The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4+ T cells

doi:10.1084/jem.173.3.759

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The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4+ T cells

L Koulova, EA Clark, G Shu and B Dupont
Human Immunogenetics Laboratory, Sloan-Kettering Institute for Cancer Research, New York, New York 10021.

Activation via the T lymphocyte cell surface molecule CD28 provides a potent amplification signal for interleukin 2 (IL-2) production in several in vitro systems. The B lymphocyte activation antigen, B7/BB1, is a natural ligand for CD28. Here we investigate the role of CD28 and B7/BB1 in primary activation of CD4+ T lymphocytes stimulated with allogeneic B lymphoblastoid cell lines. A subset of peripheral CD4+ T cells that is unresponsive to crosslinking of CD3/T cell receptor (TCR) with CD3 monoclonal antibody (mAb) does proliferate in response to allogeneic B lymphoblasts. TCR binding to allogeneic major histocompatibility complex antigens was an absolute requirement for activation of these cells because mAbs to either CD3 or human histocompatibility leukocyte antigen (HLA) class II completely inhibited activation. CD28 and B7/BB1 antibodies inhibited T cell proliferation 90% and 84%, respectively. Similar results were obtained with the total CD4+ T lymphocyte population. Crosslinking of HLA-DR antigens on small, resting B cells induced rapid expression of B7/BB1, which peaked at 6 h and returned to baseline levels within 18 h. These data demonstrate that CD28-B7/BB1 binding provides an important early second signal for alloactivation of CD4+ T lymphocyte by B lymphoblasts. The results also suggest that T cells interacting with allogeneic resting B cells may induce B7/BB1 expression in the alloantigen-presenting cell as a consequence of interaction between the TCR and class II molecules.
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Zang, X., Allison, J. P. (2007). The B7 Family and Cancer Therapy: Costimulation and Coinhibition. Clin. Cancer Res. 13: 5271-5279 [Abstract] [Full Text]
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Podojil, J. R., Kin, N. W., Sanders, V. M. (2004). CD86 and {beta}2-Adrenergic Receptor Signaling Pathways, Respectively, Increase Oct-2 and OCA-B Expression and Binding to the 3'-IgH Enhancer in B Cells. J. Biol. Chem. 279: 23394-23404 [Abstract] [Full Text]
Kremer, J. M., Westhovens, R., Leon, M., Di Giorgio, E., Alten, R., Steinfeld, S., Russell, A., Dougados, M., Emery, P., Nuamah, I. F., Williams, G. R., Becker, J.-C., Hagerty, D. T., Moreland, L. W. (2003). Treatment of Rheumatoid Arthritis by Selective Inhibition of T-Cell Activation with Fusion Protein CTLA4Ig. NEJM 349: 1907-1915 [Abstract] [Full Text]
Podojil, J. R., Sanders, V. M. (2003). Selective Regulation of Mature IgG1 Transcription by CD86 and {beta}2-Adrenergic Receptor Stimulation. J. Immunol. 170: 5143-5151 [Abstract] [Full Text]
Kohm, A. P., Mozaffarian, A., Sanders, V. M. (2002). B Cell Receptor- and {beta}2-Adrenergic Receptor-Induced Regulation of B7-2 (CD86) Expression in B Cells. J. Immunol. 168: 6314-6322 [Abstract] [Full Text]
Zhou, X.-Y., Yashiro-Ohtani, Y., Nakahira, M., Park, W. R., Abe, R., Hamaoka, T., Naramura, M., Gu, H., Fujiwara, H. (2002). Molecular Mechanisms Underlying Differential Contribution of CD28 Versus Non-CD28 Costimulatory Molecules to IL-2 Promoter Activation. J. Immunol. 168: 3847-3854 [Abstract] [Full Text]
Haupt, K., Roggendorf, M., Mann, K. (2002). The Potential of DNA Vaccination against Tumor-Associated Antigens for Antitumor Therapy. Exp. Biol. Med. 227: 227-237 [Abstract] [Full Text]
Bostik, P., Mayne, A. E., Villinger, F., Greenberg, K. P., Powell, J. D., Ansari, A. A. (2001). Relative Resistance in the Development of T Cell Anergy in CD4+ T Cells from Simian Immunodeficiency Virus Disease-Resistant Sooty Mangabeys. J. Immunol. 166: 506-516 [Abstract] [Full Text]
Shimizu, K., Schonbeck, U., Mach, F., Libby, P., Mitchell, R. N. (2000). Host CD40 Ligand Deficiency Induces Long-Term Allograft Survival and Donor-Specific Tolerance in Mouse Cardiac Transplantation But Does Not Prevent Graft Arteriosclerosis. J. Immunol. 165: 3506-3518 [Abstract] [Full Text]
Mandik-Nayak, L., Seo, S.-j., Eaton-Bassiri, A., Allman, D., Hardy, R. R., Erikson, J. (2000). Functional Consequences of the Developmental Arrest and Follicular Exclusion of Anti-Double-Stranded DNA B Cells. J. Immunol. 164: 1161-1168 [Abstract] [Full Text]
Yashiro-Ohtani, Y., Zhou, X.-Y., Toyo-oka, K., Tai, X.-G., Park, C.-S., Hamaoka, T., Abe, R., Miyake, K., Fujiwara, H. (2000). Non-CD28 Costimulatory Molecules Present in T Cell Rafts Induce T Cell Costimulation by Enhancing the Association of TCR with Rafts. J. Immunol. 164: 1251-1259 [Abstract] [Full Text]
Hanabuchi, S., Ohashi, T., Koya, Y., Kato, H., Takemura, F., Hirokawa, K., Yoshiki, T., Yagita, H., Okumura, K., Kannagi, M. (2000). Development of Human T-Cell Leukemia Virus Type 1-Transformed Tumors in Rats following Suppression of T-Cell Immunity by CD80 and CD86 Blockade. J. Virol. 74: 428-435 [Abstract] [Full Text]
Matsubara, T., Pararajasegaram, G., Wu, G.-S., Rao, N. A. (1999). Retinal Microglia Differentially Express Phenotypic Markers of Antigen-Presenting Cells In Vitro. IOVS 40: 3186-3193 [Abstract] [Full Text]
Metz, D. P., Farber, D. L., Taylor, T., Bottomly, K. (1998). Differential Role of CTLA-4 in Regulation of Resting Memory Versus Naive CD4 T Cell Activation. J. Immunol. 161: 5855-5861 [Abstract] [Full Text]
Chen, F., Maldonado, M. A., Madaio, M., Eisenberg, R. A. (1998). The Role of Host (Endogenous) T Cells in Chronic Graft-Versus-Host Autoimmune Disease. J. Immunol. 161: 5880-5885 [Abstract] [Full Text]
Niimi, M., Pearson, T. C., Larsen, C. P., Alexander, D. Z., Hollenbaugh, D., Aruffo, A., Linsley, P. S., Thomas, E., Campbell, K., Fanslow, W. C., Geha, R. S., Morris, P. J., Wood, K. J. (1998). The Role of the CD40 Pathway in Alloantigen-Induced Hyporesponsiveness In Vivo. J. Immunol. 161: 5331-5337 [Abstract] [Full Text]
Doty, R. T., Clark, E. A. (1998). Two Regions in the CD80 Cytoplasmic Tail Regulate CD80 Redistribution and T Cell Costimulation. J. Immunol. 161: 2700-2707 [Abstract] [Full Text]
Freeman, G. J., Cardoso, A. A., Boussiotis, V. A., Anumanthan, A., Groves, R. W., Kupper, T. S., Clark, E. A., Nadler, L. M. (1998). The BB1 Monoclonal Antibody Recognizes Both Cell Surface CD74 (MHC Class II-Associated Invariant Chain) as Well as B7-1 (CD80), Resolving the Question Regarding a Third CD28/CTLA-4 Counterreceptor. J. Immunol. 161: 2708-2715 [Abstract] [Full Text]
Murakami, S., Okada, H. (1997). Lymphocyte-Fibroblast Interactions. CROBM 8: 40-50 [Abstract] [Full Text]
Vinay, D. S., Raje, M., Verma, R. K., Mishra, G. C. (1995). Characterization of Novel Costimulatory Molecules. J. Biol. Chem. 270: 23429-23436 [Abstract] [Full Text]
Shahinian, A, Pfeffer, K, Lee, K., Kundig, T., Kishihara, K, Wakeham, A, Kawai, K, Ohashi, P., Thompson, C., Mak, T. (1993). Differential T cell costimulatory requirements in CD28-deficient mice. Science 261: 609-612 [Abstract]
Kang, S.-M., Beverly, B., Tran, A.-C., Brorson, K., Schwartz, R. H., Lenardot, M. J. (1992). Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy. Science 257: 1134-1138 [Abstract]
Linsley, P., Wallace, P., Johnson, J, Gibson, M., Greene, J., Ledbetter, J., Singh, C, Tepper, M. (1992). Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science 257: 792-795 [Abstract]