A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31)

doi:10.1084/jem.175.5.1401

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A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31)

WA Muller, ME Berman, PJ Newman, HM DeLisser and SM Albelda
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, New York 10021.

The molecular nature of cell adhesion mediated by platelet/endothelial cell adhesion molecule 1 (PECAM-1; CD31) was examined using stably transfected L cells in a PECAM-dependent aggregation assay. This adhesion was temperature sensitive and divalent cation dependent, with Mg2+ supporting aggregation to a greater degree than Ca2+. PECAM- dependent aggregation was heterophilic: PECAM-1 transfectants bound as readily to control-transfected L cells as to other PECAM-1 transfectants, demonstrating that a molecule endogenously expressed on the L cells serves as the ligand for PECAM in this system and presumably substitutes for the natural human ligand.
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