Dendritic cells pulsed with protein antigens in vitro can prime antigen- specific, MHC-restricted T cells in situ [published erratum appears in J Exp Med 1990 Oct 1;172(4):1275]

doi:10.1084/jem.172.2.631

This Article

	Full Text (PDF, 907K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Inaba, K.
	Articles by Steinman, R. M.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Inaba, K.
	Articles by Steinman, R. M.


Social Bookmarking

	What's this?

ARTICLES

Dendritic cells pulsed with protein antigens in vitro can prime antigen- specific, MHC-restricted T cells in situ [published erratum appears in J Exp Med 1990 Oct 1;172(4):1275]

K Inaba, JP Metlay, MT Crowley and RM Steinman
Rockefeller University, Irvington Institute, New York, New York 10021.

T cells recognize peptides that are bound to MHC molecules on the surface of different types of antigen-presenting cells (APC). Antigen presentation most often is studied using T cells that have undergone priming in situ, or cell lines that have been chronically stimulated in vitro. The use of primed cells provides sufficient numbers of antigen- reactive lymphocytes for experimental study. A more complete understanding of immunogenicity, however, requires that one develop systems for studying the onset of a T cell response from unprimed lymphocytes, especially in situ. Here it is shown that mouse T cells can be reliably primed in situ using dendritic cells as APC. The dendritic cells were isolated from spleen, pulsed with protein antigens, and then administered to naive mice. Antigen-responsive T cells developed in the draining lymphoid tissue, and these T cells only recognized protein when presented on cells bearing the same MHC products as the original priming dendritic cells. In contrast, little or no priming was seen if antigen-pulsed spleen cells or peritoneal cells were injected. Since very small amounts of the foreign protein were visualized within endocytic vacuoles of antigen-pulsed dendritic cells, it is suggested that dendritic cells have a small but relevant vacuolar system for presenting antigens over a several day period in situ.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Swee, L. K., Bosco, N., Malissen, B., Ceredig, R., Rolink, A. (2009). Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment. Blood 113: 6277-6287 [Abstract] [Full Text]
Vasilevsky, S., Colino, J., Puliaev, R., Canaday, D. H., Snapper, C. M. (2008). Macrophages Pulsed with Streptococcus pneumoniae Elicit a T Cell-Dependent Antibody Response upon Transfer into Naive Mice. J. Immunol. 181: 1787-1797 [Abstract] [Full Text]
de Heusch, M., Blocklet, D., Egrise, D., Hauquier, B., Vermeersch, M., Goldman, S., Moser, M. (2007). Bidirectional MHC molecule exchange between migratory and resident dendritic cells. J. Leukoc. Biol. 82: 861-868 [Abstract] [Full Text]
Bashyam, H. (2007). Ralph Steinman: Dendritic cells bring home the Lasker. JEM 204: 2245-2248 [Abstract] [Full Text]
Raveney, B. J. E., Morgan, D. J. (2007). Dynamic Control of Self-Specific CD8+ T Cell Responses via a Combination of Signals Mediated by Dendritic Cells. J. Immunol. 179: 2870-2879 [Abstract] [Full Text]
Hagymasi, A. T., Slaiby, A. M., Mihalyo, M. A., Qui, H. Z., Zammit, D. J., Lefrancois, L., Adler, A. J. (2007). Steady State Dendritic Cells Present Parenchymal Self-Antigen and Contribute to, but Are Not Essential for, Tolerization of Naive and Th1 Effector CD4 Cells. J. Immunol. 179: 1524-1531 [Abstract] [Full Text]
Tang, J., Zhu, W., Silver, P. B., Su, S.-B., Chan, C.-C., Caspi, R. R. (2007). Autoimmune Uveitis Elicited with Antigen-Pulsed Dendritic Cells Has a Distinct Clinical Signature and Is Driven by Unique Effector Mechanisms: Initial Encounter with Autoantigen Defines Disease Phenotype. J. Immunol. 178: 5578-5587 [Abstract] [Full Text]
Meraner, P., Horejsi, V., Wolpl, A., Fischer, G. F., Stingl, G., Maurer, D. (2007). Dendritic Cells Sensitize TCRs through Self-MHC-Mediated Src Family Kinase Activation. J. Immunol. 178: 2262-2271 [Abstract] [Full Text]
Sheasley-O'Neill, S. L., Brinkman, C. C., Ferguson, A. R., Dispenza, M. C., Engelhard, V. H. (2007). Dendritic Cell Immunization Route Determines Integrin Expression and Lymphoid and Nonlymphoid Tissue Distribution of CD8 T Cells. J. Immunol. 178: 1512-1522 [Abstract] [Full Text]
Trumpfheller, C., Finke, J. S., Lopez, C. B., Moran, T. M., Moltedo, B., Soares, H., Huang, Y., Schlesinger, S. J., Park, C. G., Nussenzweig, M. C., Granelli-Piperno, A., Steinman, R. M. (2006). Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine. JEM 203: 607-617 [Abstract] [Full Text]
Lang, M. L., Glatman-Freedman, A. (2006). Do CD1-Restricted T Cells Contribute to Antibody-Mediated Immunity against Mycobacterium tuberculosis?. Infect. Immun. 74: 803-809 [Full Text]
Haase, C., Ejrnaes, M., Juedes, A. E., Wolfe, T., Markholst, H., von Herrath, M. G. (2005). Immunomodulatory dendritic cells require autologous serum to circumvent nonspecific immunosuppressive activity in vivo. Blood 106: 4225-4233 [Abstract] [Full Text]
Hardin, J A (2005). Dendritic cells: potential triggers of autoimmunity and targets for therapy. Ann Rheum Dis 64: iv86-iv90 [Full Text]
Kikuchi, T., Willis, D.L., Liu, M., Purkall, D.B., Sukumar, S., Barbour, S.E., Schenkein, H.A., Tew, J.G. (2005). Dendritic-NK Cell Interactions in P. gingivalis-specific Responses. JDR 84: 858-862 [Abstract] [Full Text]
Pozzi, L.-A. M., Maciaszek, J. W., Rock, K. L. (2005). Both Dendritic Cells and Macrophages Can Stimulate Naive CD8 T Cells In Vivo to Proliferate, Develop Effector Function, and Differentiate into Memory Cells. J. Immunol. 175: 2071-2081 [Abstract] [Full Text]
Mascarell, L., Fayolle, C., Bauche, C., Ladant, D., Leclerc, C. (2005). Induction of Neutralizing Antibodies and Th1-Polarized and CD4-Independent CD8+ T-Cell Responses following Delivery of Human Immunodeficiency Virus Type 1 Tat Protein by Recombinant Adenylate Cyclase of Bordetella pertussis. J. Virol. 79: 9872-9884 [Abstract] [Full Text]
Moghaddami, M., Mayrhofer, G., Cleland, L. G. (2005). MHC class II compartment, endocytosis and phagocytic activity of macrophages and putative dendritic cells isolated from normal tissues rich in synovium. Int Immunol 17: 1117-1130 [Abstract] [Full Text]
Groh, V., Li, Y. Q., Cioca, D., Hunder, N. N., Wang, W., Riddell, S. R., Yee, C., Spies, T. (2005). From The Cover: Efficient cross-priming of tumor antigen-specific T cells by dendritic cells sensitized with diverse anti-MICA opsonized tumor cells. Proc. Natl. Acad. Sci. USA 102: 6461-6466 [Abstract] [Full Text]
Maeda, Y., Mukai, T., Spencer, J., Makino, M. (2005). Identification of an Immunomodulating Agent from Mycobacterium leprae. Infect. Immun. 73: 2744-2750 [Abstract] [Full Text]
Schnurr, M., Chen, Q., Shin, A., Chen, W., Toy, T., Jenderek, C., Green, S., Miloradovic, L., Drane, D., Davis, I. D., Villadangos, J., Shortman, K., Maraskovsky, E., Cebon, J. (2005). Tumor antigen processing and presentation depend critically on dendritic cell type and the mode of antigen delivery. Blood 105: 2465-2472 [Abstract] [Full Text]
Delamarre, L., Pack, M., Chang, H., Mellman, I., Trombetta, E. S. (2005). Differential Lysosomal Proteolysis in Antigen-Presenting Cells Determines Antigen Fate. Science 307: 1630-1634 [Abstract] [Full Text]
Rey-Ladino, J., Koochesfahani, K. M., Zaharik, M. L., Shen, C., Brunham, R. C. (2005). A Live and Inactivated Chlamydia trachomatis Mouse Pneumonitis Strain Induces the Maturation of Dendritic Cells That Are Phenotypically and Immunologically Distinct. Infect. Immun. 73: 1568-1577 [Abstract] [Full Text]
Yasumi, T., Katamura, K., Okafuji, I., Yoshioka, T., Meguro, T.-a., Nishikomori, R., Kusunoki, T., Heike, T., Nakahata, T. (2005). Limited Ability of Antigen-Specific Th1 Responses to Inhibit Th2 Cell Development In Vivo. J. Immunol. 174: 1325-1331 [Abstract] [Full Text]
Koller, M., Zwolfer, B., Steiner, G., Smolen, J. S., Scheinecker, C. (2004). Phenotypic and functional deficiencies of monocyte-derived dendritic cells in systemic lupus erythematosus (SLE) patients. Int Immunol 16: 1595-1604 [Abstract] [Full Text]
Rieger, L., Honig, A., Sutterlin, M., Kapp, M., Dietl, J., Ruck, P., Kammerer, U. (2004). Antigen-Presenting Cells in Human Endometrium During the Menstrual Cycle Compared to Early Pregnancy. Reproductive Sciences 11: 488-493 [Abstract]
Kikuchi, T., Hahn, C. L., Tanaka, S., Barbour, S. E., Schenkein, H. A., Tew, J. G. (2004). Dendritic Cells Stimulated with Actinobacillus actinomycetemcomitans Elicit Rapid Gamma Interferon Responses by Natural Killer Cells. Infect. Immun. 72: 5089-5096 [Abstract] [Full Text]
van Broekhoven, C. L., Parish, C. R., Demangel, C., Britton, W. J., Altin, J. G. (2004). Targeting Dendritic Cells with Antigen-Containing Liposomes: A Highly Effective Procedure for Induction of Antitumor Immunity and for Tumor Immunotherapy. Cancer Res. 64: 4357-4365 [Abstract] [Full Text]
Wu, S.-F., Liu, T.-M., Lin, Y.-C., Sytwu, H.-K., Juan, H.-F., Chen, S.-T., Shen, K.-L., Hsi, S.-C., Hsieh, S.-L. (2004). Immunomodulatory effect of decoy receptor 3 on the differentiation and function of bone marrow-derived dendritic cells in nonobese diabetic mice: from regulatory mechanism to clinical implication. J. Leukoc. Biol. 75: 293-306 [Abstract] [Full Text]
Geisbert, T. W., Hensley, L. E., Larsen, T., Young, H. A., Reed, D. S., Geisbert, J. B., Scott, D. P., Kagan, E., Jahrling, P. B., Davis, K. J. (2003). Pathogenesis of Ebola Hemorrhagic Fever in Cynomolgus Macaques: Evidence that Dendritic Cells Are Early and Sustained Targets of Infection. Am. J. Pathol. 163: 2347-2370 [Abstract] [Full Text]
Matsuyama, W., Faure, M., Yoshimura, T. (2003). Activation of Discoidin Domain Receptor 1 Facilitates the Maturation of Human Monocyte-Derived Dendritic Cells Through the TNF Receptor Associated Factor 6/TGF-{beta}-Activated Protein Kinase 1 Binding Protein 1{beta}/p38{alpha} Mitogen-Activated Protein Kinase Signaling Cascade. J. Immunol. 171: 3520-3532 [Abstract] [Full Text]
Xu, S., Koski, G. K., Faries, M., Bedrosian, I., Mick, R., Maeurer, M., Cheever, M. A., Cohen, P. A., Czerniecki, B. J. (2003). Rapid High Efficiency Sensitization of CD8+ T Cells to Tumor Antigens by Dendritic Cells Leads to Enhanced Functional Avidity and Direct Tumor Recognition Through an IL-12-Dependent Mechanism. J. Immunol. 171: 2251-2261 [Abstract] [Full Text]
Oldenhove, G., de Heusch, M., Urbain-Vansanten, G., Urbain, J., Maliszewski, C., Leo, O., Moser, M. (2003). CD4+ CD25+ Regulatory T Cells Control T Helper Cell Type 1 Responses to Foreign Antigens Induced by Mature Dendritic Cells In Vivo. JEM 198: 259-266 [Abstract] [Full Text]
Fujii, S.-i., Shimizu, K., Smith, C., Bonifaz, L., Steinman, R. M. (2003). Activation of Natural Killer T Cells by {alpha}-Galactosylceramide Rapidly Induces the Full Maturation of Dendritic Cells In Vivo and Thereby Acts as an Adjuvant for Combined CD4 and CD8 T Cell Immunity to a Coadministered Protein. JEM 198: 267-279 [Abstract] [Full Text]
Tschoep, K., Manning, T. C., Harlin, H., George, C., Johnson, M., Gajewski, T. F. (2003). Disparate functions of immature and mature human myeloid dendritic cells: implications for dendritic cell-based vaccines. J. Leukoc. Biol. 74: 69-80 [Abstract] [Full Text]
Saha, A., Chatterjee, S. K., Foon, K. A., Primus, F. J., Bhattacharya-Chatterjee, M. (2003). Murine Dendritic Cells Pulsed with an Anti-Idiotype Antibody Induce Antigen-specific Protective Antitumor Immunity. Cancer Res. 63: 2844-2854 [Abstract] [Full Text]
Kammerer, U., Eggert, A. O., Kapp, M., McLellan, A. D., Geijtenbeek, T. B. H., Dietl, J., van Kooyk, Y., Kampgen, E. (2003). Unique Appearance of Proliferating Antigen-Presenting Cells Expressing DC-SIGN (CD209) in the Decidua of Early Human Pregnancy. Am. J. Pathol. 162: 887-896 [Abstract] [Full Text]
Liu, K., Iyoda, T., Saternus, M., Kimura, Y., Inaba, K., Steinman, R. M. (2002). Immune Tolerance After Delivery of Dying Cells to Dendritic Cells In Situ. JEM 196: 1091-1097 [Abstract] [Full Text]
Laderach, D., Movassagh, M., Johnson, A., Mittler, R. S., Galy, A. (2002). 4-1BB co-stimulation enhances human CD8+ T cell priming by augmenting the proliferation and survival of effector CD8+ T cells. Int Immunol 14: 1155-1167 [Abstract] [Full Text]
Legge, K. L., Gregg, R. K., Maldonado-Lopez, R., Li, L., Caprio, J. C., Moser, M., Zaghouani, H. (2002). On the Role of Dendritic Cells in Peripheral T Cell Tolerance and Modulation of Autoimmunity. JEM 196: 217-227 [Abstract] [Full Text]
Shirota, H., Sano, K., Hirasawa, N., Terui, T., Ohuchi, K., Hattori, T., Tamura, G. (2002). B Cells Capturing Antigen Conjugated with CpG Oligodeoxynucleotides Induce Th1 Cells by Elaborating IL-12. J. Immunol. 169: 787-794 [Abstract] [Full Text]
Hiromatsu, K., Dascher, C. C., LeClair, K. P., Sugita, M., Furlong, S. T., Brenner, M. B., Porcelli, S. A. (2002). Induction of CD1-Restricted Immune Responses in Guinea Pigs by Immunization with Mycobacterial Lipid Antigens. J. Immunol. 169: 330-339 [Abstract] [Full Text]
Olasz, E. B., Linton, J., Katz, S. I. (2002). Soluble proteins and haptens on bone marrow-derived dendritic cells are presented to host CD4 T cells in an MHC-restricted manner. Int Immunol 14: 493-502 [Abstract] [Full Text]
McShane, H., Behboudi, S., Goonetilleke, N., Brookes, R., Hill, A. V. S. (2002). Protective Immunity against Mycobacterium tuberculosis Induced by Dendritic Cells Pulsed with both CD8+- and CD4+-T-Cell Epitopes from Antigen 85A. Infect. Immun. 70: 1623-1626 [Abstract] [Full Text]
Koido, S., Tanaka, Y., Chen, D., Kufe, D., Gong, J. (2002). The Kinetics of In Vivo Priming of CD4 and CD8 T Cells by Dendritic/Tumor Fusion Cells in MUC1-Transgenic Mice. J. Immunol. 168: 2111-2117 [Abstract] [Full Text]
De Smedt, T., Smith, J., Baum, P., Fanslow, W., Butz, E., Maliszewski, C. (2002). Ox40 Costimulation Enhances the Development of T Cell Responses Induced by Dendritic Cells In Vivo. J. Immunol. 168: 661-670 [Abstract] [Full Text]
Lyakh, L. A., Koski, G. K., Young, H. A., Spence, S. E., Cohen, P. A., Rice, N. R. (2002). Adenovirus type 5 vectors induce dendritic cell differentiation in human CD14+ monocytes cultured under serum-free conditions. Blood 99: 600-608 [Abstract] [Full Text]
Colino, J., Shen, Y., Snapper, C. M. (2001). Dendritic Cells Pulsed with Intact Streptococcus pneumoniae Elicit both Protein- and Polysaccharide-specific Immunoglobulin Isotype Responses In Vivo through Distinct Mechanisms. JEM 195: 1-14 [Abstract] [Full Text]
Kirk, C. J., Hartigan-O'Connor, D., Mule, J. J. (2001). The Dynamics of the T-Cell Antitumor Response: Chemokine-secreting Dendritic Cells Can Prime Tumor-reactive T Cells Extranodally. Cancer Res. 61: 8794-8802 [Abstract] [Full Text]
Qi, H., Popov, V., Soong, L. (2001). Leishmania amazonensis-Dendritic Cell Interactions In Vitro and the Priming of Parasite-Specific CD4+ T Cells In Vivo. J. Immunol. 167: 4534-4542 [Abstract] [Full Text]
Hawiger, D., Inaba, K., Dorsett, Y., Guo, M., Mahnke, K., Rivera, M., Ravetch, J. V., Steinman, R. M., Nussenzweig, M. C. (2001). Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo. JEM 194: 769-780 [Abstract] [Full Text]
Hogan, R. J., VanBeek, J., Broussard, D. R., Surman, S. L., Woodland, D. L. (2001). Identification of MHC Class II-Associated Peptides That Promote the Presentation of Toxic Shock Syndrome Toxin-1 to T Cells. J. Immunol. 166: 6514-6522 [Abstract] [Full Text]
McIlroy, D., Troadec, C., Grassi, F., Samri, A., Barrou, B., Autran, B., Debre, P., Feuillard, J., Hosmalin, A. (2001). Investigation of human spleen dendritic cell phenotype and distribution reveals evidence of in vivo activation in a subset of organ donors. Blood 97: 3470-3477 [Abstract] [Full Text]
Lenz, P., Day, P. M., Pang, Y.-Y. S., Frye, S. A., Jensen, P. N., Lowy, D. R., Schiller, J. T. (2001). Papillomavirus-Like Particles Induce Acute Activation of Dendritic Cells. J. Immunol. 166: 5346-5355 [Abstract] [Full Text]
Matsuoka, T., Tabata, H., Matsushita, S. (2001). Monocytes Are Differentially Activated Through HLA-DR, -DQ, and -DP Molecules Via Mitogen-Activated Protein Kinases. J. Immunol. 166: 2202-2208 [Abstract] [Full Text]
Sung, S.-s. J., Rose, C. E. Jr., Fu, S. M. (2001). Intratracheal Priming with Ovalbumin- and Ovalbumin 323-339 Peptide-Pulsed Dendritic Cells Induces Airway Hyperresponsiveness, Lung Eosinophilia, Goblet Cell Hyperplasia, and Inflammation. J. Immunol. 166: 1261-1271 [Abstract] [Full Text]
Yamamoto, N., Suzuki, S., Suzuki, Y., Shirai, A., Nakazawa, M., Suzuki, M., Takamasu, T., Nagashima, Y., Minami, M., Ishigatsubo, Y. (2001). Immune Response Induced by Airway Sensitization after Influenza A Virus Infection Depends on Timing of Antigen Exposure in Mice. J. Virol. 75: 499-505 [Abstract] [Full Text]
Nishiyama, T., Tachibana, M., Horiguchi, Y., Nakamura, K., Ikeda, Y., Takesako, K., Murai, M. (2001). Immunotherapy of Bladder Cancer Using Autologous Dendritic Cells Pulsed with Human Lymphocyte Antigen-A24-specific MAGE-3 Peptide. Clin. Cancer Res. 7: 23-31 [Abstract] [Full Text]
Kato, M., Neil, T. K., Fearnley, D. B., McLellan, A. D., Vuckovic, S., Hart, D. N. J. (2000). Expression of multilectin receptors and comparative FITC-dextran uptake by human dendritic cells. Int Immunol 12: 1511-1519 [Abstract] [Full Text]
Moulin, V., Andris, F., Thielemans, K., Maliszewski, C., Urbain, J., Moser, M. (2000). B Lymphocytes Regulate Dendritic Cell (Dc) Function in Vivo: Increased Interleukin 12 Production by DCs from B Cell-Deficient Mice Results in T Helper Cell Type 1 Deviation. JEM 192: 475-482 [Abstract] [Full Text]
Subauste, C. S., Wessendarp, M. (2000). Human Dendritic Cells Discriminate Between Viable and Killed Toxoplasma gondii Tachyzoites: Dendritic Cell Activation After Infection with Viable Parasites Results in CD28 and CD40 Ligand Signaling That Controls IL-12-Dependent and -Independent T Cell Production of IFN-{gamma}. J. Immunol. 165: 1498-1505 [Abstract] [Full Text]
Igietseme, J. U., Ananaba, G. A., Bolier, J., Bowers, S., Moore, T., Belay, T., Eko, F. O., Lyn, D., Black, C. M. (2000). Suppression of Endogenous IL-10 Gene Expression in Dendritic Cells Enhances Antigen Presentation for Specific Th1 Induction: Potential for Cellular Vaccine Development. J. Immunol. 164: 4212-4219 [Abstract] [Full Text]
Lambrecht, B. N., Pauwels, R. A., Fazekas de St. Groth, B. (2000). Induction of Rapid T Cell Activation, Division, and Recirculation by Intratracheal Injection of Dendritic Cells in a TCR Transgenic Model. J. Immunol. 164: 2937-2946 [Abstract] [Full Text]
Josien, R., Li, H.-L., Ingulli, E., Sarma, S., R.Wong, B., Vologodskaia, M., Steinman, R. M., Choi, Y. (2000). Trance, a Tumor Necrosis Factor Family Member, Enhances the Longevity and Adjuvant Properties of Dendritic Cells in Vivo. JEM 191: 495-502 [Abstract] [Full Text]
Liu, L., Usherwood, E. J., Blackman, M. A., Woodland, D. L. (1999). T-Cell Vaccination Alters the Course of Murine Herpesvirus 68 Infection and the Establishment of Viral Latency in Mice. J. Virol. 73: 9849-9857 [Abstract] [Full Text]
Crawford, K., Gabuzda, D., Pantazopoulos, V., Xu, J., Clement, C., Reinherz, E., Alper, C. A. (1999). Circulating CD2+ Monocytes Are Dendritic Cells. J. Immunol. 163: 5920-5928 [Abstract] [Full Text]
Baribaud, F., Maillard, I., Vacheron, S., Brocker, T., Diggelmann, H., Acha-Orbea, H. (1999). Role of Dendritic Cells in the Immune Response Induced by Mouse Mammary Tumor Virus Superantigen. J. Virol. 73: 8403-8410 [Abstract] [Full Text]
Ito, T., Inaba, M., Inaba, K., Toki, J., Sogo, S., Iguchi, T., Adachi, Y., Yamaguchi, K., Amakawa, R., Valladeau, J., Saeland, S., Fukuhara, S., Ikehara, S. (1999). A CD1a+/CD11c+ Subset of Human Blood Dendritic Cells Is a Direct Precursor of Langerhans Cells. J. Immunol. 163: 1409-1419 [Abstract] [Full Text]
Eggert, A. A. O., Schreurs, M. W. J., Boerman, O. C., Oyen, W. J. C., de Boer, A. J., Punt, C. J. A., Figdor, C. G., Adema, G. J. (1999). Biodistribution and Vaccine Efficiency of Murine Dendritic Cells Are Dependent on the Route of Administration. Cancer Res. 59: 3340-3345 [Abstract] [Full Text]
Dittel, B. N., Visintin, I., Merchant, R. M., Janeway, C. A. Jr. (1999). Presentation of the Self Antigen Myelin Basic Protein by Dendritic Cells Leads to Experimental Autoimmune Encephalomyelitis. J. Immunol. 163: 32-39 [Abstract] [Full Text]
Lambrecht, B. N., Carro-Muino, I., Vermaelen, K., Pauwels, R. A. (1999). Allergen-Induced Changes in Bone-Marrow Progenitor and Airway Dendritic Cells in Sensitized Rats. Am. J. Respir. Cell Mol. Bio. 20: 1165-1174 [Abstract] [Full Text]
Lu, H., Zhong, G. (1999). Interleukin-12 Production Is Required for Chlamydial Antigen-Pulsed Dendritic Cells To Induce Protection against Live Chlamydia trachomatis Infection. Infect. Immun. 67: 1763-1769 [Abstract] [Full Text]
Frank, I., Kacani, L., Stoiber, H., Stössel, H., Spruth, M., Steindl, F., Romani, N., Dierich, M. P. (1999). Human Immunodeficiency Virus Type 1�Derived from Cocultures of Immature Dendritic Cells with Autologous T Cells Carries T-Cell-Specific Molecules on Its Surface and Is Highly Infectious. J. Virol. 73: 3449-3454 [Abstract] [Full Text]
Murakami, M., Gurski, K. J., Marincola, F. M., Ackland, J., Steller, M. A. (1999). Induction of Specific CD8+ T-Lymphocyte Responses Using a Human Papillomavirus-16 E6/E7 Fusion Protein and Autologous Dendritic Cells. Cancer Res. 59: 1184-1187 [Abstract] [Full Text]
Maldonado-Lopez, R., De Smedt, T., Michel, P., Godfroid, J., Pajak, B., Heirman, C., Thielemans, K., Leo, O., Urbain, J., Moser, M. (1999). CD8{alpha}+ and CD8{alpha}- Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In Vivo. JEM 189: 587-592 [Abstract] [Full Text]
Smith, A. L., de St. Groth, B. F. (1999). Antigen-pulsed CD8{alpha}+ Dendritic Cells Generate an Immune Response after Subcutaneous Injection without Homing to the Draining Lymph Node. JEM 189: 593-598 [Abstract] [Full Text]
Jenkins, D. E., Yasukawa, L. L., Bergen, R., Benike, C., Engleman, E. G., Arvin, A. M. (1999). Comparison of Primary Sensitization of Naive Human T Cells to Varicella-Zoster Virus Peptides by Dendritic Cells In Vitro with Responses Elicited In Vivo by Varicella Vaccination. J. Immunol. 162: 560-567 [Abstract] [Full Text]
Stumbles, P. A., Thomas, J. A., Pimm, C. L., Lee, P. T., Venaille, T. J., Proksch, S., Holt, P. G. (1998). Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of Th1 Immunity. JEM 188: 2019-2031 [Abstract] [Full Text]
Porgador, A., Staats, H. F., Itoh, Y., Kelsall, B. L. (1998). Intranasal Immunization with Cytotoxic T-Lymphocyte Epitope Peptide and Mucosal Adjuvant Cholera Toxin: Selective Augmentation of Peptide-Presenting Dendritic Cells in Nasal Mucosa-Associated Lymphoid Tissue. Infect. Immun. 66: 5876-5881 [Abstract] [Full Text]
Brossart, P., Grunebach, F., Stuhler, G., Reichardt, V. L., Mohle, R., Kanz, L., Brugger, W. (1998). Generation of Functional Human Dendritic Cells From Adherent Peripheral Blood Monocytes by CD40 Ligation in the Absence of Granulocyte-Macrophage Colony-Stimulating Factor. Blood 92: 4238-4247 [Abstract] [Full Text]
Shimizu, Y., Guidotti, L. G., Fowler, P., Chisari, F. V. (1998). Dendritic Cell Immunization Breaks Cytotoxic T Lymphocyte Tolerance in Hepatitis B Virus Transgenic Mice. J. Immunol. 161: 4520-4529 [Abstract] [Full Text]
Bourguin, I., Moser, M., Buzoni-Gatel, D., Tielemans, F., Bout, D., Urbain, J., Leo, O. (1998). Murine Dendritic Cells Pulsed In Vitro with Toxoplasma gondii Antigens Induce Protective Immunity In Vivo. Infect. Immun. 66: 4867-4874 [Abstract] [Full Text]
Stenger, S., Niazi, K. R., Modlin, R. L. (1998). Down-Regulation of CD1 on Antigen-Presenting Cells by Infection with Mycobacterium tuberculosis. J. Immunol. 161: 3582-3588 [Abstract] [Full Text]
Dubois, B., Massacrier, C., Vanbervliet, B., Fayette, J., Briere, F., Banchereau, J., Caux, C. (1998). Critical Role of IL-12 in Dendritic Cell-Induced Differentiation of Naive B Lymphocytes. J. Immunol. 161: 2223-2231 [Abstract] [Full Text]
Guillaume, T., Rubinstein, D. B., Symann, M. (1998). Immune Reconstitution and Immunotherapy After Autologous Hematopoietic Stem Cell Transplantation. Blood 92: 1471-1490 [Full Text]
Wykes, M., Pombo, A., Jenkins, C., MacPherson, G. G. (1998). Dendritic Cells Interact Directly with Naive B Lymphocytes to Transfer Antigen and Initiate Class Switching in a Primary T-Dependent Response. J. Immunol. 161: 1313-1319 [Abstract] [Full Text]
Dieu, M.-C., Vanbervliet, B., Vicari, A., Bridon, J.-M., Oldham, E., Ait-Yahia, S., Briere, F., Zlotnik, A., Lebecque, S., Caux, C. (1998). Selective Recruitment of Immature and Mature Dendritic Cells by Distinct Chemokines Expressed in Different Anatomic Sites. JEM 188: 373-386 [Abstract] [Full Text]
Gong, J., Chen, D., Kashiwaba, M., Li, Y., Chen, L., Takeuchi, H., Qu, H., Rowse, G. J., Gendler, S. J., Kufe, D. (1998). Reversal of tolerance to human MUC1 antigen in MUC1 transgenic mice immunized with fusions of dendritic and carcinoma cells. Proc. Natl. Acad. Sci. USA 95: 6279-6283 [Abstract] [Full Text]
Singh, N., Bhatia, S., Abraham, R., Basu, S. K., George, A., Bal, V., Rath, S. (1998). Modulation of T Cell Cytokine Profiles and Peptide-MHC Complex Availability In Vivo by Delivery to Scavenger Receptors via Antigen Maleylation. J. Immunol. 160: 4869-4880 [Abstract] [Full Text]
Lambrecht, B. N., Salomon, B., Klatzmann, D., Pauwels, R. A. (1998). Dendritic Cells Are Required for the Development of Chronic Eosinophilic Airway Inflammation in Response to Inhaled Antigen in Sensitized Mice. J. Immunol. 160: 4090-4097 [Abstract] [Full Text]
Saudrais, C., Spehner, D., de la Salle, H., Bohbot, A., Cazenave, J.-P., Goud, B., Hanau, D., Salamero, J. (1998). Intracellular Pathway for the Generation of Functional MHC Class II Peptide Complexes in Immature Human Dendritic Cells. J. Immunol. 160: 2597-2607 [Abstract] [Full Text]
Dietz, A. B., Vuk-Pavlovic, S. (1998). High Efficiency Adenovirus-Mediated Gene Transfer to Human Dendritic Cells. Blood 91: 392-398 [Abstract] [Full Text]
Hart, D. N.J. (1997). Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response. Blood 90: 3245-3287 [Full Text]
Szabolcs, P., Gallardo, H.F., Ciocon, D. H., Sadelain, M., Young, J. W. (1997). Retrovirally Transduced Human Dendritic Cells Express a Normal Phenotype and Potent T-Cell Stimulatory Capacity. Blood 90: 2160-2167 [Abstract] [Full Text]
Zhong, G., Sousa, C. R. e, Germain, R. N. (1997). Antigen-unspecific B Cells and Lymphoid Dendritic Cells Both Show Extensive Surface Expression of Processed Antigen-Major Histocompatibility Complex Class II Complexes after Soluble Protein Exposure In Vivo or In Vitro. JEM 186: 673-682 [Abstract] [Full Text]
Brossart, P., Bevan, M. J. (1997). Presentation of Exogenous Protein Antigens on Major Histocompatability Complex Class I Molecules by Dendritic Cells: Pathway of Presentation and Regulation by Cytokines. Blood 90: 1594-1599 [Abstract] [Full Text]
Josien, R., Heslan, M., Soulillou, J.-P., Cuturi, M.-C. (1997). Rat Spleen Dendritic Cells Express Natural Killer Cell Receptor Protein 1 (NKR-P1) and Have Cytotoxic Activity to Select Targets via a Ca2+-dependent Mechanism. JEM 186: 467-472 [Abstract] [Full Text]
Chesney, J., Bacher, M., Bender, A., Bucala, R. (1997). The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naive T cells in�situ. Proc. Natl. Acad. Sci. USA 94: 6307-6312 [Abstract] [Full Text]
Song, E. S., Lee, V., Surh, C. D., Lynn, A., Brumm, D., Jolly, D. J., Warner, J. F., Chada, S. (1997). Antigen presentation in retroviral vector-mediated gene transfer�in�vivo. Proc. Natl. Acad. Sci. USA 94: 1943-1948 [Abstract] [Full Text]