Genetically determined lack of CD45R- T cells in healthy individuals. Evidence for a regulatory polymorphism of CD45R antigen expression

doi:10.1084/jem.171.5.1803

This Article

	Full Text (PDF, 394K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Schwinzer, R.
	Articles by Wonigeit, K.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Schwinzer, R.
	Articles by Wonigeit, K.


Social Bookmarking

	What's this?

ARTICLES

Genetically determined lack of CD45R- T cells in healthy individuals. Evidence for a regulatory polymorphism of CD45R antigen expression

R Schwinzer and K Wonigeit
Klinik fur Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, Federal Republic of Germany.

A genetic polymorphism of CD45R expression was identified resulting in a lack of CD45R- lymphocytes in approximately 8% of healthy individuals. Family studies revealed an autosomal dominant mode of inheritance of the variant CD45R expression pattern. PBMC from donors possessing the variant type did not lose the CD45R antigen after in vitro activation, whereas a decrease of CD45R molecules was readily detected in individuals with the normal pattern. The expression of CD45RO antigens, as well as memory cell function, did not differ between both groups. These data show that activation and in vivo priming of T cells is not necessarily associated with a loss of CD45R antigen expression.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Do, H.-T., Baars, W., Borns, K., Windhagen, A., Schwinzer, R. (2006). The 77C->G Mutation in the Human CD45 (PTPRC) Gene Leads to Increased Intensity of TCR Signaling in T Cell Lines from Healthy Individuals and Patients with Multiple Sclerosis. J. Immunol. 176: 931-938 [Abstract] [Full Text]
Tchilian, E. Z., Dawes, R., Hyland, L., Montoya, M., Le Bon, A., Borrow, P., Hou, S., Tough, D., Beverley, P. C. L. (2004). Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice. Int Immunol 16: 1323-1332 [Abstract] [Full Text]
Stanton, T., Boxall, S., Hirai, K., Dawes, R., Tonks, S., Yasui, T., Kanaoka, Y., Yuldasheva, N., Ishiko, O., Bodmer, W., Beverley, P. C. L., Tchilian, E. Z. (2003). A high-frequency polymorphism in exon 6 of the CD45 tyrosine phosphatase gene (PTPRC) resulting in altered isoform expression. Proc. Natl. Acad. Sci. USA 100: 5997-6002 [Abstract] [Full Text]
Tchilian, E. Z., Wallace, D. L., Imami, N., Liao, H.-X., Burton, C., Gotch, F., Martinson, J., Haynes, B. F., Beverley, P. C. L. (2001). The Exon A (C77G) Mutation Is a Common Cause of Abnormal CD45 Splicing in Humans. J. Immunol. 166: 6144-6148 [Abstract] [Full Text]
Liao, H.-X., Montefiori, D. C., Patel, D. D., Lee, D. M., Scott, W. K., Pericak-Vance, M., Haynes, B. F. (2000). Linkage of the CCR5{Delta}32 Mutation with a Functional Polymorphism of CD45RA. J. Immunol. 165: 148-157 [Abstract] [Full Text]
Holland, S. M., Eisenstein, E. M., Kuhns, D. B., Turner, M. L., Fleisher, T. A., Strober, W., Gallin, J. I. (1994). Treatment of Refractory Disseminated Nontuberculous Mycobacterial Infection With Interferon Gamma: A Preliminary Report. NEJM 330: 1348-1355 [Abstract] [Full Text]
Lynch, K. W., Weiss, A. (2001). A CD45 Polymorphism Associated with Multiple Sclerosis Disrupts an Exonic Splicing Silencer. J. Biol. Chem. 276: 24341-24347 [Abstract] [Full Text]