Journal of Experimental Medicine, Vol 171, 1785-1790, Copyright © 1990 by Rockefeller University Press
Synthesis of granulocyte colony-stimulating factor and its requirement for terminal divisions in chronic myelogenous leukemia
H Klein, R Becher, M Lubbert, W Oster, E Schleiermacher, MA Brach, L Souza, A Lindemann, RH Mertelsmann and F Herrmann
University of Freiburg, Department of Hematology and Oncology, Federal Republic of Germany.
In this paper we demonstrate that maturing neoplastic cells from patients
with chronic myelogenous leukemia (CML) constitutively produce G-CSF and
are also receptive for this molecule. G-CSF functions as an autocrine
growth factor in stable phase CML, and thus is responsible for divisions of
maturing leukemic cells leading to an expansion of the compartment of
mature cells. This observation is well in line with in vivo features of CML
in stable phase, i.e., the hyperplasia of the mature granulocyte
compartment. In acute blastic phase of CML expression of the G-CSF gene
seems to be less common and not related to autonomous blast growth.
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