Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors

doi:10.1084/jem.172.5.1517

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Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors

MR Shalaby, A Sundan, H Loetscher, M Brockhaus, W Lesslauer and T Espevik
Institute of Cancer Research, University of Trondheim, Norway.

The present study was undertaken to further characterize the interaction of monoclonal antibodies (mAbs) against tumor necrosis factor (TNF) receptors with different targets, and to assess their ability to influence TNF effects on U937 and human endothelial cell (HEC) functions. Actions of recombinant TNF-alpha on U937 and HEC were effectively inhibited by Htr-5 and Utr-1, and to a greater extent by a combination of both mAbs. These observations indicate that TNF interaction with antigenically different components of membrane receptors (p55 and p75) represents a crucial step in transduction of signals for TNF toxicity against U937 and TNF activation of HEC functions.
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