Human immunodeficiency virus (HIV) Tat-reactive antibodies present in normal HIV-negative sera and depleted in HIV-positive sera. Identification of the epitope

doi:10.1084/jem.175.5.1247

This Article

	Full Text (PDF, 820K)
	Alert me when this article is cited

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Rodman, T. C.
	Articles by Winston, R.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Rodman, T. C.
	Articles by Winston, R.


Social Bookmarking

	What's this?

ARTICLES

Human immunodeficiency virus (HIV) Tat-reactive antibodies present in normal HIV-negative sera and depleted in HIV-positive sera. Identification of the epitope

TC Rodman, FH Pruslin, SE To and R Winston
Laboratory of Cell Biology, Rockefeller University, New York, New York 10021.

We have detected, in sera of normal human immunodeficiency virus (HIV)- free subjects, IgM antibodies reactive with the Tat protein of HIV in significant titers and at very high frequency, and, in HIV-positive sera, progressively lower titers as HIV pathogenesis ensues. Epitope analysis indicates that the Tat-reactive antibodies of both HIV- negative and HIV-positive sera are homologous, suggesting, therefore, that their decline in HIV-positive sera may represent attrition of a host defense factor. The identified epitope displays minimal homology with that previously defined for another set of IgM antibodies shown to be present in normal sera, deficient in HIV-positive sera, and postulated to be natural antibodies. We propose that the Tat-reactive antibodies, as well, are a set of natural antibodies and that the normal humoral immune system includes a repertoire of antibodies, nonimmunogenic in origin, that contribute to immune homeostasis and, consequently, to host resistance to HIV pathogenesis.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Lobo, P. I., Schlegel, K. H., Yuan, W., Townsend, G. C., White, J. A. (2008). Inhibition of HIV-1 Infectivity through an Innate Mechanism Involving Naturally Occurring IgM Anti-Leukocyte Autoantibodies. J. Immunol. 180: 1769-1779 [Abstract] [Full Text]
Caselli, E., Boni, M., Bracci, A., Rotola, A., Cermelli, C., Castellazzi, M., Di Luca, D., Cassai, E. (2002). Detection of Antibodies Directed against Human Herpesvirus 6 U94/REP in Sera of Patients Affected by Multiple Sclerosis. J. Clin. Microbiol. 40: 4131-4137 [Abstract] [Full Text]
Cohen, S. S., Li, C., Ding, L., Cao, Y., Pardee, A. B., Shevach, E. M., Cohen, D. I. (1999). Pronounced acute immunosuppression in vivo mediated by HIV Tat challenge. Proc. Natl. Acad. Sci. USA 96: 10842-10847 [Abstract] [Full Text]
Caselli, E., Betti, M., Grossi, M. P., Balboni, P. G., Rossi, C., Boarini, C., Cafaro, A., Barbanti-Brodano, G., Ensoli, B., Caputo, A. (1999). DNA Immunization with HIV-1 tat Mutated in the trans Activation Domain Induces Humoral and Cellular Immune Responses Against Wild-Type Tat. J. Immunol. 162: 5631-5638 [Abstract] [Full Text]