Expression of functional high affinity immunoglobulin E receptors (Fc epsilon RI) on monocytes of atopic individuals

doi:10.1084/jem.179.2.745

This Article

	Full Text (PDF, 802K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Maurer, D.
	Articles by Stingl, G.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Maurer, D.
	Articles by Stingl, G.


Social Bookmarking

	What's this?

ARTICLES

Expression of functional high affinity immunoglobulin E receptors (Fc epsilon RI) on monocytes of atopic individuals

D Maurer, E Fiebiger, B Reininger, B Wolff-Winiski, MH Jouvin, O Kilgus, JP Kinet and G Stingl
Department of Dermatology, University of Vienna Medical School, Austria.

Suggestive evidence indicates that immunoglobulin E (IgE)-dependent activation of mononuclear phagocytes plays an important pathogenic role in allergic tissue inflammation. Prevailing opinion holds that low affinity IgE receptors are the relevant IgE-binding structures on monocytes/macrophages and that functional events occurring after cross- linking of membrane-bound IgE on these cells are mediated by these receptors. Here we demonstrate that peripheral blood monocytes can bind monomeric IgE via the high affinity IgE receptor (Fc epsilon RI) and that Fc epsilon RI expression on these cells is upregulated in atopic persons. Further, we demonstrate that, upon monocyte adherence to substrate, bridging of monocyte Fc epsilon RI is followed by cell activation. We propose that direct interaction of multivalent allergen with Fc epsilon RI(+)-bound IgE on mononuclear phagocytes results in cell signaling via Fc epsilon RI and that the biological consequences of this event may critically influence the outcome of allergic reactions.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Subrata, L. S., Bizzintino, J., Mamessier, E., Bosco, A., McKenna, K. L., Wikstrom, M. E., Goldblatt, J., Sly, P. D., Hales, B. J., Thomas, W. R., Laing, I. A., LeSouef, P. N., Holt, P. G. (2009). Interactions between Innate Antiviral and Atopic Immunoinflammatory Pathways Precipitate and Sustain Asthma Exacerbations in Children. J. Immunol. 183: 2793-2800 [Abstract] [Full Text]
Sun, J., Arias, K., Alvarez, D., Fattouh, R., Walker, T., Goncharova, S., Kim, B., Waserman, S., Reed, J., Coyle, A. J., Jordana, M. (2007). Impact of CD40 Ligand, B Cells, and Mast Cells in Peanut-Induced Anaphylactic Responses. J. Immunol. 179: 6696-6703 [Abstract] [Full Text]
Saffar, A. S., Alphonse, M. P., Shan, L., HayGlass, K. T., Simons, F. E. R., Gounni, A. S. (2007). IgE Modulates Neutrophil Survival in Asthma: Role of Mitochondrial Pathway. J. Immunol. 178: 2535-2541 [Abstract] [Full Text]
Takahashi, K., Hayashi, N., Kaminogawa, S., Ra, C. (2006). Molecular Mechanisms for Transcriptional Regulation of Human High-Affinity IgE Receptor beta-Chain Gene Induced by GM-CSF. J. Immunol. 177: 4605-4611 [Abstract] [Full Text]
Gounni, A. S. (2006). The high-affinity IgE receptor (Fc{epsilon}RI): a critical regulator of airway smooth muscle cells?. Am. J. Physiol. Lung Cell. Mol. Physiol. 291: L312-L321 [Abstract] [Full Text]
Maeda, K., Nishiyama, C., Tokura, T., Nakano, H., Kanada, S., Nishiyama, M., Okumura, K., Ogawa, H. (2006). FOG-1 represses GATA-1-dependent Fc{epsilon}RI beta-chain transcription: transcriptional mechanism of mast-cell-specific gene expression in mice. Blood 108: 262-269 [Abstract] [Full Text]
Kubota, T., Mukai, K., Minegishi, Y., Karasuyama, H. (2006). Different Stabilities of the Structurally Related Receptors for IgE and IgG on the Cell Surface Are Determined by Length of the Stalk Region in Their {alpha}-Chains.. J. Immunol. 176: 7008-7014 [Abstract] [Full Text]
Molfetta, R., Belleudi, F., Peruzzi, G., Morrone, S., Leone, L., Dikic, I., Piccoli, M., Frati, L., Torrisi, M. R., Santoni, A., Paolini, R. (2005). CIN85 Regulates the Ligand-Dependent Endocytosis of the IgE Receptor: A New Molecular Mechanism to Dampen Mast Cell Function. J. Immunol. 175: 4208-4216 [Abstract] [Full Text]
Kriehuber, E., Bauer, W., Charbonnier, A.-S., Winter, D., Amatschek, S., Tamandl, D., Schweifer, N., Stingl, G., Maurer, D. (2005). Balance between NF-{kappa}B and JNK/AP-1 activity controls dendritic cell life and death. Blood 106: 175-183 [Abstract] [Full Text]
Fiebiger, E., Tortorella, D., Jouvin, M.-H., Kinet, J.-P., Ploegh, H. L. (2005). Cotranslational endoplasmic reticulum assembly of Fc{varepsilon}RI controls the formation of functional IgE-binding receptors. JEM 201: 267-277 [Abstract] [Full Text]
Jaksits, S., Bauer, W., Kriehuber, E., Zeyda, M., Stulnig, T. M., Stingl, G., Fiebiger, E., Maurer, D. (2004). Lipid Raft-Associated GTPase Signaling Controls Morphology and CD8+ T Cell Stimulatory Capacity of Human Dendritic Cells. J. Immunol. 173: 1628-1639 [Abstract] [Full Text]
Takahashi, K., Nishiyama, C., Hasegawa, M., Akizawa, Y., Ra, C. (2003). Regulation of the Human High Affinity IgE Receptor {beta}-Chain Gene Expression Via an Intronic Element. J. Immunol. 171: 2478-2484 [Abstract] [Full Text]
Qi, J. C., Li, L., Li, Y., Moore, K., Madigan, M. C., Katsoulotos, G., Krilis, S. A. (2003). An Antibody Raised Against In Vitro-derived Human Mast Cells Identifies Mature Mast Cells and a Population of Cells that are Fc{varepsilon}RI+, Tryptase-, and Chymase- in a Variety of Human Tissues. J. Histochem. Cytochem. 51: 643-653 [Abstract] [Full Text]
Akizawa, Y., Nishiyama, C., Hasegawa, M., Maeda, K., Nakahata, T., Okumura, K., Ra, C., Ogawa, H. (2003). Regulation of human Fc{epsilon}RI {beta} chain gene expression by Oct-1. Int Immunol 15: 549-556 [Abstract] [Full Text]
Maeda, K., Nishiyama, C., Tokura, T., Akizawa, Y., Nishiyama, M., Ogawa, H., Okumura, K., Ra, C. (2003). Regulation of Cell Type-Specific Mouse Fc{epsilon}RI {beta}-Chain Gene Expression by GATA-1 Via Four GATA Motifs in the Promoter. J. Immunol. 170: 334-340 [Abstract] [Full Text]
von Bubnoff, D., Matz, H., Cazenave, J.-P., Hanau, D., Bieber, T., de la Salle, H. (2002). Kinetics of Gene Induction After Fc{epsilon}RI Ligation of Atopic Monocytes Identified by Suppression Subtractive Hybridization. J. Immunol. 169: 6170-6177 [Abstract] [Full Text]
von Bubnoff, D., Matz, H., Frahnert, C., Rao, M. L., Hanau, D., de la Salle, H., Bieber, T. (2002). Fc{epsilon}RI Induces the Tryptophan Degradation Pathway Involved in Regulating T Cell Responses. J. Immunol. 169: 1810-1816 [Abstract] [Full Text]
Shikanai, T., Silverman, E. S., Morse, B. W., Lilly, C. M., Inoue, H., Drazen, J. M. (2002). Sequence variants in the Fcepsilon RI alpha chain gene. J. Appl. Physiol. 93: 37-41 [Abstract] [Full Text]
Borkowski, T. A., Jouvin, M.-H., Lin, S.-Y., Kinet, J.-P. (2001). Minimal Requirements for IgE-Mediated Regulation of Surface Fc{epsilon}RI. J. Immunol. 167: 1290-1296 [Abstract] [Full Text]
Novak, N., Bieber, T., Katoh, N. (2001). Engagement of Fc{{epsilon}}RI on Human Monocytes Induces the Production of IL-10 and Prevents Their Differentiation in Dendritic Cells. J. Immunol. 167: 797-804 [Abstract] [Full Text]
Kayaba, H., Dombrowicz, D., Woerly, G., Papin, J.-P., Loiseau, S., Capron, M. (2001). Human Eosinophils and Human High Affinity IgE Receptor Transgenic Mouse Eosinophils Express Low Levels of High Affinity IgE Receptor, but Release IL-10 upon Receptor Activation. J. Immunol. 167: 995-1003 [Abstract] [Full Text]
Nechansky, A., Robertson, M. W., Albrecht, B. A., Apgar, J. R., Kricek, F. (2001). Inhibition of Antigen-Induced Mediator Release from IgE-Sensitized Cells by a Monoclonal Anti-Fc{{epsilon}}RI {{alpha}}-Chain Receptor Antibody: Implications for the Involvement of the Membrane-Proximal {{alpha}}-Chain Region in Fc{{epsilon}}RI-Mediated Cell Activation. J. Immunol. 166: 5979-5990 [Abstract] [Full Text]
Fiebiger, E., Meraner, P., Weber, E., Fang, I-F., Stingl, G., Ploegh, H., Maurer, D. (2001). Cytokines Regulate Proteolysis in Major Histocompatibility Complex Class II-Dependent Antigen Presentation by Dendritic Cells. JEM 193: 881-892 [Abstract] [Full Text]
GOUNNI, A. S., LAMKHIOUED, B., KOUSSIH, L., RA, C., RENZI, P. M., HAMID, Q. (2001). Human neutrophils express the high-affinity receptor for immunoglobulin E (Fc{varepsilon}RI): role in asthma. FASEB J. 15: 940-949 [Abstract] [Full Text]
Falcone, F. H., Haas, H., Gibbs, B. F. (2000). The human basophil: a new appreciation of its role in immune responses. Blood 96: 4028-4038 [Full Text]
Asai, K., Fujimoto, K., Harazaki, M., Kusunoki, T., Korematsu, S., Ide, C., Ra, C., Hosoi, S. (2000). Distinct Aggregation of {beta}- and {gamma}-Chains of the High-affinity IgE Receptor on Cross-Linking. J. Histochem. Cytochem. 48: 1705-1716 [Abstract] [Full Text]
Albrecht, B., Woisetschlager, M., Robertson, M. W. (2000). Export of the High Affinity IgE Receptor From the Endoplasmic Reticulum Depends on a Glycosylation-Mediated Quality Control Mechanism. J. Immunol. 165: 5686-5694 [Abstract] [Full Text]
Dombrowicz, D., Quatannens, B., Papin, J.-P., Capron, A., Capron, M. (2000). Expression of a Functional Fc{epsilon}RI on Rat Eosinophils and Macrophages. J. Immunol. 165: 1266-1271 [Abstract] [Full Text]
McElveen, J E, Furtado, P B, Smith, S J, Clark, M R, Spendlove, I, Sewell, H F, Shakib, F (2000). Characterisation of a mouse monoclonal anti-idiotype reactive with a V region sequence commonly used by human immunoglobulins. Mol. Pathol. 53: 77-82 [Abstract] [Full Text]
Honda, Z.-i., Suzuki, T., Kono, H., Okada, M., Yamamoto, T., Ra, C., Morita, Y., Yamamoto, K. (2000). Sequential Requirements of the N-Terminal Palmitoylation Site and SH2 Domain of Src Family Kinases in the Initiation and Progression of Fcvarepsilon RI Signaling. Mol. Cell. Biol. 20: 1759-1771 [Abstract] [Full Text]
Zuberi, R. I., Apgar, J. R., Chen, S.-S., Liu, F.-T. (2000). Role for IgE in Airway Secretions: IgE Immune Complexes Are More Potent Inducers Than Antigen Alone of Airway Inflammation in a Murine Model. J. Immunol. 164: 2667-2673 [Abstract] [Full Text]
Lu-Kuo, J. M., Fruman, D. A., Joyal, D. M., Cantley, L. C., Katz, H. R. (2000). Impaired Kit- but Not Fcepsilon RI-initiated Mast Cell Activation in the Absence of Phosphoinositide 3-Kinase p85alpha Gene Products. J. Biol. Chem. 275: 6022-6029 [Abstract] [Full Text]
Jaksits, S., Kriehuber, E., Charbonnier, A. S., Rappersberger, K., Stingl, G., Maurer, D. (1999). CD34+ Cell-Derived CD14+ Precursor Cells Develop into Langerhans Cells in a TGF-{beta}1-Dependent Manner. J. Immunol. 163: 4869-4877 [Abstract] [Full Text]
van Neerven, R. J. J., Wikborg, T., Lund, G., Jacobsen, B., Brinch-Nielsen, A., Arnved, J., Ipsen, H. (1999). Blocking Antibodies Induced by Specific Allergy Vaccination Prevent the Activation of CD4+ T Cells by Inhibiting Serum-IgE-Facilitated Allergen Presentation. J. Immunol. 163: 2944-2952 [Abstract] [Full Text]
Kita, H., Kaneko, M., Bartemes, K. R., Weiler, D. A., Schimming, A. W., Reed, C. E., Gleich, G. J. (1999). Does IgE Bind to and Activate Eosinophils from Patients with Allergy?. J. Immunol. 162: 6901-6911 [Abstract] [Full Text]
Hulett, M. D., Brinkworth, R. I., McKenzie, I. F.�C., Hogarth, P. M. (1999). Fine Structure Analysis of Interaction of Fcepsilon RI with IgE. J. Biol. Chem. 274: 13345-13352 [Abstract] [Full Text]
Yamaguchi, M., Sayama, K., Yano, K., Lantz, C. S., Noben-Trauth, N., Ra, C., Costa, J. J., Galli, S. J. (1999). IgE Enhances Fc{epsilon} Receptor I Expression and IgE-Dependent Release of Histamine and Lipid Mediators from Human Umbilical Cord Blood-Derived Mast Cells: Synergistic Effect of IL-4 and IgE on Human Mast Cell Fc{epsilon} Receptor I Expression and Mediator Release. J. Immunol. 162: 5455-5465 [Abstract] [Full Text]
Saini, S. S., MacGlashan, D. W. Jr., Sterbinsky, S. A., Togias, A., Adelman, D. C., Lichtenstein, L. M., Bochner, B. S. (1999). Down-Regulation of Human Basophil IgE and FC{epsilon}RI{alpha} Surface Densities and Mediator Release by Anti-IgE-Infusions Is Reversible In Vitro and In Vivo. J. Immunol. 162: 5624-5630 [Abstract] [Full Text]
Hasegawa, S., Pawankar, R., Suzuki, K., Nakahata, T., Furukawa, S., Okumura, K., Ra, C. (1999). Functional Expression of the High Affinity Receptor for IgE (Fcvarepsilon RI) in Human Platelets and Its' Intracellular Expression in Human Megakaryocytes. Blood 93: 2543-2551 [Abstract] [Full Text]
Déry, R. E., Bissonnette, E. Y. (1999). IFN-gamma Potentiates the Release of TNF-alpha and MIP-1alpha by Alveolar Macrophages during Allergic Reactions. Am. J. Respir. Cell Mol. Bio. 20: 407-412 [Abstract] [Full Text]
Ryan, J. J., DeSimone, S., Klisch, G., Shelburne, C., McReynolds, L. J., Han, K., Kovacs, R., Mirmonsef, P., Huff, T. F. (1998). IL-4 Inhibits Mouse Mast Cell Fc{epsilon}RI Expression Through a STAT6-Dependent Mechanism. J. Immunol. 161: 6915-6923 [Abstract] [Full Text]
Choi, I. H., Shin, Y. M., Park, J. S., Lee, M. S., Han, E. H., Chai, O. H., Im, S. Y., Ha, T. Y., Lee, H.-K. (1998). Immunoglobulin E-dependent Active Fatal Anaphylaxis in Mast Cell-deficient Mice. JEM 188: 1587-1592 [Abstract] [Full Text]
Maurer, D., Fiebiger, E., Reininger, B., Ebner, C., Petzelbauer, P., Shi, G.-P., Chapman, H. A., Stingl, G. (1998). Fc{epsilon} Receptor I on Dendritic Cells Delivers IgE-Bound Multivalent Antigens into a Cathepsin S-Dependent Pathway of MHC Class II Presentation. J. Immunol. 161: 2731-2739 [Abstract] [Full Text]
Ezumi, Y., Shindoh, K., Tsuji, M., Takayama, H. (1998). Physical and Functional Association of the Src Family Kinases Fyn and Lyn with the Collagen Receptor Glycoprotein VI-Fc Receptor {gamma} Chain Complex on Human Platelets. JEM 188: 267-276 [Abstract] [Full Text]
Kraft, S., We{beta}endorf, J. H. M., Hanau, D., Bieber, T. (1998). Regulation of the High Affinity Receptor for IgE on Human Epidermal Langerhans Cells. J. Immunol. 161: 1000-1006 [Abstract] [Full Text]
Campbell, A. M., Vachier, I., Chanez, P., Vignola, A. M., Lebel, B., Kochan, J., Godard, P., Bousquet, J. (1998). Expression of the High-affinity Receptor for IgE on Bronchial Epithelial Cells of Asthmatics. Am. J. Respir. Cell Mol. Bio. 19: 92-97 [Abstract] [Full Text]
RAJAKULASINGAM, K., TILL, S., YING, S., HUMBERT, M., BARKANS, J., SULLIVAN, M., MENG, Q., CORRIGAN, C.�J., BUNGRE, J., ANDREW�GRANT, J., BARRY�KAY, A., DURHAM, S.�R. (1998). Increased Expression of High Affinity IgE (Fcvarepsilon RI) Receptor-alpha Chain mRNA and Protein-bearing Eosinophils in Human Allergen-induced Atopic Asthma. Am. J. Respir. Crit. Care Med. 158: 233-240 [Abstract] [Full Text]
Eigenmann, P. A., Sicherer, S. H., Borkowski, T. A., Cohen, B. A., Sampson, H. A. (1998). Prevalence of IgE-Mediated Food Allergy Among Children With Atopic Dermatitis. Pediatrics 101 : e8-e8 [Abstract] [Full Text]
Letourneur, O., Sechi, S., Willette-Brown, J., Robertson, M. W., Kinet, J.-P. (1995). Glycosylation of Human Truncated Fc[IMAGE]RI alpha Chain Is Necessary for Efficient Folding in the Endoplasmic Reticulum. J. Biol. Chem. 270: 8249-8256 [Abstract] [Full Text]