The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 178, 1819-1824, Copyright © 1993 by Rockefeller University Press

ARTICLES

The presence of an endogenous murine leukemia virus sequence correlates with the peripheral expansion of gamma delta T cells bearing the BALB invariant delta (BID) T cell receptor delta

GK Sim and A Augustin
Basel Institute for Immunology, Switzerland.

gamma delta T cells participate in immune responses during viral, bacterial, and parasitic infections. However, it is not clear whether they recognize antigens produced by pathogens, or are actually reactive to self-ligands generated during the course of infection. In this paper, we report that the presence of the self-ligand that selectively expands a subset of gamma delta T cells correlates with the presence of an endogenous murine leukemia virus (MuLV) in inbred strains of mice. The implications of this observation for gamma delta T cell specificity and function is discussed.
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