Intracerebroventricular injection of interleukin 1 induces high circulating levels of interleukin 6

doi:10.1084/jem.171.5.1773

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Intracerebroventricular injection of interleukin 1 induces high circulating levels of interleukin 6

MG De Simoni, M Sironi, A De Luigi, A Manfridi, A Mantovani and P Ghezzi
Unit of Neurotransmitter Metabolism, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

IL-1 is known to have a central role in the induction of acute-phase response, and some of its activities (including induction of some acute- phase proteins) were reported to be mediated by an induction of IL-6. Administration to rats of 200 ng of human rIL-1 by intracerebroventricular injection resulted in a more marked induction of circulating IL-6 than the same dose of IL-1 administered systemically (intravenously or intraperitoneally). Induction of serum IL-6 by centrally administered IL-1 was also observed in hypophysectomized or adrenalectomized rats, suggesting that activation of the hypothalamus-pituitary-adrenal axis is not essential for this effect of IL-1. IL-6 induction was also observed after pretreatment with indomethacin, indicating that the effect was dissociated from the pyrogenic activity of IL-1. Induction of IL-6 by a central action could represent a novel pathway in IL-1-induced acute-phase response.
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