Differential expression of CD45RO (UCHL1) and its functional relevance in two subpopulations of circulating TCR-gamma/delta+ lymphocytes

doi:10.1084/jem.171.5.1833

This Article

	Full Text (PDF, 413K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Miyawaki, T.
	Articles by Taniguchi, N.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Miyawaki, T.
	Articles by Taniguchi, N.


Social Bookmarking

	What's this?

ARTICLES

Differential expression of CD45RO (UCHL1) and its functional relevance in two subpopulations of circulating TCR-gamma/delta+ lymphocytes

T Miyawaki, Y Kasahara, K Taga, A Yachie and N Taniguchi
Department of Pediatrics, School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan.

We examined the developmental profile of TCR-gamma/delta+ cells with respect to CD45RO expression. Although total TCR-gamma/delta+ cells were negligible in the neonatal blood and increased with advancing age, most blood TCR-gamma/delta+ cells markedly expressed CD45RO without a distinction of age, probably reflecting a different CD45RO expression of two subsets defined by BB3 and delta TCS1 mAbs. The vast majority of BB3+ cells expressed CD45RO, whereas expression of CD45RO was virtually absent in the delta TCS1+ population. Functional studies revealed that, while both TCR-gamma/delta+ cell subsets showed CD3-mediated activation, only BB3+ (or Ti gamma A+) cells, but not delta TCS1+ cells, appeared to proliferate in response to PPD in PPD-reactive individuals. The results suggested that the CD45RO+ (BB3+ or Ti gamma A+) subset among blood TCR-gamma/delta+ cells may be mainly involved in the memory or primed component of the immune system responding to some foreign antigens.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Oberg, H.-H., Wesch, D., Grussel, S., Rose-John, S., Kabelitz, D. (2006). Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25- and CD25high regulatory T cells. Int Immunol 18: 555-563 [Abstract] [Full Text]
De Rosa, S. C., Andrus, J. P., Perfetto, S. P., Mantovani, J. J., Herzenberg, L. A., Herzenberg, L. A., Roederer, M. (2004). Ontogeny of {gamma}{delta} T Cells in Humans. J. Immunol. 172: 1637-1645 [Abstract] [Full Text]
Glatzel, A., Wesch, D., Schiemann, F., Brandt, E., Janssen, O., Kabelitz, D. (2002). Patterns of Chemokine Receptor Expression on Peripheral Blood {gamma}{delta} T Lymphocytes: Strong Expression of CCR5 Is a Selective Feature of V{delta}2/V{gamma}9 {gamma}{delta} T Cells. J. Immunol. 168: 4920-4929 [Abstract] [Full Text]
De Rosa, S. C., Mitra, D. K., Watanabe, N., Herzenberg, L. A., Herzenberg, L. A., Roederer, M. (2001). V{delta}1 and V{delta}2 {gamma}{delta} T cells express distinct surface markers and might be developmentally distinct lineages. J. Leukoc. Biol. 70: 518-526 [Abstract] [Full Text]
Yamamoto, J., Adachi, Y., Onoue, Y., Adachi, Y. S., Okabe, Y., Itazawa, T., Toyoda, M., Seki, T., Morohashi, M., Matsushima, K., Miyawaki, T. (2000). Differential expression of the chemokine receptors by the Th1- and Th2-type effector populations within circulating CD4+ T cells. J. Leukoc. Biol. 68: 568-574 [Abstract] [Full Text]