Fibrin(ogen) mediates acute inflammatory responses to biomaterials

doi:10.1084/jem.178.6.2147

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Fibrin(ogen) mediates acute inflammatory responses to biomaterials

L Tang and JW Eaton
Division of Experimental Pathology, Albany Medical College, New York 12208.

Although "biocompatible" polymeric elastomers are generally nontoxic, nonimmunogenic, and chemically inert, implants made of these materials may trigger acute and chronic inflammatory responses. Early interactions between implants and inflammatory cells are probably mediated by a layer of host proteins on the material surface. To evaluate the importance of this protein layer, we studied acute inflammatory responses of mice to samples of polyester terephthalate film (PET) that were implanted intraperitoneally for short periods. Material preincubated with albumin is "passivated," accumulating very few adherent neutrophils or macrophages, whereas uncoated or plasma- coated PET attracts large numbers of phagocytes. Neither IgG adsorption nor surface complement activation is necessary for this acute inflammation; phagocyte accumulation on uncoated implants is normal in hypogammaglobulinemic mice and in severely hypocomplementemic mice. Rather, spontaneous adsorption of fibrinogen appears to be critical: (a) PET coated with serum or hypofibrinogenemic plasma attracts as few phagocytes as does albumin-coated material; (b) in contrast, PET preincubated with serum or hypofibrinogenemic plasma containing physiologic amounts of fibrinogen elicits "normal" phagocyte recruitment; (c) most importantly, hypofibrinogenemic mice do not mount an inflammatory response to implanted PET unless the material is coated with fibrinogen or the animals are injected with fibrinogen before implantation. Thus, spontaneous adsorption of fibrinogen appears to initiate the acute inflammatory response to an implanted polymer, suggesting an interesting nexus between two major iatrogenic effects of biomaterials: clotting and inflammation.
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Szaba, F. M., Smiley, S. T. (2002). Roles for thrombin and fibrin(ogen) in cytokine/chemokine production and macrophage adhesion in vivo. Blood 99: 1053-1059 [Abstract] [Full Text]
Lishko, V. K., Yakubenko, V. P., Hertzberg, K. M., Grieninger, G., Ugarova, T. P. (2001). The alternatively spliced {alpha}EC domain of human fibrinogen-420 is a novel ligand for leukocyte integrins {alpha}M{beta}2 and {alpha}X{beta}2. Blood 98: 2448-2455 [Abstract] [Full Text]
Hu, W.-J., Eaton, J. W., Ugarova, T. P., Tang, L. (2001). Molecular basis of biomaterial-mediated foreign body reactions. Blood 98: 1231-1238 [Abstract] [Full Text]
Forsyth, C. B., Solovjov, D. A., Ugarova, T. P., Plow, E. F. (2001). Integrin {alpha}M{beta}2-Mediated Cell Migration to Fibrinogen and Its Recognition Peptides. JEM 193: 1123-1134 [Abstract] [Full Text]
Roux, D. T.-L., Roullot, V., Poujol, C., Kortulewski, T., Nurden, P., Marguerie, G. (2000). Thrombasthenic mice generated by replacement of the integrin alpha IIb gene: demonstration that transcriptional activation of this megakaryocytic locus precedes lineage commitment. Blood 96: 1399-1408 [Abstract] [Full Text]
Akassoglou, K., Kombrinck, K. W., Degen, J. L., Strickland, S. (2000). Tissue Plasminogen Activator-Mediated Fibrinolysis Protects against Axonal Degeneration and Demyelination after Sciatic Nerve Injury. JCB 149: 1157-1166 [Abstract] [Full Text]
ALLAN, B. (1999). Closer to nature: new biomaterials and tissue engineering in ophthalmology. Br J Ophthalmol 83: 1235-1240 [Full Text]
The AGFID project team, (1999). Cell and protein adhesion studies in glaucoma drainage device development. Br J Ophthalmol 83: 1168-1171 [Abstract] [Full Text]
Kyriakides, T. R., Leach, K. J., Hoffman, A. S., Ratner, B. D., Bornstein, P. (1999). Mice that lack the angiogenesis inhibitor, thrombospondin 2,�mount an altered foreign body reaction characterized by increased vascularity. Proc. Natl. Acad. Sci. USA 96: 4449-4454 [Abstract] [Full Text]
Retzinger, G. S., DeAnglis, A. P., Patuto, S. J. (1998). Adsorption of Fibrinogen to Droplets of Liquid Hydrophobic Phases : Functionality of the Bound Protein and Biological Implications. Arterioscler. Thromb. Vasc. Bio. 18: 1948-1957 [Abstract] [Full Text]
Lim, K S, Allan, B D S, Lloyd, A W, Muir, A, Khaw, P T, LIM, K S, ALLAN, B D S, LLOYD, A W, MUIR, A, KHAW, P T (1998). Glaucoma drainage devices; past, present, and future. Br J Ophthalmol 82: 1083-1089 [Full Text]
Ugarova, T. P., Solovjov, D. A., Zhang, L., Loukinov, D. I., Yee, V. C., Medved, L. V., Plow, E. F. (1998). Identification of a Novel Recognition Sequence for Integrin alpha Mbeta 2 within the gamma -chain of Fibrinogen. J. Biol. Chem. 273: 22519-22527 [Abstract] [Full Text]
Tang, L., Jennings, T. A., Eaton, J. W. (1998). Mast cells mediate acute inflammatory responses to implanted biomaterials. Proc. Natl. Acad. Sci. USA 95: 8841-8846 [Abstract] [Full Text]
BUSSO, N., SO, A. (1997). Urokinase in rheumatoid arthritis: causal or coincidental?. Ann Rheum Dis 56: 705-706 [Full Text]
D'Souza, S. E., Byers-Ward, V. J., Gardiner, E. E., Wang, H., Sung, S.-S. (1996). Identification of an Active Sequence within the First Immunoglobulin Domain of Intercellular Cell Adhesion Molecule-1 (ICAM-1) That Interacts with Fibrinogen. J. Biol. Chem. 271: 24270-24277 [Abstract] [Full Text]
Suh, T T, Holmback, K, Jensen, N J, Daugherty, C C, Small, K, Simon, D I, Potter, S, Degen, J L (1995). Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice.. Genes Dev. 9: 2020-2033 [Abstract]
Altieri, D. C., Duperray, A., Plescia, J., Thornton, G. B., Languino, L. R. (1995). Structural Recognition of a Novel Fibrinogen [IMAGE] Chain Sequence (117-133) by Intercellular Adhesion Molecule-1 Mediates Leukocyte-Endothelium Interaction. J. Biol. Chem. 270: 696-699 [Abstract] [Full Text]