An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice

doi:10.1084/jem.171.6.1919

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An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice

A Puccetti, T Koizumi, P Migliorini, J Andre-Schwartz, KJ Barrett and RS Schwartz
Department of Medicine, Tufts University School of Medicine, Boston, MA 02111.

Autoantibodies against the 70-kD U1 RNP nucleoprotein autoantigen and DNA were elicited in normal BALB/c mice with a purified Ig light chain. This light chain, derived from a lupus-prone MRL-lpr/lpr mouse, has two distinctive properties: it contains an idiotypic marker recognized by a monoclonal MRL-lpr/lpr anti-snRNP autoantibody, and the amino acid sequence of its third hypervariable region (CDR3) is homologous to a sequence in an antigenic region of the 70-kD U1 RNP polypeptide. The results demonstrate that an Ig idiotype that mimics an autoantigen can induce autoimmunization.
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