Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice

doi:10.1084/jem.178.5.1783

This Article

	Full Text (PDF, 513K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Hoyne, G. F.
	Articles by Lamb, J. R.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Hoyne, G. F.
	Articles by Lamb, J. R.


Social Bookmarking

	What's this?

ARTICLES

Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice

GF Hoyne, RE O'Hehir, DC Wraith, WR Thomas and JR Lamb
Division of Molecular Biology, Western Australian Research Institute for Child Health, Princess Margaret Hospital, Subiaco.

Antigen-specific CD4+ T cells play an important role in the allergic immune response to house dust mite (HDM) allergens in humans. The group 1 allergen of Dermatophagoides spp. is a major target antigen in both B and T cell recognition of HDM. In vitro studies have shown that the presentation of peptides to human T cells under appropriate conditions may lead to a state of specific nonresponsiveness. Therefore, to determine if peptides are able to modulate the function of allergen- reactive T cells in vivo, we have used a murine model of T cell recognition of the HDM allergen Der p 1. The results demonstrate that inhalation of low concentrations of peptide containing the major T cell epitope of Der p 1 (residues 111-139), induces tolerance in naive C57BL/6J mice such that they become profoundly unresponsive to an immunogenic challenge with the intact allergen. When restimulated in vitro with antigen, lymph node T cells isolated from tolerant mice secrete very low levels of interleukin 2, proliferative poorly, and are unable to provide cognate help to stimulate specific antibody production. Furthermore, intranasal peptide therapy was able to inhibit an ongoing immune response to the allergen in mice and this has potential implications in the development of allergen-based immunotherapy.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Gabrysova, L., Nicolson, K. S., Streeter, H. B., Verhagen, J., Sabatos-Peyton, C. A., Morgan, D. J., Wraith, D. C. (2009). Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting Th1 cells. JEM 206: 1755-1767 [Abstract] [Full Text]
Niu, N., Cohn, L. (2007). Response to Comment on "A Novel Pathway That Regulates Inflammatory Disease in the Respiratory Tract". J. Immunol. 178: 7501-7502 [Full Text]
Niu, N., Le Goff, M. K., Li, F., Rahman, M., Homer, R. J., Cohn, L. (2007). A Novel Pathway That Regulates Inflammatory Disease in the Respiratory Tract. J. Immunol. 178: 3846-3855 [Abstract] [Full Text]
Nicolson, K. S., O'Neill, E. J., Sundstedt, A., Streeter, H. B., Minaee, S., Wraith, D. C. (2006). Antigen-Induced IL-10+ Regulatory T Cells Are Independent of CD25+ Regulatory Cells for Their Growth, Differentiation, and Function. J. Immunol. 176: 5329-5337 [Abstract] [Full Text]
Tedgui, A., Mallat, Z. (2006). Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways. Physiol. Rev. 86: 515-581 [Abstract] [Full Text]
Takagi, H., Hiroi, T., Yang, L., Tada, Y., Yuki, Y., Takamura, K., Ishimitsu, R., Kawauchi, H., Kiyono, H., Takaiwa, F. (2005). From The Cover: A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses. Proc. Natl. Acad. Sci. USA 102: 17525-17530 [Abstract] [Full Text]
Wilson, M. S., Taylor, M. D., Balic, A., Finney, C. A.M., Lamb, J. R., Maizels, R. M. (2005). Suppression of allergic airway inflammation by helminth-induced regulatory T cells. JEM 202: 1199-1212 [Abstract] [Full Text]
Immonen, A., Farci, S., Taivainen, A., Partanen, J., Pouvelle-Moratille, S., Narvanen, A., Kinnunen, T., Saarelainen, S., Rytkonen-Nissinen, M., Maillere, B., Virtanen, T. (2005). T Cell Epitope-Containing Peptides of the Major Dog Allergen Can f 1 as Candidates for Allergen Immunotherapy. J. Immunol. 175: 3614-3620 [Abstract] [Full Text]
Johnson, A. J., Mendez-Fernandez, Y., Moyer, A. M., Sloma, C. R., Pirko, I., Block, M. S., Rodriguez, M., Pease, L. R. (2005). Antigen-Specific CD8+ T Cells Mediate a Peptide-Induced Fatal Syndrome. J. Immunol. 174: 6854-6862 [Abstract] [Full Text]
Riedl, M. A., Landaw, E. M., Saxon, A., Diaz-Sanchez, D. (2005). Initial High-Dose Nasal Allergen Exposure Prevents Allergic Sensitization to a Neoantigen. J. Immunol. 174: 7440-7445 [Abstract] [Full Text]
Hall, A. M., Cairns, L. S., Altmann, D. M., Barker, R. N., Urbaniak, S. J. (2005). Immune responses and tolerance to the RhD blood group protein in HLA-transgenic mice. Blood 105: 2175-2179 [Abstract] [Full Text]
Cates, E. C., Fattouh, R., Wattie, J., Inman, M. D., Goncharova, S., Coyle, A. J., Gutierrez-Ramos, J.-C., Jordana, M. (2004). Intranasal Exposure of Mice to House Dust Mite Elicits Allergic Airway Inflammation via a GM-CSF-Mediated Mechanism. J. Immunol. 173: 6384-6392 [Abstract] [Full Text]
Epardaud, M., Bonneau, M., Payot, F., Cordier, C., Megret, J., Howard, C., Schwartz-Cornil, I. (2004). Enrichment for a CD26hi SIRP- subset in lymph dendritic cells from the upper aero-digestive tract. J. Leukoc. Biol. 76: 553-561 [Abstract] [Full Text]
Boulet, L.-P. (2004). Allergen-derived T Cell Peptides and Late Asthmatic Responses. Am. J. Respir. Crit. Care Med. 169: 2-3 [Full Text]
Ali, F. R., Oldfield, W. L. G., Higashi, N., Larche, M., Kay, A. B. (2004). Late Asthmatic Reactions Induced by Inhalation of Allergen-derived T Cell Peptides. Am. J. Respir. Crit. Care Med. 169: 20-26 [Abstract] [Full Text]
Chatel, J.-M., Nouaille, S., Adel-Patient, K., Le Loir, Y., Boe, H., Gruss, A., Wal, J.-M., Langella, P. (2003). Characterization of a Lactococcus lactis Strain That Secretes a Major Epitope of Bovine Beta-Lactoglobulin and Evaluation of Its Immunogenicity in Mice. Appl. Environ. Microbiol. 69: 6620-6627 [Abstract] [Full Text]
Hardy, C. L., Kenins, L., Drew, A. C., Rolland, J. M., O'Hehir, R. E. (2003). Characterization of a Mouse Model of Allergy to a Major Occupational Latex Glove Allergen Hev b 5. Am. J. Respir. Crit. Care Med. 167: 1393-1399 [Abstract] [Full Text]
Wu, H. Y., Ward, F. J., Staines, N. A. (2002). Histone Peptide-Induced Nasal Tolerance: Suppression of Murine Lupus. J. Immunol. 169: 1126-1134 [Abstract] [Full Text]
Staats, H. F., Bradney, C. P., Gwinn, W. M., Jackson, S. S., Sempowski, G. D., Liao, H.-X., Letvin, N. L., Haynes, B. F. (2001). Cytokine Requirements for Induction of Systemic and Mucosal CTL After Nasal Immunization. J. Immunol. 167: 5386-5394 [Abstract] [Full Text]
Jarnicki, A. G., Tsuji, T., Thomas, W. R. (2001). Inhibition of mucosal and systemic Th2-type immune responses by intranasal peptides containing a dominant T cell epitope of the allergen Der p 1. Int Immunol 13: 1223-1231 [Abstract] [Full Text]
King, T. P., Jim, S. Y., Monsalve, R. I., Kagey-Sobotka, A., Lichtenstein, L. M., Spangfort, M. D. (2001). Recombinant Allergens with Reduced Allergenicity but Retaining Immunogenicity of the Natural Allergens: Hybrids of Yellow Jacket and Paper Wasp Venom Allergen Antigen 5s. J. Immunol. 166: 6057-6065 [Abstract] [Full Text]
Kamradt, T., Mitchison, N. A. (2001). Tolerance and Autoimmunity. NEJM 344: 655-664 [Full Text]
HOYNE, G. F., TAN, K., CORSIN-JIMENEZ, M., WAHL, K., STEWART, M., HOWIE, S. E. M., LAMB, J. R. (2000). Immunological Tolerance to Inhaled Antigen. Am. J. Respir. Crit. Care Med. 162: S169-174 [Abstract] [Full Text]
Astori, M., von Garnier, C., Kettner, A., Dufour, N., Corradin, G., Spertini, F. (2000). Inducing Tolerance by Intranasal Administration of Long Peptides in Naive and Primed CBA/J Mice. J. Immunol. 165: 3497-3505 [Abstract] [Full Text]
Hoyne, G. F., Le Roux, I., Corsin-Jimenez, M., Tan, K., Dunne, J., Forsyth, L. M. G., Dallman, M. J., Owen, M. J., Ish-Horowicz, D., Lamb, J. R. (2000). Serrate1-induced Notch signalling regulates the decision between immunity and tolerance made by peripheral CD4+ T cells. Int Immunol 12: 177-185 [Abstract] [Full Text]
Hirschberg, S., Layton, G. T., Harris, S. J., Savage, N., Dallman, M. J., Lamb, J. R. (1999). CD4+ T cells induced by virus-like particles expressing a major T cell epitope down-regulate IL-5 production in an ongoing immune response to Der p 1 independently of IFN-{gamma} production. Int Immunol 11: 1927-1934 [Abstract] [Full Text]
Jaffar, Z. H., Stanciu, L., Pandit, A., Lordan, J., Holgate, S. T., Roberts, K. (1999). Essential Role for Both CD80 and CD86 Costimulation, But Not CD40 Interactions, in Allergen-Induced Th2 Cytokine Production from Asthmatic Bronchial Tissue: Role for {alpha}{beta}, But Not {gamma}{delta}, T Cells. J. Immunol. 163: 6283-6291 [Abstract] [Full Text]
Burkhart, C., Liu, G. Y., Anderton, S. M., Metzler, B., Wraith, D. C. (1999). Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10. Int Immunol 11: 1625-1634 [Abstract] [Full Text]
de Lalla, C., Sturniolo, T., Abbruzzese, L., Hammer, J., Sidoli, A., Sinigaglia, F., Panina-Bordignon, P. (1999). Cutting Edge: Identification of Novel T Cell Epitopes in Lol p5a by Computational Prediction. J. Immunol. 163: 1725-1729 [Abstract] [Full Text]
Haneda, K., Sano, K., Tamura, G., Shirota, H., Ohkawara, Y., Sato, T., Habu, S., Shirato, K. (1999). Transforming Growth Factor-beta Secreted from CD4+ T Cells Ameliorates Antigen-Induced Eosinophilic Inflammation . A Novel High-Dose Tolerance in the Trachea. Am. J. Respir. Cell Mol. Bio. 21: 268-274 [Abstract] [Full Text]
Lee, S.-C., Jaffar, Z. H., Wan, K.-S., Holgate, S. T., Roberts, K. (1999). Regulation of Pulmonary T Cell Responses to Inhaled Antigen: Role in Th1- and Th2-Mediated Inflammation. J. Immunol. 162: 6867-6879 [Abstract] [Full Text]
Staats, H. F., Ennis, F. A. Jr. (1999). IL-1 Is an Effective Adjuvant for Mucosal and Systemic Immune Responses When Coadministered with Protein Immunogens. J. Immunol. 162: 6141-6147 [Abstract] [Full Text]
AKDIS, C. A., BLASER, K. (1999). IL-10-induced anergy in peripheral T cell and reactivation by microenvironmental cytokines: two key steps in specific immunotherapy. FASEB J. 13: 603-609 [Abstract] [Full Text]
Wolvers, D. A. W., Coenen-de Roo, C. J. J., Mebius, R. E., van der Cammen, M. J. F., Tirion, F., Miltenburg, A. M. M., Kraal, G. (1999). Intranasally Induced Immunological Tolerance Is Determined by Characteristics of the Draining Lymph Nodes: Studies with OVA and Human Cartilage gp-39. J. Immunol. 162: 1994-1998 [Abstract] [Full Text]
Schramm, G., Kahlert, H., Suck, R., Weber, B., Stuwe, H.-T., Muller, W.-D., Bufe, A., Becker, W.-M., Schlaak, M. W., Jager, L., Cromwell, O., Fiebig, H. (1999). ""Allergen Engineering"": Variants of the Timothy Grass Pollen Allergen Phl p 5b with Reduced IgE-Binding Capacity but Conserved T Cell Reactivity. J. Immunol. 162: 2406-2414 [Abstract] [Full Text]
Zeiler, T., Mantyjarvi, R., Rautiainen, J., Rytkonen-Nissinen, M., Vilja, P., Taivainen, A., Kauppinen, J., Virtanen, T. (1999). T Cell Epitopes of a Lipocalin Allergen Colocalize with the Conserved Regions of the Molecule. J. Immunol. 162: 1415-1422 [Abstract] [Full Text]
Porgador, A., Staats, H. F., Itoh, Y., Kelsall, B. L. (1998). Intranasal Immunization with Cytotoxic T-Lymphocyte Epitope Peptide and Mucosal Adjuvant Cholera Toxin: Selective Augmentation of Peptide-Presenting Dendritic Cells in Nasal Mucosa-Associated Lymphoid Tissue. Infect. Immun. 66: 5876-5881 [Abstract] [Full Text]
Sone, T., Morikubo, K., Miyahara, M., Komiyama, N., Shimizu, K., Tsunoo, H., Kino, K. (1998). T Cell Epitopes in Japanese Cedar (Cryptomeria japonica) Pollen Allergens: Choice of Major T Cell Epitopes in Cry j 1 and Cry j 2 Toward Design of the Peptide-Based Immunotherapeutics for the Management of Japanese Cedar Pollinosis. J. Immunol. 161: 448-457 [Abstract] [Full Text]
Prakken, B. J., van der Zee, R., Anderton, S. M., van Kooten, P. J.�S., Kuis, W., van Eden, W. (1997). Peptide-induced nasal tolerance for a mycobacterial heat shock protein 60�T cell epitope in rats suppresses both adjuvant arthritis and nonmicrobially induced�experimental�arthritis. Proc. Natl. Acad. Sci. USA 94: 3284-3289 [Abstract] [Full Text]
Lu, G., Kochoumian, L., King, T. P. (1995). Sequence Identity and Antigenic Cross-reactivity of White Face Hornet Venom Allergen, Also a Hyaluronidase, with Other Proteins. J. Biol. Chem. 270: 4457-4465 [Abstract] [Full Text]