Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration

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Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration

M Clauss, M Gerlach, H Gerlach, J Brett, F Wang, PC Familletti, YC Pan, JV Olander, DT Connolly and D Stern
Department of Physiology, Columbia University, College of Physicians and Surgeons, New York, New York 10032.

Systemic infusion of low concentrations of tumor necrosis factor/cachectin (TNF) into mice that bear TNF-sensitive tumors leads to activation of coagulation, fibrin formation, and occlusive thrombosis exclusively within the tumor vascular bed. To identify mechanisms underlying the localization of this vascular procoagulant response, a tumor-derived polypeptide has been purified to homogeneity from supernatants of murine methylcholanthrene A-induced fibrosarcomas that induces endothelial tissue factor synthesis and expression (half- maximal response at approximately 300 pM), and augments the procoagulant response to TNF in a synergistic fashion. This tumor- derived polypeptide was identified as the murine homologue of vascular permeability factor (VPF) based on similar mobility on SDS-PAGE, an homologous NH2-terminal amino acid sequence, and recognition by a monospecific antibody to guinea pig VPF. In addition, VPF was shown to induce monocyte activation, as evidenced by expression of tissue factor. Finally, VPF was shown to induce monocyte chemotaxis across collagen membranes and endothelial cell monolayers. Taken together, these results indicate that VPF can modulate the coagulant properties of endothelium and monocytes, and can promote monocyte migration into the tumor bed. This suggests one mechanism through which tumor-derived mediators can alter properties of the vessel wall.
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Corral, C. J., Siddiqui, A., Wu, L., Farrell, C. L., Lyons, D., Mustoe, T. A. (1999). Vascular Endothelial Growth Factor Is More Important Than Basic Fibroblastic Growth Factor During Ischemic Wound Healing. Arch Surg 134: 200-205 [Abstract] [Full Text]
Clark, D. E., Smith, S. K., He, Y., Day, K. A., Licence, D. R., Corps, A. N., Lammoglia, R., Charnock-Jones, D. S. (1998). A Vascular Endothelial Growth Factor Antagonist Is Produced by the Human Placenta and Released into the Maternal Circulation. Biol. Reprod. 59: 1540-1548 [Abstract] [Full Text]
Inoue, M., Itoh, H., Ueda, M., Naruko, T., Kojima, A., Komatsu, R., Doi, K., Ogawa, Y., Tamura, N., Takaya, K., Igaki, T., Yamashita, J., Chun, T.-H., Masatsugu, K., Becker, A. E., Nakao, K. (1998). Vascular Endothelial Growth Factor (VEGF) Expression in Human Coronary Atherosclerotic Lesions : Possible Pathophysiological Significance of VEGF in Progression of Atherosclerosis. Circulation 98: 2108-2116 [Abstract] [Full Text]
Knies, U. E., Behrensdorf, H. A., Mitchell, C. A., Deutsch, U., Risau, W., Drexler, H. C.�A., Clauss, M. (1998). Regulation of endothelial monocyte-activating polypeptide II release by apoptosis. Proc. Natl. Acad. Sci. USA 95: 12322-12327 [Abstract] [Full Text]
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Shen, W Y, Yu, M J T, Barry, C J, Constable, I J, Rakoczy, P E (1998). Expression of cell adhesion molecules and vascular endothelial growth factor in experimental choroidal neovascularisation in the rat. Br J Ophthalmol 82: 1063-1071 [Abstract] [Full Text]
Xu, F., Severinghaus, J. W. (1998). Rat brain VEGF expression in alveolar hypoxia: possible role in high-altitude cerebral edema. J. Appl. Physiol. 85: 53-57 [Abstract] [Full Text]
Ramos, M. A., Kuzuya, M., Esaki, T., Miura, S., Satake, S., Asai, T., Kanda, S., Hayashi, T., Iguchi, A. (1998). Induction of Macrophage VEGF in Response to Oxidized LDL and VEGF Accumulation in Human Atherosclerotic Lesions. Arterioscler. Thromb. Vasc. Bio. 18: 1188-1196 [Abstract] [Full Text]
Hippenstiel, S., Krull, M., Ikemann, A., Risau, W., Clauss, M., Suttorp, N. (1998). VEGF induces hyperpermeability by a direct action on endothelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 274: L678-L684 [Abstract] [Full Text]
Otani, A., Takagi, H., Suzuma, K., Honda, Y. (1998). Angiotensin II Potentiates Vascular Endothelial Growth Factor�Induced Angiogenic Activity in Retinal Microcapillary Endothelial Cells. Circ. Res. 82: 619-628 [Abstract] [Full Text]
Ott, I., Fischer, E. G., Miyagi, Y., Mueller, B. M., Ruf, W. (1998). A Role for Tissue Factor in Cell Adhesion and Migration Mediated by Interaction with Actin-binding Protein 280. JCB 140: 1241-1253 [Abstract] [Full Text]
Kroll, J., Waltenberger, J. (1997). The Vascular Endothelial Growth Factor Receptor KDR Activates Multiple Signal Transduction Pathways in Porcine Aortic Endothelial Cells. J. Biol. Chem. 272: 32521-32527 [Abstract] [Full Text]
Natarajan, R., Bai, W., Lanting, L., Gonzales, N., Nadler, J. (1997). Effects of high glucose on vascular endothelial growth factor expression in vascular smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 273: H2224-H2231 [Abstract] [Full Text]
Mitola, S., Sozzani, S., Luini, W., Primo, L., Borsatti, A., Weich, H., Bussolino, F. (1997). Tat-Human Immunodeficiency Virus-1 Induces Human Monocyte Chemotaxis by Activation of Vascular Endothelial Growth Factor Receptor-1. Blood 90: 1365-1372 [Abstract] [Full Text]
Abedi, H., Zachary, I. (1997). Vascular Endothelial Growth Factor Stimulates Tyrosine Phosphorylation and Recruitment to New Focal Adhesions of Focal Adhesion Kinase and Paxillin in Endothelial Cells. J. Biol. Chem. 272: 15442-15451 [Abstract] [Full Text]
SCHLINGEMANN, R. O, VAN HINSBERGH, V. W M (1997). Role of vascular permeability factor/vascular endothelial growth factor in eye disease. Br J Ophthalmol 81: 501-512 [Full Text]