Induction of IgG3 secretion by interferon gamma: a model for T cell- independent class switching in response to T cell-independent type 2 antigens

doi:10.1084/jem.175.5.1367

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Induction of IgG3 secretion by interferon gamma: a model for T cell- independent class switching in response to T cell-independent type 2 antigens

CM Snapper, TM McIntyre, R Mandler, LM Pecanha, FD Finkelman, A Lees and JJ Mond
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.

T cell-independent type 2 (TI-2), in contrast to T-dependent, antigens stimulate the production of murine IgG3. To investigate a possible role for cytokines in mediating the induction of this IgG subclass, we established an in vitro polyclonal model system for studying TI-2 antigen-mediated B cell activation by using dextran-conjugated anti-IgD antibody (alpha delta-dex). We demonstrate that interferon gamma (IFN- gamma) stimulates, and interleukin 4 inhibits, the expression of IgG3 by alpha delta-dexactivated cells. The production of IFN-gamma by non-T cells in response to bacterial products, possibly capsular polysaccharides, may provide an explanation underlying the ability of TI antigens, which are unable to directly stimulate T cell-derived cytokines to induce Ig isotype switching.
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