapeutic Potential of B7-DC (PD-L2) Cross-Linking Antibody In Conferring Antitumor Immunity. Cancer Res. 64: 4965-4972 [Abstract] [Full Text]
Danese, S, Sans, M, Fiocchi, C (2004). The CD40/CD40L costimulatory pathway in inflammatory bowel disease. Gut 53: 1035-1043 [Full Text]
Ruth, A.-J., Kitching, A. R., Li, M., Semple, T. J., Timoshanko, J. R., Tipping, P. G., Holdsworth, S. R. (2004). An IL-12-Independent Role for CD40-CD154 in Mediating Effector Responses: Studies in Cell-Mediated Glomerulonephritis and Dermal Delayed-Type Hypersensitivity. J. Immunol. 173: 136-144 [Abstract] [Full Text]
Fujii, S.-i., Liu, K., Smith, C., Bonito, A. J., Steinman, R. M. (2004). The Linkage of Innate to Adaptive Immunity via Maturing Dendritic Cells In Vivo Requires CD40 Ligation in Addition to Antigen Presentation and CD80/86 Costimulation. JEM 199: 1607-1618 [Abstract] [Full Text]
Drakes, M., Blanchard, T., Czinn, S. (2004). Bacterial Probiotic Modulation of Dendritic Cells. Infect. Immun. 72: 3299-3309 [Abstract] [Full Text]
Nathan, M. J., Mold, J. E., Wood, S. C., Csencsits, K., Lu, G., Eichwald, E. J., Bishop, D. K. (2004). Requirement for Donor and Recipient CD40 Expression in Cardiac Allograft Rejection: Induction of Th1 Responses and Influence of Donor-Derived Dendritic Cells. J. Immunol. 172: 6626-6633 [Abstract] [Full Text]
Yu, Q., Kovacs, C., Yue, F. Y., Ostrowski, M. A. (2004). The Role of the p38 Mitogen-Activated Protein Kinase, Extracellular Signal-Regulated Kinase, and Phosphoinositide-3-OH Kinase Signal Transduction Pathways in CD40 Ligand-Induced Dendritic Cell Activation and Expansion of Virus-Specific CD8+ T Cell Memory Responses . J. Immunol. 172: 6047-6056 [Abstract] [Full Text]
Sidiropoulos, P I, Boumpas, D T (2004). Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients. Lupus 13: 391-397 [Abstract]
Elsen, S., Doussiere, J., Villiers, C. L., Faure, M., Berthier, R., Papaioannou, A., Grandvaux, N., Marche, P. N., Vignais, P. V. (2004). Cryptic O2--generating NADPH oxidase in dendritic cells. J. Cell Sci. 117: 2215-2226 [Abstract] [Full Text]
Rouas, R., Lewalle, P., El Ouriaghli, F., Nowak, B., Duvillier, H., Martiat, P. (2004). Poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12. Int Immunol 16: 767-773 [Abstract] [Full Text]
Hagihara, M., Higuchi, A., Tamura, N., Ueda, Y., Hirabayashi, K., Ikeda, Y., Kato, S., Sakamoto, S., Hotta, T., Handa, S., Goto, S. (2004). Platelets, after Exposure to a High Shear Stress, Induce IL-10-Producing, Mature Dendritic Cells In Vitro. J. Immunol. 172: 5297-5303 [Abstract] [Full Text]
Bjorck, P. (2004). Dendritic Cells Exposed to Herpes Simplex Virus In Vivo Do Not Produce IFN-{alpha} after Rechallenge with Virus In Vitro and Exhibit Decreased T Cell Alloreactivity. J. Immunol. 172: 5396-5404 [Abstract] [Full Text]
Misra, N., Bayry, J., Lacroix-Desmazes, S., Kazatchkine, M. D., Kaveri, S. V. (2004). Cutting Edge: Human CD4+CD25+ T Cells Restrain the Maturation and Antigen-Presenting Function of Dendritic Cells. J. Immunol. 172: 4676-4680 [Abstract] [Full Text]
Koschella, M., Voehringer, D., Pircher, H. (2004). CD40 Ligation In Vivo Induces Bystander Proliferation of Memory Phenotype CD8 T Cells. J. Immunol. 172: 4804-4811 [Abstract] [Full Text]
Yasumi, T., Katamura, K., Yoshioka, T., Meguro, T.-a., Nishikomori, R., Heike, T., Inobe, M., Kon, S., Uede, T., Nakahata, T. (2004). Differential Requirement for the CD40-CD154 Costimulatory Pathway during Th Cell Priming by CD8{alpha}+ and CD8{alpha}− Murine Dendritic Cell Subsets. J. Immunol. 172: 4826-4833 [Abstract] [Full Text]
Ahonen, C. L., Doxsee, C. L., McGurran, S. M., Riter, T. R., Wade, W. F., Barth, R. J., Vasilakos, J. P., Noelle, R. J., Kedl, R. M. (2004). Combined TLR and CD40 Triggering Induces Potent CD8+ T Cell Expansion with Variable Dependence on Type I IFN. JEM 199: 775-784 [Abstract] [Full Text]
Bonifaz, L. C., Bonnyay, D. P., Charalambous, A., Darguste, D. I., Fujii, S.-I., Soares, H., Brimnes, M. K., Moltedo, B., Moran, T. M., Steinman, R. M. (2004). In Vivo Targeting of Antigens to Maturing Dendritic Cells via the DEC-205 Receptor Improves T Cell Vaccination. JEM 199: 815-824 [Abstract] [Full Text]
Megjugorac, N. J., Young, H. A., Amrute, S. B., Olshalsky, S. L., Fitzgerald-Bocarsly, P. (2004). Virally stimulated plasmacytoid dendritic cells produce chemokines and induce migration of T and NK cells. J. Leukoc. Biol. 75: 504-514 [Abstract] [Full Text]
Chaput, N., Schartz, N. E. C., Andre, F., Taieb, J., Novault, S., Bonnaventure, P., Aubert, N., Bernard, J., Lemonnier, F., Merad, M., Adema, G., Adams, M., Ferrantini, M., Carpentier, A. F., Escudier, B., Tursz, T., Angevin, E., Zitvogel, L. (2004). Exosomes as Potent Cell-Free Peptide-Based Vaccine. II. Exosomes in CpG Adjuvants Efficiently Prime Naive Tc1 Lymphocytes Leading to Tumor Rejection. J. Immunol. 172: 2137-2146 [Abstract] [Full Text]
O'Gradaigh, D., Compston, J. E. (2004). T-cell involvement in osteoclast biology: implications for rheumatoid bone erosion. Rheumatology (Oxford) 43: 122-130 [Full Text]
Larregina, A. T., Morelli, A. E., Tkacheva, O., Erdos, G., Donahue, C., Watkins, S. C., Thomson, A. W., Falo, L. D. Jr (2004). Highly efficient expression of transgenic proteins by naked DNA-transfected dendritic cells through terminal differentiation. Blood 103: 811-819 [Abstract] [Full Text]
Korokhov, N., Mikheeva, G., Krendelshchikov, A., Belousova, N., Simonenko, V., Krendelshchikova, V., Pereboev, A., Kotov, A., Kotova, O., Triozzi, P. L., Aldrich, W. A., Douglas, J. T., Lo, K.-M., Banerjee, P. T., Gillies, S. D., Curiel, D. T., Krasnykh, V. (2003). Targeting of Adenovirus via Genetic Modification of the Viral Capsid Combined with a Protein Bridge. J. Virol. 77: 12931-12940 [Abstract] [Full Text]
Andrade, R. M., Wessendarp, M., Subauste, C. S. (2003). CD154 Activates Macrophage Antimicrobial Activity in the Absence of IFN-{gamma} through a TNF-{alpha}-Dependent Mechanism. J. Immunol. 171: 6750-6756 [Abstract] [Full Text]
Lee, B. O., Hartson, L., Randall, T. D. (2003). CD40-deficient, Influenza-specific CD8 Memory T Cells Develop and Function Normally in a CD40-sufficient Environment. JEM 198: 1759-1764 [Abstract] [Full Text]
Lee, B. O., Moyron-Quiroz, J., Rangel-Moreno, J., Kusser, K. L., Hartson, L., Sprague, F., Lund, F. E., Randall, T. D. (2003). CD40, but Not CD154, Expression on B Cells Is Necessary for Optimal Primary B Cell Responses. J. Immunol. 171: 5707-5717 [Abstract] [Full Text]
Fontana, S., Moratto, D., Mangal, S., De Francesco, M., Vermi, W., Ferrari, S., Facchetti, F., Kutukculer, N., Fiorini, C., Duse, M., Das, P. K., Notarangelo, L. D., Plebani, A., Badolato, R. (2003). Functional defects of dendritic cells in patients with CD40 deficiency. Blood 102: 4099-4106 [Abstract] [Full Text]
Hermans, I. F., Silk, J. D., Gileadi, U., Salio, M., Mathew, B., Ritter, G., Schmidt, R., Harris, A. L., Old, L., Cerundolo, V. (2003). NKT Cells Enhance CD4+ and CD8+ T Cell Responses to Soluble Antigen In Vivo through Direct Interaction with Dendritic Cells. J. Immunol. 171: 5140-5147 [Abstract] [Full Text]
Chougnet, C. (2003). Role of CD40 Ligand dysregulation in HIV-associated dysfunction of antigen-presenting cells. J. Leukoc. Biol. 74: 702-709 [Abstract] [Full Text]