CD4+ cytolytic T cell clone confers protection against murine malaria

doi:10.1084/jem.172.5.1353

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CD4+ cytolytic T cell clone confers protection against murine malaria

M Tsuji, P Romero, RS Nussenzweig and F Zavala
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York 10010.

A CD4+ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms of Plasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, produces IFN-gamma and IL-2 in vitro, and recognizes the plasmodial antigen in the context of the class II I-Ed molecule. Passive transfer of this CD4+ clone into naive mice resulted in a high degree of protection against sporozoite challenge.
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