Predominance of fetal type DJH joining in young children with B precursor lymphoblastic leukemia as evidence for an in utero transforming event

doi:10.1084/jem.176.6.1577

This Article

	Full Text (PDF, 502K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Wasserman, R.
	Articles by Rovera, G.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Wasserman, R.
	Articles by Rovera, G.


Social Bookmarking

	What's this?

ARTICLES

Predominance of fetal type DJH joining in young children with B precursor lymphoblastic leukemia as evidence for an in utero transforming event

R Wasserman, N Galili, Y Ito, BA Reichard, S Shane and G Rovera
Division of Oncology, Children's Hospital of Philadelphia, Pennsylvania.

The presence of N sequences in the complementarity determining region 3 (CDR3) of the rearranged immunoglobulin H chain is developmentally regulated: N regions are generally present in the DJH joinings of adult B cells but are often absent in fetal B cells. Analysis of the CDR3 in 61 B precursor acute lymphoblastic leukemias indicated that 87.5% of the leukemias obtained from children < or = 3 yr old lacked N regions at the DJH junction. In contrast, in children > 3 yr old, only 11.1% of the leukemias lacked N regions at this junction, a frequency similar to what we have observed in B cells from children and adults. These findings suggest that the majority of leukemias presenting within the first 3 yr of age arise from an in utero transforming event.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Spector, L. G., Hooten, A. J., Ross, J. A. (2008). Ontogeny of Gene Expression: A Changing Environment for Malignancy. Cancer Epidemiol. Biomarkers Prev. 17: 1021-1023 [Full Text]
Panzer-Grumayer, E. R., Cazzaniga, G., van der Velden, V. H.J., del Giudice, L., Peham, M., Mann, G., Eckert, C., Schrauder, A., Germano, G., Harbott, J., Basso, G., Biondi, A., van Dongen, J. J.M., Gadner, H., Haas, O. A. (2005). Immunogenotype Changes Prevail in Relapses of Young Children with TEL-AML1-Positive Acute Lymphoblastic Leukemia and Derive Mainly from Clonal Selection. Clin. Cancer Res. 11: 7720-7727 [Abstract] [Full Text]
Li, A., Rue, M., Zhou, J., Wang, H., Goldwasser, M. A., Neuberg, D., Dalton, V., Zuckerman, D., Lyons, C., Silverman, L. B., Sallan, S. E., Gribben, J. G. (2004). Utilization of Ig heavy chain variable, diversity, and joining gene segments in children with B-lineage acute lymphoblastic leukemia: implications for the mechanisms of VDJ recombination and for pathogenesis. Blood 103: 4602-4609 [Abstract] [Full Text]
Konrad, M., Metzler, M., Panzer, S., Ostreicher, I., Peham, M., Repp, R., Haas, O. A., Gadner, H., Panzer-Grumayer, E. R. (2003). Late relapses evolve from slow-responding subclones in t(12;21)-positive acute lymphoblastic leukemia: evidence for the persistence of a preleukemic clone. Blood 101: 3635-3640 [Abstract] [Full Text]
Wang, Y.-H., Zhang, Z., Burrows, P. D., Kubagawa, H., Bridges, S. L. Jr, Findley, H. W., Cooper, M. D. (2003). V(D)J recombinatorial repertoire diversification during intraclonal pro-B to B-cell differentiation. Blood 101: 1030-1037 [Abstract] [Full Text]
Wiemels, J. L., Leonard, B. C., Wang, Y., Segal, M. R., Hunger, S. P., Smith, M. T., Crouse, V., Ma, X., Buffler, P. A., Pine, S. R. (2002). Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proc. Natl. Acad. Sci. USA 99: 15101-15106 [Abstract] [Full Text]
Fasching, K., Panzer, S., Haas, O. A., Borkhardt, A., Marschalek, R., Griesinger, F., Panzer-Grumayer, E. R. (2001). Presence of N regions in the clonotypic DJ rearrangements of the immunoglobulin heavy-chain genes indicates an exquisitely short latency in t(4;11)-positive infant acute lymphoblastic leukemia. Blood 98: 2272-2274 [Abstract] [Full Text]
Mortuza, F. Y., Moreira, I. M., Papaioannou, M., Gameiro, P., Coyle, L. A., Gricks, C. S., Amlot, P., Prentice, H. G., Madrigal, A., Hoffbrand, A. V., Foroni, L. (2001). Immunoglobulin heavy-chain gene rearrangement in adult acute lymphoblastic leukemia reveals preferential usage of JH-proximal variable gene segments. Blood 97: 2716-2726 [Abstract] [Full Text]
Brumpt, C., Delabesse, E., Beldjord, K., Davi, F., Cayuela, J.-M., Millien, C., Villarese, P., Quartier, P., Buzyn, A., Valensi, F., Macintyre, E. (2000). The incidence of clonal T-cell receptor rearrangements in B-cell precursor acute lymphoblastic leukemia varies with age and genotype. Blood 96: 2254-2261 [Abstract] [Full Text]
Yagi, T., Hibi, S., Tabata, Y., Kuriyama, K., Teramura, T., Hashida, T., Shimizu, Y., Takimoto, T., Todo, S., Sawada, T., Imashuku, S. (2000). Detection of clonotypic IGH and TCR rearrangements in the neonatal blood spots of infants and children with B-cell precursor acute lymphoblastic leukemia. Blood 96: 264-268 [Abstract] [Full Text]
Fasching, K., Panzer, S., Haas, O. A., Marschalek, R., Gadner, H., Panzer-Grumayer, E. R. (2000). Presence of clone-specific antigen receptor gene rearrangements at birth indicates an in utero origin of diverse types of early childhood acute lymphoblastic leukemia. Blood 95: 2722-2724 [Abstract] [Full Text]
Felix, C. A., Lange, B. J., Chessells, J. M. (2000). Pediatric Acute Lymphoblastic Leukemia: Challenges and Controversies in 2000. ASH Education Book 2000: 285-302 [Abstract] [Full Text]
Wiemels, J. L., Ford, A. M., Van Wering, E. R., Postma, A., Greaves, M. (1999). Protracted and Variable Latency of Acute Lymphoblastic Leukemia After TEL-AML1 Gene Fusion In Utero. Blood 94: 1057-1062 [Abstract] [Full Text]
Shiokawa, S., Mortari, F., Lima, J. O., Nunez, C., Bertrand, F. E. III, Kirkham, P. M., Zhu, S., Dasanayake, A. P., Schroeder, H. W. Jr. (1999). IgM Heavy Chain Complementarity-Determining Region 3 Diversity Is Constrained by Genetic and Somatic Mechanisms Until Two Months After Birth. J. Immunol. 162: 6060-6070 [Abstract] [Full Text]
Pui, C.-H., Evans, W. E. (1999). Acute Lymphoblastic Leukemia in Infants. JCO 17: 438-438 [Full Text]
Zeng, X.-X., Zhang, H., Hardy, R. R., Wasserman, R. (1998). The Fetal Origin of B-Precursor Leukemia in the E�-ret Mouse. Blood 92: 3529-3536 [Abstract] [Full Text]
Shiokawa, S., Nishimura, J., Ohshima, K., Uike, N., Yamamoto, K. (1998). Establishment of a Novel B Cell Clonality Analysis Using Single-Strand Conformation Polymorphism of Immunoglobulin Light Chain Messenger Signals. Am. J. Pathol. 153: 1393-1400 [Abstract] [Full Text]
Ford, A. M., Bennett, C. A., Price, C. M., Bruin, M. C.�A., Van Wering, E. R., Greaves, M. (1998). Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia. Proc. Natl. Acad. Sci. USA 95: 4584-4588 [Abstract] [Full Text]
Ford, A. M., Pombo-de-Oliveira, M. S., McCarthy, K. P., MacLean, J. M., Carrico, K. C., Vincent, R. F., Greaves, M. (1997). Monoclonal Origin of Concordant T-Cell Malignancy in Identical Twins. Blood 89: 281-285 [Abstract] [Full Text]
Cline, M. J. (1994). The Molecular Basis of Leukemia. NEJM 330: 328-336 [Full Text]