Journal of Experimental Medicine, Vol 174, 815-819, Copyright © 1991 by Rockefeller University Press

ARTICLES

Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes

JP van Meerwijk, P Romagnoli, A Iglesias, H Bluethmann and M Steinmetz
Biological Department, F. Hoffmann-La Roche Ltd., Basel, Switzerland.

In mice double transgenic for functionally rearranged T cell receptor (TCR) V beta 2 and V beta 8.2 genes we found that most T lymphocytes express both TCR beta chains simultaneously. These T cells show no abnormality in thymic selection in vivo and their TCRs are capable of transducing activation signals in vitro. These results indicate that multispecific T cells may appear in the periphery if allelic exclusion of TCR beta genes is not established at the level of gene rearrangement.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

• Sieh, P., Chen, J. (2001). Distinct Control of the Frequency and Allelic Exclusion of the V{beta} Gene Rearrangement at the TCR{beta} Locus. J. Immunol. 167: 2121-2129 [Abstract] [Full Text]  
• Sant'Angelo, D. B., Cresswell, P., Janeway, C. A. Jr., Denzin, L. K. (2001). Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers. Proc. Natl. Acad. Sci. USA 10.1073/pnas.121179998v1 [Abstract] [Full Text]  
• Fernandez-Miguel, G., Alarcon, B., Iglesias, A., Bluethmann, H., Alvarez-Mon, M., Sanz, E., de la Hera, A. (1999). Multivalent structure of an alpha beta T cell receptor. Proc. Natl. Acad. Sci. USA 96: 1547-1552 [Abstract] [Full Text]  
• Sant'Angelo, D. B., Cresswell, P., Janeway, C. A. Jr., Denzin, L. K. (2001). Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers. Proc. Natl. Acad. Sci. USA 98: 6824-6829 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS