Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection

doi:10.1084/jem.172.5.1495

This Article

Full Text (PDF, 843K)

Alert me when this article is cited

Citation Map

Services

Email this article

Similar articles in this journal

Similar articles in PubMed

Alert me to new content in the JEM

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via CrossRef

Citing Articles via Google Scholar

Google Scholar

Articles by Karupiah, G.

Articles by Ramshaw, I. A.

Search for Related Content

PubMed

PubMed Citation

Articles by Karupiah, G.

Articles by Ramshaw, I. A.

Pubmed/NCBI databases

Substance via MeSH

Social Bookmarking

What's this?

ARTICLES

Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection

G Karupiah, RV Blanden and IA Ramshaw
Division of Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT.

Athymic nude mice recover from an infection with recombinant vaccinia virus (VV) encoding murine interleukin 2 (IL-2), but treatment with a mAb to IL-2 accentuated infection. Administration of a mAb against interferon gamma (IFN-gamma) to mice infected with the IL-2-encoding virus completely prevented the IL-2-induced mechanisms of recovery. Both asialo-GM1+ (NK) and asialo-GM1- (non-NK) cells were participants in the IFN-gamma-mediated recovery of nude mice from infection with the IL-2-encoding VV recombinant. Depletion of asialo-GM1+ cells exacerbated infection, though not as much as anti-IFN-gamma mAb. In vitro, both asialo-GM1+ and asialo-GM1- nude mouse splenocytes produced IFN-gamma in response to IL-2.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Moraes, M. P., de los Santos, T., Koster, M., Turecek, T., Wang, H., Andreyev, V. G., Grubman, M. J. (2007). Enhanced Antiviral Activity against Foot-and-Mouth Disease Virus by a Combination of Type I and II Porcine Interferons. J. Virol. 81: 7124-7135 [Abstract] [Full Text]
Sakala, I. G., Chaudhri, G., Buller, R. M., Nuara, A. A., Bai, H., Chen, N., Karupiah, G. (2007). Poxvirus-Encoded Gamma Interferon Binding Protein Dampens the Host Immune Response to Infection. J. Virol. 81: 3346-3353 [Abstract] [Full Text]
Nuara, A. A., Buller, R. M. L., Bai, H. (2007). Identification of residues in the ectromelia virus gamma interferon-binding protein involved in expanded species specificity. J. Gen. Virol. 88: 51-60 [Abstract] [Full Text]
Chisholm, S. E., Reyburn, H. T. (2006). Recognition of Vaccinia Virus-Infected Cells by Human Natural Killer Cells Depends on Natural Cytotoxicity Receptors. J. Virol. 80: 2225-2233 [Abstract] [Full Text]
Prlic, M., Gibbs, J., Jameson, S. C. (2005). Characteristics of NK Cell Migration Early after Vaccinia Infection. J. Immunol. 175: 2152-2157 [Abstract] [Full Text]
Chaudhri, G., Panchanathan, V., Buller, R. M. L., van den Eertwegh, A. J. M., Claassen, E., Zhou, J., de Chazal, R., Laman, J. D., Karupiah, G. (2004). Polarized type 1 cytokine response and cell-mediated immunity determine genetic resistance to mousepox. Proc. Natl. Acad. Sci. USA 101: 9057-9062 [Abstract] [Full Text]
Reading, P. C., Smith, G. L. (2003). Vaccinia Virus Interleukin-18-Binding Protein Promotes Virulence by Reducing Gamma Interferon Production and Natural Killer and T-Cell Activity. J. Virol. 77: 9960-9968 [Abstract] [Full Text]
Reading, P. C., Smith, G. L. (2003). A kinetic analysis of immune mediators in the lungs of mice infected with vaccinia virus and comparison with intradermal infection. J. Gen. Virol. 84: 1973-1983 [Abstract] [Full Text]
Reading, P. C., Moore, J. B., Smith, G. L. (2003). Steroid Hormone Synthesis by Vaccinia Virus Suppresses the Inflammatory Response to Infection. JEM 197: 1269-1278 [Abstract] [Full Text]
Perera, L. P., Goldman, C. K., Waldmann, T. A. (2001). Comparative assessment of virulence of recombinant vaccinia viruses expressing IL-2 and IL-15 in immunodeficient mice. Proc. Natl. Acad. Sci. USA 10.1073/pnas.081080298v1 [Abstract] [Full Text]
Raggo, C., Habermehl, M., Babiuk, L. A., Griebel, P. (2000). The in vivo effects of recombinant bovine herpesvirus-1 expressing bovine interferon-{gamma}. J. Gen. Virol. 81: 2665-2673 [Abstract] [Full Text]
Bukreyev, A., Whitehead, S. S., Prussin, C., Murphy, B. R., Collins, P. L. (2000). Effect of Coexpression of Interleukin-2 by Recombinant Respiratory Syncytial Virus on Virus Replication, Immunogenicity, and Production of Other Cytokines. J. Virol. 74: 7151-7157 [Abstract] [Full Text]
Liu, Z.-X., Govindarajan, S., Okamoto, S., Dennert, G. (2000). NK Cells Cause Liver Injury and Facilitate the Induction of T Cell-Mediated Immunity to a Viral Liver Infection. J. Immunol. 164: 6480-6486 [Abstract] [Full Text]
Zhong, W., Marshall, D., Coleclough, C., Woodland, D. L. (2000). CD4+ T Cell Priming Accelerates the Clearance of Sendai Virus in Mice, but Has a Negative Effect on CD8+ T Cell Memory. J. Immunol. 164: 3274-3282 [Abstract] [Full Text]
van den Broek, M., Bachmann, M. F., Kohler, G., Barner, M., Escher, R., Zinkernagel, R., Kopf, M. (2000). IL-4 and IL-10 Antagonize IL-12-Mediated Protection Against Acute Vaccinia Virus Infection with a Limited Role of IFN-{gamma} and Nitric Oxide Synthetase 2. J. Immunol. 164: 371-378 [Abstract] [Full Text]
Mahalingam, S., Farber, J. M., Karupiah, G. (1999). The Interferon-Inducible Chemokines MuMig and Crg-2 Exhibit Antiviral Activity In Vivo. J. Virol. 73: 1479-1491 [Abstract] [Full Text]
Panoutsakopoulou, V., Little, C. S., Sieck, T. G., Blankenhorn, E. P., Blank, K. J. (1998). Differences in the Immune Response During the Acute Phase of E-55+ Murine Leukemia Virus Infection in Progressor BALB and Long Term Nonprogressor C57BL Mice. J. Immunol. 161: 17-26 [Abstract] [Full Text]
Binder, D., Fehr, J., Hengartner, H., Zinkernagel, R. M. (1997). Virus-induced Transient Bone Marrow Aplasia: Major Role of Interferon-{alpha}/{beta} during Acute Infection with the Noncytopathic Lymphocytic Choriomeningitis Virus. JEM 185: 517-530 [Abstract] [Full Text]
Colamonici, O. R., Domanski, P., Sweitzer, S. M., Larner, A., Buller, R. M. L. (1995). Vaccinia Virus B18R Gene Encodes a Type I Interferon-binding Protein That Blocks Interferon [IMAGE] Transmembrane Signaling. J. Biol. Chem. 270: 15974-15978 [Abstract] [Full Text]
Karupiah, G, Xie, Q., Buller, R., Nathan, C, Duarte, C, MacMicking, J. (1993). Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase. Science 261: 1445-1448 [Abstract]
Moss, B (1991). Vaccinia virus: a tool for research and vaccine development. Science 252: 1662-1667 [Abstract]
Perera, L. P., Goldman, C. K., Waldmann, T. A. (2001). Comparative assessment of virulence of recombinant vaccinia viruses expressing IL-2 and IL-15 in immunodeficient mice. Proc. Natl. Acad. Sci. USA 98: 5146-5151 [Abstract] [Full Text]