Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor

doi:10.1084/jem.175.5.1413

This Article

	Full Text (PDF, 680K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Johnson, R. J.
	Articles by Ross, R.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Johnson, R. J.
	Articles by Ross, R.


Social Bookmarking

	What's this?

ARTICLES

Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor

RJ Johnson, EW Raines, J Floege, A Yoshimura, P Pritzl, C Alpers and R Ross
Department of Medicine, University of Washington Medical Center, Seattle 98195.

Platelet-derived growth factor (PDGF), a potent mitogen for mesenchymal cells in culture, is expressed in vivo in a variety of inflammatory conditions associated with cell proliferation, including atherosclerosis, wound repair, pulmonary fibrosis, and glomerulonephritis. However, it is not known if PDGF mediates the fibroproliferative responses that characterize these inflammatory disorders. We administered neutralizing anti-PDGF IgG or control IgG to rats with mesangial proliferative nephritis. Inhibition of PDGF resulted in a significant reduction in mesangial cell proliferation, and largely prevented the increased deposition of extracellular matrix associated with the disease. This suggests that PDGF may have a central role in proliferative glomerular disease.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Ishizawa, K., Izawa-Ishizawa, Y., Dorjsuren, N., Miki, E., Kihira, Y., Ikeda, Y., Hamano, S., Kawazoe, K., Minakuchi, K., Tomita, S., Tsuchiya, K., Tamaki, T. (2009). Angiotensin II receptor blocker attenuates PDGF-induced mesangial cell migration in a receptor-independent manner. Nephrol Dial Transplant 0: gfp520v2-gfp520 [Abstract] [Full Text]
Venkatesan, B., Ghosh-Choudhury, N., Das, F., Mahimainathan, L., Kamat, A., Kasinath, B. S., Abboud, H. E., Choudhury, G. G. (2008). Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B. FASEB J. 22: 3469-3482 [Abstract] [Full Text]
Leipner, C., Grun, K., Muller, A., Buchdunger, E., Borsi, L., Kosmehl, H., Berndt, A., Janik, T., Uecker, A., Kiehntopf, M., Bohmer, F.-D. (2008). Imatinib mesylate attenuates fibrosis in coxsackievirus b3-induced chronic myocarditis. Cardiovasc Res 79: 118-126 [Abstract] [Full Text]
Weber, M. L., Farooqui, M., Nguyen, J., Ansonoff, M., Pintar, J. E., Hebbel, R. P., Gupta, K. (2008). Morphine induces mesangial cell proliferation and glomerulopathy via {kappa}-opioid receptors. Am. J. Physiol. Renal Physiol. 294: F1388-F1397 [Abstract] [Full Text]
Andrae, J., Gallini, R., Betsholtz, C. (2008). Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 22: 1276-1312 [Abstract] [Full Text]
Floege, J., Eitner, F., Alpers, C. E. (2008). A New Look at Platelet-Derived Growth Factor in Renal Disease. J. Am. Soc. Nephrol. 19: 12-23 [Abstract] [Full Text]
Alvarez, R. H., Kantarjian, H. M., Cortes, J. E. (2006). Biology of Platelet-Derived Growth Factor and Its Involvement in Disease. Mayo Clin Proc. 81: 1241-1257 [Abstract] [Full Text]
Rodgers, K., McMahon, B., Mitchell, D., Sadlier, D., Godson, C. (2005). Lipoxin A4 Modifies Platelet-Derived Growth Factor-Induced Profibrotic Gene Expression in Human Renal Mesangial Cells. Am. J. Pathol. 167: 683-694 [Abstract] [Full Text]
Beck, K.-F., Guder, G., Schaefer, L., Pleskova, M., Babelova, A., Behrens, M. H., Mihalik, D., Beck, M., Schaefer, R. M., Pfeilschifter, J. (2005). Nitric Oxide Upregulates Induction of PDGF Receptor-{alpha} Expression in Rat Renal Mesangial Cells and in Anti-Thy-1 Glomerulonephritis. J. Am. Soc. Nephrol. 16: 1948-1957 [Abstract] [Full Text]
Zhang, A., Ding, G., Huang, S., Wu, Y., Pan, X., Guan, X., Chen, R., Yang, T. (2005). c-Jun NH2-terminal kinase mediation of angiotensin II-induced proliferation of human mesangial cells. Am. J. Physiol. Renal Physiol. 288: F1118-F1124 [Abstract] [Full Text]
Wu, D., Chen, X., Guo, D., Hong, Q., Fu, B., Ding, R., Yu, L., Hou, K., Feng, Z., Zhang, X., Wang, J. (2005). Knockdown of Fibronectin Induces Mitochondria-Dependent Apoptosis in Rat Mesangial Cells. J. Am. Soc. Nephrol. 16: 646-657 [Abstract] [Full Text]
Takahashi, T., Abe, H., Arai, H., Matsubara, T., Nagai, K., Matsuura, M., Iehara, N., Yokode, M., Nishikawa, S., Kita, T., Doi, T. (2005). Activation of STAT3/Smad1 Is a Key Signaling Pathway for Progression to Glomerulosclerosis in Experimental Glomerulonephritis. J. Biol. Chem. 280: 7100-7106 [Abstract] [Full Text]
Mahimainathan, L., Choudhury, G. G. (2004). Inactivation of Platelet-derived Growth Factor Receptor by the Tumor Suppressor PTEN Provides a Novel Mechanism of Action of the Phosphatase. J. Biol. Chem. 279: 15258-15268 [Abstract] [Full Text]
Mitchell, D., Rodgers, K., Hanly, J., McMahon, B., Brady, H. R., Martin, F., Godson, C. (2004). Lipoxins Inhibit Akt/PKB Activation and Cell Cycle Progression in Human Mesangial Cells. Am. J. Pathol. 164: 937-946 [Abstract] [Full Text]
Hashimoto, N., Maeshima, Y., Satoh, M., Odawara, M., Sugiyama, H., Kashihara, N., Matsubara, H., Yamasaki, Y., Makino, H. (2004). Overexpression of angiotensin type 2 receptor ameliorates glomerular injury in a mouse remnant kidney model. Am. J. Physiol. Renal Physiol. 286: F516-F525 [Abstract] [Full Text]
Lin, S.-L., Chen, R.-H., Chen, Y.-M., Chiang, W.-C., Tsai, T.-J., Hsieh, B.-S. (2003). Pentoxifylline Inhibits Platelet-Derived Growth Factor-Stimulated Cyclin D1 Expression in Mesangial Cells by Blocking Akt Membrane Translocation. Mol. Pharmacol. 64: 811-822 [Abstract] [Full Text]
Rossert, J., Fouqueray, B., Boffa, J. J. (2003). Anemia Management and the Delay of Chronic Renal Failure Progression. J. Am. Soc. Nephrol. 14: S173-177 [Abstract] [Full Text]
Bessho, K., Mizuno, S., Matsumoto, K., Nakamura, T. (2003). Counteractive effects of HGF on PDGF-induced mesangial cell proliferation in a rat model of glomerulonephritis. Am. J. Physiol. Renal Physiol. 284: F1171-F1180 [Abstract] [Full Text]
Ikezumi, Y., Atkins, R. C., Nikolic-Paterson, D. J. (2003). Interferon-{gamma} Augments Acute Macrophage-Mediated Renal Injury Via a Glucocorticoid-Sensitive Mechanism. J. Am. Soc. Nephrol. 14: 888-898 [Abstract] [Full Text]
Kalechman, Y., Sredni, B., Weinstein, T., Freidkin, I., Tobar, A., Albeck, M., Gafter, U. (2003). Production of the Novel Mesangial Autocrine Growth Factors GDNF and IL-10 Is Regulated by the Immunomodulator AS101. J. Am. Soc. Nephrol. 14: 620-630 [Abstract] [Full Text]
Lopez-Franco, O., Suzuki, Y., Sanjuan, G., Blanco, J., Hernandez-Vargas, P., Yo, Y., Kopp, J., Egido, J., Gomez-Guerrero, C. (2002). Nuclear Factor-{kappa}B Inhibitors as Potential Novel Anti-Inflammatory Agents for the Treatment of Immune Glomerulonephritis. Am. J. Pathol. 161: 1497-1505 [Abstract] [Full Text]
Ostendorf, T., Kunter, U., van Roeyen, C., Dooley, S., Janjic, N., Ruckman, J., Eitner, F., Floege, J. (2002). The Effects of Platelet-Derived Growth Factor Antagonism in Experimental Glomerulonephritis Are Independent of the Transforming Growth Factor-{beta} System. J. Am. Soc. Nephrol. 13: 658-667 [Abstract] [Full Text]
Tsiani, E., Lekas, P., Fantus, I. G., Dlugosz, J., Whiteside, C. (2002). High glucose-enhanced activation of mesangial cell p38 MAPK by ET-1, ANG II, and platelet-derived growth factor. Am. J. Physiol. Endocrinol. Metab. 282: E161-E169 [Abstract] [Full Text]
Yanagita, M., Arai, H., Nakano, T., Ohashi, K., Mizuno, K., Fukatsu, A., Doi, T., Kita, T. (2001). Gas6 Induces Mesangial Cell Proliferation via Latent Transcription Factor STAT3. J. Biol. Chem. 276: 42364-42369 [Abstract] [Full Text]
Yu, J.-C., Lokker, N. A., Hollenbach, S., Apatira, M., Li, J., Betz, A., Sedlock, D., Oda, S., Nomoto, Y., Matsuno, K., Ide, S.-i., Tsukuda, E., Giese, N. A. (2001). Efficacy of the Novel Selective Platelet-Derived Growth Factor Receptor Antagonist CT52923 on Cellular Proliferation, Migration, and Suppression of Neointima following Vascular Injury. J. Pharmacol. Exp. Ther. 298: 1172-1178 [Abstract] [Full Text]
Pillebout, E., Burtin, M., Yuan, H. T., Briand, P., Woolf, A. S., Friedlander, G., Terzi, F. (2001). Proliferation and Remodeling of the Peritubular Microcirculation after Nephron Reduction : Association with the Progression of Renal Lesions. Am. J. Pathol. 159: 547-560 [Abstract] [Full Text]
Zhang, Z., Nagata, I., Kikuchi, H., Xue, J-H., Sakai, N., Sakai, H., Yanamoto, H. (2001). Broad-Spectrum and Selective Serine Protease Inhibitors Prevent Expression of Platelet-Derived Growth Factor-BB and Cerebral Vasospasm After Subarachnoid Hemorrhage : Vasospasm Caused by Cisternal Injection of Recombinant Platelet-Derived Growth Factor-BB. Stroke 32: 1665-1672 [Abstract] [Full Text]
Blom, I. E., van Dijk, A. J., Wieten, L., Duran, K., Ito, Y., Kleij, L., deNichilo, M., Rabelink, T. J., Weening, J. J., Aten, J., Goldschmeding, R. (2001). In vitro evidence for differential involvement of CTGF, TGF{beta}, and PDGF-BB in mesangial response to injury. Nephrol Dial Transplant 16: 1139-1148 [Abstract] [Full Text]
OSTENDORF, T., KUNTER, U., GRÖNE, H. J., BAHLMANN, F., KAWACHI, H., SHIMIZU, F., KOCH, K. M., JANJIC, N., FLOEGE, J. (2001). Specific Antagonism of PDGF Prevents Renal Scarring in Experimental Glomerulonephritis. J. Am. Soc. Nephrol. 12: 909-918 [Abstract] [Full Text]
Sodhi, C. P., Phadke, S. A., Batlle, D., Sahai, A. (2001). Hypoxia and high glucose cause exaggerated mesangial cell growth and collagen synthesis: role of osteopontin. Am. J. Physiol. Renal Physiol. 280: F667-F674 [Abstract] [Full Text]
ITO, Y., GOLDSCHMEDING, R., BENDE, R. J., CLAESSEN, N., CHAND, M. A., KLEIJ, L., RABELINK, T. J., WEENING, J. J., ATEN, J. (2001). Kinetics of Connective Tissue Growth Factor Expression during Experimental Proliferative Glomerulonephritis. J. Am. Soc. Nephrol. 12: 472-484 [Abstract] [Full Text]
Tallquist, M. D., Klinghoffer, R. A., Heuchel, R., Mueting-Nelsen, P. F., Corrin, P. D., Heldin, C.-H., Johnson, R. J., Soriano, P. (2000). Retention of PDGFR-{beta} function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase C{gamma} signaling pathways. Genes Dev. 14: 3179-3190 [Abstract] [Full Text]
LANG, S., HARTNER, A., STERZEL, R. B., SCHÖCKLMANN, H. O. (2000). Requirement of Cyclin D1 in Mesangial Cell Mitogenesis. J. Am. Soc. Nephrol. 11: 1398-1408 [Abstract] [Full Text]
Yamabe, H., Osawa, H., Kaizuka, M., Tsunoda, S., Shirato, K.-i., Tateyama, F., Okumura, K. (2000). Platelet-derived growth factor, basic fibroblast growth factor, and interferon {gamma} increase type IV collagen production in human fetal mesangial cells via a transforming growth factor-{beta}-dependent mechanism. Nephrol Dial Transplant 15: 872-876 [Abstract] [Full Text]
TAMURA, M., TANAKA, H., YASHIRO, A., OSAJIMA, A., OKAZAKI, M., KUDO, H., DOI, Y., FUJIMOTO, S., HIGASHI, K., NAKASHIMA, Y., HIRANO, H. (2000). Expression of Profilin, an Actin-Binding Protein, in Rat Experimental Glomerulonephritis and Its Upregulation by Basic Fibroblast Growth Factor in Cultured Rat Mesangial Cells. J. Am. Soc. Nephrol. 11: 423-433 [Abstract] [Full Text]
Francki, A., Bradshaw, A. D., Bassuk, J. A., Howe, C. C., Couser, W. G., Sage, E. H. (1999). SPARC Regulates the Expression of Collagen Type I and Transforming Growth Factor-beta 1 in Mesangial Cells. J. Biol. Chem. 274: 32145-32152 [Abstract] [Full Text]
Nakagawa, T., Sasahara, M., Haneda, M., Kataoka, H., Nakagawa, H., Yagi, M., Kikkawa, R., Hazama, F. (1999). Role of PDGF B-Chain and PDGF Receptors in Rat Tubular Regeneration after Acute Injury. Am. J. Pathol. 155: 1689-1699 [Abstract] [Full Text]
Sandau, K. B., Callsen, D., Brüne, B. (1999). Protection against Nitric Oxide-Induced Apoptosis in Rat Mesangial Cells Demands Mitogen-Activated Protein Kinases and Reduced Glutathione. Mol. Pharmacol. 56: 744-751 [Abstract] [Full Text]
Heldin, C.-H., Westermark, B. (1999). Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor. Physiol. Rev. 79: 1283-1316 [Abstract] [Full Text]
Mooney, A., Jackson, K., Bacon, R., Streuli, C., Edwards, G., Bassuk, J., Savill, J. (1999). Type IV Collagen and Laminin Regulate Glomerular Mesangial Cell Susceptibility to Apoptosis Via {beta}1 Integrin-Mediated Survival Signals. Am. J. Pathol. 155: 599-606 [Abstract] [Full Text]
Sawada, M., Yanamoto, H., Nagata, I., Hashimoto, N., Nakahara, I., Akiyama, Y., Kikuchi, H., Macdonald, R. L. (1999). Prevention of Neointimal Formation by a Serine Protease Inhibitor, FUT-175, After Carotid Balloon Injury in Rats � Editorial Comment. Stroke 30: 644-650 [Abstract] [Full Text]
Floege, J., Ostendorf, T., Janssen, U., Burg, M., Radeke, H. H., Vargeese, C., Gill, S. C., Green, L. S., Janjic, N. (1999). Novel Approach to Specific Growth Factor Inhibition in Vivo : Antagonism of Platelet-Derived Growth Factor inGlomerulonephritis by Aptamers. Am. J. Pathol. 154: 169-179 [Abstract] [Full Text]
Wright, M. B., Hugo, C., Seifert, R., Disteche, C. M., Bowen-Pope, D. F. (1998). Proliferating and Migrating Mesangial Cells Responding to Injury Express a Novel Receptor Protein-tyrosine Phosphatase in Experimental Mesangial Proliferative Glomerulonephritis. J. Biol. Chem. 273: 23929-23937 [Abstract] [Full Text]
Saleem, S., Dai, Z., Coelho, S. N., Konieczny, B. T., Assmann, K. J. M., Baddoura, F. K., Lakkis, F. G. (1998). IL-4 Is an Endogenous Inhibitor of Neutrophil Influx and Subsequent Pathology in Acute Antibody-Mediated Inflammation. J. Immunol. 160: 979-984 [Abstract] [Full Text]
Lokker, N. A., O'Hare, J. P., Barsoumian, A., Tomlinson, J. E., Ramakrishnan, V., Fretto, L. J., Giese, N. A. (1997). Functional Importance of Platelet-derived Growth Factor (PDGF) Receptor Extracellular Immunoglobulin-like Domains. IDENTIFICATION OF PDGF BINDING SITE AND NEUTRALIZING MONOCLONAL ANTIBODIES. J. Biol. Chem. 272: 33037-33044 [Abstract] [Full Text]
Choudhury, G. G., Karamitsos, C., Hernandez, J., Gentilini, A., Bardgette, J., Abboud, H. E. (1997). PI-3-kinase and MAPK regulate mesangial cell proliferation and migration in response to PDGF. Am. J. Physiol. Renal Physiol. 273: F931-F938 [Abstract] [Full Text]
LASKY, J.�A., TONTHAT, B., LIU, J.-Y., FRIEDMAN, M., BRODY, A.�R. (1997). Upregulation of the PDGF-alpha Receptor Precedes Asbestos-induced Lung Fibrosis in Rats. Am. J. Respir. Crit. Care Med. 157: 1652-1657 [Abstract] [Full Text]
Choudhury, G. G. (2001). Akt Serine Threonine Kinase Regulates Platelet-derived Growth Factor-induced DNA Synthesis in Glomerular Mesangial Cells. REGULATION OF c-fos AND p27kip1 GENE EXPRESSION. J. Biol. Chem. 276: 35636-35643 [Abstract] [Full Text]