A variable number of tandem repeats locus within the human complement C2 gene is associated with a retroposon derived from a human endogenous retrovirus

doi:10.1084/jem.175.6.1783

This Article

	Full Text (PDF, 511K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Zhu, Z. B.
	Articles by Volanakis, J. E.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Zhu, Z. B.
	Articles by Volanakis, J. E.


Social Bookmarking

	What's this?

ARTICLES

A variable number of tandem repeats locus within the human complement C2 gene is associated with a retroposon derived from a human endogenous retrovirus

ZB Zhu, SL Hsieh, DR Bentley, RD Campbell and JE Volanakis
Department of Medicine, University of Alabama, Birmingham 35294.

We have previously described multiallelic restriction fragment length polymorphisms of the C2 gene, suggesting the presence of a variable number of tandem repeats (VNTR) locus. We report here the cloning and sequencing of the polymorphic fragments from the two most common alleles of the gene, a and b. The results confirm the presence of a VNTR locus consisting of a nucleotide sequence, 41 bp in average length, repeated tandemly 23 and 17 times in alleles a and b, respectively. The difference in the number of repeats between the two alleles is due to the deletion/insertion of two noncontiguous segments, 143 and 118 bp long, of allele a, and of a 40-bp segment of allele b. The VNTR region is associated with a SINE (short interspersed sequence)- type retroposon, SINE-R.C2, located within the third intron of the C2 gene. SINE-R.C2 is a member of a previously described large retroposon family of the human genome, apparently derived from the human endogenous retrovirus, (HERV) K10, which is homologous to the mouse mammary tumor virus.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Sebastiani, G. D., Galeazzi, M. (2009). Infection--genetics relationship in systemic lupus erythematosus. Lupus 18: 1169-1175 [Abstract]
Damert, A., Lower, J., Lower, R. (2004). Leptin Receptor Isoform 219.1: An Example of Protein Evolution by LINE-1-Mediated Human-Specific Retrotransposition of a Coding SVA Element. Mol Biol Evol 21: 647-651 [Abstract] [Full Text]
Anway, M. D., Johnston, D. S., Crawford, D., Griswold, M. D. (2001). Identification of a Novel Retrovirus Expressed in Rat Sertoli Cells and Granulosa Cells. Biol. Reprod. 65: 1289-1296 [Abstract] [Full Text]
Casau, A. E., Vaughan, J. E., Lozano, G., Levine, A. J. (1999). Germ Cell Expression of an Isolated Human Endogenous Retroviral Long Terminal Repeat of the HERV-K/HTDV Family in Transgenic Mice. J. Virol. 73: 9976-9983 [Abstract] [Full Text]
PERL, A. (1999). Mechanisms of viral pathogenesis in rheumatic disease. Ann Rheum Dis 58: 454-461 [Full Text]
Strichman-Almashanu, L. Z., Lee, R. S., Onyango, P. O., Perlman, E., Flam, F., Frieman, M. B., Feinberg, A. P. (2002). A Genome-Wide Screen for Normally Methylated Human CpG Islands That Can Identify Novel Imprinted Genes. Genome Res 12: 543-554 [Abstract] [Full Text]