Identification of target antigens for the human cytotoxic T cell response to Epstein-Barr virus (EBV): implications for the immune control of EBV-positive malignancies

doi:10.1084/jem.176.1.157

This Article

	Full Text (PDF, 1191K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Murray, R. J.
	Articles by Rickinson, A. B.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Murray, R. J.
	Articles by Rickinson, A. B.


Social Bookmarking

	What's this?

ARTICLES

Identification of target antigens for the human cytotoxic T cell response to Epstein-Barr virus (EBV): implications for the immune control of EBV-positive malignancies

RJ Murray, MG Kurilla, JM Brooks, WA Thomas, M Rowe, E Kieff and AB Rickinson
Department of Cancer Studies, University of Birmingham, United Kingdom.

Epstein-Barr virus (EBV), a human herpes virus with oncogenic potential, persists in B lymphoid tissues and is controlled by virus- specific cytotoxic T lymphocyte (CTL) surveillance. On reactivation in vitro, these CTLs recognize EBV-transformed lymphoblastoid cell lines (LCLs) in an HLA class I antigen-restricted fashion, but the viral antigens providing target epitopes for such recognition remain largely undefined. Here we have tested EBV-induced polyclonal CTL preparations from 16 virus-immune donors on appropriate fibroblast targets in which the eight EBV latent proteins normally found in LCLs (Epstein-Barr nuclear antigen [EBNA] 1, 2, 3A, 3B, 3C, leader protein [LP], and latent membrane protein [LMP] 1 and 2) have been expressed individually from recombinant vaccinia virus vectors. Most donors gave multicomponent responses with two or more separate reactivities against different viral antigens. Although precise target antigen choice was clearly influenced by the donor's HLA class I type, a subset of latent proteins, namely EBNA 3A, 3B, and 3C, provided the dominant targets on a range of HLA backgrounds; thus, 15 of 16 donors gave CTL responses that contained reactivities to one or more proteins of this subset. Examples of responses to other latent proteins, namely LMP 2 and EBNA 2, were detected through specific HLA determinants, but we did not observe reactivities to EBNA 1, EBNA LP, or LMP 1. The bulk polyclonal CTL response in one donor, and components of that response in others, did not map to any of the known latent proteins, suggesting that other viral target antigens remain to be identified. This work has important implications for CTL control over EBV-positive malignancies where virus gene expression is often limited to specific subsets of latent proteins.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Nicholls, S., Piper, K. P., Mohammed, F., Dafforn, T. R., Tenzer, S., Salim, M., Mahendra, P., Craddock, C., van Endert, P., Schild, H., Cobbold, M., Engelhard, V. H., Moss, P. A. H., Willcox, B. E. (2009). Secondary anchor polymorphism in the HA-1 minor histocompatibility antigen critically affects MHC stability and TCR recognition. Proc. Natl. Acad. Sci. USA 106: 3889-3894 [Abstract] [Full Text]
Brooks, J. M., Lee, S. P., Leese, A. M., Thomas, W. A., Rowe, M., Rickinson, A. B. (2009). Cyclical Expression of EBV Latent Membrane Protein 1 in EBV-Transformed B Cells Underpins Heterogeneity of Epitope Presentation and CD8+ T Cell Recognition. J. Immunol. 182: 1919-1928 [Abstract] [Full Text]
Liu, A., Claesson, H.-E., Mahshid, Y., Klein, G., Klein, E. (2008). Leukotriene B4 activates T cells that inhibit B-cell proliferation in EBV-infected cord blood-derived mononuclear cell cultures. Blood 111: 2693-2703 [Abstract] [Full Text]
Haigh, T. A., Lin, X., Jia, H., Hui, E. P., Chan, A. T. C., Rickinson, A. B., Taylor, G. S. (2008). EBV Latent Membrane Proteins (LMPs) 1 and 2 as Immunotherapeutic Targets: LMP-Specific CD4+ Cytotoxic T Cell Recognition of EBV-Transformed B Cell Lines. J. Immunol. 180: 1643-1654 [Abstract] [Full Text]
Bhaduri-McIntosh, S., Rotenberg, M. J., Gardner, B., Robert, M., Miller, G. (2008). Repertoire and frequency of immune cells reactive to Epstein-Barr virus-derived autologous lymphoblastoid cell lines. Blood 111: 1334-1343 [Abstract] [Full Text]
Niens, M., Jarrett, R. F., Hepkema, B., Nolte, I. M., Diepstra, A., Platteel, M., Kouprie, N., Delury, C. P., Gallagher, A., Visser, L., Poppema, S., te Meerman, G. J., van den Berg, A. (2007). HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV+ Hodgkin lymphoma. Blood 110: 3310-3315 [Abstract] [Full Text]
Ito, Y., Demachi-Okamura, A., Ohta, R., Akatsuka, Y., Nishida, K., Tsujimura, K., Morishima, Y., Takahashi, T., Kuzushima, K. (2007). Full-length EBNA1 mRNA-transduced dendritic cells stimulate cytotoxic T lymphocytes recognizing a novel HLA-Cw*0303- and -Cw*0304-restricted epitope on EBNA1-expressing cells. J. Gen. Virol. 88: 770-780 [Abstract] [Full Text]
Piper, K. P., McLarnon, A., Arrazi, J., Horlock, C., Ainsworth, J., Kilby, M. D., Martin, W. L., Moss, P. A. (2007). Functional HY-Specific CD8+ T Cells Are Found in a High Proportion of Women Following Pregnancy with a Male Fetus. Biol. Reprod. 76: 96-101 [Abstract] [Full Text]
Chen, A., Zhao, B., Kieff, E., Aster, J. C., Wang, F. (2006). EBNA-3B- and EBNA-3C-Regulated Cellular Genes in Epstein-Barr Virus-Immortalized Lymphoblastoid Cell Lines.. J. Virol. 80: 10139-10150 [Abstract] [Full Text]
Taylor, G. S., Long, H. M., Haigh, T. A., Larsen, M., Brooks, J., Rickinson, A. B. (2006). A Role for Intercellular Antigen Transfer in the Recognition of EBV-Transformed B Cell Lines by EBV Nuclear Antigen-Specific CD4+ T Cells. J. Immunol. 177: 3746-3756 [Abstract] [Full Text]
Fogg, M. H., Garry, D., Awad, A., Wang, F., Kaur, A. (2006). The BZLF1 Homolog of an Epstein-Barr-Related {gamma}-Herpesvirus Is a Frequent Target of the CTL Response in Persistently Infected Rhesus Macaques. J. Immunol. 176: 3391-3401 [Abstract] [Full Text]
Fogg, M. H., Kaur, A., Cho, Y.-G., Wang, F. (2005). The CD8+ T-Cell Response to an Epstein-Barr Virus-Related Gammaherpesvirus Infecting Rhesus Macaques Provides Evidence for Immune Evasion by the EBNA-1 Homologue. J. Virol. 79: 12681-12691 [Abstract] [Full Text]
Kotsiopriftis, M., Tanner, J. E., Alfieri, C. (2005). Heat Shock Protein 90 Expression in Epstein-Barr Virus-Infected B Cells Promotes {gamma}{delta} T-Cell Proliferation In Vitro. J. Virol. 79: 7255-7261 [Abstract] [Full Text]
Ressing, M. E., Keating, S. E., van Leeuwen, D., Koppers-Lalic, D., Pappworth, I. Y., Wiertz, E. J. H. J., Rowe, M. (2005). Impaired Transporter Associated with Antigen Processing-Dependent Peptide Transport during Productive EBV Infection. J. Immunol. 174: 6829-6838 [Abstract] [Full Text]
Gudgeon, N. H., Taylor, G. S., Long, H. M., Haigh, T. A., Rickinson, A. B. (2005). Regression of Epstein-Barr Virus-Induced B-Cell Transformation In Vitro Involves Virus-Specific CD8+ T Cells as the Principal Effectors and a Novel CD4+ T-Cell Reactivity. J. Virol. 79: 5477-5488 [Abstract] [Full Text]
Long, H. M., Haigh, T. A., Gudgeon, N. H., Leen, A. M., Tsang, C.-W., Brooks, J., Landais, E., Houssaint, E., Lee, S. P., Rickinson, A. B., Taylor, G. S. (2005). CD4+ T-Cell Responses to Epstein-Barr Virus (EBV) Latent-Cycle Antigens and the Recognition of EBV-Transformed Lymphoblastoid Cell Lines. J. Virol. 79: 4896-4907 [Abstract] [Full Text]
May, K. F. Jr, Roychowdhury, S., Bhatt, D., Kocak, E., Bai, X.-F., Liu, J.-Q., Ferketich, A. K., Martin, E. W. Jr, Caligiuri, M. A., Zheng, P., Liu, Y. (2005). Anti-human CTLA-4 monoclonal antibody promotes T-cell expansion and immunity in a hu-PBL-SCID model: a new method for preclinical screening of costimulatory monoclonal antibodies. Blood 105: 1114-1120 [Abstract] [Full Text]
Lee, S. P., Brooks, J. M., Al-Jarrah, H., Thomas, W. A., Haigh, T. A., Taylor, G. S., Humme, S., Schepers, A., Hammerschmidt, W., Yates, J. L., Rickinson, A. B., Blake, N. W. (2004). CD8 T Cell Recognition of Endogenously Expressed Epstein-Barr Virus Nuclear Antigen 1. JEM 199: 1409-1420 [Abstract] [Full Text]
Tellam, J., Connolly, G., Green, K. J., Miles, J. J., Moss, D. J., Burrows, S. R., Khanna, R. (2004). Endogenous Presentation of CD8+ T Cell Epitopes from Epstein-Barr Virus-encoded Nuclear Antigen 1. JEM 199: 1421-1431 [Abstract] [Full Text]
Landais, E., Saulquin, X., Scotet, E., Trautmann, L., Peyrat, M.-A., Yates, J. L., Kwok, W. W., Bonneville, M., Houssaint, E. (2004). Direct killing of Epstein-Barr virus (EBV)-infected B cells by CD4 T cells directed against the EBV lytic protein BHRF1. Blood 103: 1408-1416 [Abstract] [Full Text]
Thompson, M. P., Kurzrock, R. (2004). Epstein-Barr Virus and Cancer. Clin. Cancer Res. 10: 803-821 [Abstract] [Full Text]
Edwards, R. H., Sitki-Green, D., Moore, D. T., Raab-Traub, N. (2004). Potential Selection of LMP1 Variants in Nasopharyngeal Carcinoma. J. Virol. 78: 868-881 [Abstract] [Full Text]
Bickham, K., Goodman, K., Paludan, C., Nikiforow, S., Tsang, M. L., Steinman, R. M., Munz, C. (2003). Dendritic Cells Initiate Immune Control of Epstein-Barr Virus Transformation of B Lymphocytes In Vitro. JEM 198: 1653-1663 [Abstract] [Full Text]
Nikiforow, S., Bottomly, K., Miller, G., Munz, C. (2003). Cytolytic CD4+-T-Cell Clones Reactive to EBNA1 Inhibit Epstein-Barr Virus-Induced B-Cell Proliferation. J. Virol. 77: 12088-12104 [Abstract] [Full Text]
Aljurf, M. D., Owaidah, T. W., Ezzat, A., Ibrahim, E., Tbakhi, A. (2003). Antigen- and/or immune-driven lymphoproliferative disorders. Ann Oncol 14: 1595-1606 [Full Text]
Amrolia, P. J., Muccioli-Casadei, G., Yvon, E., Huls, H., Sili, U., Wieder, E. D., Bollard, C., Michalek, J., Ghetie, V., Heslop, H. E., Molldrem, J. J., Rooney, C. M., Schlinder, J., Vitetta, E., Brenner, M. K. (2003). Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses. Blood 102: 2292-2299 [Abstract] [Full Text]
Alimonti, J. B., Ball, T. B., Fowke, K. R. (2003). Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS. J. Gen. Virol. 84: 1649-1661 [Abstract] [Full Text]
Duraiswamy, J., Burrows, J. M., Bharadwaj, M., Burrows, S. R., Cooper, L., Pimtanothai, N., Khanna, R. (2003). Ex Vivo Analysis of T-Cell Responses to Epstein-Barr Virus-Encoded Oncogene Latent Membrane Protein 1 Reveals Highly Conserved Epitope Sequences in Virus Isolates from Diverse Geographic Regions. J. Virol. 77: 7401-7410 [Abstract] [Full Text]
Marshall, N. A., Vickers, M. A., Barker, R. N. (2003). Regulatory T Cells Secreting IL-10 Dominate the Immune Response to EBV Latent Membrane Protein 1. J. Immunol. 170: 6183-6189 [Abstract] [Full Text]
Santodonato, L., D'Agostino, G., Nisini, R., Mariotti, S., Monque, D. M., Spada, M., Lattanzi, L., Paola Perrone, M., Andreotti, M., Belardelli, F., Ferrantini, M. (2003). Monocyte-Derived Dendritic Cells Generated After a Short-Term Culture with IFN-{alpha} and Granulocyte-Macrophage Colony-Stimulating Factor Stimulate a Potent Epstein-Barr Virus-Specific CD8+ T Cell Response. J. Immunol. 170: 5195-5202 [Abstract] [Full Text]
Gottschalk, S., Edwards, O. L., Sili, U., Huls, M. H., Goltsova, T., Davis, A. R., Heslop, H. E., Rooney, C. M. (2003). Generating CTLs against the subdominant Epstein-Barr virus LMP1 antigen for the adoptive immunotherapy of EBV-associated malignancies. Blood 101: 1905-1912 [Abstract] [Full Text]
Lautscham, G., Haigh, T., Mayrhofer, S., Taylor, G., Croom-Carter, D., Leese, A., Gadola, S., Cerundolo, V., Rickinson, A., Blake, N. (2003). Identification of a TAP-Independent, Immunoproteasome-Dependent CD8+ T-Cell Epitope in Epstein-Barr Virus Latent Membrane Protein 2. J. Virol. 77: 2757-2761 [Abstract] [Full Text]
Sitki-Green, D., Covington, M., Raab-Traub, N. (2003). Compartmentalization and Transmission of Multiple Epstein-Barr Virus Strains in Asymptomatic Carriers. J. Virol. 77: 1840-1847 [Abstract] [Full Text]
Charo, J., Sundback, M., Wasserman, K., Ciupitu, A.-M. T., Mirzai, B., van der Zee, R., Kiessling, R. (2002). Marked Enhancement of the Antigen-Specific Immune Response by Combining Plasmid DNA-Based Immunization with a Schiff Base-Forming Drug. Infect. Immun. 70: 6652-6657 [Abstract] [Full Text]
Lin, C.-L., Lo, W.-F., Lee, T.-H., Ren, Y., Hwang, S.-L., Cheng, Y.-F., Chen, C.-L., Chang, Y.-S., Lee, S. P., Rickinson, A. B., Tam, P. K. H. (2002). Immunization with Epstein-Barr Virus (EBV) Peptide-pulsed Dendritic Cells Induces Functional CD8+ T-Cell Immunity and May Lead to Tumor Regression in Patients with EBV-positive Nasopharyngeal Carcinoma. Cancer Res. 62: 6952-6958 [Abstract] [Full Text]
Sitki-Green, D., Edwards, R. H., Webster-Cyriaque, J., Raab-Traub, N. (2002). Identification of Epstein-Barr Virus Strain Variants in Hairy Leukoplakia and Peripheral Blood by Use of a Heteroduplex Tracking Assay. J. Virol. 76: 9645-9656 [Abstract] [Full Text]
Moosmann, A., Khan, N., Cobbold, M., Zentz, C., Delecluse, H.-J., Hollweck, G., Hislop, A. D., Blake, N. W., Croom-Carter, D., Wollenberg, B., Moss, P. A. H., Zeidler, R., Rickinson, A. B., Hammerschmidt, W. (2002). B cells immortalized by a mini-Epstein-Barr virus encoding a foreign antigen efficiently reactivate specific cytotoxic T cells. Blood 100: 1755-1764 [Abstract] [Full Text]
Paludan, C., Bickham, K., Nikiforow, S., Tsang, M. L., Goodman, K., Hanekom, W. A., Fonteneau, J.-F., Stevanovic, S., Munz, C. (2002). Epstein-Barr Nuclear Antigen 1-Specific CD4+ Th1 Cells Kill Burkitt's Lymphoma Cells. J. Immunol. 169: 1593-1603 [Abstract] [Full Text]
Tao, Q., Yang, J., Huang, H., Swinnen, L. J., Ambinder, R. F. (2002). Conservation of Epstein-Barr Virus Cytotoxic T-Cell Epitopes in Posttransplant Lymphomas : Implications for Immune Therapy. Am. J. Pathol. 160: 1839-1845 [Abstract] [Full Text]
Staege, M. S., Lee, S. P., Frisan, T., Mautner, J., Scholz, S., Pajic, A., Rickinson, A. B., Masucci, M. G., Polack, A., Bornkamm, G. W. (2002). MYC overexpression imposes a nonimmunogenic phenotype on Epstein-Barr virus-infected B cells. Proc. Natl. Acad. Sci. USA 99: 4550-4555 [Abstract] [Full Text]
Lautscham, G., Mayrhofer, S., Taylor, G., Haigh, T., Leese, A., Rickinson, A., Blake, N. (2001). Processing of a Multiple Membrane Spanning Epstein-Barr Virus Protein for Cd8+T Cell Recognition Reveals a Proteasome-Dependent, Transporter Associated with Antigen Processing-Independent Pathway. JEM 194: 1053-1068 [Abstract] [Full Text]
Leen, A., Meij, P., Redchenko, I., Middeldorp, J., Bloemena, E., Rickinson, A., Blake, N. (2001). Differential Immunogenicity of Epstein-Barr Virus Latent-Cycle Proteins for Human CD4+ T-Helper 1 Responses. J. Virol. 75: 8649-8659 [Abstract] [Full Text]
Jager, D, Jager, E, Knuth, A (2001). Immune responses to tumour antigens: implications for antigen specific immunotherapy of cancer. J. Clin. Pathol. 54: 669-674 [Abstract] [Full Text]
Chapman, A. L. N., Rickinson, A. B., Thomas, W. A., Jarrett, R. F., Crocker, J., Lee, S. P. (2001). Epstein-Barr Virus-specific Cytotoxic T Lymphocyte Responses in the Blood and Tumor Site of Hodgkin's Disease Patients: Implications for a T-cell-based Therapy. Cancer Res. 61: 6219-6226 [Abstract] [Full Text]
Trivedi, P., Spinsanti, P., Cuomo, L., Volpe, M., Takada, K., Frati, L., Faggioni, A. (2001). Differential Regulation of Epstein-Barr Virus (EBV) Latent Gene Expression in Burkitt Lymphoma Cells Infected with a Recombinant EBV Strain. J. Virol. 75: 4929-4935 [Abstract] [Full Text]
Gottschalk, S., Ng, C. Y. C., Perez, M., Smith, C. A., Sample, C., Brenner, M. K., Heslop, H. E., Rooney, C. M. (2001). An Epstein-Barr virus deletion mutant associated with fatal lymphoproliferative disease unresponsive to therapy with virus-specific CTLs. Blood 97: 835-843 [Abstract] [Full Text]
Subklewe, M., Paludan, C., Tsang, M. L., Mahnke, K., Steinman, R. M., Munz, C. (2001). Dendritic Cells Cross-Present Latency Gene Products from Epstein-Barr Virus-Transformed B Cells and Expand Tumor-Reactive Cd8+ Killer T Cells. JEM 193: 405-412 [Abstract] [Full Text]
Blake, N., Haigh, T., Shaka'a, G., Croom-Carter, D., Rickinson, A. (2000). The Importance of Exogenous Antigen in Priming the Human CD8+ T Cell Response: Lessons from the EBV Nuclear Antigen EBNA1. J. Immunol. 165: 7078-7087 [Abstract] [Full Text]
Annels, N. E., Callan, M. F. C., Tan, L., Rickinson, A. B. (2000). Changing Patterns of Dominant TCR Usage with Maturation of an EBV-Specific Cytotoxic T Cell Response. J. Immunol. 165: 4831-4841 [Abstract] [Full Text]
Sun, Q., Burton, R. L., Dai, L.-J., Britt, W. J., Lucas, K. G. (2000). B Lymphoblastoid Cell Lines as Efficient APC to Elicit CD8+ T Cell Responses Against a Cytomegalovirus Antigen. J. Immunol. 165: 4105-4111 [Abstract] [Full Text]
Steigerwald-Mullen, P., Kurilla, M. G., Braciale, T. J. (2000). Type 2 Cytokines Predominate in the Human CD4+ T-Lymphocyte Response to Epstein-Barr Virus Nuclear Antigen 1. J. Virol. 74: 6748-6759 [Abstract] [Full Text]
Lee, S. P., Chan, A. T. C., Cheung, S.-T., Thomas, W. A., CroomCarter, D., Dawson, C. W., Tsai, C.-H., Leung, S.-F., Johnson, P. J., Huang, D. P. (2000). CTL Control of EBV in Nasopharyngeal Carcinoma (NPC): EBV-Specific CTL Responses in the Blood and Tumors of NPC Patients and the Antigen-Processing Function of the Tumor Cells. J. Immunol. 165: 573-582 [Abstract] [Full Text]
Ibisch, C., Saulquin, X., Gallot, G., Vivien, R., Ferrand, C., Tiberghien, P., Houssaint, E., Vie, H. (2000). The T Cell Repertoire Selected In Vitro Against EBV: Diversity, Specificity, and Improved Purification Through Early IL-2 Receptor {alpha}-Chain (CD25)-Positive Selection. J. Immunol. 164: 4924-4932 [Abstract] [Full Text]
Blake, N. W., Moghaddam, A., Rao, P., Kaur, A., Glickman, R., Cho, Y.-g., Marchini, A., Haigh, T., Johnson, R. P., Rickinson, A. B., Wang, F. (1999). Inhibition of Antigen Presentation by the Glycine/Alanine Repeat Domain Is Not Conserved in Simian Homologues of Epstein-Barr Virus Nuclear Antigen 1. J. Virol. 73: 7381-7389 [Abstract] [Full Text]
Chu, P. G., Chang, K. L., Chen, W.-G., Chen, Y.-Y., Shibata, D., Hayashi, K., Bacchi, C., Bacchi, M., Weiss, L. M. (1999). Epstein-Barr Virus (EBV) Nuclear Antigen (EBNA)-4 Mutation in EBV-Associated Malignancies in Three Different Populations. Am. J. Pathol. 155: 941-947 [Abstract] [Full Text]
Subklewe, M., Chahroudi, A., Schmaljohn, A., Kurilla, M. G., Bhardwaj, N., Steinman, R. M. (1999). Induction of Epstein-Barr Virus-Specific Cytotoxic T-Lymphocyte Responses Using Dendritic Cells Pulsed With EBNA-3A Peptides or UV-Inactivated, Recombinant EBNA-3A Vaccinia Virus. Blood 94: 1372-1381 [Abstract] [Full Text]
Tao, Q., Swinnen, L. J., Yang, J., Srivastava, G., Robertson, K. D., Ambinder, R. F. (1999). Methylation Status of the Epstein-Barr Virus Major Latent Promoter C in Iatrogenic B Cell Lymphoproliferative Disease : Application of PCR-Based Analysis. Am. J. Pathol. 155: 619-625 [Abstract] [Full Text]
Khatri, V. P., Baiocchi, R. A., Peng, R., Oberkircher, A. R., Dolce, J. M., Ward, P. M., Herzig, G. P., Caligiuri, M. A. (1999). Endogenous CD8+ T Cell Expansion During Regression of Monoclonal EBV-Associated Posttransplant Lymphoproliferative Disorder. J. Immunol. 163: 500-506 [Abstract] [Full Text]
Chen, H., Smith, P., Ambinder, R. F., Hayward, S. D. (1999). Expression of Epstein-Barr Virus BamHI-A Rightward Transcripts in Latently Infected B Cells From Peripheral Blood. Blood 93: 3026-3032 [Abstract] [Full Text]
Ruf, I. K., Moghaddam, A., Wang, F., Sample, J. (1999). Mechanisms That Regulate Epstein-Barr Virus EBNA-1 Gene Transcription during Restricted Latency Are Conserved among Lymphocryptoviruses of Old World Primates. J. Virol. 73: 1980-1989 [Abstract] [Full Text]
Ruf, I. K., Rhyne, P. W., Yang, H., Borza, C. M., Hutt-Fletcher, L. M., Cleveland, J. L., Sample, J. T. (1999). Epstein-Barr Virus Regulates c-MYC, Apoptosis, and Tumorigenicity in Burkitt Lymphoma. Mol. Cell. Biol. 19: 1651-1660 [Abstract] [Full Text]
Tan, L. C., Gudgeon, N., Annels, N. E., Hansasuta, P., O'Callaghan, C. A., Rowland-Jones, S., McMichael, A. J., Rickinson, A. B., Callan, M. F. C. (1999). A Re-Evaluation of the Frequency of CD8+ T Cells Specific for EBV in Healthy Virus Carriers. J. Immunol. 162: 1827-1835 [Abstract] [Full Text]
Redchenko, I. V., Rickinson, A. B. (1999). Accessing Epstein-Barr Virus-Specific T-Cell Memory with Peptide-Loaded Dendritic Cells. J. Virol. 73: 334-342 [Abstract] [Full Text]
Kalams, S. A., Walker, B. D. (1998). The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses. JEM 188: 2199-2204 [Full Text]
Brooks, J. M., Colbert, R. A., Mear, J. P., Leese, A. M., Rickinson, A. B. (1998). HLA-B27 Subtype Polymorphism and CTL Epitope Choice: Studies with EBV Peptides Link Immunogenicity with Stability of the B27:Peptide Complex. J. Immunol. 161: 5252-5259 [Abstract] [Full Text]
Murray, P. G., Constandinou, C. M., Crocker, J., Young, L. S., Ambinder, R. F. (1998). Analysis of Major Histocompatibility Complex Class I, TAP Expression, and LMP2 Epitope Sequence in Epstein-Barr Virus-Positive Hodgkin's Disease. Blood 92: 2477-2483 [Abstract] [Full Text]
Lee, S. P., Constandinou, C. M., Thomas, W. A., Croom-Carter, D., Blake, N. W., Murray, P. G., Crocker, J., Rickinson, A. B. (1998). Antigen Presenting Phenotype of Hodgkin Reed-Sternberg Cells: Analysis of the HLA Class I Processing Pathway and the Effects of Interleukin-10 on Epstein-Barr Virus-Specific Cytotoxic T-Cell Recognition. Blood 92: 1020-1030 [Abstract] [Full Text]
Lucas, K. G., Burton, R. L., Zimmerman, S. E., Wang, J., Cornetta, K. G., Robertson, K. A., Lee, C. H., Emanuel, D. J. (1998). Semiquantitative Epstein-Barr Virus (EBV) Polymerase Chain Reaction for the Determination of Patients at Risk for EBV-Induced Lymphoproliferative Disease After Stem Cell Transplantation. Blood 91: 3654-3661 [Abstract] [Full Text]
Callan, M.F.C., Tan, L., Annels, N., Ogg, G.S., Wilson, J.D.K., O'Callaghan, C.A., Steven, N., McMichael, A.J., Rickinson, A.B. (1998). Direct Visualization of Antigen-specific CD8+T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo. JEM 187: 1395-1402 [Abstract] [Full Text]
Roskrow, M. A., Suzuki, N., Gan, Y.-j., Sixbey, J. W., Ng, C. Y.C., Kimbrough, S., Hudson, M., Brenner, M. K., Heslop, H. E., Rooney, C. M. (1998). Epstein-Barr Virus (EBV)-Specific Cytotoxic T Lymphocytes for the Treatment of Patients With EBV-Positive Relapsed Hodgkin's Disease. Blood 91: 2925-2934 [Abstract] [Full Text]
Kieff, E. (1998). Current Perspectives on the Molecular Pathogenesis of Virus-Induced Cancers in Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome. J Natl Cancer Inst Monogr 1998: 7-14 [Abstract] [Full Text]
Lukacher, A. E., Wilson, C. S. (1998). Resistance to Polyoma Virus-Induced Tumors Correlates with CTL Recognition of an Immunodominant H-2Dk-Restricted Epitope in the Middle T Protein. J. Immunol. 160: 1724-1734 [Abstract] [Full Text]
Mukherjee, S., Trivedi, P., Dorfman, D. M., Klein, G., Townsend, A. (1998). Murine Cytotoxic T Lymphocytes Recognize an Epitope in an EBNA-1 Fragment, but Fail to Lyse EBNA-1-expressing Mouse Cells. JEM 187: 445-450 [Abstract] [Full Text]
Robertson, K. D., Ambinder, R. F. (1997). Methylation of the Epstein-Barr Virus Genome in Normal Lymphocytes. Blood 90: 4480-4484 [Abstract] [Full Text]
Levitskaya, J., Sharipo, A., Leonchiks, A., Ciechanover, A., Masucci, M. G. (1997). Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen�1. Proc. Natl. Acad. Sci. USA 94: 12616-12621 [Abstract] [Full Text]
Niedobitek, G., Kremmer, E., Herbst, H., Whitehead, L., Dawson, C.W., Niedobitek, E., von Ostau, C., Rooney, N., Grasser, F.A., Young, L.S. (1997). Immunohistochemical Detection of the Epstein-Barr Virus-Encoded Latent Membrane Protein 2A in Hodgkin's Disease and Infectious Mononucleosis. Blood 90: 1664-1672 [Abstract] [Full Text]
Cardoso, A. A., Seamon, M. J., Afonso, H. M., Ghia, P., Boussiotis, V. A., Freeman, G. J., Gribben, J. G., Sallan, S. E., Nadler, L. M. (1997). Ex Vivo Generation of Human Anti-Pre-B Leukemia-Specific Autologous Cytolytic T Cells. Blood 90: 549-561 [Abstract] [Full Text]
Paul, C., Tourneau, A. L., Cayuela, J. M., Devidas, A., Robert, C., Molinie, V., Dubertret, L. (1997). Epstein-Barr Virus-Associated Lymphoproliferative Disease During Methotrexate Therapy for Psoriasis. Arch Dermatol 133: 867-871 [Abstract]
Steven, N.M., Annels, N.E., Kumar, A., Leese, A.M., Kurilla, M.G., Rickinson, A.B. (1997). Immediate Early and Early Lytic Cycle Proteins Are Frequent Targets of the Epstein-Barr Virus-induced Cytotoxic T Cell Response. JEM 185: 1605-1618 [Abstract] [Full Text]
Sing, A. P., Ambinder, R. F., Hong, D. J., Jensen, M., Batten, W., Petersdorf, E., Greenberg, P. D. (1997). Isolation of Epstein-Barr Virus (EBV)-Specific Cytotoxic T Lymphocytes That Lyse Reed-Sternberg Cells: Implications for Immune-Mediated Therapy of EBV+ Hodgkin's Disease. Blood 89: 1978-1986 [Abstract] [Full Text]
Prang, N. S., Hornef, M. W., Jager, M., Wagner, H. J., Wolf, H., Schwarzmann, F. M. (1997). Lytic Replication of Epstein-Barr Virus in the Peripheral Blood: Analysis of Viral Gene Expression in B Lymphocytes During Infectious Mononucleosis and in the Normal Carrier State. Blood 89: 1665-1677 [Abstract] [Full Text]
DiMaio, J. M., Van Trigt, P., Gaynor, J. W., Davis, R. D., Coveney, E., Clary, B. M., Lyerly, H. K. (1995). Generation of Tumor-Specific T Lymphocytes for the Treatment of Posttransplant Lymphoma. Circulation 92: 202-205 [Abstract] [Full Text]
Papadopoulos, E. B., Ladanyi, M., Emanuel, D., Mackinnon, S., Boulad, F., Carabasi, M. H., Castro-Malaspina, H., Childs, B. H., Gillio, A. P., Small, T. N., Young, J. W., Kernan, N. A., O'Reilly, R. J. (1994). Infusions of Donor Leukocytes to Treat Epstein-Barr Virus-Associated Lymphoproliferative Disorders after Allogeneic Bone Marrow Transplantation. NEJM 330: 1185-1191 [Abstract] [Full Text]
de Campos-Lima, P., Gavioli, R, Zhang, Q., Wallace, L., Dolcetti, R, Rowe, M, Rickinson, A., Masucci, M. (1993). HLA-A11 epitope loss isolates of Epstein-Barr virus from a highly A11+ population. Science 260: 98-100 [Abstract]
Staege, M. S., Lee, S. P., Frisan, T., Mautner, J., Scholz, S., Pajic, A., Rickinson, A. B., Masucci, M. G., Polack, A., Bornkamm, G. W. (2002). MYC overexpression imposes a nonimmunogenic phenotype on Epstein-Barr virus-infected B cells. Proc. Natl. Acad. Sci. USA 99: 4550-4555 [Abstract] [Full Text]
Hislop, A. D., Annels, N. E., Gudgeon, N. H., Leese, A. M., Rickinson, A. B. (2002). Epitope-specific Evolution of Human CD8+ T Cell Responses from Primary to Persistent Phases of Epstein-Barr Virus Infection. JEM 195: 893-905 [Abstract] [Full Text]