Disseminated tuberculosis in interferon gamma gene-disrupted mice

doi:10.1084/jem.178.6.2243

This Article

	Full Text (PDF, 605K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Cooper, A. M.
	Articles by Orme, I. M.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Cooper, A. M.
	Articles by Orme, I. M.


Social Bookmarking

	What's this?

ARTICLES

Disseminated tuberculosis in interferon gamma gene-disrupted mice

AM Cooper, DK Dalton, TA Stewart, JP Griffin, DG Russell and IM Orme
Department of Microbiology, Colorado State University, Fort Collins 80523.

The expression of protective immunity to Mycobacterium tuberculosis in mice is mediated by T lymphocytes that secrete cytokines. These molecules then mediate a variety of roles, including the activation of parasitized host macrophages, and the recruitment of other mononuclear phagocytes to the site of the infection in order to initiate granuloma formation. Among these cytokines, interferon gamma (IFN-gamma) is believed to play a key role is these events. In confirmation of this hypothesis, we show in this study that mice in which the IFN-gamma gene has been disrupted were unable to contain or control a normally sublethal dose of M. tuberculosis, delivered either intravenously or aerogenically. In such mice, a progressive and widespread tissue destruction and necrosis, associated with very high numbers of acid- fast bacilli, was observed. In contrast, despite the lack of protective immunity, some DTH-like reactivity could still be elicited. These data, therefore, indicate that although IFN-gamma may not be needed for DTH expression, it plays a pivotal and essential role in protective cellular immunity to tuberculosis infection.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Hinks, T. S. C., Dosanjh, D. P. S., Innes, J. A., Pasvol, G., Hackforth, S., Varia, H., Millington, K. A., Liu, X.-Q., Bakir, M., Soysal, A., Davidson, R. N., Gunatheesan, R., Lalvani, A. (2009). Frequencies of Region of Difference 1 Antigen-Specific but Not Purified Protein Derivative-Specific Gamma Interferon-Secreting T Cells Correlate with the Presence of Tuberculosis Disease but Do Not Distinguish Recent from Remote Latent Infections. Infect. Immun. 77: 5486-5495 [Abstract] [Full Text]
Wong, C. E., Sad, S., Coombes, B. K. (2009). Salmonella enterica Serovar Typhimurium Exploits Toll-Like Receptor Signaling during the Host-Pathogen Interaction. Infect. Immun. 77: 4750-4760 [Abstract] [Full Text]
Grover, A., Taylor, J., Troudt, J., Keyser, A., Arnett, K., Izzo, L., Rholl, D., Izzo, A. (2009). Kinetics of the Immune Response Profile in Guinea Pigs after Vaccination with Mycobacterium bovis BCG and Infection with Mycobacterium tuberculosis. Infect. Immun. 77: 4837-4846 [Abstract] [Full Text]
Wan, Y. Y., Flavell, R. A. (2009). How Diverse--CD4 Effector T Cells and their Functions. J Mol Cell Biol 1: 20-36 [Abstract] [Full Text]
Rosas-Taraco, A. G., Higgins, D. M., Sanchez-Campillo, J., Lee, E. J., Orme, I. M., Gonzalez-Juarrero, M. (2009). Intrapulmonary Delivery of XCL1-Targeting Small Interfering RNA in Mice Chronically Infected with Mycobacterium tuberculosis. Am. J. Respir. Cell Mol. Bio. 41: 136-145 [Abstract] [Full Text]
Paidipally, P., Periasamy, S., Barnes, P. F., Dhiman, R., Indramohan, M., Griffith, D. E., Cosman, D., Vankayalapati, R. (2009). NKG2D-Dependent IL-17 Production by Human T Cells in Response to an Intracellular Pathogen. J. Immunol. 183: 1940-1945 [Abstract] [Full Text]
Schreiber, T., Ehlers, S., Heitmann, L., Rausch, A., Mages, J., Murray, P. J., Lang, R., Holscher, C. (2009). Autocrine IL-10 Induces Hallmarks of Alternative Activation in Macrophages and Suppresses Antituberculosis Effector Mechanisms without Compromising T Cell Immunity. J. Immunol. 183: 1301-1312 [Abstract] [Full Text]
Mikhak, Z., Farsidjani, A., Luster, A. D. (2009). Endotoxin Augmented Antigen-Induced Th1 Cell Trafficking Amplifies Airway Neutrophilic Inflammation. J. Immunol. 182: 7946-7956 [Abstract] [Full Text]
Cirillo, S. L. G., Subbian, S., Chen, B., Weisbrod, T. R., Jacobs, W. R. Jr., Cirillo, J. D. (2009). Protection of Mycobacterium tuberculosis from Reactive Oxygen Species Conferred by the mel2 Locus Impacts Persistence and Dissemination. Infect. Immun. 77: 2557-2567 [Abstract] [Full Text]
Ogilvie, R. L., SternJohn, J. R., Rattenbacher, B., Vlasova, I. A., Williams, D. A., Hau, H. H., Blackshear, P. J., Bohjanen, P. R. (2009). Tristetraprolin Mediates Interferon-{gamma} mRNA Decay. J. Biol. Chem. 284: 11216-11223 [Abstract] [Full Text]
Blackwell, J. M., Jamieson, S. E., Burgner, D. (2009). HLA and Infectious Diseases. Clin. Microbiol. Rev. 22: 370-385 [Abstract] [Full Text]
Gonzalez-Juarrero, M., Kingry, L. C., Ordway, D. J., Henao-Tamayo, M., Harton, M., Basaraba, R. J., Hanneman, W. H., Orme, I. M., Slayden, R. A. (2009). Immune Response to Mycobacterium tuberculosis and Identification of Molecular Markers of Disease. Am. J. Respir. Cell Mol. Bio. 40: 398-409 [Abstract] [Full Text]
Wang, X., Barnes, P. F., Dobos-Elder, K. M., Townsend, J. C., Chung, Y.-t., Shams, H., Weis, S. E., Samten, B. (2009). ESAT-6 Inhibits Production of IFN-{gamma} by Mycobacterium tuberculosis-Responsive Human T Cells. J. Immunol. 182: 3668-3677 [Abstract] [Full Text]
Marquis, J.-F., LaCourse, R., Ryan, L., North, R. J., Gros, P. (2009). Disseminated and Rapidly Fatal Tuberculosis in Mice Bearing a Defective Allele at IFN Regulatory Factor 8. J. Immunol. 182: 3008-3015 [Abstract] [Full Text]
Sarfo, F. S., Phillips, R. O., Ampadu, E., Sarpong, F., Adentwe, E., Wansbrough-Jones, M. (2009). Dynamics of the Cytokine Response to Mycobacterium ulcerans during Antibiotic Treatment for M. ulcerans Disease (Buruli Ulcer) in Humans. CVI 16: 61-65 [Abstract] [Full Text]
Bertholet, S., Ireton, G. C., Kahn, M., Guderian, J., Mohamath, R., Stride, N., Laughlin, E. M., Baldwin, S. L., Vedvick, T. S., Coler, R. N., Reed, S. G. (2008). Identification of Human T Cell Antigens for the Development of Vaccines against Mycobacterium tuberculosis. J. Immunol. 181: 7948-7957 [Abstract] [Full Text]
Watford, W. T., Hissong, B. D., Durant, L. R., Yamane, H., Muul, L. M., Kanno, Y., Tato, C. M., Ramos, H. L., Berger, A. E., Mielke, L., Pesu, M., Solomon, B., Frucht, D. M., Paul, W. E., Sher, A., Jankovic, D., Tsichlis, P. N., O'Shea, J. J. (2008). Tpl2 kinase regulates T cell interferon-{gamma} production and host resistance to Toxoplasma gondii. JEM 205: 2803-2812 [Abstract] [Full Text]
O'Day, K. (2008). Andrea Cooper: Using pathogens to probe the immune response. JEM 205: 2690-2691 [Full Text]
Lee, J., Reinke, E. K., Zozulya, A. L., Sandor, M., Fabry, Z. (2008). Mycobacterium bovis Bacille Calmette-Guerin Infection in the CNS Suppresses Experimental Autoimmune Encephalomyelitis and Th17 Responses in an IFN-{gamma}-Independent Manner. J. Immunol. 181: 6201-6212 [Abstract] [Full Text]
Skold, M., Behar, S. M. (2008). Tuberculosis Triggers a Tissue-Dependent Program of Differentiation and Acquisition of Effector Functions by Circulating Monocytes. J. Immunol. 181: 6349-6360 [Abstract] [Full Text]
Gallegos, A. M., Pamer, E. G., Glickman, M. S. (2008). Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection. JEM 205: 2359-2368 [Abstract] [Full Text]
Villar, R., Vicente, E., Solano, B., Perez-Silanes, S., Aldana, I., Maddry, J. A., Lenaerts, A. J., Franzblau, S. G., Cho, S.-H., Monge, A., Goldman, R. C. (2008). In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide. J Antimicrob Chemother 62: 547-554 [Abstract] [Full Text]
Vicente, E., Villar, R., Burguete, A., Solano, B., Perez-Silanes, S., Aldana, I., Maddry, J. A., Lenaerts, A. J., Franzblau, S. G., Cho, S.-h., Monge, A., Goldman, R. C. (2008). Efficacy of Quinoxaline-2-Carboxylate 1,4-Di-N-Oxide Derivatives in Experimental Tuberculosis. Antimicrob. Agents Chemother. 52: 3321-3326 [Abstract] [Full Text]
Di Liberto, D., Locati, M., Caccamo, N., Vecchi, A., Meraviglia, S., Salerno, A., Sireci, G., Nebuloni, M., Caceres, N., Cardona, P.-J., Dieli, F., Mantovani, A. (2008). Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial resistance in Mycobacterium tuberculosis infection. JEM 205: 2075-2084 [Abstract] [Full Text]
Chiba, A., Dascher, C. C., Besra, G. S., Brenner, M. B. (2008). Rapid NKT Cell Responses Are Self-Terminating during the Course of Microbial Infection. J. Immunol. 181: 2292-2302 [Abstract] [Full Text]
Dudani, R., Murali-Krishna, K., Krishnan, L., Sad, S. (2008). IFN-{gamma} Induces the Erosion of Preexisting CD8 T Cell Memory during Infection with a Heterologous Intracellular Bacterium. J. Immunol. 181: 1700-1709 [Abstract] [Full Text]
Samten, B., Townsend, J. C., Weis, S. E., Bhoumik, A., Klucar, P., Shams, H., Barnes, P. F. (2008). CREB, ATF, and AP-1 Transcription Factors Regulate IFN-{gamma} Secretion by Human T Cells in Response to Mycobacterial Antigen. J. Immunol. 181: 2056-2064 [Abstract] [Full Text]
Ito, T., Hasegawa, A., Hosokawa, H., Yamashita, M., Motohashi, S., Naka, T., Okamoto, Y., Fujita, Y., Ishii, Y., Taniguchi, M., Yano, I., Nakayama, T. (2008). Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172. Int Immunol 20: 849-860 [Abstract] [Full Text]
Lei, L., Plattner, B. L., Hostetter, J. M. (2008). Live Mycobacterium avium subsp. paratuberculosis and a Killed-Bacterium Vaccine Induce Distinct Subcutaneous Granulomas, with Unique Cellular and Cytokine Profiles. CVI 15: 783-793 [Abstract] [Full Text]
Irwin, S. M., Goodyear, A., Keyser, A., Christensen, R., Troudt, J. M., Taylor, J. L., Bohsali, A., Briken, V., Izzo, A. A. (2008). Immune Response Induced by Three Mycobacterium bovis BCG Substrains with Diverse Regions of Deletion in a C57BL/6 Mouse Model. CVI 15: 750-756 [Abstract] [Full Text]
Pandey, A. K., Sassetti, C. M. (2008). Mycobacterial persistence requires the utilization of host cholesterol. Proc. Natl. Acad. Sci. USA 105: 4376-4380 [Abstract] [Full Text]
Beamer, G. L., Flaherty, D. K., Vesosky, B., Turner, J. (2008). Peripheral Blood Gamma Interferon Release Assays Predict Lung Responses and Mycobacterium tuberculosis Disease Outcome in Mice. CVI 15: 474-483 [Abstract] [Full Text]
Maglione, P. J., Xu, J., Casadevall, A., Chan, J. (2008). Fc{gamma} Receptors Regulate Immune Activation and Susceptibility during Mycobacterium tuberculosis Infection. J. Immunol. 180: 3329-3338 [Abstract] [Full Text]
Fuschillo, S., De Felice, A., Balzano, G. (2008). Mucosal inflammation in idiopathic bronchiectasis: cellular and molecular mechanisms. Eur Respir J 31: 396-406 [Abstract] [Full Text]
Barrionuevo, P., Cassataro, J., Delpino, M. V., Zwerdling, A., Pasquevich, K. A., Samartino, C. G., Wallach, J. C., Fossati, C. A., Giambartolomei, G. H. (2008). Brucella abortus Inhibits Major Histocompatibility Complex Class II Expression and Antigen Processing through Interleukin-6 Secretion via Toll-Like Receptor 2. Infect. Immun. 76: 250-262 [Abstract] [Full Text]
Ryan, A. A., Wozniak, T. M., Shklovskaya, E., O'Donnell, M. A., Fazekas de St. Groth, B., Britton, W. J., Triccas, J. A. (2007). Improved Protection against Disseminated Tuberculosis by Mycobacterium bovis Bacillus Calmette-Guerin Secreting Murine GM-CSF Is Associated with Expansion and Activation of APCs. J. Immunol. 179: 8418-8424 [Abstract] [Full Text]
Rottman, M., Catherinot, E., Hochedez, P., Emile, J.-F., Casanova, J.-L., Gaillard, J.-L., Soudais, C. (2007). Importance of T Cells, Gamma Interferon, and Tumor Necrosis Factor in Immune Control of the Rapid Grower Mycobacterium abscessus in C57BL/6 Mice. Infect. Immun. 75: 5898-5907 [Abstract] [Full Text]
Hussain, R., Talat, N., Shahid, F., Dawood, G. (2007). Longitudinal Tracking of Cytokines after Acute Exposure to Tuberculosis: Association of Distinct Cytokine Patterns with Protection and Disease Development. CVI 14: 1578-1586 [Abstract] [Full Text]
Pennini, M. E., Liu, Y., Yang, J., Croniger, C. M., Boom, W. H., Harding, C. V. (2007). CCAAT/Enhancer-Binding Protein beta and {delta} Binding to CIITA Promoters Is Associated with the Inhibition of CIITA Expression in Response to Mycobacterium tuberculosis 19-kDa Lipoprotein. J. Immunol. 179: 6910-6918 [Abstract] [Full Text]
Yan, B.-S., Pichugin, A. V., Jobe, O., Helming, L., Eruslanov, E. B., Gutierrez-Pabello, J. A., Rojas, M., Shebzukhov, Y. V., Kobzik, L., Kramnik, I. (2007). Progression of Pulmonary Tuberculosis and Efficiency of Bacillus Calmette-Guerin Vaccination Are Genetically Controlled via a Common sst1-Mediated Mechanism of Innate Immunity. J. Immunol. 179: 6919-6932 [Abstract] [Full Text]
Ordway, D., Higgins, D. M., Sanchez-Campillo, J., Spencer, J. S., Henao-Tamayo, M., Harton, M., Orme, I. M., Gonzalez Juarrero, M. (2007). XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-{gamma} by CD4 T cells and participates in granuloma stability. J. Leukoc. Biol. 82: 1221-1229 [Abstract] [Full Text]
Sow, F. B., Florence, W. C., Satoskar, A. R., Schlesinger, L. S., Zwilling, B. S., Lafuse, W. P. (2007). Expression and localization of hepcidin in macrophages: a role in host defense against tuberculosis. J. Leukoc. Biol. 82: 934-945 [Abstract] [Full Text]
Billeskov, R., Vingsbo-Lundberg, C., Andersen, P., Dietrich, J. (2007). Induction of CD8 T Cells against a Novel Epitope in TB10.4: Correlation with Mycobacterial Virulence and the Presence of a Functional Region of Difference-1. J. Immunol. 179: 3973-3981 [Abstract] [Full Text]
Divangahi, M., Yang, T., Kugathasan, K., McCormick, S., Takenaka, S., Gaschler, G., Ashkar, A., Stampfli, M., Gauldie, J., Bramson, J., Takai, T., Brown, E., Yokoyama, W. M., Aoki, N., Xing, Z. (2007). Critical Negative Regulation of Type 1 T Cell Immunity and Immunopathology by Signaling Adaptor DAP12 during Intracellular Infection. J. Immunol. 179: 4015-4026 [Abstract] [Full Text]
Kincaid, E. Z., Wolf, A. J., Desvignes, L., Mahapatra, S., Crick, D. C., Brennan, P. J., Pavelka, M. S. Jr., Ernst, J. D. (2007). Codominance of TLR2-Dependent and TLR2-Independent Modulation of MHC Class II in Mycobacterium tuberculosis Infection In Vivo. J. Immunol. 179: 3187-3195 [Abstract] [Full Text]
Wolf, A. J., Linas, B., Trevejo-Nunez, G. J., Kincaid, E., Tamura, T., Takatsu, K., Ernst, J. D. (2007). Mycobacterium tuberculosis Infects Dendritic Cells with High Frequency and Impairs Their Function In Vivo. J. Immunol. 179: 2509-2519 [Abstract] [Full Text]
Jacobsen, M., Detjen, A. K., Mueller, H., Gutschmidt, A., Leitner, S., Wahn, U., Magdorf, K., Kaufmann, S. H. E. (2007). Clonal Expansion of CD8+ Effector T Cells in Childhood Tuberculosis. J. Immunol. 179: 1331-1339 [Abstract] [Full Text]
Uchiyama, R., Kawamura, I., Fujimura, T., Kawanishi, M., Tsuchiya, K., Tominaga, T., Kaku, T., Fukasawa, Y., Sakai, S., Nomura, T., Mitsuyama, M. (2007). Involvement of Caspase-9 in the Inhibition of Necrosis of RAW 264 Cells Infected with Mycobacterium tuberculosis. Infect. Immun. 75: 2894-2902 [Abstract] [Full Text]
Ngai, P., McCormick, S., Small, C., Zhang, X., Zganiacz, A., Aoki, N., Xing, Z. (2007). Gamma Interferon Responses of CD4 and CD8 T-Cell Subsets Are Quantitatively Different and Independent of Each Other during Pulmonary Mycobacterium bovis BCG Infection. Infect. Immun. 75: 2244-2252 [Abstract] [Full Text]
Singhal, A., Jaiswal, A., Arora, V. K., Prasad, H. K. (2007). Modulation of Gamma Interferon Receptor 1 by Mycobacterium tuberculosis: a Potential Immune Response Evasive Mechanism. Infect. Immun. 75: 2500-2510 [Abstract] [Full Text]
Millington, K. A., Innes, J. A., Hackforth, S., Hinks, T. S. C., Deeks, J. J., Dosanjh, D. P. S., Guyot-Revol, V., Gunatheesan, R., Klenerman, P., Lalvani, A. (2007). Dynamic Relationship between IFN-{gamma} and IL-2 Profile of Mycobacterium tuberculosis-Specific T Cells and Antigen Load. J. Immunol. 178: 5217-5226 [Abstract] [Full Text]
Chaitra, M. G., Shaila, M. S., Nayak, R. (2007). Evaluation of T-cell responses to peptides with MHC class I-binding motifs derived from PE_PGRS 33 protein of Mycobacterium tuberculosis. J Med Microbiol 56: 466-474 [Abstract] [Full Text]
Kursar, M., Koch, M., Mittrucker, H.-W., Nouailles, G., Bonhagen, K., Kamradt, T., Kaufmann, S. H. E. (2007). Cutting Edge: Regulatory T Cells Prevent Efficient Clearance of Mycobacterium tuberculosis. J. Immunol. 178: 2661-2665 [Abstract] [Full Text]
Kapina, M. A., Shepelkova, G. S., Mischenko, V. V., Sayles, P., Bogacheva, P., Winslow, G., Apt, A. S., Lyadova, I. V. (2007). CD27low CD4 T Lymphocytes That Accumulate in the Mouse Lungs during Mycobacterial Infection Differentiate from CD27high Precursors In Situ, Produce IFN-{gamma}, and Protect the Host against Tuberculosis Infection. J. Immunol. 178: 976-985 [Abstract] [Full Text]
Luke Seneviratne, S., Doffinger, R., Macfarlane, J., Ceron-Gutierrez, L, Amel Kashipaz, M R, Robbins, A, Patel, T, Powell, P T, Kumararatne, D S, Powell, R. J (2007). Disseminated Mycobacterium tuberculosis infection due to interferon {gamma} deficiency. Response to replacement therapy. Thorax 62: 97-99 [Abstract] [Full Text]
Wozniak, T. M., Ryan, A. A., Britton, W. J. (2006). Interleukin-23 Restores Immunity to Mycobacterium tuberculosis Infection in IL-12p40-Deficient Mice and Is Not Required for the Development of IL-17-Secreting T Cell Responses. J. Immunol. 177: 8684-8692 [Abstract] [Full Text]
Guidry, T. V., Hunter, R. L. Jr, Actor, J. K. (2006). CD3+ cells transfer the hypersensitive granulomatous response to mycobacterial glycolipid trehalose 6,6'-dimycolate in mice. Microbiology 152: 3765-3775 [Abstract] [Full Text]
Sopp, P., Howard, C. J., Hope, J. C. (2006). Flow Cytometric Detection of Gamma Interferon Can Effectively Discriminate Mycobacterium bovis BCG-Vaccinated Cattle from M. bovis-Infected Cattle. CVI 13: 1343-1348 [Abstract] [Full Text]
Feng, C. G., Kaviratne, M., Rothfuchs, A. G., Cheever, A., Hieny, S., Young, H. A., Wynn, T. A., Sher, A. (2006). NK Cell-Derived IFN-{gamma} Differentially Regulates Innate Resistance and Neutrophil Response in T Cell-Deficient Hosts Infected with Mycobacterium tuberculosis. J. Immunol. 177: 7086-7093 [Abstract] [Full Text]
Taylor, J. L., Hattle, J. M., Dreitz, S. A., Troudt, J. M., Izzo, L. S., Basaraba, R. J., Orme, I. M., Matrisian, L. M., Izzo, A. A. (2006). Role for Matrix Metalloproteinase 9 in Granuloma Formation during Pulmonary Mycobacterium tuberculosis Infection. Infect. Immun. 74: 6135-6144 [Abstract] [Full Text]
Cooke, G. S., Campbell, S. J., Sillah, J., Gustafson, P., Bah, B., Sirugo, G., Bennett, S., McAdam, K. P. W. J., Sow, O., Lienhardt, C., Hill, A. V. S. (2006). Polymorphism within the Interferon-{gamma}/Receptor Complex Is Associated with Pulmonary Tuberculosis. Am. J. Respir. Crit. Care Med. 174: 339-343 [Abstract] [Full Text]
Vesosky, B., Flaherty, D. K., Turner, J. (2006). Th1 Cytokines Facilitate CD8-T-Cell-Mediated Early Resistance to Infection with Mycobacterium tuberculosis in Old Mice.. Infect. Immun. 74: 3314-3324 [Abstract] [Full Text]
Quiroga, M. F., Pasquinelli, V., Martinez, G. J., Jurado, J. O., Zorrilla, L. C., Musella, R. M., Abbate, E., Sieling, P. A., Garcia, V. E. (2006). Inducible Costimulator: A Modulator of IFN-{gamma} Production in Human Tuberculosis. J. Immunol. 176: 5965-5974 [Abstract] [Full Text]
D'Souza, S., Romano, M., Korf, J., Wang, X.-M., Adnet, P.-Y., Huygen, K. (2006). Partial Reconstitution of the CD4+-T-Cell Compartment in CD4 Gene Knockout Mice Restores Responses to Tuberculosis DNA Vaccines.. Infect. Immun. 74: 2751-2759 [Abstract] [Full Text]
Demissie, A., Wassie, L., Abebe, M., Aseffa, A., Rook, G., Zumla, A., Andersen, P., Doherty, T. M., the VACSEL Study Group, (2006). The 6-kilodalton early secreted antigenic target-responsive, asymptomatic contacts of tuberculosis patients express elevated levels of interleukin-4 and reduced levels of gamma interferon.. Infect. Immun. 74: 2817-2822 [Abstract] [Full Text]
Nambu, A., Nakae, S., Iwakura, Y. (2006). IL-1{beta}, but not IL-1{alpha}, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses. Int Immunol 18: 701-712 [Abstract] [Full Text]
Fricke, I., Mitchell, D., Mittelstadt, J., Lehan, N., Heine, H., Goldmann, T., Bohle, A., Brandau, S. (2006). Mycobacteria Induce IFN-{gamma} Production in Human Dendritic Cells via Triggering of TLR2. J. Immunol. 176: 5173-5182 [Abstract] [Full Text]
Majlessi, L., Simsova, M., Jarvis, Z., Brodin, P., Rojas, M.-J., Bauche, C., Nouze, C., Ladant, D., Cole, S. T., Sebo, P., Leclerc, C. (2006). An Increase in Antimycobacterial Th1-Cell Responses by Prime-Boost Protocols of Immunization Does Not Enhance Protection against Tuberculosis. Infect. Immun. 74: 2128-2137 [Abstract] [Full Text]
Sud, D., Bigbee, C., Flynn, J. L., Kirschner, D. E. (2006). Contribution of CD8+ T Cells to Control of Mycobacterium tuberculosis Infection. J. Immunol. 176: 4296-4314 [Abstract] [Full Text]
Pennini, M. E., Pai, R. K., Schultz, D. C., Boom, W. H., Harding, C. V. (2006). Mycobacterium tuberculosis 19-kDa Lipoprotein Inhibits IFN-{gamma}-Induced Chromatin Remodeling of MHC2TA by TLR2 and MAPK Signaling. J. Immunol. 176: 4323-4330 [Abstract] [Full Text]
Logsdon, L. K., Mecsas, J. (2006). The Proinflammatory Response Induced by Wild-Type Yersinia pseudotuberculosis Infection Inhibits Survival of yop Mutants in the Gastrointestinal Tract and Peyer's Patches. Infect. Immun. 74: 1516-1527 [Abstract] [Full Text]
Saito, K., Yajima, T., Kumabe, S., Doi, T., Yamada, H., Sad, S., Shen, H., Yoshikai, Y. (2006). Impaired Protection against Mycobacterium bovis Bacillus Calmette-Guerin Infection in IL-15-Deficient Mice. J. Immunol. 176: 2496-2504 [Abstract] [Full Text]
Wieland, C. W., Florquin, S., Pater, J. M., Weijer, S., van der Poll, T. (2006). CD4+ Cells Play a Limited Role in Murine Lung Infection with Mycobacterium kansasii. Am. J. Respir. Cell Mol. Bio. 34: 167-173 [Abstract] [Full Text]
Delgado, J. C., Baena, A., Thim, S., Goldfeld, A. E. (2006). Aspartic Acid Homozygosity at Codon 57 of HLA-DQ {beta} Is Associated with Susceptibility to Pulmonary Tuberculosis in Cambodia. J. Immunol. 176: 1090-1097 [Abstract] [Full Text]
Carranza, C., Juarez, E., Torres, M., Ellner, J. J., Sada, E., Schwander, S. K. (2006). Mycobacterium tuberculosis Growth Control by Lung Macrophages and CD8 Cells from Patient Contacts. Am. J. Respir. Crit. Care Med. 173: 238-245 [Abstract] [Full Text]
Jeevan, A., McFarland, C. T., Yoshimura, T., Skwor, T., Cho, H., Lasco, T., McMurray, D. N. (2006). Production and Characterization of Guinea Pig Recombinant Gamma Interferon and Its Effect on Macrophage Activation. Infect. Immun. 74: 213-224 [Abstract] [Full Text]
Wozniak, T. M., Ryan, A. A., Triccas, J. A., Britton, W. J. (2006). Plasmid Interleukin-23 (IL-23), but Not Plasmid IL-27, Enhances the Protective Efficacy of a DNA Vaccine against Mycobacterium tuberculosis Infection. Infect. Immun. 74: 557-565 [Abstract] [Full Text]
Stewart, J. N., Rivera, H. N., Karls, R., Quinn, F. D., Roman, J., Rivera-Marrero, C. A. (2006). Increased pathology in lungs of mice after infection with an {alpha}-crystallin mutant of Mycobacterium tuberculosis: changes in cathepsin proteases and certain cytokines. Microbiology 152: 233-244 [Abstract] [Full Text]
Flores-Villanueva, P. O., Ruiz-Morales, J. A., Song, C.-H., Flores, L. M., Jo, E.-K., Montano, M., Barnes, P. F., Selman, M., Granados, J. (2005). A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis. JEM 202: 1649-1658 [Abstract] [Full Text]
Bafica, A., Scanga, C. A., Feng, C. G., Leifer, C., Cheever, A., Sher, A. (2005). TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis. JEM 202: 1715-1724 [Abstract] [Full Text]
Spencer, J. S., Dockrell, H. M., Kim, H. J., Marques, M. A. M., Williams, D. L., Martins, M. V. S. B., Martins, M. L. F., Lima, M. C. B. S., Sarno, E. N., Pereira, G. M. B., Matos, H., Fonseca, L. S., Sampaio, E. P., Ottenhoff, T. H. M., Geluk, A., Cho, S.-N., Stoker, N. G., Cole, S. T., Brennan, P. J., Pessolani, M. C. V. (2005). Identification of Specific Proteins and Peptides in Mycobacterium leprae Suitable for the Selective Diagnosis of Leprosy. J. Immunol. 175: 7930-7938 [Abstract] [Full Text]
Kipnis, A., Irwin, S., Izzo, A. A., Basaraba, R. J., Orme, I. M. (2005). Memory T Lymphocytes Generated by Mycobacterium bovis BCG Vaccination Reside within a CD4 CD44lo CD62 Ligandhi Population. Infect. Immun. 73: 7759-7764 [Abstract] [Full Text]
Wieland, C. W., Florquin, S., Chan, E. D., Leemans, J. C., Weijer, S., Verbon, A., Fantuzzi, G., van der Poll, T. (2005). Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob mice. Int Immunol 17: 1399-1408 [Abstract] [Full Text]
Doherty, T. M., Andersen, P. (2005). Vaccines for Tuberculosis: Novel Concepts and Recent Progress. Clin. Microbiol. Rev. 18: 687-702 [Abstract] [Full Text]
Maue, A. C., Waters, W. R., Davis, W. C., Palmer, M. V., Minion, F. C., Estes, D. M. (2005). Analysis of Immune Responses Directed toward a Recombinant Early Secretory Antigenic Target Six-Kilodalton Protein-Culture Filtrate Protein 10 Fusion Protein in Mycobacterium bovis-Infected Cattle. Infect. Immun. 73: 6659-6667 [Abstract] [Full Text]
Fukasawa, Y., Kawamura, I., Uchiyama, R., Yamamoto, K., Kaku, T., Tominaga, T., Nomura, T., Ichiyama, S., Ezaki, T., Mitsuyama, M. (2005). Streptomycin-Dependent Exhibition of Cytokine-Inducing Activity in Streptomycin-Dependent Mycobacterium tuberculosis Strain 18b. Infect. Immun. 73: 7051-7055 [Abstract] [Full Text]
Sullivan, B. M., Jobe, O., Lazarevic, V., Vasquez, K., Bronson, R., Glimcher, L. H., Kramnik, I. (2005). Increased Susceptibility of Mice Lacking T-bet to Infection with Mycobacterium tuberculosis Correlates with Increased IL-10 and Decreased IFN-{gamma} Production. J. Immunol. 175: 4593-4602 [Abstract] [Full Text]
Happel, K. I., Dubin, P. J., Zheng, M., Ghilardi, N., Lockhart, C., Quinton, L. J., Odden, A. R., Shellito, J. E., Bagby, G. J., Nelson, S., Kolls, J. K. (2005). Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. JEM 202: 761-769 [Abstract] [Full Text]
Ordway, D., Henao-Tamayo, M., Orme, I. M., Gonzalez-Juarrero, M. (2005). Foamy Macrophages within Lung Granulomas of Mice Infected with Mycobacterium tuberculosis Express Molecules Characteristic of Dendritic Cells and Antiapoptotic Markers of the TNF Receptor-Associated Factor Family. J. Immunol. 175: 3873-3881 [Abstract] [Full Text]
Irwin, S. M., Izzo, A. A., Dow, S. W., Skeiky, Y. A. W., Reed, S. G., Alderson, M. R., Orme, I. M. (2005). Tracking Antigen-Specific CD8 T Lymphocytes in the Lungs of Mice Vaccinated with the Mtb72F Polyprotein. Infect. Immun. 73: 5809-5816 [Abstract] [Full Text]
Shin, S. J., Chang, C.-F., Chang, C.-D., McDonough, S. P., Thompson, B., Yoo, H. S., Chang, Y.-F. (2005). In Vitro Cellular Immune Responses to Recombinant Antigens of Mycobacterium avium subsp. paratuberculosis. Infect. Immun. 73: 5074-5085 [Abstract] [Full Text]
Matsumoto, S., Matsumoto, M., Umemori, K., Ozeki, Y., Furugen, M., Tatsuo, T., Hirayama, Y., Yamamoto, S., Yamada, T., Kobayashi, K. (2005). DNA Augments Antigenicity of Mycobacterial DNA-Binding Protein 1 and Confers Protection against Mycobacterium tuberculosis Infection in Mice. J. Immunol. 175: 441-449 [Abstract] [Full Text]