A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice

doi:10.1084/jem.175.1.49

This Article

	Full Text (PDF, 820K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Hiromatsu, K.
	Articles by Nomoto, K.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Hiromatsu, K.
	Articles by Nomoto, K.


Social Bookmarking

	What's this?

ARTICLES

A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice

K Hiromatsu, Y Yoshikai, G Matsuzaki, S Ohga, K Muramori, K Matsumoto, JA Bluestone and K Nomoto
Department of Immunology, Kyushu University, Fukuoka, Japan.

We have previously reported that T cells bearing T cell receptors (TCRs) of gamma/delta type appear at a relatively early stage of primary infection with Listeria monocytogenes in mice. To characterize the early-appearing gamma/delta T cells during listeriosis, we analyzed the specificity and cytokine production of the gamma/delta T cells in the peritoneal cavity in mice inoculated intraperitoneally with a sublethal dose of L. monocytogenes. The early-appearing gamma/delta T cells, most of which were of CD4-CD8- phenotype, proliferated and secreted IFN-gamma and macrophage chemotactic factor in response to purified protein derivative from Mycobacterium tuberculosis, or recombinant 65-kD heat-shock protein derived from M. bovis but not to heat-killed Listeria. To further elucidate the potential role of the gamma/delta T cells in the host-defense mechanism against primary infection with Listeria, we examined the effects of in vivo administration of monoclonal antibodies (mAbs) against TCR-gamma/delta or TCR-alpha/beta on the bacterial eradication in mice infected with Listeria. Most of alpha/beta T cells or gamma/delta T cells were depleted in the peripheral lymphoid organs at least for 12 d after an intraperitoneal injection of 200 micrograms TCR-alpha/beta mAb or 200 micrograms TCR-gamma/delta mAb, respectively. An exaggerated bacterial multiplication was evident at the early stage of listerial infection in the gamma/delta T cells-depleted mice, whereas the alpha/beta T cell- depleted mice exhibited much the same resistance level as the control mice at this stage although the resistance was severely impaired at the late stage after listerial infection.(ABSTRACT TRUNCATED AT 250 WORDS)
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Hayashi, T., Nagai, S., Fujii, H., Baba, Y., Ikeda, E., Kawase, T., Koyasu, S. (2009). Critical Roles of NK and CD8+ T Cells in Central Nervous System Listeriosis. J. Immunol. 182: 6360-6368 [Abstract] [Full Text]
Shibata, K., Yamada, H., Nakamura, R., Sun, X., Itsumi, M., Yoshikai, Y. (2008). Identification of CD25+ {gamma}{delta} T Cells As Fetal Thymus-Derived Naturally Occurring IL-17 Producers. J. Immunol. 181: 5940-5947 [Abstract] [Full Text]
Hamada, S., Umemura, M., Shiono, T., Tanaka, K., Yahagi, A., Begum, M. D., Oshiro, K., Okamoto, Y., Watanabe, H., Kawakami, K., Roark, C., Born, W. K., O'Brien, R., Ikuta, K., Ishikawa, H., Nakae, S., Iwakura, Y., Ohta, T., Matsuzaki, G. (2008). IL-17A Produced by {gamma}{delta} T Cells Plays a Critical Role in Innate Immunity against Listeria monocytogenes Infection in the Liver. J. Immunol. 181: 3456-3463 [Abstract] [Full Text]
Collins, C., Shi, C., Russell, J. Q., Fortner, K. A., Budd, R. C. (2008). Activation of {gamma}{delta} T Cells by Borrelia burgdorferi Is Indirect via a TLR- and Caspase-Dependent Pathway. J. Immunol. 181: 2392-2398 [Abstract] [Full Text]
Nakamura, R., Shibata, K., Yamada, H., Shimoda, K., Nakayama, K., Yoshikai, Y. (2008). Tyk2-Signaling Plays an Important Role in Host Defense against Escherichia coli through IL-23-Induced IL-17 Production by {gamma}{delta} T Cells. J. Immunol. 181: 2071-2075 [Abstract] [Full Text]
Rowe, C. A., Nantz, M. P., Bukowski, J. F., Percival, S. S. (2007). Specific Formulation of Camellia sinensis Prevents Cold and Flu Symptoms and Enhances {gamma}{delta} T Cell Function: A Randomized, Double-Blind, Placebo-Controlled Study. J. Am. Coll. Nutr. 26: 445-452 [Abstract] [Full Text]
Shibata, K., Yamada, H., Hara, H., Kishihara, K., Yoshikai, Y. (2007). Resident V{delta}1+ {gamma}{delta} T Cells Control Early Infiltration of Neutrophils after Escherichia coli Infection via IL-17 Production. J. Immunol. 178: 4466-4472 [Abstract] [Full Text]
Li, W., Yamada, H., Yajima, T., Nakagawa, R., Shimoda, K., Nakayama, K., Yoshikai, Y. (2007). Tyk2 Signaling in Host Environment Plays an Important Role in Contraction of Antigen-Specific CD8+ T Cells following a Microbial Infection. J. Immunol. 178: 4482-4488 [Abstract] [Full Text]
Chung, C.-S., Watkins, L., Funches, A., Lomas-Neira, J., Cioffi, W. G., Ayala, A. (2006). Deficiency of {gamma}{delta} T lymphocytes contributes to mortality and immunosuppression in sepsis. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291: R1338-R1343 [Abstract] [Full Text]
Yoshihara, K, Yajima, T, Kubo, C, Yoshikai, Y (2006). Role of interleukin 15 in colitis induced by dextran sulphate sodium in mice. Gut 55: 334-341 [Abstract] [Full Text]
Newton, D. J., Andrew, E. M., Dalton, J. E., Mears, R., Carding, S. R. (2006). Identification of Novel {gamma}{delta} T-Cell Subsets following Bacterial Infection in the Absence of V{gamma}1+ T Cells: Homeostatic Control of {gamma}{delta} T-Cell Responses to Pathogen Infection by V{gamma}1+ T Cells. Infect. Immun. 74: 1097-1105 [Abstract] [Full Text]
Collins, C., Wolfe, J., Roessner, K., Shi, C., Sigal, L. H., Budd, R. C. (2005). Lyme Arthritis Synovial {gamma}{delta} T Cells Instruct Dendritic Cells via Fas Ligand. J. Immunol. 175: 5656-5665 [Abstract] [Full Text]
Li, W., Yajima, T., Saito, K., Nishimura, H., Fushimi, T., Ohshima, Y., Tsukamoto, Y., Yoshikai, Y. (2004). Immunostimulating Properties of Intragastrically Administered Acetobacter-Derived Soluble Branched (1,4)-{beta}-D-Glucans Decrease Murine Susceptibility to Listeria monocytogenes. Infect. Immun. 72: 7005-7011 [Abstract] [Full Text]
Deng, J. C., Moore, T. A., Newstead, M. W., Zeng, X., Krieg, A. M., Standiford, T. J. (2004). CpG Oligodeoxynucleotides Stimulate Protective Innate Immunity against Pulmonary Klebsiella Infection. J. Immunol. 173: 5148-5155 [Abstract] [Full Text]
Tagawa, T., Nishimura, H., Yajima, T., Hara, H., Kishihara, K., Matsuzaki, G., Yoshino, I., Maehara, Y., Yoshikai, Y. (2004). V{delta}1+ {gamma}{delta} T Cells Producing CC Chemokines May Bridge a Gap between Neutrophils and Macrophages in Innate Immunity during Escherichia coli Infection in Mice. J. Immunol. 173: 5156-5164 [Abstract] [Full Text]
Uezu, K., Kawakami, K., Miyagi, K., Kinjo, Y., Kinjo, T., Ishikawa, H., Saito, A. (2004). Accumulation of {gamma}{delta} T Cells in the Lungs and Their Regulatory Roles in Th1 Response and Host Defense against Pulmonary Infection with Cryptococcus neoformans. J. Immunol. 172: 7629-7634 [Abstract] [Full Text]
Jonasson, R., Johannisson, A., Jacobson, M., Fellstrom, C., Jensen-Waern, M. (2004). Differences in lymphocyte subpopulations and cell counts before and after experimentally induced swine dysentery. J Med Microbiol 53: 267-272 [Abstract] [Full Text]
Dalton, J. E., Pearson, J., Scott, P., Carding, S. R. (2003). The Interaction of {gamma}{delta} T Cells with Activated Macrophages Is a Property of the V{gamma}1 Subset. J. Immunol. 171: 6488-6494 [Abstract] [Full Text]
Kamath, A. B., Wang, L., Das, H., Li, L., Reinhold, V. N., Bukowski, J. F. (2003). Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses. Proc. Natl. Acad. Sci. USA 100: 6009-6014 [Abstract] [Full Text]
Bockenstedt, L. K., Shanafelt, M.-C., Belperron, A., Mao, J., Barthold, S. W. (2003). Humoral Immunity Reflects Altered T Helper Cell Bias in Borrelia burgdorferi-Infected {gamma}{delta} T-Cell-Deficient Mice. Infect. Immun. 71: 2938-2940 [Abstract] [Full Text]
Roessner, K., Wolfe, J., Shi, C., Sigal, L. H., Huber, S., Budd, R. C. (2003). High Expression of Fas Ligand by Synovial Fluid-Derived {gamma}{delta} T Cells in Lyme Arthritis. J. Immunol. 170: 2702-2710 [Abstract] [Full Text]
Hedges, J. F., Cockrell, D., Jackiw, L., Meissner, N., Jutila, M. A. (2003). Differential mRNA expression in circulating {gamma}{delta} T lymphocyte subsets defines unique tissue-specific functions. J. Leukoc. Biol. 73: 306-314 [Abstract] [Full Text]
Naiman, B. M., Blumerman, S., Alt, D., Bolin, C. A., Brown, R., Zuerner, R., Baldwin, C. L. (2002). Evaluation of Type 1 Immune Response in Naive and Vaccinated Animals following Challenge with Leptospira borgpetersenii Serovar Hardjo: Involvement of WC1+{gamma}{delta} and CD4 T Cells. Infect. Immun. 70: 6147-6157 [Abstract] [Full Text]
Ellis, J., Oyston, P. C. F., Green, M., Titball, R. W. (2002). Tularemia. Clin. Microbiol. Rev. 15: 631-646 [Abstract] [Full Text]
Dandekar, A. A., Perlman, S. (2002). Virus-Induced Demyelination in Nude Mice Is Mediated by {gamma}{delta} T Cells. Am. J. Pathol. 161: 1255-1263 [Abstract] [Full Text]
Huber, S., Shi, C., Budd, R. C. (2002). {gamma}{delta} T Cells Promote a Th1 Response during Coxsackievirus B3 Infection In Vivo: Role of Fas and Fas Ligand. J. Virol. 76: 6487-6494 [Abstract] [Full Text]
Nagata, T., Aoshi, T., Suzuki, M., Uchijima, M., Kim, Y.-H., Yang, Z., Koide, Y. (2002). Induction of Protective Immunity to Listeria monocytogenes by Immunization with Plasmid DNA Expressing a Helper T-Cell Epitope That Replaces the Class II-Associated Invariant Chain Peptide of the Invariant Chain. Infect. Immun. 70: 2676-2680 [Abstract] [Full Text]
Dudani, R., Chapdelaine, Y., van Faassen, H., Smith, D. K., Shen, H., Krishnan, L., Sad, S. (2002). Preexisting Inflammation Due to Mycobacterium bovis BCG Infection Differentially Modulates T-Cell Priming against a Replicating or Nonreplicating Immunogen. Infect. Immun. 70: 1957-1964 [Abstract] [Full Text]
Okamoto, S., Kawabata, S., Nakagawa, I., Hamada, S. (2001). Administration of Superantigens Protects Mice from Lethal Listeria monocytogenes Infection by Enhancing Cytotoxic T Cells. Infect. Immun. 69: 6633-6642 [Abstract] [Full Text]
Walker, A M (2001). Unmodified and phosphorylated prolactin and gamma delta T cell development and function. Lupus 10: 735-741 [Abstract]
Moretto, M., Durell, B., Schwartzman, J. D., Khan, I. A. (2001). {{gamma}}{{delta}}T Cell-Deficient Mice Have a Down-Regulated CD8+ T Cell Immune Response Against Encephalitozoon cuniculi Infection. J. Immunol. 166: 7389-7397 [Abstract] [Full Text]
Huleatt, J. W., Pilip, I., Kerksiek, K., Pamer, E. G. (2001). Intestinal and Splenic T Cell Responses to Enteric Listeria monocytogenes Infection: Distinct Repertoires of Responding CD8 T Lymphocytes. J. Immunol. 166: 4065-4073 [Abstract] [Full Text]
O'Brien, R. L., Yin, X., Huber, S. A., Ikuta, K., Born, W. K. (2000). Depletion of a {gamma}{delta} T Cell Subset Can Increase Host Resistance to a Bacterial Infection. J. Immunol. 165: 6472-6479 [Abstract] [Full Text]
Soloski, M. J., Szperka, M. E., Davies, A., Wooden, S. L. (2000). Host Immune Response to Intracellular Bacteria: A Role for MHC-Linked Class-Ib Antigen-Presenting Molecules. Exp. Biol. Med. 224: 231-239 [Abstract] [Full Text]
Egan, P. J., Carding, S. R. (2000). Downmodulation of the Inflammatory Response to Bacterial Infection by {gamma}{delta} T Cells Cytotoxic for Activated Macrophages. JEM 191: 2145-2158 [Abstract] [Full Text]
McKenna, K. C., Tsuji, M., Sarzotti, M., Sacci, J. B. Jr., Witney, A. A., Azad, A. F. (2000). gamma delta T Cells Are a Component of Early Immunity against Preerythrocytic Malaria Parasites. Infect. Immun. 68: 2224-2230 [Abstract] [Full Text]
Spada, F. M., Grant, E. P., Peters, P. J., Sugita, M., Melian, A., Leslie, D. S., Lee, H. K., van Donselaar, E., Hanson, D. A., Krensky, A. M., Majdic, O., Porcelli, S. A., Morita, C. T., Brenner, M. B. (2000). Self-Recognition of Cd1 by {gamma}/{delta} T Cells: Implications for Innate Immunity. JEM 191: 937-948 [Abstract] [Full Text]
Belles, C., Kuhl, A., Nosheny, R., Carding, S. R. (1999). Plasma Membrane Expression of Heat Shock Protein 60 In Vivo in Response to Infection. Infect. Immun. 67: 4191-4200 [Abstract] [Full Text]
Sciorati, C., Rovere, P., Ferrarini, M., Paolucci, C., Heltai, S., Vaiani, R., Clementi, E., Manfredi, A. A. (1999). Generation of Nitric Oxide by the Inducible Nitric Oxide Synthase Protects {gamma}{delta} T Cells from Mycobacterium tuberculosis-Induced Apoptosis. J. Immunol. 163: 1570-1576 [Abstract] [Full Text]
Hampl, J., Schild, H., Litzenberger, C., Baron, M., Crowley, M. P., Chien, Y.-h. (1999). The Specificity of a Weak {gamma}{delta} TCR Interaction Can Be Modulated by the Glycosylation of the Ligand. J. Immunol. 163: 288-294 [Abstract] [Full Text]
King, D. P., Hyde, D. M., Jackson, K. A., Novosad, D. M., Ellis, T. N., Putney, L., Stovall, M. Y., Van Winkle, L. S., Beaman, B. L., Ferrick, D. A. (1999). Cutting Edge: Protective Response to Pulmonary Injury Requires {gamma}{delta} T Lymphocytes. J. Immunol. 162: 5033-5036 [Abstract] [Full Text]
Seixas, E. M. G., Langhorne, J. (1999). {gamma}{delta}T Cells Contribute to Control of Chronic Parasitemia in Plasmodium chabaudi Infections in Mice. J. Immunol. 162: 2837-2841 [Abstract] [Full Text]
Nishimura, H., Washizu, J., Naiki, Y., Hara, T., Fukui, Y., Sasazuki, T., Yoshikai, Y. (1999). MHC Class II-Dependent NK1.1+ {gamma}{delta} T Cells Are Induced in Mice by Salmonella Infection. J. Immunol. 162: 1573-1581 [Abstract] [Full Text]
Zugel, U., Kaufmann, S. H.�E. (1999). Role of Heat Shock Proteins in Protection from and Pathogenesis of Infectious Diseases. Clin. Microbiol. Rev. 12: 19-39 [Abstract] [Full Text]
Hirose, K., Suzuki, H., Nishimura, H., Mitani, A., Washizu, J., Matsuguchi, T., Yoshikai, Y. (1998). Interleukin-15 May Be Responsible for Early Activation of Intestinal Intraepithelial Lymphocytes after Oral Infection with Listeria monocytogenes in Rats. Infect. Immun. 66: 5677-5683 [Abstract] [Full Text]
Vincent, M. S., Roessner, K., Sellati, T., Huston, C. D., Sigal, L. H., Behar, S. M., Radolf, J. D., Budd, R. C. (1998). Lyme Arthritis Synovial {gamma}{delta} T Cells Respond to Borrelia burgdorferi Lipoproteins and Lipidated Hexapeptides. J. Immunol. 161: 5762-5771 [Abstract] [Full Text]
Takano, M., Nishimura, H., Kimura, Y., Washizu, J., Mokuno, Y., Nimura, Y., Yoshikai, Y. (1998). Prostaglandin E2 Protects Against Liver Injury After Escherichia coli Infection but Hampers the Resolution of the Infection in Mice. J. Immunol. 161: 3019-3025 [Abstract] [Full Text]
Takano, M., Nishimura, H., Kimura, Y., Mokuno, Y., Washizu, J., Itohara, S., Nimura, Y., Yoshikai, Y. (1998). Protective Roles of gamma delta T Cells and Interleukin-15 in Escherichia coli Infection in Mice. Infect. Immun. 66: 3270-3278 [Abstract] [Full Text]
Rajan, A. J., Klein, J. D. S., Brosnan, C. F. (1998). The Effect of {gamma}{delta} T Cell Depletion on Cytokine Gene Expression in Experimental Allergic Encephalomyelitis. J. Immunol. 160: 5955-5962 [Abstract] [Full Text]
Geginat, G., Lalic, M., Kretschmar, M., Goebel, W., Hof, H., Palm, D., Bubert, A. (1998). Th1 Cells Specific for a Secreted Protein of Listeria monocytogenes Are Protective In Vivo. J. Immunol. 160: 6046-6055 [Abstract] [Full Text]
Lahn, M., Kalataradi, H., Mittelstadt, P., Pflum, E., Vollmer, M., Cady, C., Mukasa, A., Vella, A. T., Ikle, D., Harbeck, R., O'Brien, R., Born, W. (1998). Early Preferential Stimulation of {gamma}{delta} T Cells by TNF-{alpha}. J. Immunol. 160: 5221-5230 [Abstract] [Full Text]
Pauly, T, Konig, M, Thiel, H., Saalmuller, A (1998). Infection with classical swine fever virus: effects on phenotype and immune responsiveness of porcine T lymphocytes. J. Gen. Virol. 79: 31-40 [Abstract]
Sciammas, R., Kodukula, P., Tang, Q., Hendricks, R.L., Bluestone, J.A. (1997). T Cell Receptor-{gamma}/{delta} Cells Protect Mice from Herpes Simplex Virus Type 1-induced Lethal Encephalitis. JEM 185: 1969-1975 [Abstract] [Full Text]
Crowley, M. P., Reich, Z., Mavaddat, N., Altman, J. D., Chien, Y.-h. (1997). The Recognition of the Nonclassical Major Histocompatibility Complex (MHC) Class I Molecule, T10, by the {gamma}{delta} T Cell, G8. JEM 185: 1223-1230 [Abstract] [Full Text]
Fehr, T., Schoedon, G., Odermatt, B., Holtschke, T., Schneemann, M., Bachmann, M. F., Mak, T. W., Horak, I., Zinkernagel, R. M. (1997). Crucial Role of Interferon Consensus Sequence Binding Protein, but neither of Interferon Regulatory Factor 1 nor of Nitric Oxide Synthesis for Protection Against Murine Listeriosis. JEM 185: 921-932 [Abstract] [Full Text]