Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion

doi:10.1084/jem.175.2.577

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Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion

Y Shimizu, GA van Seventer, E Ennis, W Newman, KJ Horgan and S Shaw
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109.

Regulated adhesion enables T cells to migrate through tissue and transiently interact with an endless succession of cells. Monoclonal antibody (mAb) engagement of the CD3/T cell receptor (TCR) complex results in a rapid and transient augmentation of the adhesion function of LFA-1 and VLA integrin molecules on human T cells. We show in this study that mAb crosslinking of the T cell-specific accessory molecules CD7 and CD28, or treatment with the Ca2+ ionophore A23187, results in the rapid induction of integrin-mediated adhesion to three distinct ligands: the extracellular matrix protein fibronectin, and the cell surface molecules ICAM-1 and VCAM-1. Like CD3 crosslinking, increased adhesion via CD7 and CD28 crosslinking appears to involve both protein kinase C (PKC) and cAMP-dependent protein kinases. In contrast, A23187 induction of adhesion is unaffected by PKC inhibitors. CD7 is preferentially expressed on naive T cells and is unique in being a potent inducer of naive T cell adhesion. Enhanced expression/function of adhesion-inducing molecules thus overcomes relative deficits in adhesion receptor expression.
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Crucian, B., Nelman-Gonzalez, M., Sams, C. (2006). Rapid Flow Cytometry Method for Quantitation of LFA-1-Adhesive T Cells.. CVI 13: 403-408 [Abstract] [Full Text]
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Greening, J. E., Tree, T. I.M., Kotowicz, K. T., van Halteren, A. G., Roep, B. O., Klein, N. J., Peakman, M. (2003). Processing and Presentation of the Islet Autoantigen GAD by Vascular Endothelial Cells Promotes Transmigration of Autoreactive T-Cells. Diabetes 52: 717-725 [Abstract] [Full Text]
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Barber, D. F., Long, E. O. (2003). Coexpression of CD58 or CD48 with Intercellular Adhesion Molecule 1 on Target Cells Enhances Adhesion of Resting NK Cells. J. Immunol. 170: 294-299 [Abstract] [Full Text]
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Flaishon, L., Topilski, I., Shoseyov, D., Hershkoviz, R., Fireman, E., Levo, Y., Marmor, S., Shachar, I. (2002). Cutting Edge: Anti-Inflammatory Properties of Low Levels of IFN-{gamma}. J. Immunol. 168: 3707-3711 [Abstract] [Full Text]
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Beals, C. R., Edwards, A. C., Gottschalk, R. J., Kuijpers, T. W., Staunton, D. E. (2001). CD18 Activation Epitopes Induced by Leukocyte Activation. J. Immunol. 167: 6113-6122 [Abstract] [Full Text]
Cherry, L. K., Weber, K. S. C., Klickstein, L. B. (2001). A Dominant Jurkat T Cell Mutation That Inhibits LFA-1-Mediated Cell Adhesion Is Associated with Increased Cell Growth. J. Immunol. 167: 6171-6179 [Abstract] [Full Text]
Morgan, M. M., Labno, C. M., Van Seventer, G. A., Denny, M. F., Straus, D. B., Burkhardt, J. K. (2001). Superantigen-Induced T Cell:B Cell Conjugation Is Mediated by LFA-1 and Requires Signaling Through Lck, But Not ZAP-70. J. Immunol. 167: 5708-5718 [Abstract] [Full Text]
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Woods, M. L., Shimizu, Y. (2001). Signaling networks regulating {beta}1 integrin-mediated adhesion of T lymphocytes to extracellular matrix. J. Leukoc. Biol. 69: 874-880 [Abstract] [Full Text]
Flaishon, L., Hershkoviz, R., Lantner, F., Lider, O., Alon, R., Levo, Y., Flavell, R. A., Shachar, I. (2000). Autocrine Secretion of Interferon {gamma} Negatively Regulates Homing of Immature B Cells. JEM 192: 1381-1388 [Abstract] [Full Text]
Coito, A. J., Onodera, K., Kato, H., Busuttil, R. W., Kupiec-Weglinski, J. W. (2000). Fibronectin-Mononuclear Cell Interactions Regulate Type 1 Helper T Cell Cytokine Network in Tolerant Transplant Recipients. Am. J. Pathol. 157: 1207-1218 [Abstract] [Full Text]
Pace, K. E., Hahn, H. P., Pang, M., Nguyen, J. T., Baum, L. G. (2000). Cutting Edge: CD7 Delivers a Pro-Apoptotic Signal During Galectin-1-Induced T Cell Death. J. Immunol. 165: 2331-2334 [Abstract] [Full Text]
Lyman, S. D., Escobar, S., Rousseau, A.-M., Armstrong, A., Fanslow, W. C. (2000). Identification of CD7 as a Cognate of the Human K12 (SECTM1) Protein. J. Biol. Chem. 275: 3431-3437 [Abstract] [Full Text]
Fujisaki, T., Tanaka, Y., Fujii, K., Mine, S., Saito, K., Yamada, S., Yamashita, U., Irimura, T., Eto, S. (1999). CD44 Stimulation Induces Integrin-mediated Adhesion of Colon Cancer Cell Lines to Endothelial Cells by Up-Regulation of Integrins and c-Met and Activation of Integrins. Cancer Res. 59: 4427-4434 [Abstract] [Full Text]
Chiba, R., Nakagawa, N., Kurasawa, K., Tanaka, Y., Saito, Y., Iwamoto, I. (1999). Ligation of CD31 (PECAM-1) on Endothelial Cells Increases Adhesive Function of alpha vbeta 3 Integrin and Enhances beta 1 Integrin-Mediated Adhesion of Eosinophils to Endothelial Cells. Blood 94: 1319-1329 [Abstract] [Full Text]
Loo, D. T., Kanner, S. B., Aruffo, A. (1998). Filamin Binds to the Cytoplasmic Domain of the beta 1-Integrin. IDENTIFICATION OF AMINO ACIDS RESPONSIBLE FOR THIS INTERACTION. J. Biol. Chem. 273: 23304-23312 [Abstract] [Full Text]
Kivens, W. J., Hunt, S. W. III, Mobley, J. L., Zell, T., Dell, C. L., Bierer, B. E., Shimizu, Y. (1998). Identification of a Proline-Rich Sequence in the CD2 Cytoplasmic Domain Critical for Regulation of Integrin-Mediated Adhesion and Activation of Phosphoinositide 3-Kinase. Mol. Cell. Biol. 18: 5291-5307 [Abstract] [Full Text]
Lee, D. M., Staats, H. F., Sundy, J. S., Patel, D. D., Sempowski, G. D., Scearce, R. M., Jones, D. M., Haynes, B. F. (1998). Immunologic Characterization of CD7-Deficient Mice. J. Immunol. 160: 5749-5756 [Abstract] [Full Text]
Pollok, K. E., Hanenberg, H., Noblitt, T. W., Schroeder, W. L., Kato, I., Emanuel, D., Williams, D. A. (1998). High-Efficiency Gene Transfer into Normal and Adenosine Deaminase-Deficient T Lymphocytes Is Mediated by Transduction on Recombinant Fibronectin Fragments. J. Virol. 72: 4882-4892 [Abstract] [Full Text]
Feigelson, S. W., Grabovsky, V., Winter, E., Chen, L. L., Pepinsky, R. B., Yednock, T., Yablonski, D., Lobb, R., Alon, R. (2001). The Src Kinase p56lck Up-regulates VLA-4 Integrin Affinity. IMPLICATIONS FOR RAPID SPONTANEOUS AND CHEMOKINE-TRIGGERED T CELL ADHESION TO VCAM-1 AND FIBRONECTIN. J. Biol. Chem. 276: 13891-13901 [Abstract] [Full Text]
Zhang, X. A., Bontrager, A. L., Hemler, M. E. (2001). Transmembrane-4 Superfamily Proteins Associate with Activated Protein Kinase C (PKC) and Link PKC to Specific beta 1 Integrins. J. Biol. Chem. 276: 25005-25013 [Abstract] [Full Text]
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