Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide

doi:10.1084/jem.171.5.1815

This Article

	Full Text (PDF, 328K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Aichele, P.
	Articles by Schulz, M.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Aichele, P.
	Articles by Schulz, M.


Social Bookmarking

	What's this?

ARTICLES

Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide

P Aichele, H Hengartner, RM Zinkernagel and M Schulz
Institute of Pathology, University Hospital, Zurich, Switzerland.

Induction in vivo of antiviral cytotoxic T cell response was achieved in a MHC class I-dependent fashion by immunizing mice three times with a free unmodified 15-mer peptide derived from the nucleoprotein of lymphocytic choriomeningitis virus in IFA. The effector T cells are CD8+, restricted to the class I Ld allele of the analyzed mouse strain, and are specific both at the level of secondary restimulation in vitro and at the effector T cell level. These results suggest that cocktails of viral peptides may be used as antiviral T cell vaccines.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Bijker, M. S., van den Eeden, S. J. F., Franken, K. L., Melief, C. J. M., Offringa, R., van der Burg, S. H. (2007). CD8+ CTL Priming by Exact Peptide Epitopes in Incomplete Freund's Adjuvant Induces a Vanishing CTL Response, whereas Long Peptides Induce Sustained CTL Reactivity. J. Immunol. 179: 5033-5040 [Abstract] [Full Text]
Regner, M., Martinez, X., Belnoue, E., Sun, C.-M., Boisgerault, F., Lambert, P.-H., Leclerc, C., Siegrist, C.-A. (2004). Partial Activation of Neonatal CD11c+ Dendritic Cells and Induction of Adult-Like CD8+ Cytotoxic T Cell Responses by Synthetic Microspheres. J. Immunol. 173: 2669-2674 [Abstract] [Full Text]
Bansal-Pakala, P., Halteman, B. S., Cheng, M. H.-Y., Croft, M. (2004). Costimulation of CD8 T Cell Responses by OX40. J. Immunol. 172: 4821-4825 [Abstract] [Full Text]
Deliyannis, G., Jackson, D. C., Ede, N. J., Zeng, W., Hourdakis, I., Sakabetis, E., Brown, L. E. (2002). Induction of Long-Term Memory CD8+ T Cells for Recall of Viral Clearing Responses against Influenza Virus. J. Virol. 76: 4212-4221 [Abstract] [Full Text]
Dadaglio, G., Sun, C.-M., Lo-Man, R., Siegrist, C. A., Leclerc, C. (2002). Efficient In Vivo Priming of Specific Cytotoxic T Cell Responses by Neonatal Dendritic Cells. J. Immunol. 168: 2219-2224 [Abstract] [Full Text]
Vogel, T. U., Beer, B. E., zur Megede, J., Ihlenfeldt, H.-G., Jung, G., Holzammer, S., Watkins, D. I., Altman, J. D., Kurth, R., Norley, S. (2002). Induction of anti-simian immunodeficiency virus cellular and humoral immune responses in rhesus macaques by peptide immunogens: correlation of CTL activity and reduction of cell-associated but not plasma virus load following challenge. J. Gen. Virol. 83: 81-91 [Abstract] [Full Text]
Schlecht, G., Leclerc, C., Dadaglio, G. (2001). Induction of CTL and Nonpolarized Th Cell Responses by CD8{alpha}+ and CD8{alpha}- Dendritic Cells. J. Immunol. 167: 4215-4221 [Abstract] [Full Text]
Fayolle, C., Osickova, A., Osicka, R., Henry, T., Rojas, M.-J., Saron, M.-F., Sebo, P., Leclerc, C. (2001). Delivery of Multiple Epitopes by Recombinant Detoxified Adenylate Cyclase of Bordetella pertussis Induces Protective Antiviral Immunity. J. Virol. 75: 7330-7338 [Abstract] [Full Text]
Muderspach, L., Wilczynski, S., Roman, L., Bade, L., Felix, J., Small, L. A., Kast, W. M., Fascio, G., Marty, V., Weber, J. (2000). A Phase I Trial of a Human Papillomavirus (HPV) Peptide Vaccine for Women with High-Grade Cervical and Vulvar Intraepithelial Neoplasia Who Are HPV 16 Positive. Clin. Cancer Res. 6: 3406-3416 [Abstract] [Full Text]
Dadaglio, G., Moukrim, Z., Lo-Man, R., Sheshko, V., Sebo, P., Leclerc, C. (2000). Induction of a Polarized Th1 Response by Insertion of Multiple Copies of a Viral T-Cell Epitope into Adenylate Cyclase of Bordetella pertussis. Infect. Immun. 68: 3867-3872 [Abstract] [Full Text]
Sedlik, C., Dadaglio, G., Saron, M. F., Deriaud, E., Rojas, M., Casal, S. I., Leclerc, C. (2000). In Vivo Induction of a High-Avidity, High-Frequency Cytotoxic T-Lymphocyte Response Is Associated with Antiviral Protective Immunity. J. Virol. 74: 5769-5775 [Abstract] [Full Text]
Tan, J. T., Whitmire, J. K., Murali-Krishna, K., Ahmed, R., Altman, J. D., Mittler, R. S., Sette, A., Pearson, T. C., Larsen, C. P. (2000). 4-1BB Costimulation Is Required for Protective Anti-Viral Immunity After Peptide Vaccination. J. Immunol. 164: 2320-2325 [Abstract] [Full Text]
de Cerio, A. L.-D., Casares, N., Lasarte, J. J., Sarobe, P., Perez-Mediavilla, L. A., Ruiz, M., Prieto, J., Borras-Cuesta, F. (1999). Th1 but not Th0 cell help is efficient to induce cytotoxic T lymphocytes by immunization with short synthetic peptides. Int Immunol 11: 2025-2034 [Abstract] [Full Text]
Desmézières, E., Jacob, Y., Saron, M.-F., Delpeyroux, F., Tordo, N., Perrin, P. (1999). Lyssavirus glycoproteins expressing immunologically potent foreign B cell and cytotoxic T lymphocyte epitopes as prototypes for multivalent vaccines. J. Gen. Virol. 80: 2343-2351 [Abstract] [Full Text]
Ludewig, B., Oehen, S., Barchiesi, F., Schwendener, R. A., Hengartner, H., Zinkernagel, R. M. (1999). Protective Antiviral Cytotoxic T Cell Memory Is Most Efficiently Maintained by Restimulation Via Dendritic Cells. J. Immunol. 163: 1839-1844 [Abstract] [Full Text]
Sedlik, C., Dridi, A., Deriaud, E., Saron, M. F., Rueda, P., Sarraseca, J., Casal, J. I., Leclerc, C. (1999). Intranasal Delivery of Recombinant Parvovirus-Like Particles Elicits Cytotoxic T-Cell and Neutralizing Antibody Responses. J. Virol. 73: 2739-2744 [Abstract] [Full Text]
Ludewig, B., Ehl, S., Karrer, U., Odermatt, B., Hengartner, H., Zinkernagel, R. M. (1998). Dendritic Cells Efficiently Induce Protective Antiviral Immunity. J. Virol. 72: 3812-3818 [Abstract] [Full Text]
Sedlik, C., Saron, M.-F., Sarraseca, J., Casal, I., Leclerc, C. (1997). Recombinant parvovirus-like particles as an antigen carrier: A novel nonreplicative exogenous antigen to elicit protective antiviral cytotoxic�T�cells. Proc. Natl. Acad. Sci. USA 94: 7503-7508 [Abstract] [Full Text]
Saron, M. F., Fayolle, C., Sebo, P., Ladant, D., Ullmann, A., Leclerc, C. (1997). Anti-viral protection conferred by recombinant adenylate cyclase toxins from Bordetella pertussis carrying a CD8+ T cell epitope from lymphocytic choriomeningitis�virus. Proc. Natl. Acad. Sci. USA 94: 3314-3319 [Abstract] [Full Text]
Pihlgren, M., Dubois, P. M., Tomkowiak, M., Sjogren, T., Marvel, J. (1996). Resting Memory CD8+ T Cells are Hyperreactive to Antigenic Challenge In Vitro. JEM 184: 2141-2152 [Abstract] [Full Text]