Tumor necrosis factor alpha/cachectin and interleukin 1 beta initiate meningeal inflammation

doi:10.1084/jem.172.2.497

This Article

	Full Text (PDF, 983K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Ramilo, O.
	Articles by McCracken, G. H.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Ramilo, O.
	Articles by McCracken, G. H., Jr


Social Bookmarking

	What's this?

ARTICLES

Tumor necrosis factor alpha/cachectin and interleukin 1 beta initiate meningeal inflammation

O Ramilo, X Saez-Llorens, J Mertsola, H Jafari, KD Olsen, EJ Hansen, M Yoshinaga, S Ohkawara, H Nariuchi and GH McCracken Jr
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235.

Although previous studies using human cytokines in rabbits and rats have provided evidence of the participation of tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta) in the meningeal inflammatory cascade, the results obtained by several groups of investigators have been discordant or, at times, contradictory. In the present study, homologous cytokines were applied to the rabbit meningitis model. Intracisternal administration of 10(2)-10(5) IU of purified rabbit TNF-alpha (RaTNF-alpha) produced significant cerebrospinal fluid (CSF) inflammation. A similar response was observed after intracisternal inoculation of 5-200 ng of rabbit recombinant IL-1 beta (rrIL-1 beta). Preincubation of these two mediators with their specific antibodies resulted in an almost complete suppression of the CSF inflammatory response. In animals with Haemophilus influenzae type b lipooligosaccharide-induced meningitis, intracisternal administration of anti-rrIL-1 beta, anti-RaTNF-alpha, or both resulted in a significant modulation of meningeal inflammation. Simultaneous administration of 10(3) IU of RaTNF-alpha and 5 ng of rrIL-1 beta resulted in a synergistic inflammatory response manifested by a more rapid and significantly increased influx of white blood cells into the CSF compared with results after each cytokine given alone. These data provide evidence for a seminal role of TNF-alpha and IL-1 beta in the initial events of meningeal inflammation.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Tanabe, S.-i., Gottschalk, M., Grenier, D. (2008). Hemoglobin and Streptococcus suis cell wall act in synergy to potentiate the inflammatory response of monocyte-derived macrophages. Innate Immunity 14: 357-363 [Abstract]
Mildner, A., Djukic, M., Garbe, D., Wellmer, A., Kuziel, W. A., Mack, M., Nau, R., Prinz, M. (2008). Ly-6G+CCR2- Myeloid Cells Rather Than Ly-6ChighCCR2+ Monocytes Are Required for the Control of Bacterial Infection in the Central Nervous System. J. Immunol. 181: 2713-2722 [Abstract] [Full Text]
Rock, R. B., Olin, M., Baker, C. A., Molitor, T. W., Peterson, P. K. (2008). Central Nervous System Tuberculosis: Pathogenesis and Clinical Aspects. Clin. Microbiol. Rev. 21: 243-261 [Abstract] [Full Text]
Candelario-Jalil, E., Taheri, S., Yang, Y., Sood, R., Grossetete, M., Estrada, E. Y., Fiebich, B. L., Rosenberg, G. A. (2007). Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-{alpha} in the Rat. J. Pharmacol. Exp. Ther. 323: 488-498 [Abstract] [Full Text]
Virna, S., Deckert, M., Lutjen, S., Soltek, S., Foulds, K. E., Shen, H., Korner, H., Sedgwick, J. D., Schluter, D. (2006). TNF Is Important for Pathogen Control and Limits Brain Damage in Murine Cerebral Listeriosis. J. Immunol. 177: 3972-3982 [Abstract] [Full Text]
Haase, M. R. (2004). Acute Bacterial Meningitis in Children. Journal of Pharmacy Practice 17: 392-406 [Abstract]
Rios, A. M., Mejias, A., Chavez-Bueno, S., Fonseca-Aten, M., Katz, K., Hatfield, J., Gomez, A. M., Jafri, H. S., McCracken, G. H. Jr., Ramilo, O., Hardy, R. D. (2004). Impact of Cethromycin (ABT-773) Therapy on Microbiological, Histologic, Immunologic, and Respiratory Indices in a Murine Model of Mycoplasma pneumoniae Lower Respiratory Infection. Antimicrob. Agents Chemother. 48: 2897-2904 [Abstract] [Full Text]
Paul, R., Koedel, U., Winkler, F., Kieseier, B. C., Fontana, A., Kopf, M., Hartung, H.-P., Pfister, H.-W. (2003). Lack of IL-6 augments inflammatory response but decreases vascular permeability in bacterial meningitis. Brain 126: 1873-1882 [Abstract] [Full Text]
van der Flier, M., Geelen, S. P. M., Kimpen, J. L. L., Hoepelman, I. M., Tuomanen, E. I. (2003). Reprogramming the Host Response in Bacterial Meningitis: How Best To Improve Outcome?. Clin. Microbiol. Rev. 16: 415-429 [Abstract] [Full Text]
Tsenova, L., Mangaliso, B., Muller, G., Chen, Y., Freedman, V. H., Stirling, D., Kaplan, G. (2002). Use of IMiD3, a Thalidomide Analog, as an Adjunct to Therapy for Experimental Tuberculous Meningitis. Antimicrob. Agents Chemother. 46: 1887-1895 [Abstract] [Full Text]
Kolb-Maurer, A., Unkmeir, A., Kammerer, U., Hubner, C., Leimbach, T., Stade, A., Kampgen, E., Frosch, M., Dietrich, G. (2001). Interaction of Neisseria meningitidis with Human Dendritic Cells. Infect. Immun. 69: 6912-6922 [Abstract] [Full Text]
Deng, G.-M., Liu, Z.-Q., Tarkowski, A. (2001). Intracisternally Localized Bacterial DNA Containing CpG Motifs Induces Meningitis. J. Immunol. 167: 4616-4626 [Abstract] [Full Text]
Leib, S. L., Clements, J. M., Lindberg, R. L. P., Heimgartner, C., Loeffler, J. M., Pfister, L.-A., Tauber, M. G., Leppert, D. (2001). Inhibition of matrix metalloproteinases and tumour necrosis factor {alpha} converting enzyme as adjuvant therapy in pneumococcal meningitis. Brain 124: 1734-1742 [Abstract] [Full Text]
TSAO, N., HSU, H.P., WU, C.M., LIU, C.C., LEI, H.Y. (2001). Tumour necrosis factor-{alpha} causes an increase in blood-brain barrier permeability during sepsis. J Med Microbiol 50: 812-821 [Abstract] [Full Text]
Deckert, M., Soltek, S., Geginat, G., Lutjen, S., Montesinos-Rongen, M., Hof, H., Schluter, D. (2001). Endogenous Interleukin-10 Is Required for Prevention of a Hyperinflammatory Intracerebral Immune Response in Listeria monocytogenes Meningoencephalitis. Infect. Immun. 69: 4561-4571 [Abstract] [Full Text]
Galdiero, M., D'Amico, M., Gorga, F., Di Filippo, C., D'Isanto, M., Vitiello, M., Longanella, A., Tortora, A. (2001). Haemophilus influenzae Porin Contributes to Signaling of the Inflammatory Cascade in Rat Brain. Infect. Immun. 69: 221-227 [Abstract] [Full Text]
Lapinet, J. A., Scapini, P., Calzetti, F., Perez, O., Cassatella, M. A. (2000). Gene Expression and Production of Tumor Necrosis Factor Alpha, Interleukin-1beta (IL-1beta ), IL-8, Macrophage Inflammatory Protein 1alpha (MIP-1alpha ), MIP-1beta , and Gamma Interferon-Inducible Protein 10 by Human Neutrophils Stimulated with Group B Meningococcal Outer Membrane Vesicles. Infect. Immun. 68: 6917-6923 [Abstract] [Full Text]
Ostergaard, C., Yieng-Kow, R. V., Benfield, T., Frimodt-Moller, N., Espersen, F., Lundgren, J. D. (2000). Inhibition of Leukocyte Entry into the Brain by the Selectin Blocker Fucoidin Decreases Interleukin-1 (IL-1) Levels but Increases IL-8 Levels in Cerebrospinal Fluid during Experimental Pneumococcal Meningitis in Rabbits. Infect. Immun. 68: 3153-3157 [Abstract] [Full Text]
Leib, S. L., Leppert, D., Clements, J., Tauber, M. G. (2000). Matrix Metalloproteinases Contribute to Brain Damage in Experimental Pneumococcal Meningitis. Infect. Immun. 68: 615-620 [Abstract] [Full Text]
van Deuren, M., Brandtzaeg, P., van der Meer, J. W. M. (2000). Update on Meningococcal Disease with Emphasis on Pathogenesis and Clinical Management. Clin. Microbiol. Rev. 13: 144-166 [Abstract] [Full Text]
Tsao, N., Kanakamma, P. P., Luh, T.-Y., Chou, C.-K., Lei, H.-Y. (1999). Inhibition of Escherichia coli-Induced Meningitis by Carboxyfullerence. Antimicrob. Agents Chemother. 43: 2273-2277 [Abstract] [Full Text]
Segura, M., Stankova, J., Gottschalk, M. (1999). Heat-Killed Streptococcus suis Capsular Type 2 Strains Stimulate Tumor Necrosis Factor Alpha and Interleukin-6 Production by Murine Macrophages. Infect. Immun. 67: 4646-4654 [Abstract] [Full Text]
Burgner, D., Rockett, K., Kwiatkowski, D. (1999). Nitric oxide and infectious diseases. Arch. Dis. Child. 81: 185-188 [Full Text]
Ostergaard, C., Benfield, T., Gesser, B., Kharazmi, A., Frimodt-Moller, N., Espersen, F., Lundgren, J. D. (1999). Pretreatment with Granulocyte Colony-Stimulating Factor Attenuates the Inflammatory Response but Not the Bacterial Load in Cerebrospinal Fluid during Experimental Pneumococcal Meningitis in Rabbits. Infect. Immun. 67: 3430-3436 [Abstract] [Full Text]
Tsenova, L., Bergtold, A., Freedman, V. H., Young, R. A., Kaplan, G. (1999). Tumor necrosis factor alpha �is a determinant of pathogenesis and disease progression in mycobacterial infection in the central nervous system. Proc. Natl. Acad. Sci. USA 96: 5657-5662 [Abstract] [Full Text]
Diab, A., Abdalla, H., Li, H. L., Shi, F. D., Zhu, J., Hojberg, B., Lindquist, L., Wretlind, B., Bakhiet, M., Link, H. (1999). Neutralization of Macrophage Inflammatory Protein 2�(MIP-2) and MIP-1alpha Attenuates Neutrophil Recruitment in the Central Nervous System during Experimental Bacterial Meningitis. Infect. Immun. 67: 2590-2601 [Abstract] [Full Text]
Cauwels, A., Frei, K., Sansano, S., Fearns, C., Ulevitch, R., Zimmerli, W., Landmann, R. (1999). The Origin and Function of Soluble CD14 in Experimental Bacterial Meningitis. J. Immunol. 162: 4762-4772 [Abstract] [Full Text]
Wang, C. Y., Naka, Y., Liao, H., Oz, M. C., Springer, T. A., Gutierrez-Ramos, J.-C., Pinsky, D. J. (1998). Cardiac Graft Intercellular Adhesion Molecule-1 (ICAM-1) and Interleukin-1 Expression Mediate Primary Isograft Failure and Induction of ICAM-1 in Organs Remote From the Site of Transplantation. Circ. Res. 82: 762-772 [Abstract] [Full Text]
Quagliarello, V. J., Scheld, W. M. (1997). Treatment of Bacterial Meningitis. NEJM 336: 708-716 [Full Text]
Worrall, N. K., Chang, K., Suau, G. M., Allison, W. S., Misko, T. P., Sullivan, P. M., Tilton, R. G., Williamson, J. R., Ferguson, T. B. Jr (1996). Inhibition of Inducible Nitric Oxide Synthase Prevents Myocardial and Systemic Vascular Barrier Dysfunction During Early Cardiac Allograft Rejection. Circ. Res. 78: 769-779 [Abstract] [Full Text]
Mertsola, J., Kennedy, W. A., Waagner, D., Saez-Llorens, X., Olsen, K., Hansen, E. J., McCracken, G. H. Jr (1991). Endotoxin Concentrations in Cerebrospinal Fluid Correlate With Clinical Severity and Neurologic Outcome of Haemophilus influenzae Type B Meningitis. Arch Pediatr Adolesc Med 145: 1099-1103 [Abstract]