Lymphocyte function-associated antigen 1 dominates very late antigen 4 in binding of activated T cells to endothelium

doi:10.1084/jem.177.1.185

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Lymphocyte function-associated antigen 1 dominates very late antigen 4 in binding of activated T cells to endothelium

Y van Kooyk, E van de Wiel-van Kemenade, P Weder, RJ Huijbens and CG Figdor
Division of Immunology, Netherlands Cancer Institute, Amsterdam.

Lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 (LFA-1/ICAM-1)-and very late antigen 4/vascular cell adhesion molecule 1 (VLA-4/VCAM-1)-mediated adhesion of T lymphocytes to endothelial cells (EC) can be regulated by increased expression of ICAM-1 and VCAM-1 upon cytokine treatment of EC, or by activation of the integrin molecules LFA-1 and VLA-4 on T cells. Here, we provide evidence that preferential usage of LFA-1 over VLA-4 is yet another mechanism to control T cell adhesion. We observed that binding of activated T lymphocytes, as opposed to resting T cells, to EC is essentially mediated through LFA-1 and not through VLA-4. VLA-4- mediated adhesion of T cells to EC is only found when LFA-1 is not expressed or not functional, as observed for several T cell leukemia cell lines. These results suggest that LFA-1-mediated adhesion dominates and may downregulate VLA-4-mediated adhesion through an unidentified mechanism.
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