Exogenously-induced, natural killer cell-mediated neuronal killing: a novel pathogenetic mechanism

doi:10.1084/jem.176.3.811

This Article

	Full Text (PDF, 1776K)
	Alert me when this article is cited

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Hickey, W. F.
	Articles by Schmidt, R. E.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Hickey, W. F.
	Articles by Schmidt, R. E.


Social Bookmarking

	What's this?

ARTICLES

Exogenously-induced, natural killer cell-mediated neuronal killing: a novel pathogenetic mechanism

WF Hickey, K Ueno, JC Hiserodt and RE Schmidt
Division of Neuropathology, Washington University School of Medicine, St. Louis, Missouri 63110.

Many human neurodegenerative diseases are characterized by the idiopathic death of cells narrowly restricted to a subset of neurons in a specific functional neuroanatomic system. Few in vivo models exist for the analysis of these types of degeneration. This report documents the death of sympathetic neurons resident in the superior cervical ganglia of rats after exposure to an exogenous chemical agent, the drug guanethidine, as being mediated by natural killer (NK) cells. This is the first in vivo model of a disorder of the nervous system in which NK cells appear to be the principal effector cell, and thus could serve a central role in dissecting the normal and pathological function of NK cells. In addition, this pathogenetic mechanism appears to represent a novel type of autoimmune reaction that could have a direct bearing on a number of human illnesses.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Kannan-Hayashi, Y., Okamura, K., Hattori, S., Kuwamura, M., Higuchi, E., Terayama, H., Moriyama, M., Mukamoto, M., Okada, M., Ohsugi, Y., Nakamura, Y. (2008). Neuritogenic Effects of T Cell-Derived IL-3 on Mouse Splenic Sympathetic Neurons In Vivo. J. Immunol. 180: 4227-4234 [Abstract] [Full Text]
Kitaichi, N., Kotake, S., Morohashi, T., Onoe, K., Ohno, S., Taylor, A. W. (2002). Diminution of experimental autoimmune uveoretinitis (EAU) in mice depleted of NK cells. J. Leukoc. Biol. 72: 1117-1121 [Abstract] [Full Text]
Porter, B., Schatzberg, S., McDonough, S., Mertens, D., de Lahunta, A. (2002). Ganglioradiculitis (Sensory Neuronopathy) in a Dog: Clinical, Morphologic, and Immunohistochemical Findings. Vet Pathol 39: 598-602 [Abstract] [Full Text]
Backstrom, E., Chambers, B. J., Kristensson, K., Ljunggren, H.-G. (2000). Direct NK Cell-Mediated Lysis of Syngenic Dorsal Root Ganglia Neurons In Vitro. J. Immunol. 165: 4895-4900 [Abstract] [Full Text]