Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection

doi:10.1084/jem.175.1.305

This Article

	Full Text (PDF, 376K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Benichou, G.
	Articles by Sercarz, E. E.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Benichou, G.
	Articles by Sercarz, E. E.


Social Bookmarking

	What's this?

ARTICLES

Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection

G Benichou, PA Takizawa, CA Olson, M McMillan and EE Sercarz
Department of Microbiology and Molecular Genetics, University of California Los Angeles 90024.

Peptides from donor major histocompatibility complex (MHC) molecules were examined for their activation of allogeneically primed T cells. After immunization with either allogeneic spleen cells or a skin allograft, primed T cells proliferate in response to peptides derived from polymorphic regions of alpha and beta chains of class II allo-MHC molecules. The results demonstrate that presentation of donor-MHC peptides by host-derived antigen-presenting cells is a common event in vivo. Thus, self-restricted T cell recognition of processed alloantigens may play a critical role in transplantation. An in-depth understanding of this response may result in the development of additional molecular therapies to combat allograft rejection.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Das, R., Chen, X., Komorowski, R., Hessner, M. J., Drobyski, W. R. (2009). Interleukin-23 secretion by donor antigen-presenting cells is critical for organ-specific pathology in graft-versus-host disease. Blood 113: 2352-2362 [Abstract] [Full Text]
Chan, W. F. N., Razavy, H., Anderson, C. C. (2008). Differential Susceptibility of Allogeneic Targets to Indirect CD4 Immunity Generates Split Tolerance. J. Immunol. 181: 4603-4612 [Abstract] [Full Text]
Mahesh, B., Leong, H.-S., McCormack, A., Sarathchandra, P., Holder, A., Rose, M. L. (2007). Autoantibodies to Vimentin Cause Accelerated Rejection of Cardiac Allografts. Am. J. Pathol. 170: 1415-1427 [Abstract] [Full Text]
Tivol, E., Komorowski, R., Drobyski, W. R. (2005). Emergent autoimmunity in graft-versus-host disease. Blood 105: 4885-4891 [Abstract] [Full Text]
Huq, S., Liu, Y., Benichou, G., Dana, M. R. (2004). Relevance of the Direct Pathway of Sensitization in Corneal Transplantation Is Dictated by the Graft Bed Microenvironment. J. Immunol. 173: 4464-4469 [Abstract] [Full Text]
Mirenda, V., Berton, I., Read, J., Cook, T., Smith, J., Dorling, A., Lechler, R. I. (2004). Modified Dendritic Cells Coexpressing Self and Allogeneic Major Histocompatability Complex Molecules: An Efficient Way to Induce Indirect Pathway Regulation. J. Am. Soc. Nephrol. 15: 987-997 [Abstract] [Full Text]
Chen, Y., Demir, Y., Valujskikh, A., Heeger, P. S. (2004). Antigen Location Contributes to the Pathological Features of a Transplanted Heart Graft. Am. J. Pathol. 164: 1407-1415 [Abstract] [Full Text]
Chen, Y., Demir, Y., Valujskikh, A., Heeger, P. S. (2003). The Male Minor Transplantation Antigen Preferentially Activates Recipient CD4+ T Cells through the Indirect Presentation Pathway In Vivo. J. Immunol. 171: 6510-6518 [Abstract] [Full Text]
Andrassy, J., Kusaka, S., Jankowska-Gan, E., Torrealba, J. R., Haynes, L. D., Marthaler, B. R., Tam, R. C., Illigens, B. M.-W., Anosova, N., Benichou, G., Burlingham, W. J. (2003). Tolerance to Noninherited Maternal MHC Antigens in Mice. J. Immunol. 171: 5554-5561 [Abstract] [Full Text]
Chalermskulrat, W., Neuringer, I. P., Brickey, W. J., Felix, N. J., Randell, S. H., Ting, J. P., Aris, R. M. (2003). Hierarchical Contributions of Allorecognition Pathways in Chronic Lung Rejection. Am. J. Respir. Crit. Care Med. 167: 999-1007 [Abstract] [Full Text]
Fedoseyeva, E. V., Kishimoto, K., Rolls, H. K., Illigens, B. M.-W., Dong, V. M., Valujskikh, A., Heeger, P. S., Sayegh, M. H., Benichou, G. (2002). Modulation of Tissue-Specific Immune Response to Cardiac Myosin Can Prolong Survival of Allogeneic Heart Transplants. J. Immunol. 169: 1168-1174 [Abstract] [Full Text]
Guillet, M., Brouard, S., Gagne, K., Sebille, F., Cuturi, M.-C., Delsuc, M.-A., Soulillou, J.-P. (2002). Different Qualitative and Quantitative Regulation of V{beta} TCR Transcripts During Early Acute Allograft Rejection and Tolerance Induction. J. Immunol. 168: 5088-5095 [Abstract] [Full Text]
Olasz, E. B., Linton, J., Katz, S. I. (2002). Soluble proteins and haptens on bone marrow-derived dendritic cells are presented to host CD4 T cells in an MHC-restricted manner. Int Immunol 14: 493-502 [Abstract] [Full Text]
Freese, A., Zavazava, N. (2002). HLA-B7 beta -pleated sheet-derived synthetic peptides are immunodominant T-cell epitopes regulating alloresponses. Blood 99: 3286-3292 [Abstract] [Full Text]
Lovegrove, E., Pettigrew, G. J., Bolton, E. M., Bradley, J. A. (2001). Epitope Mapping of the Indirect T Cell Response to Allogeneic Class I MHC: Sequences Shared by Donor and Recipient MHC May Prime T Cells That Provide Help for Alloantibody Production. J. Immunol. 167: 4338-4344 [Abstract] [Full Text]
Boisgerault, F., Liu, Y., Anosova, N., Ehrlich, E., Dana, M. R., Benichou, G. (2001). Role of CD4+ and CD8+ T Cells in Allorecognition: Lessons from Corneal Transplantation. J. Immunol. 167: 1891-1899 [Abstract] [Full Text]
Ait-Azzouzene, D., Caucheteux, S., Tchang, F., Wantyghem, J., Moutier, R., Langkopf, A., Gendron, M.-C., Kanellopoulos-Langevin, C. (2001). Transgenic Major Histocompatibility Complex Class I Antigen Expressed in Mouse Trophoblast Affects Maternal Immature B Cells. Biol. Reprod. 65: 337-344 [Abstract] [Full Text]
Braun, M. Y., Grandjean, I., Feunou, P., Duban, L., Kiss, R., Goldman, M., Lantz, O. (2001). Acute Rejection in the Absence of Cognate Recognition of Allograft by T Cells. J. Immunol. 166: 4879-4883 [Abstract] [Full Text]
Slachta, C. A., Jeevanandam, V., Goldman, B., Lin, W. L., Platsoucas, C. D. (2000). Coronary Arteries from Human Cardiac Allografts with Chronic Rejection Contain Oligoclonal T Cells: Persistence of Identical Clonally Expanded TCR Transcripts from the Early Post-Transplantation Period (Endomyocardial Biopsies) to Chronic Rejection (Coronary Arteries). J. Immunol. 165: 3469-3483 [Abstract] [Full Text]
Watschinger, B. (1999). Indirect recognition of allo MHC peptides - potential role in human transplantation. Nephrol Dial Transplant 14: 8-11
Benichou, G., Valujskikh, A., Heeger, P. S. (1999). Contributions of Direct and Indirect T Cell Alloreactivity During Allograft Rejection in Mice. J. Immunol. 162: 352-358 [Abstract] [Full Text]
Inaba, K., Turley, S., Yamaide, F., Iyoda, T., Mahnke, K., Inaba, M., Pack, M., Subklewe, M., Sauter, B., Sheff, D., Albert, M., Bhardwaj, N., Mellman, I., Steinman, R. M. (1998). Efficient Presentation of Phagocytosed Cellular Fragments on the Major Histocompatibility Complex Class II Products of Dendritic Cells. JEM 188: 2163-2173 [Abstract] [Full Text]
Matesic, D., Valujskikh, A., Pearlman, E., Higgins, A. W., Gilliam, A. C., Heeger, P. S. (1998). Type 2 Immune Deviation Has Differential Effects on Alloreactive CD4+ and CD8+ T Cells. J. Immunol. 161: 5236-5244 [Abstract] [Full Text]
Pettigrew, G. J., Lovegrove, E., Bradley, J. A., Maclean, J., Bolton, E. M. (1998). Indirect T Cell Allorecognition and Alloantibody-Mediated Rejection of MHC Class I-Disparate Heart Grafts. J. Immunol. 161: 1292-1298 [Abstract] [Full Text]
Soares, L. R. B., Orr, P. L., Garovoy, M. R., Benichou, G. (1998). Differential Activation of T Cells by Natural Antigen Peptide Analogues: Influence on Autoimmune and Alloimmune In Vivo T Cell Responses. J. Immunol. 160: 4768-4775 [Abstract] [Full Text]