Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor

doi:10.1084/jem.180.1.25

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Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor

J Kirberg, A Baron, S Jakob, A Rolink, K Karjalainen and H von Boehmer
Basel Institute for Immunology, Switzerland.

We describe mice that express a transgenic T cell receptor alpha/beta (TCR-alpha/beta) specific for peptide 111-119 from influenza hemagglutinin presented by I-Ed class II major histocompatibility complex (MHC) molecules. The transgenic TCR is expressed on CD4+8- as well as CD4-8+ mature T cells even in mice that are deficient in rearrangement or do not express endogenous TCR-alpha genes. The CD4-8+ T cells require I-Ed class II MHC molecules for positive selection and can be activated to proliferate and to kill by I-Ed molecules presenting the relevant peptide. Full maturation of these cells, however, also requires the presence of class I MHC molecules. The results are compatible with the notion that T cell maturation requires multiple receptor-ligand interactions and establish an exception to the rule that class II-restricted TCRs are exclusively expressed by mature CD4+8- cells.
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Puls, K. L., Hogquist, K. A., Reilly, N., Wright, M. D. (2002). CD53, a thymocyte selection marker whose induction requires a lower affinity TCR-MHC interaction than CD69, but is up-regulated with slower kinetics. Int Immunol 14: 249-258 [Abstract] [Full Text]
Lunde, E., Western, K. H., Rasmussen, I. B., Sandlie, I., Bogen, B. (2002). Efficient Delivery of T Cell Epitopes to APC by Use of MHC Class II-Specific Troybodies. J. Immunol. 168: 2154-2162 [Abstract] [Full Text]
Hussain, S. F., Anderson, C. F., Farber, D. L. (2002). Differential SLP-76 Expression and TCR-Mediated Signaling in Effector and Memory CD4 T Cells. J. Immunol. 168: 1557-1565 [Abstract] [Full Text]
Mirshahidi, S., Huang, C.-T., Sadegh-Nasseri, S. (2001). Anergy in Peripheral Memory Cd4+ T Cells Induced by Low Avidity Engagement of T Cell Receptor. JEM 194: 719-732 [Abstract] [Full Text]
George-Chandy, A., Eriksson, K., Lebens, M., Nordstrom, I., Schon, E., Holmgren, J. (2001). Cholera Toxin B Subunit as a Carrier Molecule Promotes Antigen Presentation and Increases CD40 and CD86 Expression on Antigen-Presenting Cells. Infect. Immun. 69: 5716-5725 [Abstract] [Full Text]
Sotomayor, E. M., Borrello, I., Rattis, F.-M., Cuenca, A. G., Abrams, J., Staveley-O'Carroll, K., Levitsky, H. I. (2001). Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression. Blood 98: 1070-1077 [Abstract] [Full Text]
Golgher, D., Korangy, F., Gao, B., Gorski, K., Jaffee, E., Edidin, M., Pardoll, D. M., Elliott, T. (2001). An Immunodominant MHC Class II-Restricted Tumor Antigen Is Conformation Dependent and Binds to the Endoplasmic Reticulum Chaperone, Calreticulin. J. Immunol. 167: 147-155 [Abstract] [Full Text]
Gabrilovich, D. I., Velders, M. P., Sotomayor, E. M., Kast, W. M. (2001). Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells. J. Immunol. 166: 5398-5406 [Abstract] [Full Text]
Tseng, S.-Y., Otsuji, M., Gorski, K., Huang, X., Slansky, J. E., Pai, S. I., Shalabi, A., Shin, T., Pardoll, D. M., Tsuchiya, H. (2001). B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells. JEM 193: 839-846 [Abstract] [Full Text]
Sohn, S. J., Forbush, K. A., Pan, X. C., Perlmutter, R. M. (2001). Activated p56lck Directs Maturation of Both CD4 and CD8 Single-Positive Thymocytes. J. Immunol. 166: 2209-2217 [Abstract] [Full Text]
Kraj, P., Pacholczyk, R., Ignatowicz, L. (2001). {{alpha}}{{beta}}TCRs Differ in the Degree of Their Specificity for the Positively Selecting MHC/Peptide Ligand. J. Immunol. 166: 2251-2259 [Abstract] [Full Text]
Ahmadzadeh, M., Hussain, S. F., Farber, D. L. (2001). Heterogeneity of the Memory CD4 T Cell Response: Persisting Effectors and Resting Memory T Cells. J. Immunol. 166: 926-935 [Abstract] [Full Text]
Sarukhan, A., Camugli, S., Gjata, B., von Boehmer, H., Danos, O., Jooss, K. (2001). Successful Interference with Cellular Immune Responses to Immunogenic Proteins Encoded by Recombinant Viral Vectors. J. Virol. 75: 269-277 [Abstract] [Full Text]